Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus

Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granu...
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Autor*in:	Wang, Ying [verfasserIn] Zhou, Hejun Shen, Yujuan Wang, Yanjuan Wu, Weiping Liu, Haipeng Yuan, Zhongying Xu, Yuxin Hu, Yuan Cao, Jianping

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Mechanism Excretory-secretory products Dendritic cell Dendritic cell maturation Cytokine

Anmerkung:	© Wang et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC immunology - London : BioMed Central, 2000, 16(2015), 1 vom: 13. Aug.
Übergeordnetes Werk:	volume:16 ; year:2015 ; number:1 ; day:13 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12865-015-0110-3

Katalog-ID:	SPR027170322

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245	1	0	\|a Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus
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520			\|a Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner.
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allfields	10.1186/s12865-015-0110-3 doi (DE-627)SPR027170322 (SPR)s12865-015-0110-3-e DE-627 ger DE-627 rakwb eng Wang, Ying verfasserin aut Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wang et al. 2015 Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. Mechanism (dpeaa)DE-He213 Excretory-secretory products (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Dendritic cell maturation (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Zhou, Hejun aut Shen, Yujuan aut Wang, Yanjuan aut Wu, Weiping aut Liu, Haipeng aut Yuan, Zhongying aut Xu, Yuxin aut Hu, Yuan aut Cao, Jianping aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 13. Aug. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:13 month:08 https://dx.doi.org/10.1186/s12865-015-0110-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 13 08
spelling	10.1186/s12865-015-0110-3 doi (DE-627)SPR027170322 (SPR)s12865-015-0110-3-e DE-627 ger DE-627 rakwb eng Wang, Ying verfasserin aut Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wang et al. 2015 Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. Mechanism (dpeaa)DE-He213 Excretory-secretory products (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Dendritic cell maturation (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Zhou, Hejun aut Shen, Yujuan aut Wang, Yanjuan aut Wu, Weiping aut Liu, Haipeng aut Yuan, Zhongying aut Xu, Yuxin aut Hu, Yuan aut Cao, Jianping aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 13. Aug. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:13 month:08 https://dx.doi.org/10.1186/s12865-015-0110-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 13 08
allfields_unstemmed	10.1186/s12865-015-0110-3 doi (DE-627)SPR027170322 (SPR)s12865-015-0110-3-e DE-627 ger DE-627 rakwb eng Wang, Ying verfasserin aut Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wang et al. 2015 Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. Mechanism (dpeaa)DE-He213 Excretory-secretory products (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Dendritic cell maturation (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Zhou, Hejun aut Shen, Yujuan aut Wang, Yanjuan aut Wu, Weiping aut Liu, Haipeng aut Yuan, Zhongying aut Xu, Yuxin aut Hu, Yuan aut Cao, Jianping aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 13. Aug. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:13 month:08 https://dx.doi.org/10.1186/s12865-015-0110-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 13 08
allfieldsGer	10.1186/s12865-015-0110-3 doi (DE-627)SPR027170322 (SPR)s12865-015-0110-3-e DE-627 ger DE-627 rakwb eng Wang, Ying verfasserin aut Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wang et al. 2015 Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. Mechanism (dpeaa)DE-He213 Excretory-secretory products (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Dendritic cell maturation (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Zhou, Hejun aut Shen, Yujuan aut Wang, Yanjuan aut Wu, Weiping aut Liu, Haipeng aut Yuan, Zhongying aut Xu, Yuxin aut Hu, Yuan aut Cao, Jianping aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 13. Aug. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:13 month:08 https://dx.doi.org/10.1186/s12865-015-0110-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 13 08
allfieldsSound	10.1186/s12865-015-0110-3 doi (DE-627)SPR027170322 (SPR)s12865-015-0110-3-e DE-627 ger DE-627 rakwb eng Wang, Ying verfasserin aut Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wang et al. 2015 Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. Mechanism (dpeaa)DE-He213 Excretory-secretory products (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Dendritic cell maturation (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213 Zhou, Hejun aut Shen, Yujuan aut Wang, Yanjuan aut Wu, Weiping aut Liu, Haipeng aut Yuan, Zhongying aut Xu, Yuxin aut Hu, Yuan aut Cao, Jianping aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 13. Aug. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:13 month:08 https://dx.doi.org/10.1186/s12865-015-0110-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 13 08
language	English
source	Enthalten in BMC immunology 16(2015), 1 vom: 13. Aug. volume:16 year:2015 number:1 day:13 month:08
sourceStr	Enthalten in BMC immunology 16(2015), 1 vom: 13. Aug. volume:16 year:2015 number:1 day:13 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Mechanism Excretory-secretory products Dendritic cell Dendritic cell maturation Cytokine
isfreeaccess_bool	true
container_title	BMC immunology
authorswithroles_txt_mv	Wang, Ying @@aut@@ Zhou, Hejun @@aut@@ Shen, Yujuan @@aut@@ Wang, Yanjuan @@aut@@ Wu, Weiping @@aut@@ Liu, Haipeng @@aut@@ Yuan, Zhongying @@aut@@ Xu, Yuxin @@aut@@ Hu, Yuan @@aut@@ Cao, Jianping @@aut@@
publishDateDaySort_date	2015-08-13T00:00:00Z
hierarchy_top_id	326644962
id	SPR027170322
language_de	englisch
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Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mechanism</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Excretory-secretory products</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dendritic cell</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dendritic cell maturation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cytokine</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhou, Hejun</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shen, Yujuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Yanjuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Weiping</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liu, Haipeng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yuan, Zhongying</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xu, Yuxin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hu, Yuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cao, Jianping</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC immunology</subfield><subfield code="d">London : BioMed Central, 2000</subfield><subfield code="g">16(2015), 1 vom: 13. 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author	Wang, Ying
spellingShingle	Wang, Ying misc Mechanism misc Excretory-secretory products misc Dendritic cell misc Dendritic cell maturation misc Cytokine Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus
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topic_title	Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus Mechanism (dpeaa)DE-He213 Excretory-secretory products (dpeaa)DE-He213 Dendritic cell (dpeaa)DE-He213 Dendritic cell maturation (dpeaa)DE-He213 Cytokine (dpeaa)DE-He213
topic	misc Mechanism misc Excretory-secretory products misc Dendritic cell misc Dendritic cell maturation misc Cytokine
topic_unstemmed	misc Mechanism misc Excretory-secretory products misc Dendritic cell misc Dendritic cell maturation misc Cytokine
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title	Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus
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title_full	Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus
author_sort	Wang, Ying
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author_browse	Wang, Ying Zhou, Hejun Shen, Yujuan Wang, Yanjuan Wu, Weiping Liu, Haipeng Yuan, Zhongying Xu, Yuxin Hu, Yuan Cao, Jianping
container_volume	16
format_se	Elektronische Aufsätze
author-letter	Wang, Ying
doi_str_mv	10.1186/s12865-015-0110-3
title_sort	impairment of dendritic cell function and induction of $ cd4^{+} %$ cd25^{+} %$ foxp3^{+} $ t cells by excretory-secretory products: a potential mechanism of immune evasion adopted by echinococcus granulosus
title_auth	Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus
abstract	Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. © Wang et al. 2015
abstractGer	Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. © Wang et al. 2015
abstract_unstemmed	Background Cystic echinococcosis, caused by infection with Echinococcus granulosus, is one of the most widespread zoonotic helminth diseases. Modulation of host responses is an important strategy used by helminth parasites to promote infection. To better understand the mechanisms adopted by E. granulosus to escape host immune responses, we investigated the effects of excretory–secretory products (ES) and adult worm antigen (AWA) derived from adult E. granulosus on murine bone marrow-derived dendritic cells (BMDC). Results Compared with lipopolysaccharide (LPS), AWA, but not ES, induced BMDC maturation or stimulated BMDC cytokine production and co-stimulatory molecule expression (CD40, CD80 and MHC class II). Furthermore, ES-treated BMDCs pulsed with ovalbumin exhibited reduced co-stimulatory molecule expression in comparison with untreated BMDC, even in the presence of the strong Th1 inducer, CpG. Moreover, we detected the effects of ES-treated DC on T cell activation by an in vitro T cell priming assay. We observed that ES-treated BMDC co-cultured with DO11.10 transgenic $ CD4^{+} $ T cells induced the generation of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells. In addition, in contrast to AWA-treated BMDCs, which had markedly induced IFN-γ secretion and reduced of IL-4 levels in co-cultured T cells, ES-treated BMDCs did not modify their capacity to stimulate IFN-γ or IL-4 production by T cells. Conclusions We conclude that ES of adult E. granulosus inhibited DC function, impaired the development of Th1 cells induced by CpG, and induced $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ regulatory T cells in an IL-10-independent manner. © Wang et al. 2015
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container_issue	1
title_short	Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus
url	https://dx.doi.org/10.1186/s12865-015-0110-3
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author2	Zhou, Hejun Shen, Yujuan Wang, Yanjuan Wu, Weiping Liu, Haipeng Yuan, Zhongying Xu, Yuxin Hu, Yuan Cao, Jianping
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up_date	2024-07-04T00:42:42.926Z
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Impairment of dendritic cell function and induction of $ CD4^{+} %$ CD25^{+} %$ Foxp3^{+} $ T cells by excretory-secretory products: a potential mechanism of immune evasion adopted by Echinococcus granulosus

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