Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice

Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritonea...
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Autor*in:	Brand, Camila [verfasserIn] da Costa, Thayse Pinheiro Bernardes, Emerson Soares Machado, Camila Maria Longo Andrade, Leonardo Rodrigues Chammas, Roger de Oliveira, Felipe Leite El-Cheikh, Márcia Cury

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Pristane Oil granuloma Bone marrow Peritoneal cavity Inflammation

Anmerkung:	© Brand et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC immunology - London : BioMed Central, 2000, 16(2015), 1 vom: 14. Nov.
Übergeordnetes Werk:	volume:16 ; year:2015 ; number:1 ; day:14 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12865-015-0133-9

Katalog-ID:	SPR027170578

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520			\|a Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas.
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allfields	10.1186/s12865-015-0133-9 doi (DE-627)SPR027170578 (SPR)s12865-015-0133-9-e DE-627 ger DE-627 rakwb eng Brand, Camila verfasserin aut Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Brand et al. 2015 Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. Pristane (dpeaa)DE-He213 Oil granuloma (dpeaa)DE-He213 Bone marrow (dpeaa)DE-He213 Peritoneal cavity (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 da Costa, Thayse Pinheiro aut Bernardes, Emerson Soares aut Machado, Camila Maria Longo aut Andrade, Leonardo Rodrigues aut Chammas, Roger aut de Oliveira, Felipe Leite aut El-Cheikh, Márcia Cury aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 14. Nov. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:14 month:11 https://dx.doi.org/10.1186/s12865-015-0133-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 14 11
spelling	10.1186/s12865-015-0133-9 doi (DE-627)SPR027170578 (SPR)s12865-015-0133-9-e DE-627 ger DE-627 rakwb eng Brand, Camila verfasserin aut Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Brand et al. 2015 Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. Pristane (dpeaa)DE-He213 Oil granuloma (dpeaa)DE-He213 Bone marrow (dpeaa)DE-He213 Peritoneal cavity (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 da Costa, Thayse Pinheiro aut Bernardes, Emerson Soares aut Machado, Camila Maria Longo aut Andrade, Leonardo Rodrigues aut Chammas, Roger aut de Oliveira, Felipe Leite aut El-Cheikh, Márcia Cury aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 14. Nov. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:14 month:11 https://dx.doi.org/10.1186/s12865-015-0133-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 14 11
allfields_unstemmed	10.1186/s12865-015-0133-9 doi (DE-627)SPR027170578 (SPR)s12865-015-0133-9-e DE-627 ger DE-627 rakwb eng Brand, Camila verfasserin aut Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Brand et al. 2015 Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. Pristane (dpeaa)DE-He213 Oil granuloma (dpeaa)DE-He213 Bone marrow (dpeaa)DE-He213 Peritoneal cavity (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 da Costa, Thayse Pinheiro aut Bernardes, Emerson Soares aut Machado, Camila Maria Longo aut Andrade, Leonardo Rodrigues aut Chammas, Roger aut de Oliveira, Felipe Leite aut El-Cheikh, Márcia Cury aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 14. Nov. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:14 month:11 https://dx.doi.org/10.1186/s12865-015-0133-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 14 11
allfieldsGer	10.1186/s12865-015-0133-9 doi (DE-627)SPR027170578 (SPR)s12865-015-0133-9-e DE-627 ger DE-627 rakwb eng Brand, Camila verfasserin aut Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Brand et al. 2015 Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. Pristane (dpeaa)DE-He213 Oil granuloma (dpeaa)DE-He213 Bone marrow (dpeaa)DE-He213 Peritoneal cavity (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 da Costa, Thayse Pinheiro aut Bernardes, Emerson Soares aut Machado, Camila Maria Longo aut Andrade, Leonardo Rodrigues aut Chammas, Roger aut de Oliveira, Felipe Leite aut El-Cheikh, Márcia Cury aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 14. Nov. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:14 month:11 https://dx.doi.org/10.1186/s12865-015-0133-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 14 11
allfieldsSound	10.1186/s12865-015-0133-9 doi (DE-627)SPR027170578 (SPR)s12865-015-0133-9-e DE-627 ger DE-627 rakwb eng Brand, Camila verfasserin aut Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Brand et al. 2015 Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. Pristane (dpeaa)DE-He213 Oil granuloma (dpeaa)DE-He213 Bone marrow (dpeaa)DE-He213 Peritoneal cavity (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 da Costa, Thayse Pinheiro aut Bernardes, Emerson Soares aut Machado, Camila Maria Longo aut Andrade, Leonardo Rodrigues aut Chammas, Roger aut de Oliveira, Felipe Leite aut El-Cheikh, Márcia Cury aut Enthalten in BMC immunology London : BioMed Central, 2000 16(2015), 1 vom: 14. Nov. (DE-627)326644962 (DE-600)2041500-X 1471-2172 nnns volume:16 year:2015 number:1 day:14 month:11 https://dx.doi.org/10.1186/s12865-015-0133-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 1 14 11
language	English
source	Enthalten in BMC immunology 16(2015), 1 vom: 14. Nov. volume:16 year:2015 number:1 day:14 month:11
sourceStr	Enthalten in BMC immunology 16(2015), 1 vom: 14. Nov. volume:16 year:2015 number:1 day:14 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pristane Oil granuloma Bone marrow Peritoneal cavity Inflammation
isfreeaccess_bool	true
container_title	BMC immunology
authorswithroles_txt_mv	Brand, Camila @@aut@@ da Costa, Thayse Pinheiro @@aut@@ Bernardes, Emerson Soares @@aut@@ Machado, Camila Maria Longo @@aut@@ Andrade, Leonardo Rodrigues @@aut@@ Chammas, Roger @@aut@@ de Oliveira, Felipe Leite @@aut@@ El-Cheikh, Márcia Cury @@aut@@
publishDateDaySort_date	2015-11-14T00:00:00Z
hierarchy_top_id	326644962
id	SPR027170578
language_de	englisch
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The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. 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author	Brand, Camila
spellingShingle	Brand, Camila misc Pristane misc Oil granuloma misc Bone marrow misc Peritoneal cavity misc Inflammation Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice
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topic_title	Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice Pristane (dpeaa)DE-He213 Oil granuloma (dpeaa)DE-He213 Bone marrow (dpeaa)DE-He213 Peritoneal cavity (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213
topic	misc Pristane misc Oil granuloma misc Bone marrow misc Peritoneal cavity misc Inflammation
topic_unstemmed	misc Pristane misc Oil granuloma misc Bone marrow misc Peritoneal cavity misc Inflammation
topic_browse	misc Pristane misc Oil granuloma misc Bone marrow misc Peritoneal cavity misc Inflammation
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title	Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice
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title_full	Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice
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author_browse	Brand, Camila da Costa, Thayse Pinheiro Bernardes, Emerson Soares Machado, Camila Maria Longo Andrade, Leonardo Rodrigues Chammas, Roger de Oliveira, Felipe Leite El-Cheikh, Márcia Cury
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author-letter	Brand, Camila
doi_str_mv	10.1186/s12865-015-0133-9
title_sort	differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice
title_auth	Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice
abstract	Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. © Brand et al. 2015
abstractGer	Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. © Brand et al. 2015
abstract_unstemmed	Background Galectin-3 is known to be a lectin that plays an important role in inflammatory processes, acting as pro-inflammatory mediator in activation and migration of neutrophils and macrophages, as well as in the phagocytic function of these cells. The injection of mineral oils into the peritoneal cavity of mice, such as 2, 6, 10, 14-tetramethylpentadecane (pristane), induce a chronic granulomatous inflammatory reaction which is rich in macrophages, B cells and peritoneal plasma cells known as oil granuloma. In addition, this inflammatory microenvironment provided by oil granulomas is also an important site of plasmacytoma induction, which are dependent on cytokine production and cellular mobilization. Here, we have analyzed the role of galectin-3 in inflammatory cells mobilization and organization after pristane injection characterizing granulomatous reaction through the formation of oil granulomas. Results In galectin-3 deficient mice (gal-$ 3^{−/−} $), the mobilization of inflammatory cells, between peritoneal cavity and bone marrow, was responsible for the formation of disorganized oil granulomas, which presented scattered cells, large necrotic areas and low amounts of extracellular matrix. The production of inflammatory cytokines partially explained the distribution of cells through peritoneal cavity, since high levels of IL-6 in gal-$ 3^{−/−} $ mice led to drastically reduction of B1 cells. The previous pro-inflammatory status of these animals also explains the excess of cell death and disruption of oil granulomas architecture. Conclusions Our data indicate, for the first time, that the disruption in the inflammatory cells migration in the absence of galectin-3 is a crucial event in the formation and organization of oil granulomas. © Brand et al. 2015
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title_short	Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice
url	https://dx.doi.org/10.1186/s12865-015-0133-9
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author2	da Costa, Thayse Pinheiro Bernardes, Emerson Soares Machado, Camila Maria Longo Andrade, Leonardo Rodrigues Chammas, Roger de Oliveira, Felipe Leite El-Cheikh, Márcia Cury
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Differential development of oil granulomas induced by pristane injection in galectin-3 deficient mice

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