Aged garlic extract therapy for sickle cell anemia patients
Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been repo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Takasu, Junichiro [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2002 |
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| Anmerkung: |
© Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
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| Übergeordnetes Werk: |
Enthalten in: BMC hematology - London : BioMed Central, 2013, 2(2002), 1 vom: 19. Juni |
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| Übergeordnetes Werk: |
volume:2 ; year:2002 ; number:1 ; day:19 ; month:06 |
| Links: |
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| DOI / URN: |
10.1186/1471-2326-2-3 |
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| Katalog-ID: |
SPR027637654 |
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| 520 | |a Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. | ||
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10.1186/1471-2326-2-3 doi (DE-627)SPR027637654 (SPR)1471-2326-2-3-e DE-627 ger DE-627 rakwb eng Takasu, Junichiro verfasserin aut Aged garlic extract therapy for sickle cell anemia patients 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. Sickle Cell Anemia (dpeaa)DE-He213 Sickle Cell (dpeaa)DE-He213 Sickle Cell Anemia Patient (dpeaa)DE-He213 Allium Sativum (dpeaa)DE-He213 Erythrocyte Deformability (dpeaa)DE-He213 Uykimpang, Rolando aut Sunga, Maria Alenor aut Amagase, Harunobu aut Niihara, Yutaka aut Enthalten in BMC hematology London : BioMed Central, 2013 2(2002), 1 vom: 19. Juni (DE-627)773473114 (DE-600)2744433-8 2052-1839 nnns volume:2 year:2002 number:1 day:19 month:06 https://dx.doi.org/10.1186/1471-2326-2-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 2 2002 1 19 06 |
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10.1186/1471-2326-2-3 doi (DE-627)SPR027637654 (SPR)1471-2326-2-3-e DE-627 ger DE-627 rakwb eng Takasu, Junichiro verfasserin aut Aged garlic extract therapy for sickle cell anemia patients 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. Sickle Cell Anemia (dpeaa)DE-He213 Sickle Cell (dpeaa)DE-He213 Sickle Cell Anemia Patient (dpeaa)DE-He213 Allium Sativum (dpeaa)DE-He213 Erythrocyte Deformability (dpeaa)DE-He213 Uykimpang, Rolando aut Sunga, Maria Alenor aut Amagase, Harunobu aut Niihara, Yutaka aut Enthalten in BMC hematology London : BioMed Central, 2013 2(2002), 1 vom: 19. Juni (DE-627)773473114 (DE-600)2744433-8 2052-1839 nnns volume:2 year:2002 number:1 day:19 month:06 https://dx.doi.org/10.1186/1471-2326-2-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 2 2002 1 19 06 |
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10.1186/1471-2326-2-3 doi (DE-627)SPR027637654 (SPR)1471-2326-2-3-e DE-627 ger DE-627 rakwb eng Takasu, Junichiro verfasserin aut Aged garlic extract therapy for sickle cell anemia patients 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. Sickle Cell Anemia (dpeaa)DE-He213 Sickle Cell (dpeaa)DE-He213 Sickle Cell Anemia Patient (dpeaa)DE-He213 Allium Sativum (dpeaa)DE-He213 Erythrocyte Deformability (dpeaa)DE-He213 Uykimpang, Rolando aut Sunga, Maria Alenor aut Amagase, Harunobu aut Niihara, Yutaka aut Enthalten in BMC hematology London : BioMed Central, 2013 2(2002), 1 vom: 19. Juni (DE-627)773473114 (DE-600)2744433-8 2052-1839 nnns volume:2 year:2002 number:1 day:19 month:06 https://dx.doi.org/10.1186/1471-2326-2-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 2 2002 1 19 06 |
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10.1186/1471-2326-2-3 doi (DE-627)SPR027637654 (SPR)1471-2326-2-3-e DE-627 ger DE-627 rakwb eng Takasu, Junichiro verfasserin aut Aged garlic extract therapy for sickle cell anemia patients 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. Sickle Cell Anemia (dpeaa)DE-He213 Sickle Cell (dpeaa)DE-He213 Sickle Cell Anemia Patient (dpeaa)DE-He213 Allium Sativum (dpeaa)DE-He213 Erythrocyte Deformability (dpeaa)DE-He213 Uykimpang, Rolando aut Sunga, Maria Alenor aut Amagase, Harunobu aut Niihara, Yutaka aut Enthalten in BMC hematology London : BioMed Central, 2013 2(2002), 1 vom: 19. Juni (DE-627)773473114 (DE-600)2744433-8 2052-1839 nnns volume:2 year:2002 number:1 day:19 month:06 https://dx.doi.org/10.1186/1471-2326-2-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 2 2002 1 19 06 |
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10.1186/1471-2326-2-3 doi (DE-627)SPR027637654 (SPR)1471-2326-2-3-e DE-627 ger DE-627 rakwb eng Takasu, Junichiro verfasserin aut Aged garlic extract therapy for sickle cell anemia patients 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. Sickle Cell Anemia (dpeaa)DE-He213 Sickle Cell (dpeaa)DE-He213 Sickle Cell Anemia Patient (dpeaa)DE-He213 Allium Sativum (dpeaa)DE-He213 Erythrocyte Deformability (dpeaa)DE-He213 Uykimpang, Rolando aut Sunga, Maria Alenor aut Amagase, Harunobu aut Niihara, Yutaka aut Enthalten in BMC hematology London : BioMed Central, 2013 2(2002), 1 vom: 19. Juni (DE-627)773473114 (DE-600)2744433-8 2052-1839 nnns volume:2 year:2002 number:1 day:19 month:06 https://dx.doi.org/10.1186/1471-2326-2-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_110 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 AR 2 2002 1 19 06 |
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Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
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Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| abstract_unstemmed |
Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). Methods Five patients (two men and three women, mean age 40 ± 15 years, range 24–58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. Results The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 ± 20.0% at baseline to 29.8 ± 15.3% at follow-up, p = 0.03). Conclusions These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia. © Takasu et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
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