Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination...
Ausführliche Beschreibung

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Autor*in:	Jackson, Lisa A [verfasserIn] Yu, Onchee Belongia, Edward A Hambidge, Simon J Nelson, Jennifer Baxter, Roger Naleway, Allison Gay, Charlene Nordin, James Baggs, James Iskander, John

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Tetanus Local Reaction Vaccine Safety Diphtheria Toxoid Vaccine Adverse Event Reporting System

Anmerkung:	© Jackson et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 9(2009), 1 vom: 05. Okt.
Übergeordnetes Werk:	volume:9 ; year:2009 ; number:1 ; day:05 ; month:10

Links:	Volltext

DOI / URN:	10.1186/1471-2334-9-165

Katalog-ID:	SPR027764338

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245	1	0	\|a Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study
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520			\|a Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid.
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650		4	\|a Diphtheria Toxoid \|7 (dpeaa)DE-He213
650		4	\|a Vaccine Adverse Event Reporting System \|7 (dpeaa)DE-He213
700	1		\|a Yu, Onchee \|4 aut
700	1		\|a Belongia, Edward A \|4 aut
700	1		\|a Hambidge, Simon J \|4 aut
700	1		\|a Nelson, Jennifer \|4 aut
700	1		\|a Baxter, Roger \|4 aut
700	1		\|a Naleway, Allison \|4 aut
700	1		\|a Gay, Charlene \|4 aut
700	1		\|a Nordin, James \|4 aut
700	1		\|a Baggs, James \|4 aut
700	1		\|a Iskander, John \|4 aut
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allfields	10.1186/1471-2334-9-165 doi (DE-627)SPR027764338 (SPR)1471-2334-9-165-e DE-627 ger DE-627 rakwb eng Jackson, Lisa A verfasserin aut Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jackson et al; licensee BioMed Central Ltd. 2009 Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. Tetanus (dpeaa)DE-He213 Local Reaction (dpeaa)DE-He213 Vaccine Safety (dpeaa)DE-He213 Diphtheria Toxoid (dpeaa)DE-He213 Vaccine Adverse Event Reporting System (dpeaa)DE-He213 Yu, Onchee aut Belongia, Edward A aut Hambidge, Simon J aut Nelson, Jennifer aut Baxter, Roger aut Naleway, Allison aut Gay, Charlene aut Nordin, James aut Baggs, James aut Iskander, John aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 9(2009), 1 vom: 05. Okt. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:9 year:2009 number:1 day:05 month:10 https://dx.doi.org/10.1186/1471-2334-9-165 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 05 10
spelling	10.1186/1471-2334-9-165 doi (DE-627)SPR027764338 (SPR)1471-2334-9-165-e DE-627 ger DE-627 rakwb eng Jackson, Lisa A verfasserin aut Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jackson et al; licensee BioMed Central Ltd. 2009 Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. Tetanus (dpeaa)DE-He213 Local Reaction (dpeaa)DE-He213 Vaccine Safety (dpeaa)DE-He213 Diphtheria Toxoid (dpeaa)DE-He213 Vaccine Adverse Event Reporting System (dpeaa)DE-He213 Yu, Onchee aut Belongia, Edward A aut Hambidge, Simon J aut Nelson, Jennifer aut Baxter, Roger aut Naleway, Allison aut Gay, Charlene aut Nordin, James aut Baggs, James aut Iskander, John aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 9(2009), 1 vom: 05. Okt. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:9 year:2009 number:1 day:05 month:10 https://dx.doi.org/10.1186/1471-2334-9-165 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 05 10
allfields_unstemmed	10.1186/1471-2334-9-165 doi (DE-627)SPR027764338 (SPR)1471-2334-9-165-e DE-627 ger DE-627 rakwb eng Jackson, Lisa A verfasserin aut Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jackson et al; licensee BioMed Central Ltd. 2009 Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. Tetanus (dpeaa)DE-He213 Local Reaction (dpeaa)DE-He213 Vaccine Safety (dpeaa)DE-He213 Diphtheria Toxoid (dpeaa)DE-He213 Vaccine Adverse Event Reporting System (dpeaa)DE-He213 Yu, Onchee aut Belongia, Edward A aut Hambidge, Simon J aut Nelson, Jennifer aut Baxter, Roger aut Naleway, Allison aut Gay, Charlene aut Nordin, James aut Baggs, James aut Iskander, John aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 9(2009), 1 vom: 05. Okt. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:9 year:2009 number:1 day:05 month:10 https://dx.doi.org/10.1186/1471-2334-9-165 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 05 10
allfieldsGer	10.1186/1471-2334-9-165 doi (DE-627)SPR027764338 (SPR)1471-2334-9-165-e DE-627 ger DE-627 rakwb eng Jackson, Lisa A verfasserin aut Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jackson et al; licensee BioMed Central Ltd. 2009 Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. Tetanus (dpeaa)DE-He213 Local Reaction (dpeaa)DE-He213 Vaccine Safety (dpeaa)DE-He213 Diphtheria Toxoid (dpeaa)DE-He213 Vaccine Adverse Event Reporting System (dpeaa)DE-He213 Yu, Onchee aut Belongia, Edward A aut Hambidge, Simon J aut Nelson, Jennifer aut Baxter, Roger aut Naleway, Allison aut Gay, Charlene aut Nordin, James aut Baggs, James aut Iskander, John aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 9(2009), 1 vom: 05. Okt. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:9 year:2009 number:1 day:05 month:10 https://dx.doi.org/10.1186/1471-2334-9-165 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 05 10
allfieldsSound	10.1186/1471-2334-9-165 doi (DE-627)SPR027764338 (SPR)1471-2334-9-165-e DE-627 ger DE-627 rakwb eng Jackson, Lisa A verfasserin aut Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jackson et al; licensee BioMed Central Ltd. 2009 Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. Tetanus (dpeaa)DE-He213 Local Reaction (dpeaa)DE-He213 Vaccine Safety (dpeaa)DE-He213 Diphtheria Toxoid (dpeaa)DE-He213 Vaccine Adverse Event Reporting System (dpeaa)DE-He213 Yu, Onchee aut Belongia, Edward A aut Hambidge, Simon J aut Nelson, Jennifer aut Baxter, Roger aut Naleway, Allison aut Gay, Charlene aut Nordin, James aut Baggs, James aut Iskander, John aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 9(2009), 1 vom: 05. Okt. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:9 year:2009 number:1 day:05 month:10 https://dx.doi.org/10.1186/1471-2334-9-165 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2009 1 05 10
language	English
source	Enthalten in BMC infectious diseases 9(2009), 1 vom: 05. Okt. volume:9 year:2009 number:1 day:05 month:10
sourceStr	Enthalten in BMC infectious diseases 9(2009), 1 vom: 05. Okt. volume:9 year:2009 number:1 day:05 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Tetanus Local Reaction Vaccine Safety Diphtheria Toxoid Vaccine Adverse Event Reporting System
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Jackson, Lisa A @@aut@@ Yu, Onchee @@aut@@ Belongia, Edward A @@aut@@ Hambidge, Simon J @@aut@@ Nelson, Jennifer @@aut@@ Baxter, Roger @@aut@@ Naleway, Allison @@aut@@ Gay, Charlene @@aut@@ Nordin, James @@aut@@ Baggs, James @@aut@@ Iskander, John @@aut@@
publishDateDaySort_date	2009-10-05T00:00:00Z
hierarchy_top_id	326645381
id	SPR027764338
language_de	englisch
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Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. 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author	Jackson, Lisa A
spellingShingle	Jackson, Lisa A misc Tetanus misc Local Reaction misc Vaccine Safety misc Diphtheria Toxoid misc Vaccine Adverse Event Reporting System Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study
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topic_title	Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study Tetanus (dpeaa)DE-He213 Local Reaction (dpeaa)DE-He213 Vaccine Safety (dpeaa)DE-He213 Diphtheria Toxoid (dpeaa)DE-He213 Vaccine Adverse Event Reporting System (dpeaa)DE-He213
topic	misc Tetanus misc Local Reaction misc Vaccine Safety misc Diphtheria Toxoid misc Vaccine Adverse Event Reporting System
topic_unstemmed	misc Tetanus misc Local Reaction misc Vaccine Safety misc Diphtheria Toxoid misc Vaccine Adverse Event Reporting System
topic_browse	misc Tetanus misc Local Reaction misc Vaccine Safety misc Diphtheria Toxoid misc Vaccine Adverse Event Reporting System
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title	Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study
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title_full	Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study
author_sort	Jackson, Lisa A
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author_browse	Jackson, Lisa A Yu, Onchee Belongia, Edward A Hambidge, Simon J Nelson, Jennifer Baxter, Roger Naleway, Allison Gay, Charlene Nordin, James Baggs, James Iskander, John
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author-letter	Jackson, Lisa A
doi_str_mv	10.1186/1471-2334-9-165
title_sort	frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a vaccine safety datalink study
title_auth	Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study
abstract	Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. © Jackson et al; licensee BioMed Central Ltd. 2009
abstractGer	Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. © Jackson et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background Local reactions are the most commonly reported adverse events following tetanus and diphtheria toxoid (Td) vaccine and the risk of local reactions may increase with number of prior Td vaccinations. Methods To estimate the risk of medically attended local reactions following Td vaccination in adolescents and young adults we conducted a six-year retrospective cohort study assessing 436,828 Td vaccinations given to persons 9 through 25 years of age in the Vaccine Safety Datalink population from 1999 through 2004. Results Overall, the estimated risk of a medically attended local reaction was 3.6 events per 10,000 Td vaccinations. The lowest risk (2.8 events per 10,000 vaccinations) was found in the 11 to 15 year old age group. In comparison with that group, the event risks were significantly higher in both the 9 to 10 and 21 to 25 year old age groups. The risk of a local reaction was significantly higher in persons who had received another tetanus and diphtheria toxoid containing vaccine (TDCV) in the previous five years (incidence rate ratio, 2.9; 95% confidence interval, 1.2 to 7.2). Twenty-eight percent of persons with a local reaction to Td vaccine were prescribed antibiotics. Conclusion Medically attended local reactions were uncommon following Td vaccination. The risk of those reactions varied by age and by prior receipt of TDCVs. These findings provide a point of reference for future evaluations of the safety profile of newer vaccines containing tetanus or diphtheria toxoid. © Jackson et al; licensee BioMed Central Ltd. 2009
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title_short	Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study
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Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

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