Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?

Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine...
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Autor*in:	Dimi, Svetlane [verfasserIn] Zucman, David Chassany, Olivier Lalanne, Christophe Prazuck, Thierry Mortier, Emmanuel Majerholc, Catherine Aubin-Auger, Isabelle Verger, Pierre Duracinsky, Martin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	HIV Therapeutic vaccine Acceptability Acceptance Confidence

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 19(2019), 1 vom: 09. Mai
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:1 ; day:09 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12879-019-4056-6

Katalog-ID:	SPR027463346

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allfields	10.1186/s12879-019-4056-6 doi (DE-627)SPR027463346 (SPR)s12879-019-4056-6-e DE-627 ger DE-627 rakwb eng Dimi, Svetlane verfasserin (orcid)0000-0002-3434-5846 aut Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. HIV (dpeaa)DE-He213 Therapeutic vaccine (dpeaa)DE-He213 Acceptability (dpeaa)DE-He213 Acceptance (dpeaa)DE-He213 Confidence (dpeaa)DE-He213 Zucman, David aut Chassany, Olivier aut Lalanne, Christophe aut Prazuck, Thierry aut Mortier, Emmanuel aut Majerholc, Catherine aut Aubin-Auger, Isabelle aut Verger, Pierre aut Duracinsky, Martin aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 19(2019), 1 vom: 09. Mai (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:19 year:2019 number:1 day:09 month:05 https://dx.doi.org/10.1186/s12879-019-4056-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 09 05
spelling	10.1186/s12879-019-4056-6 doi (DE-627)SPR027463346 (SPR)s12879-019-4056-6-e DE-627 ger DE-627 rakwb eng Dimi, Svetlane verfasserin (orcid)0000-0002-3434-5846 aut Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. HIV (dpeaa)DE-He213 Therapeutic vaccine (dpeaa)DE-He213 Acceptability (dpeaa)DE-He213 Acceptance (dpeaa)DE-He213 Confidence (dpeaa)DE-He213 Zucman, David aut Chassany, Olivier aut Lalanne, Christophe aut Prazuck, Thierry aut Mortier, Emmanuel aut Majerholc, Catherine aut Aubin-Auger, Isabelle aut Verger, Pierre aut Duracinsky, Martin aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 19(2019), 1 vom: 09. Mai (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:19 year:2019 number:1 day:09 month:05 https://dx.doi.org/10.1186/s12879-019-4056-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 09 05
allfields_unstemmed	10.1186/s12879-019-4056-6 doi (DE-627)SPR027463346 (SPR)s12879-019-4056-6-e DE-627 ger DE-627 rakwb eng Dimi, Svetlane verfasserin (orcid)0000-0002-3434-5846 aut Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. HIV (dpeaa)DE-He213 Therapeutic vaccine (dpeaa)DE-He213 Acceptability (dpeaa)DE-He213 Acceptance (dpeaa)DE-He213 Confidence (dpeaa)DE-He213 Zucman, David aut Chassany, Olivier aut Lalanne, Christophe aut Prazuck, Thierry aut Mortier, Emmanuel aut Majerholc, Catherine aut Aubin-Auger, Isabelle aut Verger, Pierre aut Duracinsky, Martin aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 19(2019), 1 vom: 09. Mai (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:19 year:2019 number:1 day:09 month:05 https://dx.doi.org/10.1186/s12879-019-4056-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 09 05
allfieldsGer	10.1186/s12879-019-4056-6 doi (DE-627)SPR027463346 (SPR)s12879-019-4056-6-e DE-627 ger DE-627 rakwb eng Dimi, Svetlane verfasserin (orcid)0000-0002-3434-5846 aut Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. HIV (dpeaa)DE-He213 Therapeutic vaccine (dpeaa)DE-He213 Acceptability (dpeaa)DE-He213 Acceptance (dpeaa)DE-He213 Confidence (dpeaa)DE-He213 Zucman, David aut Chassany, Olivier aut Lalanne, Christophe aut Prazuck, Thierry aut Mortier, Emmanuel aut Majerholc, Catherine aut Aubin-Auger, Isabelle aut Verger, Pierre aut Duracinsky, Martin aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 19(2019), 1 vom: 09. Mai (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:19 year:2019 number:1 day:09 month:05 https://dx.doi.org/10.1186/s12879-019-4056-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 09 05
allfieldsSound	10.1186/s12879-019-4056-6 doi (DE-627)SPR027463346 (SPR)s12879-019-4056-6-e DE-627 ger DE-627 rakwb eng Dimi, Svetlane verfasserin (orcid)0000-0002-3434-5846 aut Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox? 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. HIV (dpeaa)DE-He213 Therapeutic vaccine (dpeaa)DE-He213 Acceptability (dpeaa)DE-He213 Acceptance (dpeaa)DE-He213 Confidence (dpeaa)DE-He213 Zucman, David aut Chassany, Olivier aut Lalanne, Christophe aut Prazuck, Thierry aut Mortier, Emmanuel aut Majerholc, Catherine aut Aubin-Auger, Isabelle aut Verger, Pierre aut Duracinsky, Martin aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 19(2019), 1 vom: 09. Mai (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:19 year:2019 number:1 day:09 month:05 https://dx.doi.org/10.1186/s12879-019-4056-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 09 05
language	English
source	Enthalten in BMC infectious diseases 19(2019), 1 vom: 09. Mai volume:19 year:2019 number:1 day:09 month:05
sourceStr	Enthalten in BMC infectious diseases 19(2019), 1 vom: 09. Mai volume:19 year:2019 number:1 day:09 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	HIV Therapeutic vaccine Acceptability Acceptance Confidence
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Dimi, Svetlane @@aut@@ Zucman, David @@aut@@ Chassany, Olivier @@aut@@ Lalanne, Christophe @@aut@@ Prazuck, Thierry @@aut@@ Mortier, Emmanuel @@aut@@ Majerholc, Catherine @@aut@@ Aubin-Auger, Isabelle @@aut@@ Verger, Pierre @@aut@@ Duracinsky, Martin @@aut@@
publishDateDaySort_date	2019-05-09T00:00:00Z
hierarchy_top_id	326645381
id	SPR027463346
language_de	englisch
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Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. 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author	Dimi, Svetlane
spellingShingle	Dimi, Svetlane misc HIV misc Therapeutic vaccine misc Acceptability misc Acceptance misc Confidence Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?
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topic_title	Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox? HIV (dpeaa)DE-He213 Therapeutic vaccine (dpeaa)DE-He213 Acceptability (dpeaa)DE-He213 Acceptance (dpeaa)DE-He213 Confidence (dpeaa)DE-He213
topic	misc HIV misc Therapeutic vaccine misc Acceptability misc Acceptance misc Confidence
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title	Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?
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title_full	Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?
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author_browse	Dimi, Svetlane Zucman, David Chassany, Olivier Lalanne, Christophe Prazuck, Thierry Mortier, Emmanuel Majerholc, Catherine Aubin-Auger, Isabelle Verger, Pierre Duracinsky, Martin
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title_sort	patients’ high acceptability of a future therapeutic hiv vaccine in france: a french paradox?
title_auth	Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?
abstract	Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. © The Author(s). 2019
abstractGer	Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. © The Author(s). 2019
abstract_unstemmed	Background France is the European country with the lowest level of confidence in vaccines. Measurement of patients’ acceptability towards a future therapeutic HIV vaccine is critically important. Thus, the aim of this study was to evaluate patients’ acceptability of a future therapeutic HIV vaccine in a representative cohort of French patients living with HIV-AIDS (PLWHs). Methods This multicentre study used quantitative and qualitative methods to assess PLWHs’ opinions and their potential acceptance of a future therapeutic HIV vaccine. Cross-sectional study on 220 HIV-1 infected outpatients, aged 18–75 years. Results The participants’ characteristics were similar to those of the overall French PLWH population. Responses from the questionnaires showed high indices of acceptance: the mean score for acceptability on the Visual Analog Scale VAS was 8.4 of 10, and 92% of patients agreed to be vaccinated if a therapeutic vaccine became available. Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. Trial registration This study was retroactively registered on ClinicalTrials.gov with ID: NCT02077101 in February 21, 2014. © The Author(s). 2019
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title_short	Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?
url	https://dx.doi.org/10.1186/s12879-019-4056-6
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author2	Zucman, David Chassany, Olivier Lalanne, Christophe Prazuck, Thierry Mortier, Emmanuel Majerholc, Catherine Aubin-Auger, Isabelle Verger, Pierre Duracinsky, Martin
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up_date	2024-07-04T01:58:37.687Z
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Acceptability depended on the expected characteristics of the vaccine, notably the duration of its effectiveness: 44% of participants expected it to be effective for life. This acceptance was not associated with socio-demographic, clinical (mode of contamination, duration of disease), quality of life, or illness-perception parameters. Acceptability was also strongly correlated with confidence in the treating physician. Conclusion The PLWHs within our cohort had high indices of acceptance to a future therapeutic HIV vaccine. 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Patients’ high acceptability of a future therapeutic HIV vaccine in France: a French paradox?

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