Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults
Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ r...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chow, Tiffany W [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Anmerkung: |
© Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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| Übergeordnetes Werk: |
Enthalten in: BMC medical imaging - London : BioMed Central, 2001, 9(2009), 1 vom: 06. Juli |
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| Übergeordnetes Werk: |
volume:9 ; year:2009 ; number:1 ; day:06 ; month:07 |
| Links: |
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| DOI / URN: |
10.1186/1471-2342-9-12 |
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| Katalog-ID: |
SPR02747335X |
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| 520 | |a Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. | ||
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10.1186/1471-2342-9-12 doi (DE-627)SPR02747335X (SPR)1471-2342-9-12-e DE-627 ger DE-627 rakwb eng Chow, Tiffany W verfasserin aut Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. Position Emission Tomography (dpeaa)DE-He213 Position Emission Tomography Scan (dpeaa)DE-He213 Repeatability Coefficient (dpeaa)DE-He213 Simplify Reference Tissue Model (dpeaa)DE-He213 Position Emission Tomography (dpeaa)DE-He213 Mamo, David C aut Uchida, Hiroyuki aut Graff-Guerrero, Ariel aut Houle, Sylvain aut Smith, Gwenn S aut Pollock, Bruce G aut Mulsant, Benoit H aut Enthalten in BMC medical imaging London : BioMed Central, 2001 9(2009), 1 vom: 06. Juli (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:9 year:2009 number:1 day:06 month:07 https://dx.doi.org/10.1186/1471-2342-9-12 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 06 07 |
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10.1186/1471-2342-9-12 doi (DE-627)SPR02747335X (SPR)1471-2342-9-12-e DE-627 ger DE-627 rakwb eng Chow, Tiffany W verfasserin aut Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. Position Emission Tomography (dpeaa)DE-He213 Position Emission Tomography Scan (dpeaa)DE-He213 Repeatability Coefficient (dpeaa)DE-He213 Simplify Reference Tissue Model (dpeaa)DE-He213 Position Emission Tomography (dpeaa)DE-He213 Mamo, David C aut Uchida, Hiroyuki aut Graff-Guerrero, Ariel aut Houle, Sylvain aut Smith, Gwenn S aut Pollock, Bruce G aut Mulsant, Benoit H aut Enthalten in BMC medical imaging London : BioMed Central, 2001 9(2009), 1 vom: 06. Juli (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:9 year:2009 number:1 day:06 month:07 https://dx.doi.org/10.1186/1471-2342-9-12 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 06 07 |
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10.1186/1471-2342-9-12 doi (DE-627)SPR02747335X (SPR)1471-2342-9-12-e DE-627 ger DE-627 rakwb eng Chow, Tiffany W verfasserin aut Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. Position Emission Tomography (dpeaa)DE-He213 Position Emission Tomography Scan (dpeaa)DE-He213 Repeatability Coefficient (dpeaa)DE-He213 Simplify Reference Tissue Model (dpeaa)DE-He213 Position Emission Tomography (dpeaa)DE-He213 Mamo, David C aut Uchida, Hiroyuki aut Graff-Guerrero, Ariel aut Houle, Sylvain aut Smith, Gwenn S aut Pollock, Bruce G aut Mulsant, Benoit H aut Enthalten in BMC medical imaging London : BioMed Central, 2001 9(2009), 1 vom: 06. Juli (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:9 year:2009 number:1 day:06 month:07 https://dx.doi.org/10.1186/1471-2342-9-12 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 06 07 |
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10.1186/1471-2342-9-12 doi (DE-627)SPR02747335X (SPR)1471-2342-9-12-e DE-627 ger DE-627 rakwb eng Chow, Tiffany W verfasserin aut Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. Position Emission Tomography (dpeaa)DE-He213 Position Emission Tomography Scan (dpeaa)DE-He213 Repeatability Coefficient (dpeaa)DE-He213 Simplify Reference Tissue Model (dpeaa)DE-He213 Position Emission Tomography (dpeaa)DE-He213 Mamo, David C aut Uchida, Hiroyuki aut Graff-Guerrero, Ariel aut Houle, Sylvain aut Smith, Gwenn S aut Pollock, Bruce G aut Mulsant, Benoit H aut Enthalten in BMC medical imaging London : BioMed Central, 2001 9(2009), 1 vom: 06. Juli (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:9 year:2009 number:1 day:06 month:07 https://dx.doi.org/10.1186/1471-2342-9-12 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 06 07 |
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10.1186/1471-2342-9-12 doi (DE-627)SPR02747335X (SPR)1471-2342-9-12-e DE-627 ger DE-627 rakwb eng Chow, Tiffany W verfasserin aut Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. Position Emission Tomography (dpeaa)DE-He213 Position Emission Tomography Scan (dpeaa)DE-He213 Repeatability Coefficient (dpeaa)DE-He213 Simplify Reference Tissue Model (dpeaa)DE-He213 Position Emission Tomography (dpeaa)DE-He213 Mamo, David C aut Uchida, Hiroyuki aut Graff-Guerrero, Ariel aut Houle, Sylvain aut Smith, Gwenn S aut Pollock, Bruce G aut Mulsant, Benoit H aut Enthalten in BMC medical imaging London : BioMed Central, 2001 9(2009), 1 vom: 06. Juli (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:9 year:2009 number:1 day:06 month:07 https://dx.doi.org/10.1186/1471-2342-9-12 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 06 07 |
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. 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test-retest variability of high resolution positron emission tomography (pet) imaging of cortical serotonin ($ 5ht_{2a} $) receptors in older, healthy adults |
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Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin ($ 5HT_{2A} $) receptors in older, healthy adults |
| abstract |
Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
| abstractGer |
Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
| abstract_unstemmed |
Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples. © Chow et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-$ HT_{2A} $ receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin $ 5HT_{2A} $ receptor ($ 5HT_{2A} $R) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring $ 5HT_{2A} $R availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results The average difference in the binding potential ($ BP_{ND} $) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other $ 5HT_{2A} $R radiotracers in younger subject samples.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Position Emission Tomography</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Position Emission Tomography Scan</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Repeatability Coefficient</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Simplify Reference Tissue Model</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Position Emission Tomography</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mamo, David C</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Uchida, Hiroyuki</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Graff-Guerrero, Ariel</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Houle, Sylvain</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smith, Gwenn S</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pollock, Bruce G</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mulsant, Benoit H</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC medical imaging</subfield><subfield code="d">London : BioMed Central, 2001</subfield><subfield code="g">9(2009), 1 vom: 06. 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