Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure

Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academ...
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Autor*in:	Piastra, M. [verfasserIn] Pizza, A. Gaddi, S. Luca, E. Genovese, O. Picconi, E. De Luca, D. Conti, G.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Sedation Non invasive ventilation Infant Dexmedetomidine Acute respiratory failure

Anmerkung:	© The Author(s). 2018

Übergeordnetes Werk:	Enthalten in: BMC pediatrics - London : BioMed Central, 2001, 18(2018), 1 vom: 25. Aug.
Übergeordnetes Werk:	volume:18 ; year:2018 ; number:1 ; day:25 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12887-018-1256-y

Katalog-ID:	SPR027768805

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520			\|a Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization.
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allfields	10.1186/s12887-018-1256-y doi (DE-627)SPR027768805 (SPR)s12887-018-1256-y-e DE-627 ger DE-627 rakwb eng Piastra, M. verfasserin aut Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. Sedation (dpeaa)DE-He213 Non invasive ventilation (dpeaa)DE-He213 Infant (dpeaa)DE-He213 Dexmedetomidine (dpeaa)DE-He213 Acute respiratory failure (dpeaa)DE-He213 Pizza, A. (orcid)0000-0002-3444-8335 aut Gaddi, S. aut Luca, E. aut Genovese, O. aut Picconi, E. aut De Luca, D. aut Conti, G. aut Enthalten in BMC pediatrics London : BioMed Central, 2001 18(2018), 1 vom: 25. Aug. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:18 year:2018 number:1 day:25 month:08 https://dx.doi.org/10.1186/s12887-018-1256-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 25 08
spelling	10.1186/s12887-018-1256-y doi (DE-627)SPR027768805 (SPR)s12887-018-1256-y-e DE-627 ger DE-627 rakwb eng Piastra, M. verfasserin aut Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. Sedation (dpeaa)DE-He213 Non invasive ventilation (dpeaa)DE-He213 Infant (dpeaa)DE-He213 Dexmedetomidine (dpeaa)DE-He213 Acute respiratory failure (dpeaa)DE-He213 Pizza, A. (orcid)0000-0002-3444-8335 aut Gaddi, S. aut Luca, E. aut Genovese, O. aut Picconi, E. aut De Luca, D. aut Conti, G. aut Enthalten in BMC pediatrics London : BioMed Central, 2001 18(2018), 1 vom: 25. Aug. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:18 year:2018 number:1 day:25 month:08 https://dx.doi.org/10.1186/s12887-018-1256-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 25 08
allfields_unstemmed	10.1186/s12887-018-1256-y doi (DE-627)SPR027768805 (SPR)s12887-018-1256-y-e DE-627 ger DE-627 rakwb eng Piastra, M. verfasserin aut Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. Sedation (dpeaa)DE-He213 Non invasive ventilation (dpeaa)DE-He213 Infant (dpeaa)DE-He213 Dexmedetomidine (dpeaa)DE-He213 Acute respiratory failure (dpeaa)DE-He213 Pizza, A. (orcid)0000-0002-3444-8335 aut Gaddi, S. aut Luca, E. aut Genovese, O. aut Picconi, E. aut De Luca, D. aut Conti, G. aut Enthalten in BMC pediatrics London : BioMed Central, 2001 18(2018), 1 vom: 25. Aug. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:18 year:2018 number:1 day:25 month:08 https://dx.doi.org/10.1186/s12887-018-1256-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 25 08
allfieldsGer	10.1186/s12887-018-1256-y doi (DE-627)SPR027768805 (SPR)s12887-018-1256-y-e DE-627 ger DE-627 rakwb eng Piastra, M. verfasserin aut Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. Sedation (dpeaa)DE-He213 Non invasive ventilation (dpeaa)DE-He213 Infant (dpeaa)DE-He213 Dexmedetomidine (dpeaa)DE-He213 Acute respiratory failure (dpeaa)DE-He213 Pizza, A. (orcid)0000-0002-3444-8335 aut Gaddi, S. aut Luca, E. aut Genovese, O. aut Picconi, E. aut De Luca, D. aut Conti, G. aut Enthalten in BMC pediatrics London : BioMed Central, 2001 18(2018), 1 vom: 25. Aug. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:18 year:2018 number:1 day:25 month:08 https://dx.doi.org/10.1186/s12887-018-1256-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 25 08
allfieldsSound	10.1186/s12887-018-1256-y doi (DE-627)SPR027768805 (SPR)s12887-018-1256-y-e DE-627 ger DE-627 rakwb eng Piastra, M. verfasserin aut Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2018 Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. Sedation (dpeaa)DE-He213 Non invasive ventilation (dpeaa)DE-He213 Infant (dpeaa)DE-He213 Dexmedetomidine (dpeaa)DE-He213 Acute respiratory failure (dpeaa)DE-He213 Pizza, A. (orcid)0000-0002-3444-8335 aut Gaddi, S. aut Luca, E. aut Genovese, O. aut Picconi, E. aut De Luca, D. aut Conti, G. aut Enthalten in BMC pediatrics London : BioMed Central, 2001 18(2018), 1 vom: 25. Aug. (DE-627)326643621 (DE-600)2041342-7 1471-2431 nnns volume:18 year:2018 number:1 day:25 month:08 https://dx.doi.org/10.1186/s12887-018-1256-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 25 08
language	English
source	Enthalten in BMC pediatrics 18(2018), 1 vom: 25. Aug. volume:18 year:2018 number:1 day:25 month:08
sourceStr	Enthalten in BMC pediatrics 18(2018), 1 vom: 25. Aug. volume:18 year:2018 number:1 day:25 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Sedation Non invasive ventilation Infant Dexmedetomidine Acute respiratory failure
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container_title	BMC pediatrics
authorswithroles_txt_mv	Piastra, M. @@aut@@ Pizza, A. @@aut@@ Gaddi, S. @@aut@@ Luca, E. @@aut@@ Genovese, O. @@aut@@ Picconi, E. @@aut@@ De Luca, D. @@aut@@ Conti, G. @@aut@@
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Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. 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author	Piastra, M.
spellingShingle	Piastra, M. misc Sedation misc Non invasive ventilation misc Infant misc Dexmedetomidine misc Acute respiratory failure Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure
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topic_title	Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure Sedation (dpeaa)DE-He213 Non invasive ventilation (dpeaa)DE-He213 Infant (dpeaa)DE-He213 Dexmedetomidine (dpeaa)DE-He213 Acute respiratory failure (dpeaa)DE-He213
topic	misc Sedation misc Non invasive ventilation misc Infant misc Dexmedetomidine misc Acute respiratory failure
topic_unstemmed	misc Sedation misc Non invasive ventilation misc Infant misc Dexmedetomidine misc Acute respiratory failure
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title	Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure
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title_full	Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure
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author_browse	Piastra, M. Pizza, A. Gaddi, S. Luca, E. Genovese, O. Picconi, E. De Luca, D. Conti, G.
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title_sort	dexmedetomidine is effective and safe during niv in infants and young children with acute respiratory failure
title_auth	Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure
abstract	Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. © The Author(s). 2018
abstractGer	Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. © The Author(s). 2018
abstract_unstemmed	Background Noninvasive ventilation (NIV) is increasingly utilized in infants and young children, though associated with high failure rates due to agitation and poor compliance, mostly if patient-ventilator synchronization is required. Methods A retrospective cohort study was carried out in an academic pediatric intensive care unit (PICU). Dexmedetomidine (DEX) was infused as unique sedative in 40 consecutive pediatric patients (median age 16 months) previously showing intolerance and agitation during NIV application. Results During NIV clinical application both COMFORT-B Score and Richmond Agitation-Sedation Scale (RASS) were serially evaluated. Four patients experiencing NIV failure, all due to pulmonary condition worsening, required intubation and invasive ventilation. 36 patients were successfully weaned from NIV under DEX sedation and discharged from PICU. All patients survived until home discharge. Conclusion Our data suggest that DEX may represent an effective sedative agent in infants and children showing agitation during NIV. Early use of DEX in infants/children receiving NIV for acute respiratory failure (ARF) should be considered safe and capable of improving NIV, thus permitting both lung recruitment and patient-ventilator synchronization. © The Author(s). 2018
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title_short	Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure
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author2	Pizza, A. Gaddi, S. Luca, E. Genovese, O. Picconi, E. De Luca, D. Conti, G.
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up_date	2024-07-03T15:02:41.215Z
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Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure

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