Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population

Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Method...
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Autor*in:	Villalobos-Comparán, Marisela [verfasserIn] Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Body mass index and variants Interaction

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC medical genetics - London : BioMed Central, 2000, 18(2017), 1 vom: 02. Mai
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:1 ; day:02 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12881-017-0410-y

Katalog-ID:	SPR027497003

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520			\|a Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction.
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allfields	10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05
spelling	10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05
allfields_unstemmed	10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05
allfieldsGer	10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05
allfieldsSound	10.1186/s12881-017-0410-y doi (DE-627)SPR027497003 (SPR)s12881-017-0410-y-e DE-627 ger DE-627 rakwb eng Villalobos-Comparán, Marisela verfasserin aut Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213 Antuna-Puente, Bárbara aut Villarreal-Molina, María Teresa aut Canizales-Quinteros, Samuel aut Velázquez-Cruz, Rafael aut León-Mimila, Paola aut Villamil-Ramírez, Hugo aut González-Barrios, Juan Antonio aut Merino-García, José Luis aut Thompson-Bonilla, María Rocío aut Jarquin, Diego aut Sánchez-Hernández, Osvaldo Erik aut Rodríguez-Arellano, Martha Eunice aut Posadas-Romero, Carlos aut Vargas-Alarcón, Gilberto aut Campos-Pérez, Francisco aut Quiterio, Manuel aut Salmerón-Castro, Jorge aut Carnevale, Alessandra aut Romero-Hidalgo, Sandra aut Enthalten in BMC medical genetics London : BioMed Central, 2000 18(2017), 1 vom: 02. Mai (DE-627)326643788 (DE-600)2041359-2 1471-2350 nnns volume:18 year:2017 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12881-017-0410-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 02 05
language	English
source	Enthalten in BMC medical genetics 18(2017), 1 vom: 02. Mai volume:18 year:2017 number:1 day:02 month:05
sourceStr	Enthalten in BMC medical genetics 18(2017), 1 vom: 02. Mai volume:18 year:2017 number:1 day:02 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Body mass index and variants Interaction
isfreeaccess_bool	true
container_title	BMC medical genetics
authorswithroles_txt_mv	Villalobos-Comparán, Marisela @@aut@@ Antuna-Puente, Bárbara @@aut@@ Villarreal-Molina, María Teresa @@aut@@ Canizales-Quinteros, Samuel @@aut@@ Velázquez-Cruz, Rafael @@aut@@ León-Mimila, Paola @@aut@@ Villamil-Ramírez, Hugo @@aut@@ González-Barrios, Juan Antonio @@aut@@ Merino-García, José Luis @@aut@@ Thompson-Bonilla, María Rocío @@aut@@ Jarquin, Diego @@aut@@ Sánchez-Hernández, Osvaldo Erik @@aut@@ Rodríguez-Arellano, Martha Eunice @@aut@@ Posadas-Romero, Carlos @@aut@@ Vargas-Alarcón, Gilberto @@aut@@ Campos-Pérez, Francisco @@aut@@ Quiterio, Manuel @@aut@@ Salmerón-Castro, Jorge @@aut@@ Carnevale, Alessandra @@aut@@ Romero-Hidalgo, Sandra @@aut@@
publishDateDaySort_date	2017-05-02T00:00:00Z
hierarchy_top_id	326643788
id	SPR027497003
language_de	englisch
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Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. 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author	Villalobos-Comparán, Marisela
spellingShingle	Villalobos-Comparán, Marisela misc Body mass index misc and misc variants misc Interaction Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
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topic_title	Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population Body mass index (dpeaa)DE-He213 and (dpeaa)DE-He213 variants (dpeaa)DE-He213 Interaction (dpeaa)DE-He213
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topic_unstemmed	misc Body mass index misc and misc variants misc Interaction
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title	Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
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title_full	Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
author_sort	Villalobos-Comparán, Marisela
journal	BMC medical genetics
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author_browse	Villalobos-Comparán, Marisela Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra
container_volume	18
format_se	Elektronische Aufsätze
author-letter	Villalobos-Comparán, Marisela
doi_str_mv	10.1186/s12881-017-0410-y
title_sort	interaction between fto rs9939609 and the native american-origin abca1 rs9282541 affects bmi in the admixed mexican population
title_auth	Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
abstract	Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. © The Author(s). 2017
abstractGer	Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. © The Author(s). 2017
abstract_unstemmed	Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. Methods A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression. Generalized linear models were used to test for associations and gene-gene interactions affecting BMI, WC and FTO expression. Results FTO and ABCA1 risk alleles were not individually associated with higher BMI or WC. However, in the absence of the ABCA1 risk allele, the FTO risk variant was significantly associated with higher BMI (P = 0.043) and marginally associated with higher WC (P = 0.067), as reported in Europeans. The gene-gene interaction affecting BMI and WC was statistically significant only in adults. FTO mRNA expression in subcutaneous abdominal adipose tissue according to ABCA1 genotype was consistent with these findings. Conclusions This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. © The Author(s). 2017
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title_short	Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population
url	https://dx.doi.org/10.1186/s12881-017-0410-y
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author2	Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra
author2Str	Antuna-Puente, Bárbara Villarreal-Molina, María Teresa Canizales-Quinteros, Samuel Velázquez-Cruz, Rafael León-Mimila, Paola Villamil-Ramírez, Hugo González-Barrios, Juan Antonio Merino-García, José Luis Thompson-Bonilla, María Rocío Jarquin, Diego Sánchez-Hernández, Osvaldo Erik Rodríguez-Arellano, Martha Eunice Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Campos-Pérez, Francisco Quiterio, Manuel Salmerón-Castro, Jorge Carnevale, Alessandra Romero-Hidalgo, Sandra
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Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population

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