Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)

Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echoloc...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Dong, Dong [verfasserIn] Lei, Ming Liu, Yang Zhang, Shuyi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Gene Ontology Gene Expression Divergence Ultrasonic Sound Skull Structure TMC1 Gene

Anmerkung:	© Dong et al.; licensee BioMed Central Ltd. 2013

Übergeordnetes Werk:	Enthalten in: BMC genomics - London : BioMed Central, 2000, 14(2013), 1 vom: 23. Dez.
Übergeordnetes Werk:	volume:14 ; year:2013 ; number:1 ; day:23 ; month:12

Links:	Volltext

DOI / URN:	10.1186/1471-2164-14-916

Katalog-ID:	SPR027084787

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520			\|a Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits.
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allfields	10.1186/1471-2164-14-916 doi (DE-627)SPR027084787 (SPR)1471-2164-14-916-e DE-627 ger DE-627 rakwb eng Dong, Dong verfasserin aut Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Dong et al.; licensee BioMed Central Ltd. 2013 Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. Gene Ontology (dpeaa)DE-He213 Gene Expression Divergence (dpeaa)DE-He213 Ultrasonic Sound (dpeaa)DE-He213 Skull Structure (dpeaa)DE-He213 TMC1 Gene (dpeaa)DE-He213 Lei, Ming aut Liu, Yang aut Zhang, Shuyi aut Enthalten in BMC genomics London : BioMed Central, 2000 14(2013), 1 vom: 23. Dez. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:14 year:2013 number:1 day:23 month:12 https://dx.doi.org/10.1186/1471-2164-14-916 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2013 1 23 12
spelling	10.1186/1471-2164-14-916 doi (DE-627)SPR027084787 (SPR)1471-2164-14-916-e DE-627 ger DE-627 rakwb eng Dong, Dong verfasserin aut Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Dong et al.; licensee BioMed Central Ltd. 2013 Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. Gene Ontology (dpeaa)DE-He213 Gene Expression Divergence (dpeaa)DE-He213 Ultrasonic Sound (dpeaa)DE-He213 Skull Structure (dpeaa)DE-He213 TMC1 Gene (dpeaa)DE-He213 Lei, Ming aut Liu, Yang aut Zhang, Shuyi aut Enthalten in BMC genomics London : BioMed Central, 2000 14(2013), 1 vom: 23. Dez. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:14 year:2013 number:1 day:23 month:12 https://dx.doi.org/10.1186/1471-2164-14-916 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2013 1 23 12
allfields_unstemmed	10.1186/1471-2164-14-916 doi (DE-627)SPR027084787 (SPR)1471-2164-14-916-e DE-627 ger DE-627 rakwb eng Dong, Dong verfasserin aut Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Dong et al.; licensee BioMed Central Ltd. 2013 Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. Gene Ontology (dpeaa)DE-He213 Gene Expression Divergence (dpeaa)DE-He213 Ultrasonic Sound (dpeaa)DE-He213 Skull Structure (dpeaa)DE-He213 TMC1 Gene (dpeaa)DE-He213 Lei, Ming aut Liu, Yang aut Zhang, Shuyi aut Enthalten in BMC genomics London : BioMed Central, 2000 14(2013), 1 vom: 23. Dez. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:14 year:2013 number:1 day:23 month:12 https://dx.doi.org/10.1186/1471-2164-14-916 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2013 1 23 12
allfieldsGer	10.1186/1471-2164-14-916 doi (DE-627)SPR027084787 (SPR)1471-2164-14-916-e DE-627 ger DE-627 rakwb eng Dong, Dong verfasserin aut Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Dong et al.; licensee BioMed Central Ltd. 2013 Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. Gene Ontology (dpeaa)DE-He213 Gene Expression Divergence (dpeaa)DE-He213 Ultrasonic Sound (dpeaa)DE-He213 Skull Structure (dpeaa)DE-He213 TMC1 Gene (dpeaa)DE-He213 Lei, Ming aut Liu, Yang aut Zhang, Shuyi aut Enthalten in BMC genomics London : BioMed Central, 2000 14(2013), 1 vom: 23. Dez. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:14 year:2013 number:1 day:23 month:12 https://dx.doi.org/10.1186/1471-2164-14-916 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2013 1 23 12
allfieldsSound	10.1186/1471-2164-14-916 doi (DE-627)SPR027084787 (SPR)1471-2164-14-916-e DE-627 ger DE-627 rakwb eng Dong, Dong verfasserin aut Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Dong et al.; licensee BioMed Central Ltd. 2013 Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. Gene Ontology (dpeaa)DE-He213 Gene Expression Divergence (dpeaa)DE-He213 Ultrasonic Sound (dpeaa)DE-He213 Skull Structure (dpeaa)DE-He213 TMC1 Gene (dpeaa)DE-He213 Lei, Ming aut Liu, Yang aut Zhang, Shuyi aut Enthalten in BMC genomics London : BioMed Central, 2000 14(2013), 1 vom: 23. Dez. (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:14 year:2013 number:1 day:23 month:12 https://dx.doi.org/10.1186/1471-2164-14-916 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2013 1 23 12
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topic_facet	Gene Ontology Gene Expression Divergence Ultrasonic Sound Skull Structure TMC1 Gene
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However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. 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author	Dong, Dong
spellingShingle	Dong, Dong misc Gene Ontology misc Gene Expression Divergence misc Ultrasonic Sound misc Skull Structure misc TMC1 Gene Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)
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topic_title	Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx) Gene Ontology (dpeaa)DE-He213 Gene Expression Divergence (dpeaa)DE-He213 Ultrasonic Sound (dpeaa)DE-He213 Skull Structure (dpeaa)DE-He213 TMC1 Gene (dpeaa)DE-He213
topic	misc Gene Ontology misc Gene Expression Divergence misc Ultrasonic Sound misc Skull Structure misc TMC1 Gene
topic_unstemmed	misc Gene Ontology misc Gene Expression Divergence misc Ultrasonic Sound misc Skull Structure misc TMC1 Gene
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title	Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)
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title_full	Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)
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author_browse	Dong, Dong Lei, Ming Liu, Yang Zhang, Shuyi
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title_sort	comparative inner ear transcriptome analysis between the rickett’s big-footed bats (myotis ricketti) and the greater short-nosed fruit bats (cynopterus sphinx)
title_auth	Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)
abstract	Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. © Dong et al.; licensee BioMed Central Ltd. 2013
abstractGer	Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. © Dong et al.; licensee BioMed Central Ltd. 2013
abstract_unstemmed	Background Bats have aroused great interests of researchers for the sake of their advanced echolocation system. However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. Conclusion Our work presents the first transcriptome comparison between echolocating and non-echolocating bats, and provides information about the genetic basis of their distinct hearing traits. © Dong et al.; licensee BioMed Central Ltd. 2013
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title_short	Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)
url	https://dx.doi.org/10.1186/1471-2164-14-916
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However, this highly specialized trait is not characteristic of Old World fruit bats. Results To comprehensively explore the underlying molecular basis between echolocating and non-echolocating bats, we employed a sequence-based approach to compare the inner ear expression difference between the Rickett’s big-footed bat (Myotis ricketti, echolocating bat) and the Greater short-nosed fruit bat (Cynopterus sphinx, non-echolocating bat). De novo sequence assemblies were developed for both species. The results showed that the biological implications of up-regulated genes in M. ricketti were significantly over-represented in biological process categories such as ‘cochlea morphogenesis’, ‘inner ear morphogenesis’ and ‘sensory perception of sound’, which are consistent with the inner ear morphological and physiological differentiation between the two bat species. Moreover, the expression of TMC1 gene confirmed its important function in echolocating bats. 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Comparative inner ear transcriptome analysis between the Rickett’s big-footed bats (Myotis ricketti) and the greater short-nosed fruit bats (Cynopterus sphinx)

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