SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol

Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive si...
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Autor*in:	Olson, Robert [verfasserIn] Schlijper, Roel Chng, Nick Matthews, Quinn Arimare, Marco Mathews, Lindsay Hsu, Fred Berrang, Tanya Louie, Alexander Mou, Benjamin Valev, Boris Laba, Joanna Palma, David Schellenberg, Devin Lefresne, Shilo

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Bone metastases Radiotherapy Quality of life Radiation-induced nausea and vomiting

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 19(2019), 1 vom: 28. Okt.
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:1 ; day:28 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s12885-019-6259-z

Katalog-ID:	SPR027719472

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520			\|a Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018.
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allfields	10.1186/s12885-019-6259-z doi (DE-627)SPR027719472 (SPR)s12885-019-6259-z-e DE-627 ger DE-627 rakwb eng Olson, Robert verfasserin (orcid)0000-0003-4532-6197 aut SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. Bone metastases (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Radiation-induced nausea and vomiting (dpeaa)DE-He213 Schlijper, Roel aut Chng, Nick aut Matthews, Quinn aut Arimare, Marco aut Mathews, Lindsay aut Hsu, Fred aut Berrang, Tanya aut Louie, Alexander aut Mou, Benjamin aut Valev, Boris aut Laba, Joanna aut Palma, David aut Schellenberg, Devin aut Lefresne, Shilo aut Enthalten in BMC cancer London : BioMed Central, 2001 19(2019), 1 vom: 28. Okt. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:19 year:2019 number:1 day:28 month:10 https://dx.doi.org/10.1186/s12885-019-6259-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 28 10
spelling	10.1186/s12885-019-6259-z doi (DE-627)SPR027719472 (SPR)s12885-019-6259-z-e DE-627 ger DE-627 rakwb eng Olson, Robert verfasserin (orcid)0000-0003-4532-6197 aut SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. Bone metastases (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Radiation-induced nausea and vomiting (dpeaa)DE-He213 Schlijper, Roel aut Chng, Nick aut Matthews, Quinn aut Arimare, Marco aut Mathews, Lindsay aut Hsu, Fred aut Berrang, Tanya aut Louie, Alexander aut Mou, Benjamin aut Valev, Boris aut Laba, Joanna aut Palma, David aut Schellenberg, Devin aut Lefresne, Shilo aut Enthalten in BMC cancer London : BioMed Central, 2001 19(2019), 1 vom: 28. Okt. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:19 year:2019 number:1 day:28 month:10 https://dx.doi.org/10.1186/s12885-019-6259-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 28 10
allfields_unstemmed	10.1186/s12885-019-6259-z doi (DE-627)SPR027719472 (SPR)s12885-019-6259-z-e DE-627 ger DE-627 rakwb eng Olson, Robert verfasserin (orcid)0000-0003-4532-6197 aut SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. Bone metastases (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Radiation-induced nausea and vomiting (dpeaa)DE-He213 Schlijper, Roel aut Chng, Nick aut Matthews, Quinn aut Arimare, Marco aut Mathews, Lindsay aut Hsu, Fred aut Berrang, Tanya aut Louie, Alexander aut Mou, Benjamin aut Valev, Boris aut Laba, Joanna aut Palma, David aut Schellenberg, Devin aut Lefresne, Shilo aut Enthalten in BMC cancer London : BioMed Central, 2001 19(2019), 1 vom: 28. Okt. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:19 year:2019 number:1 day:28 month:10 https://dx.doi.org/10.1186/s12885-019-6259-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 28 10
allfieldsGer	10.1186/s12885-019-6259-z doi (DE-627)SPR027719472 (SPR)s12885-019-6259-z-e DE-627 ger DE-627 rakwb eng Olson, Robert verfasserin (orcid)0000-0003-4532-6197 aut SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. Bone metastases (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Radiation-induced nausea and vomiting (dpeaa)DE-He213 Schlijper, Roel aut Chng, Nick aut Matthews, Quinn aut Arimare, Marco aut Mathews, Lindsay aut Hsu, Fred aut Berrang, Tanya aut Louie, Alexander aut Mou, Benjamin aut Valev, Boris aut Laba, Joanna aut Palma, David aut Schellenberg, Devin aut Lefresne, Shilo aut Enthalten in BMC cancer London : BioMed Central, 2001 19(2019), 1 vom: 28. Okt. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:19 year:2019 number:1 day:28 month:10 https://dx.doi.org/10.1186/s12885-019-6259-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 28 10
allfieldsSound	10.1186/s12885-019-6259-z doi (DE-627)SPR027719472 (SPR)s12885-019-6259-z-e DE-627 ger DE-627 rakwb eng Olson, Robert verfasserin (orcid)0000-0003-4532-6197 aut SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. Bone metastases (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Radiation-induced nausea and vomiting (dpeaa)DE-He213 Schlijper, Roel aut Chng, Nick aut Matthews, Quinn aut Arimare, Marco aut Mathews, Lindsay aut Hsu, Fred aut Berrang, Tanya aut Louie, Alexander aut Mou, Benjamin aut Valev, Boris aut Laba, Joanna aut Palma, David aut Schellenberg, Devin aut Lefresne, Shilo aut Enthalten in BMC cancer London : BioMed Central, 2001 19(2019), 1 vom: 28. Okt. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:19 year:2019 number:1 day:28 month:10 https://dx.doi.org/10.1186/s12885-019-6259-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 28 10
language	English
source	Enthalten in BMC cancer 19(2019), 1 vom: 28. Okt. volume:19 year:2019 number:1 day:28 month:10
sourceStr	Enthalten in BMC cancer 19(2019), 1 vom: 28. Okt. volume:19 year:2019 number:1 day:28 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Bone metastases Radiotherapy Quality of life Radiation-induced nausea and vomiting
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authorswithroles_txt_mv	Olson, Robert @@aut@@ Schlijper, Roel @@aut@@ Chng, Nick @@aut@@ Matthews, Quinn @@aut@@ Arimare, Marco @@aut@@ Mathews, Lindsay @@aut@@ Hsu, Fred @@aut@@ Berrang, Tanya @@aut@@ Louie, Alexander @@aut@@ Mou, Benjamin @@aut@@ Valev, Boris @@aut@@ Laba, Joanna @@aut@@ Palma, David @@aut@@ Schellenberg, Devin @@aut@@ Lefresne, Shilo @@aut@@
publishDateDaySort_date	2019-10-28T00:00:00Z
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author	Olson, Robert
spellingShingle	Olson, Robert misc Bone metastases misc Radiotherapy misc Quality of life misc Radiation-induced nausea and vomiting SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol
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topic_title	SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol Bone metastases (dpeaa)DE-He213 Radiotherapy (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Radiation-induced nausea and vomiting (dpeaa)DE-He213
topic	misc Bone metastases misc Radiotherapy misc Quality of life misc Radiation-induced nausea and vomiting
topic_unstemmed	misc Bone metastases misc Radiotherapy misc Quality of life misc Radiation-induced nausea and vomiting
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title	SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol
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author_browse	Olson, Robert Schlijper, Roel Chng, Nick Matthews, Quinn Arimare, Marco Mathews, Lindsay Hsu, Fred Berrang, Tanya Louie, Alexander Mou, Benjamin Valev, Boris Laba, Joanna Palma, David Schellenberg, Devin Lefresne, Shilo
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title_sort	supr-3d: a randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol
title_auth	SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol
abstract	Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. © The Author(s). 2019
abstractGer	Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. © The Author(s). 2019
abstract_unstemmed	Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018. © The Author(s). 2019
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container_issue	1
title_short	SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol
url	https://dx.doi.org/10.1186/s12885-019-6259-z
remote_bool	true
author2	Schlijper, Roel Chng, Nick Matthews, Quinn Arimare, Marco Mathews, Lindsay Hsu, Fred Berrang, Tanya Louie, Alexander Mou, Benjamin Valev, Boris Laba, Joanna Palma, David Schellenberg, Devin Lefresne, Shilo
author2Str	Schlijper, Roel Chng, Nick Matthews, Quinn Arimare, Marco Mathews, Lindsay Hsu, Fred Berrang, Tanya Louie, Alexander Mou, Benjamin Valev, Boris Laba, Joanna Palma, David Schellenberg, Devin Lefresne, Shilo
ppnlink	326643710
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doi_str	10.1186/s12885-019-6259-z
up_date	2024-07-03T14:44:04.864Z
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