Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi

Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this stu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Liu, Yu-Chen [verfasserIn] Chen, Wen Liang Kung, Wei-Hsiang Huang, Hsien-Da

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Circulating miRNAs Plant miRNAs miR2910 Cross Kingdom RNAi

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC genomics - London : BioMed Central, 2000, 18(2017), Suppl 2 vom: 14. März
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:Suppl 2 ; day:14 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s12864-017-3502-3

Katalog-ID:	SPR027138321

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520			\|a Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system.
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allfields	10.1186/s12864-017-3502-3 doi (DE-627)SPR027138321 (SPR)s12864-017-3502-3-e DE-627 ger DE-627 rakwb eng Liu, Yu-Chen verfasserin aut Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. Circulating miRNAs (dpeaa)DE-He213 Plant miRNAs (dpeaa)DE-He213 miR2910 (dpeaa)DE-He213 Cross Kingdom RNAi (dpeaa)DE-He213 Chen, Wen Liang aut Kung, Wei-Hsiang aut Huang, Hsien-Da aut Enthalten in BMC genomics London : BioMed Central, 2000 18(2017), Suppl 2 vom: 14. März (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:18 year:2017 number:Suppl 2 day:14 month:03 https://dx.doi.org/10.1186/s12864-017-3502-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 Suppl 2 14 03
spelling	10.1186/s12864-017-3502-3 doi (DE-627)SPR027138321 (SPR)s12864-017-3502-3-e DE-627 ger DE-627 rakwb eng Liu, Yu-Chen verfasserin aut Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. Circulating miRNAs (dpeaa)DE-He213 Plant miRNAs (dpeaa)DE-He213 miR2910 (dpeaa)DE-He213 Cross Kingdom RNAi (dpeaa)DE-He213 Chen, Wen Liang aut Kung, Wei-Hsiang aut Huang, Hsien-Da aut Enthalten in BMC genomics London : BioMed Central, 2000 18(2017), Suppl 2 vom: 14. März (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:18 year:2017 number:Suppl 2 day:14 month:03 https://dx.doi.org/10.1186/s12864-017-3502-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 Suppl 2 14 03
allfields_unstemmed	10.1186/s12864-017-3502-3 doi (DE-627)SPR027138321 (SPR)s12864-017-3502-3-e DE-627 ger DE-627 rakwb eng Liu, Yu-Chen verfasserin aut Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. Circulating miRNAs (dpeaa)DE-He213 Plant miRNAs (dpeaa)DE-He213 miR2910 (dpeaa)DE-He213 Cross Kingdom RNAi (dpeaa)DE-He213 Chen, Wen Liang aut Kung, Wei-Hsiang aut Huang, Hsien-Da aut Enthalten in BMC genomics London : BioMed Central, 2000 18(2017), Suppl 2 vom: 14. März (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:18 year:2017 number:Suppl 2 day:14 month:03 https://dx.doi.org/10.1186/s12864-017-3502-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 Suppl 2 14 03
allfieldsGer	10.1186/s12864-017-3502-3 doi (DE-627)SPR027138321 (SPR)s12864-017-3502-3-e DE-627 ger DE-627 rakwb eng Liu, Yu-Chen verfasserin aut Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. Circulating miRNAs (dpeaa)DE-He213 Plant miRNAs (dpeaa)DE-He213 miR2910 (dpeaa)DE-He213 Cross Kingdom RNAi (dpeaa)DE-He213 Chen, Wen Liang aut Kung, Wei-Hsiang aut Huang, Hsien-Da aut Enthalten in BMC genomics London : BioMed Central, 2000 18(2017), Suppl 2 vom: 14. März (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:18 year:2017 number:Suppl 2 day:14 month:03 https://dx.doi.org/10.1186/s12864-017-3502-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 Suppl 2 14 03
allfieldsSound	10.1186/s12864-017-3502-3 doi (DE-627)SPR027138321 (SPR)s12864-017-3502-3-e DE-627 ger DE-627 rakwb eng Liu, Yu-Chen verfasserin aut Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. Circulating miRNAs (dpeaa)DE-He213 Plant miRNAs (dpeaa)DE-He213 miR2910 (dpeaa)DE-He213 Cross Kingdom RNAi (dpeaa)DE-He213 Chen, Wen Liang aut Kung, Wei-Hsiang aut Huang, Hsien-Da aut Enthalten in BMC genomics London : BioMed Central, 2000 18(2017), Suppl 2 vom: 14. März (DE-627)326644954 (DE-600)2041499-7 1471-2164 nnns volume:18 year:2017 number:Suppl 2 day:14 month:03 https://dx.doi.org/10.1186/s12864-017-3502-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 Suppl 2 14 03
language	English
source	Enthalten in BMC genomics 18(2017), Suppl 2 vom: 14. März volume:18 year:2017 number:Suppl 2 day:14 month:03
sourceStr	Enthalten in BMC genomics 18(2017), Suppl 2 vom: 14. März volume:18 year:2017 number:Suppl 2 day:14 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Circulating miRNAs Plant miRNAs miR2910 Cross Kingdom RNAi
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container_title	BMC genomics
authorswithroles_txt_mv	Liu, Yu-Chen @@aut@@ Chen, Wen Liang @@aut@@ Kung, Wei-Hsiang @@aut@@ Huang, Hsien-Da @@aut@@
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author	Liu, Yu-Chen
spellingShingle	Liu, Yu-Chen misc Circulating miRNAs misc Plant miRNAs misc miR2910 misc Cross Kingdom RNAi Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
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topic_title	Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi Circulating miRNAs (dpeaa)DE-He213 Plant miRNAs (dpeaa)DE-He213 miR2910 (dpeaa)DE-He213 Cross Kingdom RNAi (dpeaa)DE-He213
topic	misc Circulating miRNAs misc Plant miRNAs misc miR2910 misc Cross Kingdom RNAi
topic_unstemmed	misc Circulating miRNAs misc Plant miRNAs misc miR2910 misc Cross Kingdom RNAi
topic_browse	misc Circulating miRNAs misc Plant miRNAs misc miR2910 misc Cross Kingdom RNAi
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title	Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
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title_full	Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
author_sort	Liu, Yu-Chen
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author_browse	Liu, Yu-Chen Chen, Wen Liang Kung, Wei-Hsiang Huang, Hsien-Da
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author-letter	Liu, Yu-Chen
doi_str_mv	10.1186/s12864-017-3502-3
title_sort	plant mirnas found in human circulating system provide evidences of cross kingdom rnai
title_auth	Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
abstract	Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. © The Author(s). 2017
abstractGer	Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. © The Author(s). 2017
abstract_unstemmed	Background Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system. © The Author(s). 2017
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title_short	Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
url	https://dx.doi.org/10.1186/s12864-017-3502-3
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author2	Chen, Wen Liang Kung, Wei-Hsiang Huang, Hsien-Da
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doi_str	10.1186/s12864-017-3502-3
up_date	2024-07-04T00:33:28.083Z
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Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi

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