Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone
Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique ap...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Matsuda, Hiroshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
Single Photon Emission Compute Tomography |
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| Anmerkung: |
© Matsuda et al; licensee BioMed Central Ltd. 2010 |
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| Übergeordnetes Werk: |
Enthalten in: BMC medical imaging - London : BioMed Central, 2001, 10(2010), 1 vom: 11. Aug. |
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| Übergeordnetes Werk: |
volume:10 ; year:2010 ; number:1 ; day:11 ; month:08 |
| Links: |
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| DOI / URN: |
10.1186/1471-2342-10-17 |
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| Katalog-ID: |
SPR027473694 |
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| 100 | 1 | |a Matsuda, Hiroshi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone |
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| 520 | |a Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT | ||
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| 700 | 1 | |a Imabayashi, Etsuko |4 aut | |
| 700 | 1 | |a Kuji, Ichiei |4 aut | |
| 700 | 1 | |a Seto, Akira |4 aut | |
| 700 | 1 | |a Ito, Kimiteru |4 aut | |
| 700 | 1 | |a Kikuta, Daisuke |4 aut | |
| 700 | 1 | |a Yamada, Minoru |4 aut | |
| 700 | 1 | |a Shimano, Yasumasa |4 aut | |
| 700 | 1 | |a Sato, Noriko |4 aut | |
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10.1186/1471-2342-10-17 doi (DE-627)SPR027473694 (SPR)1471-2342-10-17-e DE-627 ger DE-627 rakwb eng Matsuda, Hiroshi verfasserin aut Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Matsuda et al; licensee BioMed Central Ltd. 2010 Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT Single Photon Emission Compute Tomography (dpeaa)DE-He213 Multiple System Atrophy (dpeaa)DE-He213 Jacobian Determinant (dpeaa)DE-He213 Single Photon Emission Compute Tomography Data (dpeaa)DE-He213 Brain Single Photon Emission Compute Tomography (dpeaa)DE-He213 Imabayashi, Etsuko aut Kuji, Ichiei aut Seto, Akira aut Ito, Kimiteru aut Kikuta, Daisuke aut Yamada, Minoru aut Shimano, Yasumasa aut Sato, Noriko aut Enthalten in BMC medical imaging London : BioMed Central, 2001 10(2010), 1 vom: 11. Aug. (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:10 year:2010 number:1 day:11 month:08 https://dx.doi.org/10.1186/1471-2342-10-17 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 11 08 |
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10.1186/1471-2342-10-17 doi (DE-627)SPR027473694 (SPR)1471-2342-10-17-e DE-627 ger DE-627 rakwb eng Matsuda, Hiroshi verfasserin aut Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Matsuda et al; licensee BioMed Central Ltd. 2010 Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT Single Photon Emission Compute Tomography (dpeaa)DE-He213 Multiple System Atrophy (dpeaa)DE-He213 Jacobian Determinant (dpeaa)DE-He213 Single Photon Emission Compute Tomography Data (dpeaa)DE-He213 Brain Single Photon Emission Compute Tomography (dpeaa)DE-He213 Imabayashi, Etsuko aut Kuji, Ichiei aut Seto, Akira aut Ito, Kimiteru aut Kikuta, Daisuke aut Yamada, Minoru aut Shimano, Yasumasa aut Sato, Noriko aut Enthalten in BMC medical imaging London : BioMed Central, 2001 10(2010), 1 vom: 11. Aug. (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:10 year:2010 number:1 day:11 month:08 https://dx.doi.org/10.1186/1471-2342-10-17 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 11 08 |
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10.1186/1471-2342-10-17 doi (DE-627)SPR027473694 (SPR)1471-2342-10-17-e DE-627 ger DE-627 rakwb eng Matsuda, Hiroshi verfasserin aut Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Matsuda et al; licensee BioMed Central Ltd. 2010 Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT Single Photon Emission Compute Tomography (dpeaa)DE-He213 Multiple System Atrophy (dpeaa)DE-He213 Jacobian Determinant (dpeaa)DE-He213 Single Photon Emission Compute Tomography Data (dpeaa)DE-He213 Brain Single Photon Emission Compute Tomography (dpeaa)DE-He213 Imabayashi, Etsuko aut Kuji, Ichiei aut Seto, Akira aut Ito, Kimiteru aut Kikuta, Daisuke aut Yamada, Minoru aut Shimano, Yasumasa aut Sato, Noriko aut Enthalten in BMC medical imaging London : BioMed Central, 2001 10(2010), 1 vom: 11. Aug. (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:10 year:2010 number:1 day:11 month:08 https://dx.doi.org/10.1186/1471-2342-10-17 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 11 08 |
| allfieldsGer |
10.1186/1471-2342-10-17 doi (DE-627)SPR027473694 (SPR)1471-2342-10-17-e DE-627 ger DE-627 rakwb eng Matsuda, Hiroshi verfasserin aut Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Matsuda et al; licensee BioMed Central Ltd. 2010 Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT Single Photon Emission Compute Tomography (dpeaa)DE-He213 Multiple System Atrophy (dpeaa)DE-He213 Jacobian Determinant (dpeaa)DE-He213 Single Photon Emission Compute Tomography Data (dpeaa)DE-He213 Brain Single Photon Emission Compute Tomography (dpeaa)DE-He213 Imabayashi, Etsuko aut Kuji, Ichiei aut Seto, Akira aut Ito, Kimiteru aut Kikuta, Daisuke aut Yamada, Minoru aut Shimano, Yasumasa aut Sato, Noriko aut Enthalten in BMC medical imaging London : BioMed Central, 2001 10(2010), 1 vom: 11. Aug. (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:10 year:2010 number:1 day:11 month:08 https://dx.doi.org/10.1186/1471-2342-10-17 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 11 08 |
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10.1186/1471-2342-10-17 doi (DE-627)SPR027473694 (SPR)1471-2342-10-17-e DE-627 ger DE-627 rakwb eng Matsuda, Hiroshi verfasserin aut Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Matsuda et al; licensee BioMed Central Ltd. 2010 Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT Single Photon Emission Compute Tomography (dpeaa)DE-He213 Multiple System Atrophy (dpeaa)DE-He213 Jacobian Determinant (dpeaa)DE-He213 Single Photon Emission Compute Tomography Data (dpeaa)DE-He213 Brain Single Photon Emission Compute Tomography (dpeaa)DE-He213 Imabayashi, Etsuko aut Kuji, Ichiei aut Seto, Akira aut Ito, Kimiteru aut Kikuta, Daisuke aut Yamada, Minoru aut Shimano, Yasumasa aut Sato, Noriko aut Enthalten in BMC medical imaging London : BioMed Central, 2001 10(2010), 1 vom: 11. Aug. (DE-627)33679911X (DE-600)2061975-3 1471-2342 nnns volume:10 year:2010 number:1 day:11 month:08 https://dx.doi.org/10.1186/1471-2342-10-17 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 11 08 |
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Matsuda, Hiroshi |
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Matsuda, Hiroshi misc Single Photon Emission Compute Tomography misc Multiple System Atrophy misc Jacobian Determinant misc Single Photon Emission Compute Tomography Data misc Brain Single Photon Emission Compute Tomography Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone |
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Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone Single Photon Emission Compute Tomography (dpeaa)DE-He213 Multiple System Atrophy (dpeaa)DE-He213 Jacobian Determinant (dpeaa)DE-He213 Single Photon Emission Compute Tomography Data (dpeaa)DE-He213 Brain Single Photon Emission Compute Tomography (dpeaa)DE-He213 |
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misc Single Photon Emission Compute Tomography misc Multiple System Atrophy misc Jacobian Determinant misc Single Photon Emission Compute Tomography Data misc Brain Single Photon Emission Compute Tomography |
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misc Single Photon Emission Compute Tomography misc Multiple System Atrophy misc Jacobian Determinant misc Single Photon Emission Compute Tomography Data misc Brain Single Photon Emission Compute Tomography |
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misc Single Photon Emission Compute Tomography misc Multiple System Atrophy misc Jacobian Determinant misc Single Photon Emission Compute Tomography Data misc Brain Single Photon Emission Compute Tomography |
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Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone |
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Matsuda, Hiroshi Imabayashi, Etsuko Kuji, Ichiei Seto, Akira Ito, Kimiteru Kikuta, Daisuke Yamada, Minoru Shimano, Yasumasa Sato, Noriko |
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evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain spect alone |
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Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone |
| abstract |
Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT © Matsuda et al; licensee BioMed Central Ltd. 2010 |
| abstractGer |
Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT © Matsuda et al; licensee BioMed Central Ltd. 2010 |
| abstract_unstemmed |
Background Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT © Matsuda et al; licensee BioMed Central Ltd. 2010 |
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Imabayashi, Etsuko Kuji, Ichiei Seto, Akira Ito, Kimiteru Kikuta, Daisuke Yamada, Minoru Shimano, Yasumasa Sato, Noriko |
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To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT. Methods After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images. Results SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution. Conclusions The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Single Photon Emission Compute Tomography</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Multiple System Atrophy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Jacobian Determinant</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Single Photon Emission Compute Tomography Data</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brain Single Photon Emission Compute Tomography</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Imabayashi, Etsuko</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kuji, Ichiei</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Seto, Akira</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ito, Kimiteru</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kikuta, Daisuke</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yamada, Minoru</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shimano, Yasumasa</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sato, Noriko</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC medical imaging</subfield><subfield code="d">London : BioMed Central, 2001</subfield><subfield code="g">10(2010), 1 vom: 11. 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