Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa

Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes o...
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Autor*in:	Ndong-Atome, Guy-Roger [verfasserIn] Makuwa, Maria Njouom, Richard Branger, Michel Brun-Vézinet, Francoise Mahé, Antoine Rousset, Dominique Kazanji, Mirdad

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Pregnant Woman Reverse Transcriptase Polymerase Chain Reaction NS5B Region Nest Reverse Transcriptase Polymerase Chain Reaction Large Population Cohort

Anmerkung:	© Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 8(2008), 1 vom: 17. Juni
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1 ; day:17 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1471-2334-8-82

Katalog-ID:	SPR027735540

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520			\|a Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed.
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700	1		\|a Kazanji, Mirdad \|4 aut
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allfields	10.1186/1471-2334-8-82 doi (DE-627)SPR027735540 (SPR)1471-2334-8-82-e DE-627 ger DE-627 rakwb eng Ndong-Atome, Guy-Roger verfasserin aut Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. Pregnant Woman (dpeaa)DE-He213 Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 NS5B Region (dpeaa)DE-He213 Nest Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 Large Population Cohort (dpeaa)DE-He213 Makuwa, Maria aut Njouom, Richard aut Branger, Michel aut Brun-Vézinet, Francoise aut Mahé, Antoine aut Rousset, Dominique aut Kazanji, Mirdad aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 8(2008), 1 vom: 17. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:8 year:2008 number:1 day:17 month:06 https://dx.doi.org/10.1186/1471-2334-8-82 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 17 06
spelling	10.1186/1471-2334-8-82 doi (DE-627)SPR027735540 (SPR)1471-2334-8-82-e DE-627 ger DE-627 rakwb eng Ndong-Atome, Guy-Roger verfasserin aut Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. Pregnant Woman (dpeaa)DE-He213 Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 NS5B Region (dpeaa)DE-He213 Nest Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 Large Population Cohort (dpeaa)DE-He213 Makuwa, Maria aut Njouom, Richard aut Branger, Michel aut Brun-Vézinet, Francoise aut Mahé, Antoine aut Rousset, Dominique aut Kazanji, Mirdad aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 8(2008), 1 vom: 17. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:8 year:2008 number:1 day:17 month:06 https://dx.doi.org/10.1186/1471-2334-8-82 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 17 06
allfields_unstemmed	10.1186/1471-2334-8-82 doi (DE-627)SPR027735540 (SPR)1471-2334-8-82-e DE-627 ger DE-627 rakwb eng Ndong-Atome, Guy-Roger verfasserin aut Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. Pregnant Woman (dpeaa)DE-He213 Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 NS5B Region (dpeaa)DE-He213 Nest Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 Large Population Cohort (dpeaa)DE-He213 Makuwa, Maria aut Njouom, Richard aut Branger, Michel aut Brun-Vézinet, Francoise aut Mahé, Antoine aut Rousset, Dominique aut Kazanji, Mirdad aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 8(2008), 1 vom: 17. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:8 year:2008 number:1 day:17 month:06 https://dx.doi.org/10.1186/1471-2334-8-82 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 17 06
allfieldsGer	10.1186/1471-2334-8-82 doi (DE-627)SPR027735540 (SPR)1471-2334-8-82-e DE-627 ger DE-627 rakwb eng Ndong-Atome, Guy-Roger verfasserin aut Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. Pregnant Woman (dpeaa)DE-He213 Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 NS5B Region (dpeaa)DE-He213 Nest Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 Large Population Cohort (dpeaa)DE-He213 Makuwa, Maria aut Njouom, Richard aut Branger, Michel aut Brun-Vézinet, Francoise aut Mahé, Antoine aut Rousset, Dominique aut Kazanji, Mirdad aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 8(2008), 1 vom: 17. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:8 year:2008 number:1 day:17 month:06 https://dx.doi.org/10.1186/1471-2334-8-82 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 17 06
allfieldsSound	10.1186/1471-2334-8-82 doi (DE-627)SPR027735540 (SPR)1471-2334-8-82-e DE-627 ger DE-627 rakwb eng Ndong-Atome, Guy-Roger verfasserin aut Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. Pregnant Woman (dpeaa)DE-He213 Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 NS5B Region (dpeaa)DE-He213 Nest Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 Large Population Cohort (dpeaa)DE-He213 Makuwa, Maria aut Njouom, Richard aut Branger, Michel aut Brun-Vézinet, Francoise aut Mahé, Antoine aut Rousset, Dominique aut Kazanji, Mirdad aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 8(2008), 1 vom: 17. Juni (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:8 year:2008 number:1 day:17 month:06 https://dx.doi.org/10.1186/1471-2334-8-82 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 17 06
language	English
source	Enthalten in BMC infectious diseases 8(2008), 1 vom: 17. Juni volume:8 year:2008 number:1 day:17 month:06
sourceStr	Enthalten in BMC infectious diseases 8(2008), 1 vom: 17. Juni volume:8 year:2008 number:1 day:17 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pregnant Woman Reverse Transcriptase Polymerase Chain Reaction NS5B Region Nest Reverse Transcriptase Polymerase Chain Reaction Large Population Cohort
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Ndong-Atome, Guy-Roger @@aut@@ Makuwa, Maria @@aut@@ Njouom, Richard @@aut@@ Branger, Michel @@aut@@ Brun-Vézinet, Francoise @@aut@@ Mahé, Antoine @@aut@@ Rousset, Dominique @@aut@@ Kazanji, Mirdad @@aut@@
publishDateDaySort_date	2008-06-17T00:00:00Z
hierarchy_top_id	326645381
id	SPR027735540
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. 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author	Ndong-Atome, Guy-Roger
spellingShingle	Ndong-Atome, Guy-Roger misc Pregnant Woman misc Reverse Transcriptase Polymerase Chain Reaction misc NS5B Region misc Nest Reverse Transcriptase Polymerase Chain Reaction misc Large Population Cohort Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
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topic_title	Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa Pregnant Woman (dpeaa)DE-He213 Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 NS5B Region (dpeaa)DE-He213 Nest Reverse Transcriptase Polymerase Chain Reaction (dpeaa)DE-He213 Large Population Cohort (dpeaa)DE-He213
topic	misc Pregnant Woman misc Reverse Transcriptase Polymerase Chain Reaction misc NS5B Region misc Nest Reverse Transcriptase Polymerase Chain Reaction misc Large Population Cohort
topic_unstemmed	misc Pregnant Woman misc Reverse Transcriptase Polymerase Chain Reaction misc NS5B Region misc Nest Reverse Transcriptase Polymerase Chain Reaction misc Large Population Cohort
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title	Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
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title_full	Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
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author_browse	Ndong-Atome, Guy-Roger Makuwa, Maria Njouom, Richard Branger, Michel Brun-Vézinet, Francoise Mahé, Antoine Rousset, Dominique Kazanji, Mirdad
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doi_str_mv	10.1186/1471-2334-8-82
title_sort	hepatitis c virus prevalence and genetic diversity among pregnant women in gabon, central africa
title_auth	Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
abstract	Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women. Methods Blood samples (947) were collected from pregnant women in the five main cities of the country. The prevalence was evaluated by two ELISA tests, and the circulating genotypes were characterized by sequencing and phylogenetic analysis. Results Twenty pregnant women (2.1%) were infected with HCV. The seroprevalence differed significantly by region (p = 0.004) and increased significantly with age (p = 0.05), being 1.3% at 14–20 years, 1.1% at 21–25 years, 1.9% at 26–30 years, 4.1% at 31–35 years and 6.0% at > 35 years. Sequencing in the 5'-UTR and NS5B regions showed that the circulating strains belonged to genotypes 4 (4e and 4c). Conclusion We found that the HCV seroprevalence in pregnant women in Gabon is almost as high as that in other African countries and increases with age. Furthermore, only genotype 4 (4e and 4c) was found. More extensive studies aiming to evaluate the prevalence and heterogeneity of HCV genotypes circulating in the general population of the country are needed. © Atome et al; licensee BioMed Central Ltd. 2008. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
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author2	Makuwa, Maria Njouom, Richard Branger, Michel Brun-Vézinet, Francoise Mahé, Antoine Rousset, Dominique Kazanji, Mirdad
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Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa

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