Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A compr...
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Autor*in:	Zhou, Yanming [verfasserIn] Zhao, Yanfang Li, Bin Huang, Jiyi Wu, Lupeng Xu, Donghui Yang, Jiamei He, Jia

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Intrahepatic Cholangiocarcinoma Hepatitis Virus Infection Summary Odds Ratio Cholangiocarcinoma Cell Line Periductal Infiltrate

Anmerkung:	© Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 12(2012), 1 vom: 16. Juli
Übergeordnetes Werk:	volume:12 ; year:2012 ; number:1 ; day:16 ; month:07

Links:	Volltext

DOI / URN:	10.1186/1471-2407-12-289

Katalog-ID:	SPR027638251

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520			\|a Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC.
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allfields	10.1186/1471-2407-12-289 doi (DE-627)SPR027638251 (SPR)1471-2407-12-289-e DE-627 ger DE-627 rakwb eng Zhou, Yanming verfasserin aut Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. Intrahepatic Cholangiocarcinoma (dpeaa)DE-He213 Hepatitis Virus Infection (dpeaa)DE-He213 Summary Odds Ratio (dpeaa)DE-He213 Cholangiocarcinoma Cell Line (dpeaa)DE-He213 Periductal Infiltrate (dpeaa)DE-He213 Zhao, Yanfang aut Li, Bin aut Huang, Jiyi aut Wu, Lupeng aut Xu, Donghui aut Yang, Jiamei aut He, Jia aut Enthalten in BMC cancer London : BioMed Central, 2001 12(2012), 1 vom: 16. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:12 year:2012 number:1 day:16 month:07 https://dx.doi.org/10.1186/1471-2407-12-289 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 16 07
spelling	10.1186/1471-2407-12-289 doi (DE-627)SPR027638251 (SPR)1471-2407-12-289-e DE-627 ger DE-627 rakwb eng Zhou, Yanming verfasserin aut Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. Intrahepatic Cholangiocarcinoma (dpeaa)DE-He213 Hepatitis Virus Infection (dpeaa)DE-He213 Summary Odds Ratio (dpeaa)DE-He213 Cholangiocarcinoma Cell Line (dpeaa)DE-He213 Periductal Infiltrate (dpeaa)DE-He213 Zhao, Yanfang aut Li, Bin aut Huang, Jiyi aut Wu, Lupeng aut Xu, Donghui aut Yang, Jiamei aut He, Jia aut Enthalten in BMC cancer London : BioMed Central, 2001 12(2012), 1 vom: 16. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:12 year:2012 number:1 day:16 month:07 https://dx.doi.org/10.1186/1471-2407-12-289 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 16 07
allfields_unstemmed	10.1186/1471-2407-12-289 doi (DE-627)SPR027638251 (SPR)1471-2407-12-289-e DE-627 ger DE-627 rakwb eng Zhou, Yanming verfasserin aut Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. Intrahepatic Cholangiocarcinoma (dpeaa)DE-He213 Hepatitis Virus Infection (dpeaa)DE-He213 Summary Odds Ratio (dpeaa)DE-He213 Cholangiocarcinoma Cell Line (dpeaa)DE-He213 Periductal Infiltrate (dpeaa)DE-He213 Zhao, Yanfang aut Li, Bin aut Huang, Jiyi aut Wu, Lupeng aut Xu, Donghui aut Yang, Jiamei aut He, Jia aut Enthalten in BMC cancer London : BioMed Central, 2001 12(2012), 1 vom: 16. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:12 year:2012 number:1 day:16 month:07 https://dx.doi.org/10.1186/1471-2407-12-289 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 16 07
allfieldsGer	10.1186/1471-2407-12-289 doi (DE-627)SPR027638251 (SPR)1471-2407-12-289-e DE-627 ger DE-627 rakwb eng Zhou, Yanming verfasserin aut Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. Intrahepatic Cholangiocarcinoma (dpeaa)DE-He213 Hepatitis Virus Infection (dpeaa)DE-He213 Summary Odds Ratio (dpeaa)DE-He213 Cholangiocarcinoma Cell Line (dpeaa)DE-He213 Periductal Infiltrate (dpeaa)DE-He213 Zhao, Yanfang aut Li, Bin aut Huang, Jiyi aut Wu, Lupeng aut Xu, Donghui aut Yang, Jiamei aut He, Jia aut Enthalten in BMC cancer London : BioMed Central, 2001 12(2012), 1 vom: 16. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:12 year:2012 number:1 day:16 month:07 https://dx.doi.org/10.1186/1471-2407-12-289 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 16 07
allfieldsSound	10.1186/1471-2407-12-289 doi (DE-627)SPR027638251 (SPR)1471-2407-12-289-e DE-627 ger DE-627 rakwb eng Zhou, Yanming verfasserin aut Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. Intrahepatic Cholangiocarcinoma (dpeaa)DE-He213 Hepatitis Virus Infection (dpeaa)DE-He213 Summary Odds Ratio (dpeaa)DE-He213 Cholangiocarcinoma Cell Line (dpeaa)DE-He213 Periductal Infiltrate (dpeaa)DE-He213 Zhao, Yanfang aut Li, Bin aut Huang, Jiyi aut Wu, Lupeng aut Xu, Donghui aut Yang, Jiamei aut He, Jia aut Enthalten in BMC cancer London : BioMed Central, 2001 12(2012), 1 vom: 16. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:12 year:2012 number:1 day:16 month:07 https://dx.doi.org/10.1186/1471-2407-12-289 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 16 07
language	English
source	Enthalten in BMC cancer 12(2012), 1 vom: 16. Juli volume:12 year:2012 number:1 day:16 month:07
sourceStr	Enthalten in BMC cancer 12(2012), 1 vom: 16. Juli volume:12 year:2012 number:1 day:16 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Intrahepatic Cholangiocarcinoma Hepatitis Virus Infection Summary Odds Ratio Cholangiocarcinoma Cell Line Periductal Infiltrate
isfreeaccess_bool	false
container_title	BMC cancer
authorswithroles_txt_mv	Zhou, Yanming @@aut@@ Zhao, Yanfang @@aut@@ Li, Bin @@aut@@ Huang, Jiyi @@aut@@ Wu, Lupeng @@aut@@ Xu, Donghui @@aut@@ Yang, Jiamei @@aut@@ He, Jia @@aut@@
publishDateDaySort_date	2012-07-16T00:00:00Z
hierarchy_top_id	326643710
id	SPR027638251
language_de	englisch
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The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. 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author	Zhou, Yanming
spellingShingle	Zhou, Yanming misc Intrahepatic Cholangiocarcinoma misc Hepatitis Virus Infection misc Summary Odds Ratio misc Cholangiocarcinoma Cell Line misc Periductal Infiltrate Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis
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topic_title	Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis Intrahepatic Cholangiocarcinoma (dpeaa)DE-He213 Hepatitis Virus Infection (dpeaa)DE-He213 Summary Odds Ratio (dpeaa)DE-He213 Cholangiocarcinoma Cell Line (dpeaa)DE-He213 Periductal Infiltrate (dpeaa)DE-He213
topic	misc Intrahepatic Cholangiocarcinoma misc Hepatitis Virus Infection misc Summary Odds Ratio misc Cholangiocarcinoma Cell Line misc Periductal Infiltrate
topic_unstemmed	misc Intrahepatic Cholangiocarcinoma misc Hepatitis Virus Infection misc Summary Odds Ratio misc Cholangiocarcinoma Cell Line misc Periductal Infiltrate
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title	Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis
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title_full	Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis
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author_browse	Zhou, Yanming Zhao, Yanfang Li, Bin Huang, Jiyi Wu, Lupeng Xu, Donghui Yang, Jiamei He, Jia
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doi_str_mv	10.1186/1471-2407-12-289
title_sort	hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis
title_auth	Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis
abstract	Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship. Methods A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0. Results Thirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively. Conclusions This study suggests that both HBV and HCV infection are associated with an increased risk of ICC. © Zhou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis
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