Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Method...
Ausführliche Beschreibung
Autor*in: |
Villalobos-Comparán, Marisela [verfasserIn] Villarreal-Molina, María Teresa González-Barrios, Juan Antonio Sánchez-Hernández, Osvaldo Erik |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s). 2017 |
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Übergeordnetes Werk: |
Enthalten in: BMC medical genetics - London : BioMed Central, 2000, 18(2017), 1 vom: 02. Mai |
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Übergeordnetes Werk: |
volume:18 ; year:2017 ; number:1 ; day:02 ; month:05 |
Links: |
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DOI / URN: |
10.1186/s12881-017-0410-y |
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Katalog-ID: |
SPR027497003 |
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520 | |a Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. | ||
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10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05 |
spelling |
10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05 |
allfields_unstemmed |
10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05 |
allfieldsGer |
10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05 |
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10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05 |
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Enthalten in BMC medical genetics 18(2017), 1 vom: 02. Mai volume:18 year:2017 number:1 day:02 month:05 |
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Enthalten in BMC medical genetics 18(2017), 1 vom: 02. Mai volume:18 year:2017 number:1 day:02 month:05 |
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Villalobos-Comparán, Marisela @@aut@@ Antuna-Puente, Bárbara @@aut@@ Villarreal-Molina, María Teresa @@aut@@ Canizales-Quinteros, Samuel @@aut@@ Velázquez-Cruz, Rafael @@aut@@ León-Mimila, Paola @@aut@@ Villamil-Ramírez, Hugo @@aut@@ González-Barrios, Juan Antonio @@aut@@ Merino-García, José Luis @@aut@@ Thompson-Bonilla, María Rocío @@aut@@ Jarquin, Diego @@aut@@ Sánchez-Hernández, Osvaldo Erik @@aut@@ Rodríguez-Arellano, Martha Eunice @@aut@@ Posadas-Romero, Carlos @@aut@@ Vargas-Alarcón, Gilberto @@aut@@ Campos-Pérez, Francisco @@aut@@ Quiterio, Manuel @@aut@@ Salmerón-Castro, Jorge @@aut@@ Carnevale, Alessandra @@aut@@ Romero-Hidalgo, Sandra @@aut@@ |
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2017-05-02T00:00:00Z |
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language_de |
englisch |
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Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. 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Villalobos-Comparán, Marisela misc Body mass index misc and misc variants misc Interaction Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population |
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Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 |
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Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population |
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Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population |
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Villalobos-Comparán, Marisela Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra |
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10.1186/s12881-017-0410-y |
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interaction between fto rs9939609 and the native american-origin abca1 rs9282541 affects bmi in the admixed mexican population |
title_auth |
Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population |
abstract |
Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. © The Author(s). 2017 |
abstractGer |
Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. © The Author(s). 2017 |
abstract_unstemmed |
Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. © The Author(s). 2017 |
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title_short |
Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population |
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Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra |
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Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra |
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|
score |
7.4005365 |