No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Metho...
Ausführliche Beschreibung
Autor*in: |
Goode, Ellen L [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2009 |
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Anmerkung: |
© Goode et al; licensee BioMed Central Ltd. 2009 |
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Übergeordnetes Werk: |
Enthalten in: BMC cancer - London : BioMed Central, 2001, 9(2009), 1 vom: 04. Sept. |
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Übergeordnetes Werk: |
volume:9 ; year:2009 ; number:1 ; day:04 ; month:09 |
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DOI / URN: |
10.1186/1471-2407-9-312 |
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Katalog-ID: |
SPR02762093X |
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245 | 1 | 0 | |a No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer |
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520 | |a Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. | ||
650 | 4 | |a Breast Cancer |7 (dpeaa)DE-He213 | |
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650 | 4 | |a Familial Breast Cancer |7 (dpeaa)DE-He213 | |
650 | 4 | |a Ovarian Cancer Case |7 (dpeaa)DE-He213 | |
700 | 1 | |a Szabo, Csilla |4 aut | |
700 | 1 | |a Prokunina-Olsson, Ludmila |4 aut | |
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700 | 1 | |a Fredericksen, Zachary S |4 aut | |
700 | 1 | |a Collins, Francis S |4 aut | |
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700 | 1 | |a Schmidt, Michele |4 aut | |
700 | 1 | |a Fridley, Brooke L |4 aut | |
700 | 1 | |a Couch, Fergus J |4 aut | |
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10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09 |
spelling |
10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09 |
allfields_unstemmed |
10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09 |
allfieldsGer |
10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09 |
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10.1186/1471-2407-9-312 doi (DE-627)SPR02762093X (SPR)1471-2407-9-312-e DE-627 ger DE-627 rakwb eng Goode, Ellen L verfasserin aut No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Goode et al; licensee BioMed Central Ltd. 2009 Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. Breast Cancer (dpeaa)DE-He213 Ovarian Cancer (dpeaa)DE-He213 Breast Cancer Case (dpeaa)DE-He213 Familial Breast Cancer (dpeaa)DE-He213 Ovarian Cancer Case (dpeaa)DE-He213 Szabo, Csilla aut Prokunina-Olsson, Ludmila aut Vierkant, Robert A aut Fredericksen, Zachary S aut Collins, Francis S aut White, Kristin L aut Schmidt, Michele aut Fridley, Brooke L aut Couch, Fergus J aut Enthalten in BMC cancer London : BioMed Central, 2001 9(2009), 1 vom: 04. Sept. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:9 year:2009 number:1 day:04 month:09 https://dx.doi.org/10.1186/1471-2407-9-312 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 04 09 |
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no association between a candidate tcf7l2 variant and risk of breast or ovarian cancer |
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No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer |
abstract |
Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. © Goode et al; licensee BioMed Central Ltd. 2009 |
abstractGer |
Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. © Goode et al; licensee BioMed Central Ltd. 2009 |
abstract_unstemmed |
Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed. © Goode et al; licensee BioMed Central Ltd. 2009 |
collection_details |
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container_issue |
1 |
title_short |
No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer |
url |
https://dx.doi.org/10.1186/1471-2407-9-312 |
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author2 |
Szabo, Csilla Prokunina-Olsson, Ludmila Vierkant, Robert A Fredericksen, Zachary S Collins, Francis S White, Kristin L Schmidt, Michele Fridley, Brooke L Couch, Fergus J |
author2Str |
Szabo, Csilla Prokunina-Olsson, Ludmila Vierkant, Robert A Fredericksen, Zachary S Collins, Francis S White, Kristin L Schmidt, Michele Fridley, Brooke L Couch, Fergus J |
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doi_str |
10.1186/1471-2407-9-312 |
up_date |
2024-07-03T14:01:35.882Z |
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