Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison

Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped...
Ausführliche Beschreibung

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Autor*in:	Sun, Yong-Jiang [verfasserIn] Lim, TK Ong, Adrian Kheng Yeow Ho, Benjamin Choon Heng Seah, Geok Teng Paton, Nicholas I

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2006

Schlagwörter:	Human Immunodeficiency Virus Tuberculosis Tuberculosis Patient Night Sweat cDNA Copy

Anmerkung:	© Sun et al; licensee BioMed Central Ltd. 2006

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 6(2006), 1 vom: 05. Juli
Übergeordnetes Werk:	volume:6 ; year:2006 ; number:1 ; day:05 ; month:07

Links:	Volltext

DOI / URN:	10.1186/1471-2334-6-105

Katalog-ID:	SPR02770176X

Internformat


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100	1		\|a Sun, Yong-Jiang \|e verfasserin \|4 aut
245	1	0	\|a Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison
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520			\|a Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression.
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700	1		\|a Lim, TK \|4 aut
700	1		\|a Ong, Adrian Kheng Yeow \|4 aut
700	1		\|a Ho, Benjamin Choon Heng \|4 aut
700	1		\|a Seah, Geok Teng \|4 aut
700	1		\|a Paton, Nicholas I \|4 aut
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912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_4700
951			\|a AR
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Indexfelder

author_variant	y j s yjs t l tl a k y o aky akyo b c h h bch bchh g t s gt gts n i p ni nip
matchkey_str	article:14712334:2006----::ueclsssoitdihyoatrutbruoibiignnnejngntpsci
hierarchy_sort_str	2006
publishDate	2006
allfields	10.1186/1471-2334-6-105 doi (DE-627)SPR02770176X (SPR)1471-2334-6-105-e DE-627 ger DE-627 rakwb eng Sun, Yong-Jiang verfasserin aut Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun et al; licensee BioMed Central Ltd. 2006 Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. Human Immunodeficiency Virus (dpeaa)DE-He213 Tuberculosis (dpeaa)DE-He213 Tuberculosis Patient (dpeaa)DE-He213 Night Sweat (dpeaa)DE-He213 cDNA Copy (dpeaa)DE-He213 Lim, TK aut Ong, Adrian Kheng Yeow aut Ho, Benjamin Choon Heng aut Seah, Geok Teng aut Paton, Nicholas I aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 6(2006), 1 vom: 05. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:6 year:2006 number:1 day:05 month:07 https://dx.doi.org/10.1186/1471-2334-6-105 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2006 1 05 07
spelling	10.1186/1471-2334-6-105 doi (DE-627)SPR02770176X (SPR)1471-2334-6-105-e DE-627 ger DE-627 rakwb eng Sun, Yong-Jiang verfasserin aut Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun et al; licensee BioMed Central Ltd. 2006 Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. Human Immunodeficiency Virus (dpeaa)DE-He213 Tuberculosis (dpeaa)DE-He213 Tuberculosis Patient (dpeaa)DE-He213 Night Sweat (dpeaa)DE-He213 cDNA Copy (dpeaa)DE-He213 Lim, TK aut Ong, Adrian Kheng Yeow aut Ho, Benjamin Choon Heng aut Seah, Geok Teng aut Paton, Nicholas I aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 6(2006), 1 vom: 05. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:6 year:2006 number:1 day:05 month:07 https://dx.doi.org/10.1186/1471-2334-6-105 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2006 1 05 07
allfields_unstemmed	10.1186/1471-2334-6-105 doi (DE-627)SPR02770176X (SPR)1471-2334-6-105-e DE-627 ger DE-627 rakwb eng Sun, Yong-Jiang verfasserin aut Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun et al; licensee BioMed Central Ltd. 2006 Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. Human Immunodeficiency Virus (dpeaa)DE-He213 Tuberculosis (dpeaa)DE-He213 Tuberculosis Patient (dpeaa)DE-He213 Night Sweat (dpeaa)DE-He213 cDNA Copy (dpeaa)DE-He213 Lim, TK aut Ong, Adrian Kheng Yeow aut Ho, Benjamin Choon Heng aut Seah, Geok Teng aut Paton, Nicholas I aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 6(2006), 1 vom: 05. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:6 year:2006 number:1 day:05 month:07 https://dx.doi.org/10.1186/1471-2334-6-105 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2006 1 05 07
allfieldsGer	10.1186/1471-2334-6-105 doi (DE-627)SPR02770176X (SPR)1471-2334-6-105-e DE-627 ger DE-627 rakwb eng Sun, Yong-Jiang verfasserin aut Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun et al; licensee BioMed Central Ltd. 2006 Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. Human Immunodeficiency Virus (dpeaa)DE-He213 Tuberculosis (dpeaa)DE-He213 Tuberculosis Patient (dpeaa)DE-He213 Night Sweat (dpeaa)DE-He213 cDNA Copy (dpeaa)DE-He213 Lim, TK aut Ong, Adrian Kheng Yeow aut Ho, Benjamin Choon Heng aut Seah, Geok Teng aut Paton, Nicholas I aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 6(2006), 1 vom: 05. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:6 year:2006 number:1 day:05 month:07 https://dx.doi.org/10.1186/1471-2334-6-105 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2006 1 05 07
allfieldsSound	10.1186/1471-2334-6-105 doi (DE-627)SPR02770176X (SPR)1471-2334-6-105-e DE-627 ger DE-627 rakwb eng Sun, Yong-Jiang verfasserin aut Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Sun et al; licensee BioMed Central Ltd. 2006 Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. Human Immunodeficiency Virus (dpeaa)DE-He213 Tuberculosis (dpeaa)DE-He213 Tuberculosis Patient (dpeaa)DE-He213 Night Sweat (dpeaa)DE-He213 cDNA Copy (dpeaa)DE-He213 Lim, TK aut Ong, Adrian Kheng Yeow aut Ho, Benjamin Choon Heng aut Seah, Geok Teng aut Paton, Nicholas I aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 6(2006), 1 vom: 05. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:6 year:2006 number:1 day:05 month:07 https://dx.doi.org/10.1186/1471-2334-6-105 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2006 1 05 07
language	English
source	Enthalten in BMC infectious diseases 6(2006), 1 vom: 05. Juli volume:6 year:2006 number:1 day:05 month:07
sourceStr	Enthalten in BMC infectious diseases 6(2006), 1 vom: 05. Juli volume:6 year:2006 number:1 day:05 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Human Immunodeficiency Virus Tuberculosis Tuberculosis Patient Night Sweat cDNA Copy
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Sun, Yong-Jiang @@aut@@ Lim, TK @@aut@@ Ong, Adrian Kheng Yeow @@aut@@ Ho, Benjamin Choon Heng @@aut@@ Seah, Geok Teng @@aut@@ Paton, Nicholas I @@aut@@
publishDateDaySort_date	2006-07-05T00:00:00Z
hierarchy_top_id	326645381
id	SPR02770176X
language_de	englisch
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author	Sun, Yong-Jiang
spellingShingle	Sun, Yong-Jiang misc Human Immunodeficiency Virus misc Tuberculosis misc Tuberculosis Patient misc Night Sweat misc cDNA Copy Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison
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topic_title	Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison Human Immunodeficiency Virus (dpeaa)DE-He213 Tuberculosis (dpeaa)DE-He213 Tuberculosis Patient (dpeaa)DE-He213 Night Sweat (dpeaa)DE-He213 cDNA Copy (dpeaa)DE-He213
topic	misc Human Immunodeficiency Virus misc Tuberculosis misc Tuberculosis Patient misc Night Sweat misc cDNA Copy
topic_unstemmed	misc Human Immunodeficiency Virus misc Tuberculosis misc Tuberculosis Patient misc Night Sweat misc cDNA Copy
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title	Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison
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title_full	Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison
author_sort	Sun, Yong-Jiang
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author_browse	Sun, Yong-Jiang Lim, TK Ong, Adrian Kheng Yeow Ho, Benjamin Choon Heng Seah, Geok Teng Paton, Nicholas I
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author-letter	Sun, Yong-Jiang
doi_str_mv	10.1186/1471-2334-6-105
title_sort	tuberculosis associated with mycobacterium tuberculosisbeijing and non-beijing genotypes: a clinical and immunological comparison
title_auth	Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison
abstract	Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. © Sun et al; licensee BioMed Central Ltd. 2006
abstractGer	Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. © Sun et al; licensee BioMed Central Ltd. 2006
abstract_unstemmed	Background The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human tuberculosis caused by Beijing and non-Beijing strains. Methods Pulmonary tuberculosis patients were prospectively enrolled and grouped by their M. tuberculosis genotypes. The clinical features, plasma cytokine levels, and cytokine gene expression levels in peripheral blood mononuclear cells (PBMC) were compared between the patients in Beijing and non-Beijing groups. Results Patients in the Beijing group were characterized by significantly lower frequency of fever (odds ratio, 0.12, p = 0.008) and pulmonary cavitation (odds ratio, 0.2, p = 0.049). Night sweats were also significantly less frequent by univariate analysis, and the duration of cough prior to diagnosis was longer in Beijing compared to non-Beijing groups (medians, 60 versus 30 days, p = 0.048). The plasma and gene expression levels of interferon (IFN) γ and interleukin (IL)-18 were similar in the two groups. However, patients in the non-Beijing group had significantly increased IL-4 gene expression (p = 0.018) and lower IFN-γ : IL-4 cDNA copy number ratios (p = 0.01). Conclusion Patients with tuberculosis caused by Beijing strains appear to be less symptomatic than those who have disease caused by other strains. Th1 immune responses are similar in patients infected with Beijing and non-Beijing strains, but non-Beijing strains activate more Th2 immune responses compared with Beijing strains, as evidenced by increased IL-4 expression. © Sun et al; licensee BioMed Central Ltd. 2006
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title_short	Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison
url	https://dx.doi.org/10.1186/1471-2334-6-105
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author2	Lim, TK Ong, Adrian Kheng Yeow Ho, Benjamin Choon Heng Seah, Geok Teng Paton, Nicholas I
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up_date	2024-07-03T14:36:13.173Z
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Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison

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