A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data...
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Autor*in:	de Bock, Geertruida H [verfasserIn] Jacobi, Catharina E Seynaeve, Caroline Krol-Warmerdam, Elly MM Blom, Jannet van Asperen, Christi J Cornelisse, Cees J Klijn, Jan GM Devilee, Peter Tollenaar, Rob AEM Brekelmans, Cecile TM van Houwelingen, Johannes C

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Breast Cancer Breast Cancer Risk Breast Cancer Diagnosis Index Patient Develop Breast Cancer

Anmerkung:	© de Bock et al; licensee BioMed Central Ltd. 2008

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 8(2008), 1 vom: 23. Juli
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1 ; day:23 ; month:07

Links:	Volltext

DOI / URN:	10.1186/1471-2407-8-203

Katalog-ID:	SPR027614646

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245	1	2	\|a A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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520			\|a Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.
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publishDate	2008
allfields	10.1186/1471-2407-8-203 doi (DE-627)SPR027614646 (SPR)1471-2407-8-203-e DE-627 ger DE-627 rakwb eng de Bock, Geertruida H verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © de Bock et al; licensee BioMed Central Ltd. 2008 Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. Breast Cancer (dpeaa)DE-He213 Breast Cancer Risk (dpeaa)DE-He213 Breast Cancer Diagnosis (dpeaa)DE-He213 Index Patient (dpeaa)DE-He213 Develop Breast Cancer (dpeaa)DE-He213 Jacobi, Catharina E aut Seynaeve, Caroline aut Krol-Warmerdam, Elly MM aut Blom, Jannet aut van Asperen, Christi J aut Cornelisse, Cees J aut Klijn, Jan GM aut Devilee, Peter aut Tollenaar, Rob AEM aut Brekelmans, Cecile TM aut van Houwelingen, Johannes C aut Enthalten in BMC cancer London : BioMed Central, 2001 8(2008), 1 vom: 23. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:8 year:2008 number:1 day:23 month:07 https://dx.doi.org/10.1186/1471-2407-8-203 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 23 07
spelling	10.1186/1471-2407-8-203 doi (DE-627)SPR027614646 (SPR)1471-2407-8-203-e DE-627 ger DE-627 rakwb eng de Bock, Geertruida H verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © de Bock et al; licensee BioMed Central Ltd. 2008 Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. Breast Cancer (dpeaa)DE-He213 Breast Cancer Risk (dpeaa)DE-He213 Breast Cancer Diagnosis (dpeaa)DE-He213 Index Patient (dpeaa)DE-He213 Develop Breast Cancer (dpeaa)DE-He213 Jacobi, Catharina E aut Seynaeve, Caroline aut Krol-Warmerdam, Elly MM aut Blom, Jannet aut van Asperen, Christi J aut Cornelisse, Cees J aut Klijn, Jan GM aut Devilee, Peter aut Tollenaar, Rob AEM aut Brekelmans, Cecile TM aut van Houwelingen, Johannes C aut Enthalten in BMC cancer London : BioMed Central, 2001 8(2008), 1 vom: 23. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:8 year:2008 number:1 day:23 month:07 https://dx.doi.org/10.1186/1471-2407-8-203 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 23 07
allfields_unstemmed	10.1186/1471-2407-8-203 doi (DE-627)SPR027614646 (SPR)1471-2407-8-203-e DE-627 ger DE-627 rakwb eng de Bock, Geertruida H verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © de Bock et al; licensee BioMed Central Ltd. 2008 Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. Breast Cancer (dpeaa)DE-He213 Breast Cancer Risk (dpeaa)DE-He213 Breast Cancer Diagnosis (dpeaa)DE-He213 Index Patient (dpeaa)DE-He213 Develop Breast Cancer (dpeaa)DE-He213 Jacobi, Catharina E aut Seynaeve, Caroline aut Krol-Warmerdam, Elly MM aut Blom, Jannet aut van Asperen, Christi J aut Cornelisse, Cees J aut Klijn, Jan GM aut Devilee, Peter aut Tollenaar, Rob AEM aut Brekelmans, Cecile TM aut van Houwelingen, Johannes C aut Enthalten in BMC cancer London : BioMed Central, 2001 8(2008), 1 vom: 23. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:8 year:2008 number:1 day:23 month:07 https://dx.doi.org/10.1186/1471-2407-8-203 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 23 07
allfieldsGer	10.1186/1471-2407-8-203 doi (DE-627)SPR027614646 (SPR)1471-2407-8-203-e DE-627 ger DE-627 rakwb eng de Bock, Geertruida H verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © de Bock et al; licensee BioMed Central Ltd. 2008 Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. Breast Cancer (dpeaa)DE-He213 Breast Cancer Risk (dpeaa)DE-He213 Breast Cancer Diagnosis (dpeaa)DE-He213 Index Patient (dpeaa)DE-He213 Develop Breast Cancer (dpeaa)DE-He213 Jacobi, Catharina E aut Seynaeve, Caroline aut Krol-Warmerdam, Elly MM aut Blom, Jannet aut van Asperen, Christi J aut Cornelisse, Cees J aut Klijn, Jan GM aut Devilee, Peter aut Tollenaar, Rob AEM aut Brekelmans, Cecile TM aut van Houwelingen, Johannes C aut Enthalten in BMC cancer London : BioMed Central, 2001 8(2008), 1 vom: 23. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:8 year:2008 number:1 day:23 month:07 https://dx.doi.org/10.1186/1471-2407-8-203 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 23 07
allfieldsSound	10.1186/1471-2407-8-203 doi (DE-627)SPR027614646 (SPR)1471-2407-8-203-e DE-627 ger DE-627 rakwb eng de Bock, Geertruida H verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © de Bock et al; licensee BioMed Central Ltd. 2008 Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. Breast Cancer (dpeaa)DE-He213 Breast Cancer Risk (dpeaa)DE-He213 Breast Cancer Diagnosis (dpeaa)DE-He213 Index Patient (dpeaa)DE-He213 Develop Breast Cancer (dpeaa)DE-He213 Jacobi, Catharina E aut Seynaeve, Caroline aut Krol-Warmerdam, Elly MM aut Blom, Jannet aut van Asperen, Christi J aut Cornelisse, Cees J aut Klijn, Jan GM aut Devilee, Peter aut Tollenaar, Rob AEM aut Brekelmans, Cecile TM aut van Houwelingen, Johannes C aut Enthalten in BMC cancer London : BioMed Central, 2001 8(2008), 1 vom: 23. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:8 year:2008 number:1 day:23 month:07 https://dx.doi.org/10.1186/1471-2407-8-203 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 23 07
language	English
source	Enthalten in BMC cancer 8(2008), 1 vom: 23. Juli volume:8 year:2008 number:1 day:23 month:07
sourceStr	Enthalten in BMC cancer 8(2008), 1 vom: 23. Juli volume:8 year:2008 number:1 day:23 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Breast Cancer Breast Cancer Risk Breast Cancer Diagnosis Index Patient Develop Breast Cancer
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	de Bock, Geertruida H @@aut@@ Jacobi, Catharina E @@aut@@ Seynaeve, Caroline @@aut@@ Krol-Warmerdam, Elly MM @@aut@@ Blom, Jannet @@aut@@ van Asperen, Christi J @@aut@@ Cornelisse, Cees J @@aut@@ Klijn, Jan GM @@aut@@ Devilee, Peter @@aut@@ Tollenaar, Rob AEM @@aut@@ Brekelmans, Cecile TM @@aut@@ van Houwelingen, Johannes C @@aut@@
publishDateDaySort_date	2008-07-23T00:00:00Z
hierarchy_top_id	326643710
id	SPR027614646
language_de	englisch
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This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. 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author	de Bock, Geertruida H
spellingShingle	de Bock, Geertruida H misc Breast Cancer misc Breast Cancer Risk misc Breast Cancer Diagnosis misc Index Patient misc Develop Breast Cancer A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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topic_title	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting Breast Cancer (dpeaa)DE-He213 Breast Cancer Risk (dpeaa)DE-He213 Breast Cancer Diagnosis (dpeaa)DE-He213 Index Patient (dpeaa)DE-He213 Develop Breast Cancer (dpeaa)DE-He213
topic	misc Breast Cancer misc Breast Cancer Risk misc Breast Cancer Diagnosis misc Index Patient misc Develop Breast Cancer
topic_unstemmed	misc Breast Cancer misc Breast Cancer Risk misc Breast Cancer Diagnosis misc Index Patient misc Develop Breast Cancer
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title	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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title_full	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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author_browse	de Bock, Geertruida H Jacobi, Catharina E Seynaeve, Caroline Krol-Warmerdam, Elly MM Blom, Jannet van Asperen, Christi J Cornelisse, Cees J Klijn, Jan GM Devilee, Peter Tollenaar, Rob AEM Brekelmans, Cecile TM van Houwelingen, Johannes C
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doi_str_mv	10.1186/1471-2407-8-203
title_sort	family history of breast cancer will not predict female early onset breast cancer in a population-based setting
title_auth	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
abstract	Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. © de Bock et al; licensee BioMed Central Ltd. 2008
abstractGer	Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. © de Bock et al; licensee BioMed Central Ltd. 2008
abstract_unstemmed	Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age. © de Bock et al; licensee BioMed Central Ltd. 2008
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title_short	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

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