A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs
Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circul...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Russo, Francesco [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Anmerkung: |
© Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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| Übergeordnetes Werk: |
Enthalten in: BMC genomics - London : BioMed Central, 2000, 15(2014), Suppl 3 vom: 06. Mai |
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| Übergeordnetes Werk: |
volume:15 ; year:2014 ; number:Suppl 3 ; day:06 ; month:05 |
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| DOI / URN: |
10.1186/1471-2164-15-S3-S4 |
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| Katalog-ID: |
SPR027101592 |
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| 520 | |a Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. | ||
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| 650 | 4 | |a Extracellular miRNAs |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Exosomal miRNAs |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Di Bella, Sebastiano |4 aut | |
| 700 | 1 | |a Bonnici, Vincenzo |4 aut | |
| 700 | 1 | |a Laganà, Alessandro |4 aut | |
| 700 | 1 | |a Rainaldi, Giuseppe |4 aut | |
| 700 | 1 | |a Pellegrini, Marco |4 aut | |
| 700 | 1 | |a Pulvirenti, Alfredo |4 aut | |
| 700 | 1 | |a Giugno, Rosalba |4 aut | |
| 700 | 1 | |a Ferro, Alfredo |4 aut | |
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10.1186/1471-2164-15-S3-S4 doi (DE-627)SPR027101592 (SPR)1471-2164-15-S3-S4-e DE-627 ger DE-627 rakwb eng Russo, Francesco verfasserin aut A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. miRNA Expression (dpeaa)DE-He213 miRNA Expression Profile (dpeaa)DE-He213 Extracellular Form (dpeaa)DE-He213 Extracellular miRNAs (dpeaa)DE-He213 Exosomal miRNAs (dpeaa)DE-He213 Di Bella, Sebastiano aut Bonnici, Vincenzo aut Laganà, Alessandro aut Rainaldi, Giuseppe aut Pellegrini, Marco aut Pulvirenti, Alfredo aut Giugno, Rosalba aut Ferro, Alfredo aut Enthalten in BMC genomics London : BioMed Central, 2000 15(2014), Suppl 3 vom: 06. Mai (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:15 year:2014 number:Suppl 3 day:06 month:05 https://dx.doi.org/10.1186/1471-2164-15-S3-S4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2014 Suppl 3 06 05 |
| spelling |
10.1186/1471-2164-15-S3-S4 doi (DE-627)SPR027101592 (SPR)1471-2164-15-S3-S4-e DE-627 ger DE-627 rakwb eng Russo, Francesco verfasserin aut A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. miRNA Expression (dpeaa)DE-He213 miRNA Expression Profile (dpeaa)DE-He213 Extracellular Form (dpeaa)DE-He213 Extracellular miRNAs (dpeaa)DE-He213 Exosomal miRNAs (dpeaa)DE-He213 Di Bella, Sebastiano aut Bonnici, Vincenzo aut Laganà, Alessandro aut Rainaldi, Giuseppe aut Pellegrini, Marco aut Pulvirenti, Alfredo aut Giugno, Rosalba aut Ferro, Alfredo aut Enthalten in BMC genomics London : BioMed Central, 2000 15(2014), Suppl 3 vom: 06. Mai (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:15 year:2014 number:Suppl 3 day:06 month:05 https://dx.doi.org/10.1186/1471-2164-15-S3-S4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2014 Suppl 3 06 05 |
| allfields_unstemmed |
10.1186/1471-2164-15-S3-S4 doi (DE-627)SPR027101592 (SPR)1471-2164-15-S3-S4-e DE-627 ger DE-627 rakwb eng Russo, Francesco verfasserin aut A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. miRNA Expression (dpeaa)DE-He213 miRNA Expression Profile (dpeaa)DE-He213 Extracellular Form (dpeaa)DE-He213 Extracellular miRNAs (dpeaa)DE-He213 Exosomal miRNAs (dpeaa)DE-He213 Di Bella, Sebastiano aut Bonnici, Vincenzo aut Laganà, Alessandro aut Rainaldi, Giuseppe aut Pellegrini, Marco aut Pulvirenti, Alfredo aut Giugno, Rosalba aut Ferro, Alfredo aut Enthalten in BMC genomics London : BioMed Central, 2000 15(2014), Suppl 3 vom: 06. Mai (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:15 year:2014 number:Suppl 3 day:06 month:05 https://dx.doi.org/10.1186/1471-2164-15-S3-S4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2014 Suppl 3 06 05 |
| allfieldsGer |
10.1186/1471-2164-15-S3-S4 doi (DE-627)SPR027101592 (SPR)1471-2164-15-S3-S4-e DE-627 ger DE-627 rakwb eng Russo, Francesco verfasserin aut A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. miRNA Expression (dpeaa)DE-He213 miRNA Expression Profile (dpeaa)DE-He213 Extracellular Form (dpeaa)DE-He213 Extracellular miRNAs (dpeaa)DE-He213 Exosomal miRNAs (dpeaa)DE-He213 Di Bella, Sebastiano aut Bonnici, Vincenzo aut Laganà, Alessandro aut Rainaldi, Giuseppe aut Pellegrini, Marco aut Pulvirenti, Alfredo aut Giugno, Rosalba aut Ferro, Alfredo aut Enthalten in BMC genomics London : BioMed Central, 2000 15(2014), Suppl 3 vom: 06. Mai (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:15 year:2014 number:Suppl 3 day:06 month:05 https://dx.doi.org/10.1186/1471-2164-15-S3-S4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2014 Suppl 3 06 05 |
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10.1186/1471-2164-15-S3-S4 doi (DE-627)SPR027101592 (SPR)1471-2164-15-S3-S4-e DE-627 ger DE-627 rakwb eng Russo, Francesco verfasserin aut A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. miRNA Expression (dpeaa)DE-He213 miRNA Expression Profile (dpeaa)DE-He213 Extracellular Form (dpeaa)DE-He213 Extracellular miRNAs (dpeaa)DE-He213 Exosomal miRNAs (dpeaa)DE-He213 Di Bella, Sebastiano aut Bonnici, Vincenzo aut Laganà, Alessandro aut Rainaldi, Giuseppe aut Pellegrini, Marco aut Pulvirenti, Alfredo aut Giugno, Rosalba aut Ferro, Alfredo aut Enthalten in BMC genomics London : BioMed Central, 2000 15(2014), Suppl 3 vom: 06. Mai (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:15 year:2014 number:Suppl 3 day:06 month:05 https://dx.doi.org/10.1186/1471-2164-15-S3-S4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2014 Suppl 3 06 05 |
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Russo, Francesco Di Bella, Sebastiano Bonnici, Vincenzo Laganà, Alessandro Rainaldi, Giuseppe Pellegrini, Marco Pulvirenti, Alfredo Giugno, Rosalba Ferro, Alfredo |
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Elektronische Aufsätze |
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Russo, Francesco |
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10.1186/1471-2164-15-S3-S4 |
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knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular mirnas |
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A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs |
| abstract |
Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
| abstractGer |
Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
| abstract_unstemmed |
Background MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers. Description We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed. Conclusions This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs. © Russo et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs |
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