No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Metho...
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Autor*in:	Goode, Ellen L [verfasserIn] Szabo, Csilla Prokunina-Olsson, Ludmila Vierkant, Robert A Fredericksen, Zachary S Collins, Francis S White, Kristin L Schmidt, Michele Fridley, Brooke L Couch, Fergus J

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Breast Cancer Ovarian Cancer Breast Cancer Case Familial Breast Cancer Ovarian Cancer Case

Anmerkung:	© Goode et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 9(2009), 1 vom: 04. Sept.
Übergeordnetes Werk:	volume:9 ; year:2009 ; number:1 ; day:04 ; month:09

Links:	Volltext

DOI / URN:	10.1186/1471-2407-9-312

Katalog-ID:	SPR02762093X

Internformat


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024	7		\|a 10.1186/1471-2407-9-312 \|2 doi
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040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Goode, Ellen L \|e verfasserin \|4 aut
245	1	0	\|a No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
264		1	\|c 2009
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © Goode et al; licensee BioMed Central Ltd. 2009
520			\|a Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed.
650		4	\|a Breast Cancer \|7 (dpeaa)DE-He213
650		4	\|a Ovarian Cancer \|7 (dpeaa)DE-He213
650		4	\|a Breast Cancer Case \|7 (dpeaa)DE-He213
650		4	\|a Familial Breast Cancer \|7 (dpeaa)DE-He213
650		4	\|a Ovarian Cancer Case \|7 (dpeaa)DE-He213
700	1		\|a Szabo, Csilla \|4 aut
700	1		\|a Prokunina-Olsson, Ludmila \|4 aut
700	1		\|a Vierkant, Robert A \|4 aut
700	1		\|a Fredericksen, Zachary S \|4 aut
700	1		\|a Collins, Francis S \|4 aut
700	1		\|a White, Kristin L \|4 aut
700	1		\|a Schmidt, Michele \|4 aut
700	1		\|a Fridley, Brooke L \|4 aut
700	1		\|a Couch, Fergus J \|4 aut
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856	4	0	\|u https://dx.doi.org/10.1186/1471-2407-9-312 \|z kostenfrei \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_SPRINGER
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 9 \|j 2009 \|e 1 \|b 04 \|c 09

Indexfelder

author_variant	e l g el elg c s cs l p o lpo r a v ra rav z s f zs zsf f s c fs fsc k l w kl klw m s ms b l f bl blf f j c fj fjc
matchkey_str	article:14712407:2009----::osoitobtencniaec72ainadikfr
hierarchy_sort_str	2009
publishDate	2009
allfields	10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09
spelling	10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09
allfields_unstemmed	10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09
allfieldsGer	10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09
allfieldsSound	10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09
language	English
source	Enthalten in BMC cancer 9(2009), 1 vom: 04. Sept. volume:9 year:2009 number:1 day:04 month:09
sourceStr	Enthalten in BMC cancer 9(2009), 1 vom: 04. Sept. volume:9 year:2009 number:1 day:04 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Breast Cancer Ovarian Cancer Breast Cancer Case Familial Breast Cancer Ovarian Cancer Case
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Goode, Ellen L @@aut@@ Szabo, Csilla @@aut@@ Prokunina-Olsson, Ludmila @@aut@@ Vierkant, Robert A @@aut@@ Fredericksen, Zachary S @@aut@@ Collins, Francis S @@aut@@ White, Kristin L @@aut@@ Schmidt, Michele @@aut@@ Fridley, Brooke L @@aut@@ Couch, Fergus J @@aut@@
publishDateDaySort_date	2009-09-04T00:00:00Z
hierarchy_top_id	326643710
id	SPR02762093X
language_de	englisch
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author	Goode, Ellen L
spellingShingle	Goode, Ellen L misc Breast Cancer misc Ovarian Cancer misc Breast Cancer Case misc Familial Breast Cancer misc Ovarian Cancer Case No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
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topic_title	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213
topic	misc Breast Cancer misc Ovarian Cancer misc Breast Cancer Case misc Familial Breast Cancer misc Ovarian Cancer Case
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title	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
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title_full	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
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author_browse	Goode, Ellen L Szabo, Csilla Prokunina-Olsson, Ludmila Vierkant, Robert A Fredericksen, Zachary S Collins, Francis S White, Kristin L Schmidt, Michele Fridley, Brooke L Couch, Fergus J
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author-letter	Goode, Ellen L
doi_str_mv	10.1186/1471-2407-9-312
title_sort	no association between a candidate tcf7l2 variant and risk of breast or ovarian cancer
title_auth	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
abstract	Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. © Goode et al; licensee BioMed Central Ltd. 2009
abstractGer	Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. © Goode et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. © Goode et al; licensee BioMed Central Ltd. 2009
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title_short	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
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No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

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