Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment

Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Dao, Elizabeth [verfasserIn] Best, John R. Hsiung, Ging-Yuek Robin Sossi, Vesna Jacova, Claudia Tam, Roger Liu-Ambrose, Teresa

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Vascular cognitive impairment Alzheimer’s disease Amyloid Cognitive impairment Executive functions Falls risk

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC geriatrics - London : BioMed Central, 2001, 17(2017), 1 vom: 28. Juni
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:1 ; day:28 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12877-017-0522-4

Katalog-ID:	SPR027532275

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520			\|a Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009.
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allfields	10.1186/s12877-017-0522-4 doi (DE-627)SPR027532275 (SPR)s12877-017-0522-4-e DE-627 ger DE-627 rakwb eng Dao, Elizabeth verfasserin aut Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. Vascular cognitive impairment (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Amyloid (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functions (dpeaa)DE-He213 Falls risk (dpeaa)DE-He213 Best, John R. aut Hsiung, Ging-Yuek Robin aut Sossi, Vesna aut Jacova, Claudia aut Tam, Roger aut Liu-Ambrose, Teresa aut Enthalten in BMC geriatrics London : BioMed Central, 2001 17(2017), 1 vom: 28. Juni (DE-627)335488994 (DE-600)2059865-8 1471-2318 nnns volume:17 year:2017 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12877-017-0522-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 28 06
spelling	10.1186/s12877-017-0522-4 doi (DE-627)SPR027532275 (SPR)s12877-017-0522-4-e DE-627 ger DE-627 rakwb eng Dao, Elizabeth verfasserin aut Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. Vascular cognitive impairment (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Amyloid (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functions (dpeaa)DE-He213 Falls risk (dpeaa)DE-He213 Best, John R. aut Hsiung, Ging-Yuek Robin aut Sossi, Vesna aut Jacova, Claudia aut Tam, Roger aut Liu-Ambrose, Teresa aut Enthalten in BMC geriatrics London : BioMed Central, 2001 17(2017), 1 vom: 28. Juni (DE-627)335488994 (DE-600)2059865-8 1471-2318 nnns volume:17 year:2017 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12877-017-0522-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 28 06
allfields_unstemmed	10.1186/s12877-017-0522-4 doi (DE-627)SPR027532275 (SPR)s12877-017-0522-4-e DE-627 ger DE-627 rakwb eng Dao, Elizabeth verfasserin aut Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. Vascular cognitive impairment (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Amyloid (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functions (dpeaa)DE-He213 Falls risk (dpeaa)DE-He213 Best, John R. aut Hsiung, Ging-Yuek Robin aut Sossi, Vesna aut Jacova, Claudia aut Tam, Roger aut Liu-Ambrose, Teresa aut Enthalten in BMC geriatrics London : BioMed Central, 2001 17(2017), 1 vom: 28. Juni (DE-627)335488994 (DE-600)2059865-8 1471-2318 nnns volume:17 year:2017 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12877-017-0522-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 28 06
allfieldsGer	10.1186/s12877-017-0522-4 doi (DE-627)SPR027532275 (SPR)s12877-017-0522-4-e DE-627 ger DE-627 rakwb eng Dao, Elizabeth verfasserin aut Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. Vascular cognitive impairment (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Amyloid (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functions (dpeaa)DE-He213 Falls risk (dpeaa)DE-He213 Best, John R. aut Hsiung, Ging-Yuek Robin aut Sossi, Vesna aut Jacova, Claudia aut Tam, Roger aut Liu-Ambrose, Teresa aut Enthalten in BMC geriatrics London : BioMed Central, 2001 17(2017), 1 vom: 28. Juni (DE-627)335488994 (DE-600)2059865-8 1471-2318 nnns volume:17 year:2017 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12877-017-0522-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 28 06
allfieldsSound	10.1186/s12877-017-0522-4 doi (DE-627)SPR027532275 (SPR)s12877-017-0522-4-e DE-627 ger DE-627 rakwb eng Dao, Elizabeth verfasserin aut Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. Vascular cognitive impairment (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Amyloid (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functions (dpeaa)DE-He213 Falls risk (dpeaa)DE-He213 Best, John R. aut Hsiung, Ging-Yuek Robin aut Sossi, Vesna aut Jacova, Claudia aut Tam, Roger aut Liu-Ambrose, Teresa aut Enthalten in BMC geriatrics London : BioMed Central, 2001 17(2017), 1 vom: 28. Juni (DE-627)335488994 (DE-600)2059865-8 1471-2318 nnns volume:17 year:2017 number:1 day:28 month:06 https://dx.doi.org/10.1186/s12877-017-0522-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 28 06
language	English
source	Enthalten in BMC geriatrics 17(2017), 1 vom: 28. Juni volume:17 year:2017 number:1 day:28 month:06
sourceStr	Enthalten in BMC geriatrics 17(2017), 1 vom: 28. Juni volume:17 year:2017 number:1 day:28 month:06
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topic_facet	Vascular cognitive impairment Alzheimer’s disease Amyloid Cognitive impairment Executive functions Falls risk
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author	Dao, Elizabeth
spellingShingle	Dao, Elizabeth misc Vascular cognitive impairment misc Alzheimer’s disease misc Amyloid misc Cognitive impairment misc Executive functions misc Falls risk Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment
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topic_title	Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment Vascular cognitive impairment (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Amyloid (dpeaa)DE-He213 Cognitive impairment (dpeaa)DE-He213 Executive functions (dpeaa)DE-He213 Falls risk (dpeaa)DE-He213
topic	misc Vascular cognitive impairment misc Alzheimer’s disease misc Amyloid misc Cognitive impairment misc Executive functions misc Falls risk
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title	Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment
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title_full	Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment
author_sort	Dao, Elizabeth
journal	BMC geriatrics
journalStr	BMC geriatrics
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author_browse	Dao, Elizabeth Best, John R. Hsiung, Ging-Yuek Robin Sossi, Vesna Jacova, Claudia Tam, Roger Liu-Ambrose, Teresa
container_volume	17
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author-letter	Dao, Elizabeth
doi_str_mv	10.1186/s12877-017-0522-4
title_sort	associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment
title_auth	Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment
abstract	Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. © The Author(s). 2017
abstractGer	Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. © The Author(s). 2017
abstract_unstemmed	Background To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). Methods This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an 11C Pittsburgh compound B (PIB) scan. Cognitive function and falls risk were assessed at baseline, 6-months, and 12-months. Global cognition, executive functions, and information processing speed were measured using: 1) ADAS-Cog; 2) Trail Making Test; 3) Digit Span Test; 4) Stroop Test, and 5) Digit Symbol Substitution Test. Falls risk was measured using the Physiological Profile Assessment. Hierarchical multiple linear regression analyses determined the unique contribution of Aβ on changes in cognitive function and falls risk at 12-months after controlling for experimental group (i.e. aerobic exercise training or usual care control) and baseline performance. To correct for multiple comparisons, we applied the Benjamini-Hochberg procedure to obtain a false discovery rate corrected threshold using alpha = 0.05. Results Higher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted $ R^{2} $ = 35.3%, p = 0.002), attention and conflict resolution (Stroop Test, adjusted $ R^{2} $ = 33.4%, p = 0.01), and information processing speed (Digit Symbol Substitution Test, adjusted $ R^{2} $ = 24.4%, p = 0.001) over a 12-month period. Additionally, higher PIB retention was significantly associated with increased falls risk (Physiological Profile Assessment, adjusted $ R^{2} $ = 49.1%, p = 0.04). PIB retention was not significantly associated with change in ADAS-Cog and Verbal Digit Span Test (p > 0.05). Conclusions Symptoms associated with SIVCI may be amplified by secondary Aβ pathology. Trial registration ClinicalTrials.gov, NCT01027858, December 7, 2009. © The Author(s). 2017
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container_issue	1
title_short	Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment
url	https://dx.doi.org/10.1186/s12877-017-0522-4
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author2	Best, John R. Hsiung, Ging-Yuek Robin Sossi, Vesna Jacova, Claudia Tam, Roger Liu-Ambrose, Teresa
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doi_str	10.1186/s12877-017-0522-4
up_date	2024-07-03T13:27:24.150Z
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