JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain

Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Stelzer, Sandra [verfasserIn] Ebnet, Klaus Schwamborn, Jens C

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Neural Stem Cell Adult Brain Adult Central Nervous System Adult Mouse Brain Adult Neural Stem Cell

Anmerkung:	© Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC neuroscience - London : BioMed Central, 2000, 11(2010), 1 vom: 26. Feb.
Übergeordnetes Werk:	volume:11 ; year:2010 ; number:1 ; day:26 ; month:02

Links:	Volltext

DOI / URN:	10.1186/1471-2202-11-27

Katalog-ID:	SPR027237877

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520			\|a Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.
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allfields	10.1186/1471-2202-11-27 doi (DE-627)SPR027237877 (SPR)1471-2202-11-27-e DE-627 ger DE-627 rakwb eng Stelzer, Sandra verfasserin aut JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. Neural Stem Cell (dpeaa)DE-He213 Adult Brain (dpeaa)DE-He213 Adult Central Nervous System (dpeaa)DE-He213 Adult Mouse Brain (dpeaa)DE-He213 Adult Neural Stem Cell (dpeaa)DE-He213 Ebnet, Klaus aut Schwamborn, Jens C aut Enthalten in BMC neuroscience London : BioMed Central, 2000 11(2010), 1 vom: 26. Feb. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:11 year:2010 number:1 day:26 month:02 https://dx.doi.org/10.1186/1471-2202-11-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 26 02
spelling	10.1186/1471-2202-11-27 doi (DE-627)SPR027237877 (SPR)1471-2202-11-27-e DE-627 ger DE-627 rakwb eng Stelzer, Sandra verfasserin aut JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. Neural Stem Cell (dpeaa)DE-He213 Adult Brain (dpeaa)DE-He213 Adult Central Nervous System (dpeaa)DE-He213 Adult Mouse Brain (dpeaa)DE-He213 Adult Neural Stem Cell (dpeaa)DE-He213 Ebnet, Klaus aut Schwamborn, Jens C aut Enthalten in BMC neuroscience London : BioMed Central, 2000 11(2010), 1 vom: 26. Feb. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:11 year:2010 number:1 day:26 month:02 https://dx.doi.org/10.1186/1471-2202-11-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 26 02
allfields_unstemmed	10.1186/1471-2202-11-27 doi (DE-627)SPR027237877 (SPR)1471-2202-11-27-e DE-627 ger DE-627 rakwb eng Stelzer, Sandra verfasserin aut JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. Neural Stem Cell (dpeaa)DE-He213 Adult Brain (dpeaa)DE-He213 Adult Central Nervous System (dpeaa)DE-He213 Adult Mouse Brain (dpeaa)DE-He213 Adult Neural Stem Cell (dpeaa)DE-He213 Ebnet, Klaus aut Schwamborn, Jens C aut Enthalten in BMC neuroscience London : BioMed Central, 2000 11(2010), 1 vom: 26. Feb. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:11 year:2010 number:1 day:26 month:02 https://dx.doi.org/10.1186/1471-2202-11-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 26 02
allfieldsGer	10.1186/1471-2202-11-27 doi (DE-627)SPR027237877 (SPR)1471-2202-11-27-e DE-627 ger DE-627 rakwb eng Stelzer, Sandra verfasserin aut JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. Neural Stem Cell (dpeaa)DE-He213 Adult Brain (dpeaa)DE-He213 Adult Central Nervous System (dpeaa)DE-He213 Adult Mouse Brain (dpeaa)DE-He213 Adult Neural Stem Cell (dpeaa)DE-He213 Ebnet, Klaus aut Schwamborn, Jens C aut Enthalten in BMC neuroscience London : BioMed Central, 2000 11(2010), 1 vom: 26. Feb. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:11 year:2010 number:1 day:26 month:02 https://dx.doi.org/10.1186/1471-2202-11-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 26 02
allfieldsSound	10.1186/1471-2202-11-27 doi (DE-627)SPR027237877 (SPR)1471-2202-11-27-e DE-627 ger DE-627 rakwb eng Stelzer, Sandra verfasserin aut JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. Neural Stem Cell (dpeaa)DE-He213 Adult Brain (dpeaa)DE-He213 Adult Central Nervous System (dpeaa)DE-He213 Adult Mouse Brain (dpeaa)DE-He213 Adult Neural Stem Cell (dpeaa)DE-He213 Ebnet, Klaus aut Schwamborn, Jens C aut Enthalten in BMC neuroscience London : BioMed Central, 2000 11(2010), 1 vom: 26. Feb. (DE-627)326643648 (DE-600)2041344-0 1471-2202 nnns volume:11 year:2010 number:1 day:26 month:02 https://dx.doi.org/10.1186/1471-2202-11-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 26 02
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. 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author	Stelzer, Sandra
spellingShingle	Stelzer, Sandra misc Neural Stem Cell misc Adult Brain misc Adult Central Nervous System misc Adult Mouse Brain misc Adult Neural Stem Cell JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain
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topic_title	JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain Neural Stem Cell (dpeaa)DE-He213 Adult Brain (dpeaa)DE-He213 Adult Central Nervous System (dpeaa)DE-He213 Adult Mouse Brain (dpeaa)DE-He213 Adult Neural Stem Cell (dpeaa)DE-He213
topic	misc Neural Stem Cell misc Adult Brain misc Adult Central Nervous System misc Adult Mouse Brain misc Adult Neural Stem Cell
topic_unstemmed	misc Neural Stem Cell misc Adult Brain misc Adult Central Nervous System misc Adult Mouse Brain misc Adult Neural Stem Cell
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title	JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain
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title_full	JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain
author_sort	Stelzer, Sandra
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author_browse	Stelzer, Sandra Ebnet, Klaus Schwamborn, Jens C
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doi_str_mv	10.1186/1471-2202-11-27
title_sort	jam-a is a novel surface marker for ng2-glia in the adult mouse brain
title_auth	JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain
abstract	Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. Results So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. Conclusions Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. © Stelzer et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain
url	https://dx.doi.org/10.1186/1471-2202-11-27
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doi_str	10.1186/1471-2202-11-27
up_date	2024-07-04T01:00:47.987Z
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Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. 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JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain

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