TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glio...
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Autor*in:	Micale, Lucia [verfasserIn] Fusco, Carmela Fontana, Andrea Barbano, Raffaela Augello, Bartolomeo De Nittis, Pasquelena Copetti, Massimiliano Pellico, Maria Teresa Mandriani, Barbara Cocciadiferro, Dario Parrella, Paola Fazio, Vito Michele Dimitri, Lucia Maria Cecilia D’Angelo, Vincenzo Novielli, Chiara Larizza, Lidia Daga, Antonio Merla, Giuseppe

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	TRIM8 Glioblastoma miR-17 Cell proliferation

Anmerkung:	© Micale et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 15(2015), 1 vom: 16. Juni
Übergeordnetes Werk:	volume:15 ; year:2015 ; number:1 ; day:16 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12885-015-1449-9

Katalog-ID:	SPR02766614X

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520			\|a Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients.
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allfields	10.1186/s12885-015-1449-9 doi (DE-627)SPR02766614X (SPR)s12885-015-1449-9-e DE-627 ger DE-627 rakwb eng Micale, Lucia verfasserin aut TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Micale et al. 2015 Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. TRIM8 (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 miR-17 (dpeaa)DE-He213 Cell proliferation (dpeaa)DE-He213 Fusco, Carmela aut Fontana, Andrea aut Barbano, Raffaela aut Augello, Bartolomeo aut De Nittis, Pasquelena aut Copetti, Massimiliano aut Pellico, Maria Teresa aut Mandriani, Barbara aut Cocciadiferro, Dario aut Parrella, Paola aut Fazio, Vito Michele aut Dimitri, Lucia Maria Cecilia aut D’Angelo, Vincenzo aut Novielli, Chiara aut Larizza, Lidia aut Daga, Antonio aut Merla, Giuseppe aut Enthalten in BMC cancer London : BioMed Central, 2001 15(2015), 1 vom: 16. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:15 year:2015 number:1 day:16 month:06 https://dx.doi.org/10.1186/s12885-015-1449-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 16 06
spelling	10.1186/s12885-015-1449-9 doi (DE-627)SPR02766614X (SPR)s12885-015-1449-9-e DE-627 ger DE-627 rakwb eng Micale, Lucia verfasserin aut TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Micale et al. 2015 Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. TRIM8 (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 miR-17 (dpeaa)DE-He213 Cell proliferation (dpeaa)DE-He213 Fusco, Carmela aut Fontana, Andrea aut Barbano, Raffaela aut Augello, Bartolomeo aut De Nittis, Pasquelena aut Copetti, Massimiliano aut Pellico, Maria Teresa aut Mandriani, Barbara aut Cocciadiferro, Dario aut Parrella, Paola aut Fazio, Vito Michele aut Dimitri, Lucia Maria Cecilia aut D’Angelo, Vincenzo aut Novielli, Chiara aut Larizza, Lidia aut Daga, Antonio aut Merla, Giuseppe aut Enthalten in BMC cancer London : BioMed Central, 2001 15(2015), 1 vom: 16. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:15 year:2015 number:1 day:16 month:06 https://dx.doi.org/10.1186/s12885-015-1449-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 16 06
allfields_unstemmed	10.1186/s12885-015-1449-9 doi (DE-627)SPR02766614X (SPR)s12885-015-1449-9-e DE-627 ger DE-627 rakwb eng Micale, Lucia verfasserin aut TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Micale et al. 2015 Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. TRIM8 (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 miR-17 (dpeaa)DE-He213 Cell proliferation (dpeaa)DE-He213 Fusco, Carmela aut Fontana, Andrea aut Barbano, Raffaela aut Augello, Bartolomeo aut De Nittis, Pasquelena aut Copetti, Massimiliano aut Pellico, Maria Teresa aut Mandriani, Barbara aut Cocciadiferro, Dario aut Parrella, Paola aut Fazio, Vito Michele aut Dimitri, Lucia Maria Cecilia aut D’Angelo, Vincenzo aut Novielli, Chiara aut Larizza, Lidia aut Daga, Antonio aut Merla, Giuseppe aut Enthalten in BMC cancer London : BioMed Central, 2001 15(2015), 1 vom: 16. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:15 year:2015 number:1 day:16 month:06 https://dx.doi.org/10.1186/s12885-015-1449-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 16 06
allfieldsGer	10.1186/s12885-015-1449-9 doi (DE-627)SPR02766614X (SPR)s12885-015-1449-9-e DE-627 ger DE-627 rakwb eng Micale, Lucia verfasserin aut TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Micale et al. 2015 Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. TRIM8 (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 miR-17 (dpeaa)DE-He213 Cell proliferation (dpeaa)DE-He213 Fusco, Carmela aut Fontana, Andrea aut Barbano, Raffaela aut Augello, Bartolomeo aut De Nittis, Pasquelena aut Copetti, Massimiliano aut Pellico, Maria Teresa aut Mandriani, Barbara aut Cocciadiferro, Dario aut Parrella, Paola aut Fazio, Vito Michele aut Dimitri, Lucia Maria Cecilia aut D’Angelo, Vincenzo aut Novielli, Chiara aut Larizza, Lidia aut Daga, Antonio aut Merla, Giuseppe aut Enthalten in BMC cancer London : BioMed Central, 2001 15(2015), 1 vom: 16. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:15 year:2015 number:1 day:16 month:06 https://dx.doi.org/10.1186/s12885-015-1449-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 16 06
allfieldsSound	10.1186/s12885-015-1449-9 doi (DE-627)SPR02766614X (SPR)s12885-015-1449-9-e DE-627 ger DE-627 rakwb eng Micale, Lucia verfasserin aut TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Micale et al. 2015 Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. TRIM8 (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 miR-17 (dpeaa)DE-He213 Cell proliferation (dpeaa)DE-He213 Fusco, Carmela aut Fontana, Andrea aut Barbano, Raffaela aut Augello, Bartolomeo aut De Nittis, Pasquelena aut Copetti, Massimiliano aut Pellico, Maria Teresa aut Mandriani, Barbara aut Cocciadiferro, Dario aut Parrella, Paola aut Fazio, Vito Michele aut Dimitri, Lucia Maria Cecilia aut D’Angelo, Vincenzo aut Novielli, Chiara aut Larizza, Lidia aut Daga, Antonio aut Merla, Giuseppe aut Enthalten in BMC cancer London : BioMed Central, 2001 15(2015), 1 vom: 16. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:15 year:2015 number:1 day:16 month:06 https://dx.doi.org/10.1186/s12885-015-1449-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 16 06
language	English
source	Enthalten in BMC cancer 15(2015), 1 vom: 16. Juni volume:15 year:2015 number:1 day:16 month:06
sourceStr	Enthalten in BMC cancer 15(2015), 1 vom: 16. Juni volume:15 year:2015 number:1 day:16 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	TRIM8 Glioblastoma miR-17 Cell proliferation
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Micale, Lucia @@aut@@ Fusco, Carmela @@aut@@ Fontana, Andrea @@aut@@ Barbano, Raffaela @@aut@@ Augello, Bartolomeo @@aut@@ De Nittis, Pasquelena @@aut@@ Copetti, Massimiliano @@aut@@ Pellico, Maria Teresa @@aut@@ Mandriani, Barbara @@aut@@ Cocciadiferro, Dario @@aut@@ Parrella, Paola @@aut@@ Fazio, Vito Michele @@aut@@ Dimitri, Lucia Maria Cecilia @@aut@@ D’Angelo, Vincenzo @@aut@@ Novielli, Chiara @@aut@@ Larizza, Lidia @@aut@@ Daga, Antonio @@aut@@ Merla, Giuseppe @@aut@@
publishDateDaySort_date	2015-06-16T00:00:00Z
hierarchy_top_id	326643710
id	SPR02766614X
language_de	englisch
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author	Micale, Lucia
spellingShingle	Micale, Lucia misc TRIM8 misc Glioblastoma misc miR-17 misc Cell proliferation TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival
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topic_title	TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival TRIM8 (dpeaa)DE-He213 Glioblastoma (dpeaa)DE-He213 miR-17 (dpeaa)DE-He213 Cell proliferation (dpeaa)DE-He213
topic	misc TRIM8 misc Glioblastoma misc miR-17 misc Cell proliferation
topic_unstemmed	misc TRIM8 misc Glioblastoma misc miR-17 misc Cell proliferation
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title	TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival
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title_full	TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival
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author_browse	Micale, Lucia Fusco, Carmela Fontana, Andrea Barbano, Raffaela Augello, Bartolomeo De Nittis, Pasquelena Copetti, Massimiliano Pellico, Maria Teresa Mandriani, Barbara Cocciadiferro, Dario Parrella, Paola Fazio, Vito Michele Dimitri, Lucia Maria Cecilia D’Angelo, Vincenzo Novielli, Chiara Larizza, Lidia Daga, Antonio Merla, Giuseppe
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doi_str_mv	10.1186/s12885-015-1449-9
title_sort	trim8 downregulation in glioma affects cell proliferation and it is associated with patients survival
title_auth	TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival
abstract	Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. © Micale et al. 2015
abstractGer	Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. © Micale et al. 2015
abstract_unstemmed	Background Human gliomas are a heterogeneous group of primary malignant brain tumors whose molecular pathogenesis is not yet solved. In this regard, a major research effort has been directed at identifying novel specific glioma-associated genes. Here, we investigated the effect of TRIM8 gene in glioma. Methods TRIM8 transcriptional level was profiled in our own glioma cases collection by qPCR and confirmed in the independent TCGA glioma cohort. The association between TRIM8 expression and Overall Survival and Progression-free Survival in TCGA cohort was determined by using uni-multivariable Cox regression analysis. The effect of TRIM8 on patient glioma cell proliferation was evaluated by performing MTT and clonogenic assays. The mechanisms causing the reduction of TRIM8 expression were explored by using qPCR and in vitro assays. Results We showed that TRIM8 expression correlates with unfavorable clinical outcome in glioma patients. We found that a restored TRIM8 expression induced a significant reduction of clonogenic potential in U87MG and patient’s glioblastoma cells. Finally we provide experimental evidences showing that miR-17 directly targets the 3′ UTR of TRIM8 and post-transcriptionally represses the expression of TRIM8. Conclusions Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. © Micale et al. 2015
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title_short	TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival
url	https://dx.doi.org/10.1186/s12885-015-1449-9
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author2	Fusco, Carmela Fontana, Andrea Barbano, Raffaela Augello, Bartolomeo De Nittis, Pasquelena Copetti, Massimiliano Pellico, Maria Teresa Mandriani, Barbara Cocciadiferro, Dario Parrella, Paola Fazio, Vito Michele Dimitri, Lucia Maria Cecilia D’Angelo, Vincenzo Novielli, Chiara Larizza, Lidia Daga, Antonio Merla, Giuseppe
author2Str	Fusco, Carmela Fontana, Andrea Barbano, Raffaela Augello, Bartolomeo De Nittis, Pasquelena Copetti, Massimiliano Pellico, Maria Teresa Mandriani, Barbara Cocciadiferro, Dario Parrella, Paola Fazio, Vito Michele Dimitri, Lucia Maria Cecilia D’Angelo, Vincenzo Novielli, Chiara Larizza, Lidia Daga, Antonio Merla, Giuseppe
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TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

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