Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure

Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the...
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Autor*in:	Gaborit, F [verfasserIn] Bosselmann, H Tønder, N Iversen, K Kümler, T Kistorp, C Sölétormos, G Goetze, J P. Schou, M

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Left ventricular global longitudinal strain Systolic heart failure Natriuretic peptides

Anmerkung:	© Gaborit et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC cardiovascular disorders - London : BioMed Central, 2001, 15(2015), 1 vom: 20. Aug.
Übergeordnetes Werk:	volume:15 ; year:2015 ; number:1 ; day:20 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12872-015-0063-8

Katalog-ID:	SPR027339335

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520			\|a Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF.
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allfields	10.1186/s12872-015-0063-8 doi (DE-627)SPR027339335 (SPR)s12872-015-0063-8-e DE-627 ger DE-627 rakwb eng Gaborit, F verfasserin aut Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaborit et al. 2015 Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. Left ventricular global longitudinal strain (dpeaa)DE-He213 Systolic heart failure (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Bosselmann, H aut Tønder, N aut Iversen, K aut Kümler, T aut Kistorp, C aut Sölétormos, G aut Goetze, J P. aut Schou, M aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 15(2015), 1 vom: 20. Aug. (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:15 year:2015 number:1 day:20 month:08 https://dx.doi.org/10.1186/s12872-015-0063-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 08
spelling	10.1186/s12872-015-0063-8 doi (DE-627)SPR027339335 (SPR)s12872-015-0063-8-e DE-627 ger DE-627 rakwb eng Gaborit, F verfasserin aut Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaborit et al. 2015 Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. Left ventricular global longitudinal strain (dpeaa)DE-He213 Systolic heart failure (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Bosselmann, H aut Tønder, N aut Iversen, K aut Kümler, T aut Kistorp, C aut Sölétormos, G aut Goetze, J P. aut Schou, M aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 15(2015), 1 vom: 20. Aug. (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:15 year:2015 number:1 day:20 month:08 https://dx.doi.org/10.1186/s12872-015-0063-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 08
allfields_unstemmed	10.1186/s12872-015-0063-8 doi (DE-627)SPR027339335 (SPR)s12872-015-0063-8-e DE-627 ger DE-627 rakwb eng Gaborit, F verfasserin aut Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaborit et al. 2015 Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. Left ventricular global longitudinal strain (dpeaa)DE-He213 Systolic heart failure (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Bosselmann, H aut Tønder, N aut Iversen, K aut Kümler, T aut Kistorp, C aut Sölétormos, G aut Goetze, J P. aut Schou, M aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 15(2015), 1 vom: 20. Aug. (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:15 year:2015 number:1 day:20 month:08 https://dx.doi.org/10.1186/s12872-015-0063-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 08
allfieldsGer	10.1186/s12872-015-0063-8 doi (DE-627)SPR027339335 (SPR)s12872-015-0063-8-e DE-627 ger DE-627 rakwb eng Gaborit, F verfasserin aut Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaborit et al. 2015 Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. Left ventricular global longitudinal strain (dpeaa)DE-He213 Systolic heart failure (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Bosselmann, H aut Tønder, N aut Iversen, K aut Kümler, T aut Kistorp, C aut Sölétormos, G aut Goetze, J P. aut Schou, M aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 15(2015), 1 vom: 20. Aug. (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:15 year:2015 number:1 day:20 month:08 https://dx.doi.org/10.1186/s12872-015-0063-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 08
allfieldsSound	10.1186/s12872-015-0063-8 doi (DE-627)SPR027339335 (SPR)s12872-015-0063-8-e DE-627 ger DE-627 rakwb eng Gaborit, F verfasserin aut Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaborit et al. 2015 Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. Left ventricular global longitudinal strain (dpeaa)DE-He213 Systolic heart failure (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Bosselmann, H aut Tønder, N aut Iversen, K aut Kümler, T aut Kistorp, C aut Sölétormos, G aut Goetze, J P. aut Schou, M aut Enthalten in BMC cardiovascular disorders London : BioMed Central, 2001 15(2015), 1 vom: 20. Aug. (DE-627)335488870 (DE-600)2059859-2 1471-2261 nnns volume:15 year:2015 number:1 day:20 month:08 https://dx.doi.org/10.1186/s12872-015-0063-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 08
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Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. 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author	Gaborit, F
spellingShingle	Gaborit, F misc Left ventricular global longitudinal strain misc Systolic heart failure misc Natriuretic peptides Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
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topic_title	Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure Left ventricular global longitudinal strain (dpeaa)DE-He213 Systolic heart failure (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213
topic	misc Left ventricular global longitudinal strain misc Systolic heart failure misc Natriuretic peptides
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title	Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
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title_full	Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
author_sort	Gaborit, F
journal	BMC cardiovascular disorders
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author_browse	Gaborit, F Bosselmann, H Tønder, N Iversen, K Kümler, T Kistorp, C Sölétormos, G Goetze, J P. Schou, M
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title_sort	association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
title_auth	Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
abstract	Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. © Gaborit et al. 2015
abstractGer	Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. © Gaborit et al. 2015
abstract_unstemmed	Background Both impaired left ventricular (LV) global longitudinal strain (GLS) and increased plasma concentrations of natriuretic peptides(NP) are associated with a poor outcome in heart failure (HF). Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF. © Gaborit et al. 2015
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title_short	Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure
url	https://dx.doi.org/10.1186/s12872-015-0063-8
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author2	Bosselmann, H Tønder, N Iversen, K Kümler, T Kistorp, C Sölétormos, G Goetze, J P. Schou, M
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up_date	2024-07-04T01:26:06.667Z
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Increased levels of NP reflect increased wall stress of the LV. However, little is known about the relationship between LV GLS and NP. This aim of this study was to evaluate the relationship between the echocardiographic measure LV GLS and plasma levels of NP. Methods We prospectively included 149 patients with verified systolic HF at the baseline visit in an outpatient HF clinic. LV GLS was assessed by two dimension speckle tracking and plasma concentrations of N-terminal-pro-brain-natriuretic-peptide (NT-proBNP) and pro-atrial-natriuretic-peptide (proANP) were analysed. Results The patients had a median age of 70 years, 28.2 % were females, 26.5 % were in functional class III-IV, median left ventricular ejection fraction (LVEF) was 33 % and median LV GLS was −11 %. LV GLS was associated with increased plasma concentrations of NT-proBNP and proANP in multivariate logistic regression (NT-proBNP: Odds $ Ratio_{GLS} $: 7.25, 95 %-CI: 2.48-21.1, P < 0.001 and proANP: Odds $ Ratio_{GLS} $: 3.26, 95-%-CI: 1.28-8.30, P = 0.013) and linear regression (NT-proBNP: $ β_{GLS} $: 1.19, 95 %-CI: 0.62-1.76, P < 0.001 and proANP: $ β_{GLS} $: 0.42, 95-%-CI: 0.11-0.72, P = 0.007) models after adjustment for traditional confounders (age, gender, body-mass-index, atrial fibrillation, renal function) and left atrial volume index. Conclusion Impaired LV GLS is associated with increased plasma concentrations of NP and our data suggest that left ventricular myocardial mechanics estimated by LV GLS reflects myocardial wall stress in chronic systolic HF.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Left ventricular global longitudinal strain</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Systolic heart failure</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Natriuretic peptides</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bosselmann, H</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tønder, N</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Iversen, K</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kümler, T</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kistorp, C</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sölétormos, G</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goetze, J P.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schou, M</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC cardiovascular disorders</subfield><subfield code="d">London : BioMed Central, 2001</subfield><subfield code="g">15(2015), 1 vom: 20. 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Association between left ventricular global longitudinal strain and natriuretic peptides in outpatients with chronic systolic heart failure

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