Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis

Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterize...
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Autor*in:	Webb, Meghan [verfasserIn] Emberley, Ethan D Lizardo, Michael Alowami, Salem Qing, Gefei Alfia'ar, Abdullah Snell-Curtis, Linda J Niu, Yulian Civetta, Alberto Myal, Yvonne Shiu, Robert Murphy, Leigh C Watson, Peter H

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	Mammary Gland Skin Inflammation DMBA Amino Acid Sequence Similarity Mammary Tumorigenesis

Anmerkung:	© Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 5(2005), 1 vom: 17. Feb.
Übergeordnetes Werk:	volume:5 ; year:2005 ; number:1 ; day:17 ; month:02

Links:	Volltext

DOI / URN:	10.1186/1471-2407-5-17

Katalog-ID:	SPR027604934

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245	1	0	\|a Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
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520			\|a Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression.
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author_variant	m w mw e d e ed ede m l ml s a sa g q gq a a aa l j s c ljs ljsc y n yn a c ac y m ym r s rs l c m lc lcm p h w ph phw
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publishDate	2005
allfields	10.1186/1471-2407-5-17 doi (DE-627)SPR027604934 (SPR)1471-2407-5-17-e DE-627 ger DE-627 rakwb eng Webb, Meghan verfasserin aut Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. Mammary Gland (dpeaa)DE-He213 Skin Inflammation (dpeaa)DE-He213 DMBA (dpeaa)DE-He213 Amino Acid Sequence Similarity (dpeaa)DE-He213 Mammary Tumorigenesis (dpeaa)DE-He213 Emberley, Ethan D aut Lizardo, Michael aut Alowami, Salem aut Qing, Gefei aut Alfia'ar, Abdullah aut Snell-Curtis, Linda J aut Niu, Yulian aut Civetta, Alberto aut Myal, Yvonne aut Shiu, Robert aut Murphy, Leigh C aut Watson, Peter H aut Enthalten in BMC cancer London : BioMed Central, 2001 5(2005), 1 vom: 17. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:5 year:2005 number:1 day:17 month:02 https://dx.doi.org/10.1186/1471-2407-5-17 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 17 02
spelling	10.1186/1471-2407-5-17 doi (DE-627)SPR027604934 (SPR)1471-2407-5-17-e DE-627 ger DE-627 rakwb eng Webb, Meghan verfasserin aut Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. Mammary Gland (dpeaa)DE-He213 Skin Inflammation (dpeaa)DE-He213 DMBA (dpeaa)DE-He213 Amino Acid Sequence Similarity (dpeaa)DE-He213 Mammary Tumorigenesis (dpeaa)DE-He213 Emberley, Ethan D aut Lizardo, Michael aut Alowami, Salem aut Qing, Gefei aut Alfia'ar, Abdullah aut Snell-Curtis, Linda J aut Niu, Yulian aut Civetta, Alberto aut Myal, Yvonne aut Shiu, Robert aut Murphy, Leigh C aut Watson, Peter H aut Enthalten in BMC cancer London : BioMed Central, 2001 5(2005), 1 vom: 17. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:5 year:2005 number:1 day:17 month:02 https://dx.doi.org/10.1186/1471-2407-5-17 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 17 02
allfields_unstemmed	10.1186/1471-2407-5-17 doi (DE-627)SPR027604934 (SPR)1471-2407-5-17-e DE-627 ger DE-627 rakwb eng Webb, Meghan verfasserin aut Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. Mammary Gland (dpeaa)DE-He213 Skin Inflammation (dpeaa)DE-He213 DMBA (dpeaa)DE-He213 Amino Acid Sequence Similarity (dpeaa)DE-He213 Mammary Tumorigenesis (dpeaa)DE-He213 Emberley, Ethan D aut Lizardo, Michael aut Alowami, Salem aut Qing, Gefei aut Alfia'ar, Abdullah aut Snell-Curtis, Linda J aut Niu, Yulian aut Civetta, Alberto aut Myal, Yvonne aut Shiu, Robert aut Murphy, Leigh C aut Watson, Peter H aut Enthalten in BMC cancer London : BioMed Central, 2001 5(2005), 1 vom: 17. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:5 year:2005 number:1 day:17 month:02 https://dx.doi.org/10.1186/1471-2407-5-17 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 17 02
allfieldsGer	10.1186/1471-2407-5-17 doi (DE-627)SPR027604934 (SPR)1471-2407-5-17-e DE-627 ger DE-627 rakwb eng Webb, Meghan verfasserin aut Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. Mammary Gland (dpeaa)DE-He213 Skin Inflammation (dpeaa)DE-He213 DMBA (dpeaa)DE-He213 Amino Acid Sequence Similarity (dpeaa)DE-He213 Mammary Tumorigenesis (dpeaa)DE-He213 Emberley, Ethan D aut Lizardo, Michael aut Alowami, Salem aut Qing, Gefei aut Alfia'ar, Abdullah aut Snell-Curtis, Linda J aut Niu, Yulian aut Civetta, Alberto aut Myal, Yvonne aut Shiu, Robert aut Murphy, Leigh C aut Watson, Peter H aut Enthalten in BMC cancer London : BioMed Central, 2001 5(2005), 1 vom: 17. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:5 year:2005 number:1 day:17 month:02 https://dx.doi.org/10.1186/1471-2407-5-17 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 17 02
allfieldsSound	10.1186/1471-2407-5-17 doi (DE-627)SPR027604934 (SPR)1471-2407-5-17-e DE-627 ger DE-627 rakwb eng Webb, Meghan verfasserin aut Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. Mammary Gland (dpeaa)DE-He213 Skin Inflammation (dpeaa)DE-He213 DMBA (dpeaa)DE-He213 Amino Acid Sequence Similarity (dpeaa)DE-He213 Mammary Tumorigenesis (dpeaa)DE-He213 Emberley, Ethan D aut Lizardo, Michael aut Alowami, Salem aut Qing, Gefei aut Alfia'ar, Abdullah aut Snell-Curtis, Linda J aut Niu, Yulian aut Civetta, Alberto aut Myal, Yvonne aut Shiu, Robert aut Murphy, Leigh C aut Watson, Peter H aut Enthalten in BMC cancer London : BioMed Central, 2001 5(2005), 1 vom: 17. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:5 year:2005 number:1 day:17 month:02 https://dx.doi.org/10.1186/1471-2407-5-17 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2005 1 17 02
language	English
source	Enthalten in BMC cancer 5(2005), 1 vom: 17. Feb. volume:5 year:2005 number:1 day:17 month:02
sourceStr	Enthalten in BMC cancer 5(2005), 1 vom: 17. Feb. volume:5 year:2005 number:1 day:17 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Mammary Gland Skin Inflammation DMBA Amino Acid Sequence Similarity Mammary Tumorigenesis
isfreeaccess_bool	false
container_title	BMC cancer
authorswithroles_txt_mv	Webb, Meghan @@aut@@ Emberley, Ethan D @@aut@@ Lizardo, Michael @@aut@@ Alowami, Salem @@aut@@ Qing, Gefei @@aut@@ Alfia'ar, Abdullah @@aut@@ Snell-Curtis, Linda J @@aut@@ Niu, Yulian @@aut@@ Civetta, Alberto @@aut@@ Myal, Yvonne @@aut@@ Shiu, Robert @@aut@@ Murphy, Leigh C @@aut@@ Watson, Peter H @@aut@@
publishDateDaySort_date	2005-02-17T00:00:00Z
hierarchy_top_id	326643710
id	SPR027604934
language_de	englisch
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Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. 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author	Webb, Meghan
spellingShingle	Webb, Meghan misc Mammary Gland misc Skin Inflammation misc DMBA misc Amino Acid Sequence Similarity misc Mammary Tumorigenesis Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
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topic_title	Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis Mammary Gland (dpeaa)DE-He213 Skin Inflammation (dpeaa)DE-He213 DMBA (dpeaa)DE-He213 Amino Acid Sequence Similarity (dpeaa)DE-He213 Mammary Tumorigenesis (dpeaa)DE-He213
topic	misc Mammary Gland misc Skin Inflammation misc DMBA misc Amino Acid Sequence Similarity misc Mammary Tumorigenesis
topic_unstemmed	misc Mammary Gland misc Skin Inflammation misc DMBA misc Amino Acid Sequence Similarity misc Mammary Tumorigenesis
topic_browse	misc Mammary Gland misc Skin Inflammation misc DMBA misc Amino Acid Sequence Similarity misc Mammary Tumorigenesis
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title	Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
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title_full	Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
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author_browse	Webb, Meghan Emberley, Ethan D Lizardo, Michael Alowami, Salem Qing, Gefei Alfia'ar, Abdullah Snell-Curtis, Linda J Niu, Yulian Civetta, Alberto Myal, Yvonne Shiu, Robert Murphy, Leigh C Watson, Peter H
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doi_str_mv	10.1186/1471-2407-5-17
title_sort	expression analysis of the mouse s100a7/psoriasin gene in skin inflammation and mammary tumorigenesis
title_auth	Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
abstract	Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression. Implementation of a mouse model would facilitate further investigation of its function, however little is known of the murine psoriasin gene. In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis. Methods On the basis of chromosomal location, phylogenetic analysis, amino acid sequence similarity, conservation of a putative Jab1-binding motif, and similarities of the patterns of mouse S100A7/psoriasin gene expression (measured by RT-PCR and in-situ hybridization) with those of human S100A7/psoriasin, we propose that mouse S100A7/psoriasin is the murine ortholog of human psoriasin/S100A7. Results Although mouse S100A7/psoriasin is poorly conserved relative to other S100 family members, its pattern of expression parallels that of the human psoriasin gene. In murine skin S100A7/psoriasin was significantly upregulated in relation to inflammation. In murine mammary gland expression is also upregulated in mammary tumors, where it is localized to areas of squamous differentiation. This mirrors the context of expression in human tumor types where both squamous and glandular differentiation occur, including cervical and lung carcinomas. Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene. Conclusion These observations and results support the hypothesis that the mouse S100A7 gene is structurally and functionally similar to human S100A7 and may offer a relevant model system for studying its normal biological function and putative role in tumor progression. © Webb et al; licensee BioMed Central Ltd. 2005. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
url	https://dx.doi.org/10.1186/1471-2407-5-17
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Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis

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