Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited

Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 case...
Ausführliche Beschreibung

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Autor*in:	Martens, Pernille [verfasserIn] Worm, Signe Westring Lundgren, Bettina Konradsen, Helle Bossen Benfield, Thomas

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2004

Schlagwörter:	Conjugate Vaccine Invasive Disease Invasive Pneumococcal Disease Pneumococcal Disease Pneumococcal Serotypes

Anmerkung:	© Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 4(2004), 1 vom: 30. Juni
Übergeordnetes Werk:	volume:4 ; year:2004 ; number:1 ; day:30 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1471-2334-4-21

Katalog-ID:	SPR027670988

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520			\|a Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines.
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Indexfelder

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hierarchy_sort_str	2004
publishDate	2004
allfields	10.1186/1471-2334-4-21 doi (DE-627)SPR027670988 (SPR)1471-2334-4-21-e DE-627 ger DE-627 rakwb eng Martens, Pernille verfasserin aut Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. Conjugate Vaccine (dpeaa)DE-He213 Invasive Disease (dpeaa)DE-He213 Invasive Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Serotypes (dpeaa)DE-He213 Worm, Signe Westring aut Lundgren, Bettina aut Konradsen, Helle Bossen aut Benfield, Thomas aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 4(2004), 1 vom: 30. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:4 year:2004 number:1 day:30 month:06 https://dx.doi.org/10.1186/1471-2334-4-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 30 06
spelling	10.1186/1471-2334-4-21 doi (DE-627)SPR027670988 (SPR)1471-2334-4-21-e DE-627 ger DE-627 rakwb eng Martens, Pernille verfasserin aut Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. Conjugate Vaccine (dpeaa)DE-He213 Invasive Disease (dpeaa)DE-He213 Invasive Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Serotypes (dpeaa)DE-He213 Worm, Signe Westring aut Lundgren, Bettina aut Konradsen, Helle Bossen aut Benfield, Thomas aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 4(2004), 1 vom: 30. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:4 year:2004 number:1 day:30 month:06 https://dx.doi.org/10.1186/1471-2334-4-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 30 06
allfields_unstemmed	10.1186/1471-2334-4-21 doi (DE-627)SPR027670988 (SPR)1471-2334-4-21-e DE-627 ger DE-627 rakwb eng Martens, Pernille verfasserin aut Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. Conjugate Vaccine (dpeaa)DE-He213 Invasive Disease (dpeaa)DE-He213 Invasive Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Serotypes (dpeaa)DE-He213 Worm, Signe Westring aut Lundgren, Bettina aut Konradsen, Helle Bossen aut Benfield, Thomas aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 4(2004), 1 vom: 30. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:4 year:2004 number:1 day:30 month:06 https://dx.doi.org/10.1186/1471-2334-4-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 30 06
allfieldsGer	10.1186/1471-2334-4-21 doi (DE-627)SPR027670988 (SPR)1471-2334-4-21-e DE-627 ger DE-627 rakwb eng Martens, Pernille verfasserin aut Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. Conjugate Vaccine (dpeaa)DE-He213 Invasive Disease (dpeaa)DE-He213 Invasive Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Serotypes (dpeaa)DE-He213 Worm, Signe Westring aut Lundgren, Bettina aut Konradsen, Helle Bossen aut Benfield, Thomas aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 4(2004), 1 vom: 30. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:4 year:2004 number:1 day:30 month:06 https://dx.doi.org/10.1186/1471-2334-4-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 30 06
allfieldsSound	10.1186/1471-2334-4-21 doi (DE-627)SPR027670988 (SPR)1471-2334-4-21-e DE-627 ger DE-627 rakwb eng Martens, Pernille verfasserin aut Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. Conjugate Vaccine (dpeaa)DE-He213 Invasive Disease (dpeaa)DE-He213 Invasive Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Serotypes (dpeaa)DE-He213 Worm, Signe Westring aut Lundgren, Bettina aut Konradsen, Helle Bossen aut Benfield, Thomas aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 4(2004), 1 vom: 30. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:4 year:2004 number:1 day:30 month:06 https://dx.doi.org/10.1186/1471-2334-4-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 30 06
language	English
source	Enthalten in BMC infectious diseases 4(2004), 1 vom: 30. Juni volume:4 year:2004 number:1 day:30 month:06
sourceStr	Enthalten in BMC infectious diseases 4(2004), 1 vom: 30. Juni volume:4 year:2004 number:1 day:30 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Conjugate Vaccine Invasive Disease Invasive Pneumococcal Disease Pneumococcal Disease Pneumococcal Serotypes
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Martens, Pernille @@aut@@ Worm, Signe Westring @@aut@@ Lundgren, Bettina @@aut@@ Konradsen, Helle Bossen @@aut@@ Benfield, Thomas @@aut@@
publishDateDaySort_date	2004-06-30T00:00:00Z
hierarchy_top_id	326645381
id	SPR027670988
language_de	englisch
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author	Martens, Pernille
spellingShingle	Martens, Pernille misc Conjugate Vaccine misc Invasive Disease misc Invasive Pneumococcal Disease misc Pneumococcal Disease misc Pneumococcal Serotypes Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited
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topic_title	Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited Conjugate Vaccine (dpeaa)DE-He213 Invasive Disease (dpeaa)DE-He213 Invasive Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Disease (dpeaa)DE-He213 Pneumococcal Serotypes (dpeaa)DE-He213
topic	misc Conjugate Vaccine misc Invasive Disease misc Invasive Pneumococcal Disease misc Pneumococcal Disease misc Pneumococcal Serotypes
topic_unstemmed	misc Conjugate Vaccine misc Invasive Disease misc Invasive Pneumococcal Disease misc Pneumococcal Disease misc Pneumococcal Serotypes
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title	Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited
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title_full	Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited
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title_sort	serotype-specific mortality from invasive streptococcus pneumoniaedisease revisited
title_auth	Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited
abstract	Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
abstractGer	Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
abstract_unstemmed	Background Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Methods Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. Results After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Conclusion Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines. © Martens et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
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title_short	Serotype-specific mortality from invasive Streptococcus pneumoniaedisease revisited
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