A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons

Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sun, Qian-Quan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Dendritic Compartment Paired Recording Thalamic Input Presynaptic Spike Brain Slice Preparation

Anmerkung:	© Sun; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: BMC neuroscience - London : BioMed Central, 2000, 10(2009), 1 vom: 29. Okt.
Übergeordnetes Werk:	volume:10 ; year:2009 ; number:1 ; day:29 ; month:10

Links:	Volltext

DOI / URN:	10.1186/1471-2202-10-131

Katalog-ID:	SPR027233316

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520			\|a Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances.
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allfields	10.1186/1471-2202-10-131 doi (DE-627)SPR027233316 (SPR)1471-2202-10-131-e DE-627 ger DE-627 rakwb eng Sun, Qian-Quan verfasserin aut A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun; licensee BioMed Central Ltd. 2009 Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. Dendritic Compartment (dpeaa)DE-He213 Paired Recording (dpeaa)DE-He213 Thalamic Input (dpeaa)DE-He213 Presynaptic Spike (dpeaa)DE-He213 Brain Slice Preparation (dpeaa)DE-He213 Enthalten in BMC neuroscience London : BioMed Central, 2000 10(2009), 1 vom: 29. Okt. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:10 year:2009 number:1 day:29 month:10 https://dx.doi.org/10.1186/1471-2202-10-131 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 29 10
spelling	10.1186/1471-2202-10-131 doi (DE-627)SPR027233316 (SPR)1471-2202-10-131-e DE-627 ger DE-627 rakwb eng Sun, Qian-Quan verfasserin aut A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun; licensee BioMed Central Ltd. 2009 Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. Dendritic Compartment (dpeaa)DE-He213 Paired Recording (dpeaa)DE-He213 Thalamic Input (dpeaa)DE-He213 Presynaptic Spike (dpeaa)DE-He213 Brain Slice Preparation (dpeaa)DE-He213 Enthalten in BMC neuroscience London : BioMed Central, 2000 10(2009), 1 vom: 29. Okt. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:10 year:2009 number:1 day:29 month:10 https://dx.doi.org/10.1186/1471-2202-10-131 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 29 10
allfields_unstemmed	10.1186/1471-2202-10-131 doi (DE-627)SPR027233316 (SPR)1471-2202-10-131-e DE-627 ger DE-627 rakwb eng Sun, Qian-Quan verfasserin aut A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun; licensee BioMed Central Ltd. 2009 Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. Dendritic Compartment (dpeaa)DE-He213 Paired Recording (dpeaa)DE-He213 Thalamic Input (dpeaa)DE-He213 Presynaptic Spike (dpeaa)DE-He213 Brain Slice Preparation (dpeaa)DE-He213 Enthalten in BMC neuroscience London : BioMed Central, 2000 10(2009), 1 vom: 29. Okt. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:10 year:2009 number:1 day:29 month:10 https://dx.doi.org/10.1186/1471-2202-10-131 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 29 10
allfieldsGer	10.1186/1471-2202-10-131 doi (DE-627)SPR027233316 (SPR)1471-2202-10-131-e DE-627 ger DE-627 rakwb eng Sun, Qian-Quan verfasserin aut A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun; licensee BioMed Central Ltd. 2009 Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. Dendritic Compartment (dpeaa)DE-He213 Paired Recording (dpeaa)DE-He213 Thalamic Input (dpeaa)DE-He213 Presynaptic Spike (dpeaa)DE-He213 Brain Slice Preparation (dpeaa)DE-He213 Enthalten in BMC neuroscience London : BioMed Central, 2000 10(2009), 1 vom: 29. Okt. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:10 year:2009 number:1 day:29 month:10 https://dx.doi.org/10.1186/1471-2202-10-131 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 29 10
allfieldsSound	10.1186/1471-2202-10-131 doi (DE-627)SPR027233316 (SPR)1471-2202-10-131-e DE-627 ger DE-627 rakwb eng Sun, Qian-Quan verfasserin aut A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun; licensee BioMed Central Ltd. 2009 Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. Dendritic Compartment (dpeaa)DE-He213 Paired Recording (dpeaa)DE-He213 Thalamic Input (dpeaa)DE-He213 Presynaptic Spike (dpeaa)DE-He213 Brain Slice Preparation (dpeaa)DE-He213 Enthalten in BMC neuroscience London : BioMed Central, 2000 10(2009), 1 vom: 29. Okt. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:10 year:2009 number:1 day:29 month:10 https://dx.doi.org/10.1186/1471-2202-10-131 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 29 10
language	English
source	Enthalten in BMC neuroscience 10(2009), 1 vom: 29. Okt. volume:10 year:2009 number:1 day:29 month:10
sourceStr	Enthalten in BMC neuroscience 10(2009), 1 vom: 29. Okt. volume:10 year:2009 number:1 day:29 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dendritic Compartment Paired Recording Thalamic Input Presynaptic Spike Brain Slice Preparation
isfreeaccess_bool	true
container_title	BMC neuroscience
authorswithroles_txt_mv	Sun, Qian-Quan @@aut@@
publishDateDaySort_date	2009-10-29T00:00:00Z
hierarchy_top_id	326643648
id	SPR027233316
language_de	englisch
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author	Sun, Qian-Quan
spellingShingle	Sun, Qian-Quan misc Dendritic Compartment misc Paired Recording misc Thalamic Input misc Presynaptic Spike misc Brain Slice Preparation A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons
authorStr	Sun, Qian-Quan
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topic_title	A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons Dendritic Compartment (dpeaa)DE-He213 Paired Recording (dpeaa)DE-He213 Thalamic Input (dpeaa)DE-He213 Presynaptic Spike (dpeaa)DE-He213 Brain Slice Preparation (dpeaa)DE-He213
topic	misc Dendritic Compartment misc Paired Recording misc Thalamic Input misc Presynaptic Spike misc Brain Slice Preparation
topic_unstemmed	misc Dendritic Compartment misc Paired Recording misc Thalamic Input misc Presynaptic Spike misc Brain Slice Preparation
topic_browse	misc Dendritic Compartment misc Paired Recording misc Thalamic Input misc Presynaptic Spike misc Brain Slice Preparation
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title	A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons
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title_full	A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons
author_sort	Sun, Qian-Quan
journal	BMC neuroscience
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doi_str_mv	10.1186/1471-2202-10-131
title_sort	novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons
title_auth	A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons
abstract	Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. © Sun; licensee BioMed Central Ltd. 2009
abstractGer	Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. © Sun; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background Little is known about the roles of dendritic gap junctions (GJs) of inhibitory interneurons in modulating temporal properties of sensory induced responses in sensory cortices. Electrophysiological dual patch-clamp recording and computational simulation methods were used in combination to examine a novel role of GJs in sensory mediated feed-forward inhibitory responses in barrel cortex layer IV and its underlying mechanisms. Results Under physiological conditions, excitatory post-junctional potentials (EPJPs) interact with thalamocortical (TC) inputs within an unprecedented few milliseconds (i.e. over 200 Hz) to enhance the firing probability and synchrony of coupled fast-spiking (FS) cells. Dendritic GJ coupling allows fourfold increase in synchrony and a significant enhancement in spike transmission efficacy in excitatory spiny stellate cells. The model revealed the following novel mechanisms: 1) rapid capacitive current ($ I_{cap} $) underlies the activation of voltage-gated sodium channels; 2) there was less than 2 milliseconds in which the $ I_{cap} $ underlying TC input and EPJP was coupled effectively; 3) cells with dendritic GJs had larger input conductance and smaller membrane response to weaker inputs; 4) synchrony in inhibitory networks by GJ coupling leads to reduced sporadic lateral inhibition and increased TC transmission efficacy. Conclusion Dendritic GJs of neocortical inhibitory networks can have very powerful effects in modulating the strength and the temporal properties of sensory induced feed-forward inhibitory and excitatory responses at a very high frequency band (>200 Hz). Rapid capacitive currents are identified as main mechanisms underlying interaction between two transient synaptic conductances. © Sun; licensee BioMed Central Ltd. 2009
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title_short	A novel role of dendritic gap junction and mechanisms underlying its interaction with thalamocortical conductance in fast spiking inhibitory neurons
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