Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients

Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkin...
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Autor*in:	Clarimon, Jordi [verfasserIn] Xiromerisiou, Georgia Eerola, Johanna Gourbali, Vanesa Hellström, Olli Dardiotis, Euthimios Peuralinna, Terhi Papadimitriou, Alexandros Hadjigeorgiou, George M Tienari, Pentti J Singleton, Andrew B

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	FGF20 Gene Pedigree Disequilibrium Test Finnish Sample Biallelic Polymorphism Dopaminergic Neuron Survival

Anmerkung:	© Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC neurology - London : BioMed Central, 2001, 5(2005), 1 vom: 20. Juni
Übergeordnetes Werk:	volume:5 ; year:2005 ; number:1 ; day:20 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1471-2377-5-11

Katalog-ID:	SPR027533298

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520			\|a Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.
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allfields	10.1186/1471-2377-5-11 doi (DE-627)SPR027533298 (SPR)1471-2377-5-11-e DE-627 ger DE-627 rakwb eng Clarimon, Jordi verfasserin aut Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. FGF20 Gene (dpeaa)DE-He213 Pedigree Disequilibrium Test (dpeaa)DE-He213 Finnish Sample (dpeaa)DE-He213 Biallelic Polymorphism (dpeaa)DE-He213 Dopaminergic Neuron Survival (dpeaa)DE-He213 Xiromerisiou, Georgia aut Eerola, Johanna aut Gourbali, Vanesa aut Hellström, Olli aut Dardiotis, Euthimios aut Peuralinna, Terhi aut Papadimitriou, Alexandros aut Hadjigeorgiou, George M aut Tienari, Pentti J aut Singleton, Andrew B aut Enthalten in BMC neurology London : BioMed Central, 2001 5(2005), 1 vom: 20. Juni (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:5 year:2005 number:1 day:20 month:06 https://dx.doi.org/10.1186/1471-2377-5-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 20 06
spelling	10.1186/1471-2377-5-11 doi (DE-627)SPR027533298 (SPR)1471-2377-5-11-e DE-627 ger DE-627 rakwb eng Clarimon, Jordi verfasserin aut Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. FGF20 Gene (dpeaa)DE-He213 Pedigree Disequilibrium Test (dpeaa)DE-He213 Finnish Sample (dpeaa)DE-He213 Biallelic Polymorphism (dpeaa)DE-He213 Dopaminergic Neuron Survival (dpeaa)DE-He213 Xiromerisiou, Georgia aut Eerola, Johanna aut Gourbali, Vanesa aut Hellström, Olli aut Dardiotis, Euthimios aut Peuralinna, Terhi aut Papadimitriou, Alexandros aut Hadjigeorgiou, George M aut Tienari, Pentti J aut Singleton, Andrew B aut Enthalten in BMC neurology London : BioMed Central, 2001 5(2005), 1 vom: 20. Juni (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:5 year:2005 number:1 day:20 month:06 https://dx.doi.org/10.1186/1471-2377-5-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 20 06
allfields_unstemmed	10.1186/1471-2377-5-11 doi (DE-627)SPR027533298 (SPR)1471-2377-5-11-e DE-627 ger DE-627 rakwb eng Clarimon, Jordi verfasserin aut Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. FGF20 Gene (dpeaa)DE-He213 Pedigree Disequilibrium Test (dpeaa)DE-He213 Finnish Sample (dpeaa)DE-He213 Biallelic Polymorphism (dpeaa)DE-He213 Dopaminergic Neuron Survival (dpeaa)DE-He213 Xiromerisiou, Georgia aut Eerola, Johanna aut Gourbali, Vanesa aut Hellström, Olli aut Dardiotis, Euthimios aut Peuralinna, Terhi aut Papadimitriou, Alexandros aut Hadjigeorgiou, George M aut Tienari, Pentti J aut Singleton, Andrew B aut Enthalten in BMC neurology London : BioMed Central, 2001 5(2005), 1 vom: 20. Juni (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:5 year:2005 number:1 day:20 month:06 https://dx.doi.org/10.1186/1471-2377-5-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 20 06
allfieldsGer	10.1186/1471-2377-5-11 doi (DE-627)SPR027533298 (SPR)1471-2377-5-11-e DE-627 ger DE-627 rakwb eng Clarimon, Jordi verfasserin aut Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. FGF20 Gene (dpeaa)DE-He213 Pedigree Disequilibrium Test (dpeaa)DE-He213 Finnish Sample (dpeaa)DE-He213 Biallelic Polymorphism (dpeaa)DE-He213 Dopaminergic Neuron Survival (dpeaa)DE-He213 Xiromerisiou, Georgia aut Eerola, Johanna aut Gourbali, Vanesa aut Hellström, Olli aut Dardiotis, Euthimios aut Peuralinna, Terhi aut Papadimitriou, Alexandros aut Hadjigeorgiou, George M aut Tienari, Pentti J aut Singleton, Andrew B aut Enthalten in BMC neurology London : BioMed Central, 2001 5(2005), 1 vom: 20. Juni (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:5 year:2005 number:1 day:20 month:06 https://dx.doi.org/10.1186/1471-2377-5-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 20 06
allfieldsSound	10.1186/1471-2377-5-11 doi (DE-627)SPR027533298 (SPR)1471-2377-5-11-e DE-627 ger DE-627 rakwb eng Clarimon, Jordi verfasserin aut Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. FGF20 Gene (dpeaa)DE-He213 Pedigree Disequilibrium Test (dpeaa)DE-He213 Finnish Sample (dpeaa)DE-He213 Biallelic Polymorphism (dpeaa)DE-He213 Dopaminergic Neuron Survival (dpeaa)DE-He213 Xiromerisiou, Georgia aut Eerola, Johanna aut Gourbali, Vanesa aut Hellström, Olli aut Dardiotis, Euthimios aut Peuralinna, Terhi aut Papadimitriou, Alexandros aut Hadjigeorgiou, George M aut Tienari, Pentti J aut Singleton, Andrew B aut Enthalten in BMC neurology London : BioMed Central, 2001 5(2005), 1 vom: 20. Juni (DE-627)326643664 (DE-600)2041347-6 1471-2377 nnns volume:5 year:2005 number:1 day:20 month:06 https://dx.doi.org/10.1186/1471-2377-5-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 20 06
language	English
source	Enthalten in BMC neurology 5(2005), 1 vom: 20. Juni volume:5 year:2005 number:1 day:20 month:06
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authorswithroles_txt_mv	Clarimon, Jordi @@aut@@ Xiromerisiou, Georgia @@aut@@ Eerola, Johanna @@aut@@ Gourbali, Vanesa @@aut@@ Hellström, Olli @@aut@@ Dardiotis, Euthimios @@aut@@ Peuralinna, Terhi @@aut@@ Papadimitriou, Alexandros @@aut@@ Hadjigeorgiou, George M @@aut@@ Tienari, Pentti J @@aut@@ Singleton, Andrew B @@aut@@
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. 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author	Clarimon, Jordi
spellingShingle	Clarimon, Jordi misc FGF20 Gene misc Pedigree Disequilibrium Test misc Finnish Sample misc Biallelic Polymorphism misc Dopaminergic Neuron Survival Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
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topic_title	Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients FGF20 Gene (dpeaa)DE-He213 Pedigree Disequilibrium Test (dpeaa)DE-He213 Finnish Sample (dpeaa)DE-He213 Biallelic Polymorphism (dpeaa)DE-He213 Dopaminergic Neuron Survival (dpeaa)DE-He213
topic	misc FGF20 Gene misc Pedigree Disequilibrium Test misc Finnish Sample misc Biallelic Polymorphism misc Dopaminergic Neuron Survival
topic_unstemmed	misc FGF20 Gene misc Pedigree Disequilibrium Test misc Finnish Sample misc Biallelic Polymorphism misc Dopaminergic Neuron Survival
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title	Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
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title_full	Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
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author_browse	Clarimon, Jordi Xiromerisiou, Georgia Eerola, Johanna Gourbali, Vanesa Hellström, Olli Dardiotis, Euthimios Peuralinna, Terhi Papadimitriou, Alexandros Hadjigeorgiou, George M Tienari, Pentti J Singleton, Andrew B
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title_sort	lack of evidence for a genetic association between fgf20 and parkinson's disease in finnish and greek patients
title_auth	Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
abstract	Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. Conclusion Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. © Clarimon et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results No association was found in any of the populations studied. 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Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients

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