Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in...
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Autor*in:	Vasaikar, Suhas [verfasserIn] Tsipras, Giorgos Landázuri, Natalia Costa, Helena Wilhelmi, Vanessa Scicluna, Patrick Cui, Huanhuan L. Mohammad, Abdul-Aleem Davoudi, Belghis Shang, Mingmei Ananthaseshan, Sharan Strååt, Klas Stragliotto, Giuseppe Rahbar, Afsar Wong, Kum Thong Tegner, Jesper Yaiw, Koon-Chu Söderberg-Naucler, Cecilia

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Glioblastoma Endothelin B receptor Endothelin receptor antagonists

Anmerkung:	© The Author(s). 2018

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 18(2018), 1 vom: 06. Feb.
Übergeordnetes Werk:	volume:18 ; year:2018 ; number:1 ; day:06 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12885-018-4012-7

Katalog-ID:	SPR027694577

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520			\|a Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients.
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allfields	10.1186/s12885-018-4012-7 doi (DE-627)SPR027694577 (SPR)s12885-018-4012-7-e DE-627 ger DE-627 rakwb eng Vasaikar, Suhas verfasserin aut Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. Glioblastoma (dpeaa)DE-He213 Endothelin B receptor (dpeaa)DE-He213 Endothelin receptor antagonists (dpeaa)DE-He213 Tsipras, Giorgos aut Landázuri, Natalia aut Costa, Helena aut Wilhelmi, Vanessa aut Scicluna, Patrick aut Cui, Huanhuan L. aut Mohammad, Abdul-Aleem aut Davoudi, Belghis aut Shang, Mingmei aut Ananthaseshan, Sharan aut Strååt, Klas aut Stragliotto, Giuseppe aut Rahbar, Afsar aut Wong, Kum Thong aut Tegner, Jesper aut Yaiw, Koon-Chu (orcid)0000-0001-5329-1815 aut Söderberg-Naucler, Cecilia aut Enthalten in BMC cancer London : BioMed Central, 2001 18(2018), 1 vom: 06. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:18 year:2018 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12885-018-4012-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 06 02
spelling	10.1186/s12885-018-4012-7 doi (DE-627)SPR027694577 (SPR)s12885-018-4012-7-e DE-627 ger DE-627 rakwb eng Vasaikar, Suhas verfasserin aut Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. Glioblastoma (dpeaa)DE-He213 Endothelin B receptor (dpeaa)DE-He213 Endothelin receptor antagonists (dpeaa)DE-He213 Tsipras, Giorgos aut Landázuri, Natalia aut Costa, Helena aut Wilhelmi, Vanessa aut Scicluna, Patrick aut Cui, Huanhuan L. aut Mohammad, Abdul-Aleem aut Davoudi, Belghis aut Shang, Mingmei aut Ananthaseshan, Sharan aut Strååt, Klas aut Stragliotto, Giuseppe aut Rahbar, Afsar aut Wong, Kum Thong aut Tegner, Jesper aut Yaiw, Koon-Chu (orcid)0000-0001-5329-1815 aut Söderberg-Naucler, Cecilia aut Enthalten in BMC cancer London : BioMed Central, 2001 18(2018), 1 vom: 06. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:18 year:2018 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12885-018-4012-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 06 02
allfields_unstemmed	10.1186/s12885-018-4012-7 doi (DE-627)SPR027694577 (SPR)s12885-018-4012-7-e DE-627 ger DE-627 rakwb eng Vasaikar, Suhas verfasserin aut Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. Glioblastoma (dpeaa)DE-He213 Endothelin B receptor (dpeaa)DE-He213 Endothelin receptor antagonists (dpeaa)DE-He213 Tsipras, Giorgos aut Landázuri, Natalia aut Costa, Helena aut Wilhelmi, Vanessa aut Scicluna, Patrick aut Cui, Huanhuan L. aut Mohammad, Abdul-Aleem aut Davoudi, Belghis aut Shang, Mingmei aut Ananthaseshan, Sharan aut Strååt, Klas aut Stragliotto, Giuseppe aut Rahbar, Afsar aut Wong, Kum Thong aut Tegner, Jesper aut Yaiw, Koon-Chu (orcid)0000-0001-5329-1815 aut Söderberg-Naucler, Cecilia aut Enthalten in BMC cancer London : BioMed Central, 2001 18(2018), 1 vom: 06. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:18 year:2018 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12885-018-4012-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 06 02
allfieldsGer	10.1186/s12885-018-4012-7 doi (DE-627)SPR027694577 (SPR)s12885-018-4012-7-e DE-627 ger DE-627 rakwb eng Vasaikar, Suhas verfasserin aut Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. Glioblastoma (dpeaa)DE-He213 Endothelin B receptor (dpeaa)DE-He213 Endothelin receptor antagonists (dpeaa)DE-He213 Tsipras, Giorgos aut Landázuri, Natalia aut Costa, Helena aut Wilhelmi, Vanessa aut Scicluna, Patrick aut Cui, Huanhuan L. aut Mohammad, Abdul-Aleem aut Davoudi, Belghis aut Shang, Mingmei aut Ananthaseshan, Sharan aut Strååt, Klas aut Stragliotto, Giuseppe aut Rahbar, Afsar aut Wong, Kum Thong aut Tegner, Jesper aut Yaiw, Koon-Chu (orcid)0000-0001-5329-1815 aut Söderberg-Naucler, Cecilia aut Enthalten in BMC cancer London : BioMed Central, 2001 18(2018), 1 vom: 06. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:18 year:2018 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12885-018-4012-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 06 02
allfieldsSound	10.1186/s12885-018-4012-7 doi (DE-627)SPR027694577 (SPR)s12885-018-4012-7-e DE-627 ger DE-627 rakwb eng Vasaikar, Suhas verfasserin aut Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. Glioblastoma (dpeaa)DE-He213 Endothelin B receptor (dpeaa)DE-He213 Endothelin receptor antagonists (dpeaa)DE-He213 Tsipras, Giorgos aut Landázuri, Natalia aut Costa, Helena aut Wilhelmi, Vanessa aut Scicluna, Patrick aut Cui, Huanhuan L. aut Mohammad, Abdul-Aleem aut Davoudi, Belghis aut Shang, Mingmei aut Ananthaseshan, Sharan aut Strååt, Klas aut Stragliotto, Giuseppe aut Rahbar, Afsar aut Wong, Kum Thong aut Tegner, Jesper aut Yaiw, Koon-Chu (orcid)0000-0001-5329-1815 aut Söderberg-Naucler, Cecilia aut Enthalten in BMC cancer London : BioMed Central, 2001 18(2018), 1 vom: 06. Feb. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:18 year:2018 number:1 day:06 month:02 https://dx.doi.org/10.1186/s12885-018-4012-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 06 02
language	English
source	Enthalten in BMC cancer 18(2018), 1 vom: 06. Feb. volume:18 year:2018 number:1 day:06 month:02
sourceStr	Enthalten in BMC cancer 18(2018), 1 vom: 06. Feb. volume:18 year:2018 number:1 day:06 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Glioblastoma Endothelin B receptor Endothelin receptor antagonists
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Vasaikar, Suhas @@aut@@ Tsipras, Giorgos @@aut@@ Landázuri, Natalia @@aut@@ Costa, Helena @@aut@@ Wilhelmi, Vanessa @@aut@@ Scicluna, Patrick @@aut@@ Cui, Huanhuan L. @@aut@@ Mohammad, Abdul-Aleem @@aut@@ Davoudi, Belghis @@aut@@ Shang, Mingmei @@aut@@ Ananthaseshan, Sharan @@aut@@ Strååt, Klas @@aut@@ Stragliotto, Giuseppe @@aut@@ Rahbar, Afsar @@aut@@ Wong, Kum Thong @@aut@@ Tegner, Jesper @@aut@@ Yaiw, Koon-Chu @@aut@@ Söderberg-Naucler, Cecilia @@aut@@
publishDateDaySort_date	2018-02-06T00:00:00Z
hierarchy_top_id	326643710
id	SPR027694577
language_de	englisch
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Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. 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author	Vasaikar, Suhas
spellingShingle	Vasaikar, Suhas misc Glioblastoma misc Endothelin B receptor misc Endothelin receptor antagonists Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
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topic_title	Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? Glioblastoma (dpeaa)DE-He213 Endothelin B receptor (dpeaa)DE-He213 Endothelin receptor antagonists (dpeaa)DE-He213
topic	misc Glioblastoma misc Endothelin B receptor misc Endothelin receptor antagonists
topic_unstemmed	misc Glioblastoma misc Endothelin B receptor misc Endothelin receptor antagonists
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title	Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
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title_full	Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
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author_browse	Vasaikar, Suhas Tsipras, Giorgos Landázuri, Natalia Costa, Helena Wilhelmi, Vanessa Scicluna, Patrick Cui, Huanhuan L. Mohammad, Abdul-Aleem Davoudi, Belghis Shang, Mingmei Ananthaseshan, Sharan Strååt, Klas Stragliotto, Giuseppe Rahbar, Afsar Wong, Kum Thong Tegner, Jesper Yaiw, Koon-Chu Söderberg-Naucler, Cecilia
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title_sort	overexpression of endothelin b receptor in glioblastoma: a prognostic marker and therapeutic target?
title_auth	Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
abstract	Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. © The Author(s). 2018
abstractGer	Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. © The Author(s). 2018
abstract_unstemmed	Background Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment. Methods Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells. Results By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer. Conclusions ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients. © The Author(s). 2018
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title_short	Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
url	https://dx.doi.org/10.1186/s12885-018-4012-7
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author2	Tsipras, Giorgos Landázuri, Natalia Costa, Helena Wilhelmi, Vanessa Scicluna, Patrick Cui, Huanhuan L. Mohammad, Abdul-Aleem Davoudi, Belghis Shang, Mingmei Ananthaseshan, Sharan Strååt, Klas Stragliotto, Giuseppe Rahbar, Afsar Wong, Kum Thong Tegner, Jesper Yaiw, Koon-Chu Söderberg-Naucler, Cecilia
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