Elevated midbrain serotonin transporter availability in mixed mania: a case report

Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission com...
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Autor*in:	Tolmunen, Tommi [verfasserIn] Joensuu, Mikko Saarinen, Pirjo Irmeli Mussalo, Hanna Ahola, Pasi Vanninen, Ritva Kuikka, Jyrki Tiihonen, Jari Lehtonen, Johannes

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2004

Schlagwörter:	Single Photon Emission Compute Tomography Single Photon Emission Compute Tomography Imaging Hamilton Depression Rate Scale Single Photon Emission Compute Tomography Study Hamilton Depression Rate Scale Score

Anmerkung:	© Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC psychiatry - London : BioMed Central, 2001, 4(2004), 1 vom: 13. Sept.
Übergeordnetes Werk:	volume:4 ; year:2004 ; number:1 ; day:13 ; month:09

Links:	Volltext

DOI / URN:	10.1186/1471-244X-4-27

Katalog-ID:	SPR027777871

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520			\|a Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores.
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allfields	10.1186/1471-244X-4-27 doi (DE-627)SPR027777871 (SPR)1471-244X-4-27-e DE-627 ger DE-627 rakwb eng Tolmunen, Tommi verfasserin aut Elevated midbrain serotonin transporter availability in mixed mania: a case report 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. Single Photon Emission Compute Tomography (dpeaa)DE-He213 Single Photon Emission Compute Tomography Imaging (dpeaa)DE-He213 Hamilton Depression Rate Scale (dpeaa)DE-He213 Single Photon Emission Compute Tomography Study (dpeaa)DE-He213 Hamilton Depression Rate Scale Score (dpeaa)DE-He213 Joensuu, Mikko aut Saarinen, Pirjo Irmeli aut Mussalo, Hanna aut Ahola, Pasi aut Vanninen, Ritva aut Kuikka, Jyrki aut Tiihonen, Jari aut Lehtonen, Johannes aut Enthalten in BMC psychiatry London : BioMed Central, 2001 4(2004), 1 vom: 13. Sept. (DE-627)331018799 (DE-600)2050438-X 1471-244X nnns volume:4 year:2004 number:1 day:13 month:09 https://dx.doi.org/10.1186/1471-244X-4-27 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 13 09
spelling	10.1186/1471-244X-4-27 doi (DE-627)SPR027777871 (SPR)1471-244X-4-27-e DE-627 ger DE-627 rakwb eng Tolmunen, Tommi verfasserin aut Elevated midbrain serotonin transporter availability in mixed mania: a case report 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. Single Photon Emission Compute Tomography (dpeaa)DE-He213 Single Photon Emission Compute Tomography Imaging (dpeaa)DE-He213 Hamilton Depression Rate Scale (dpeaa)DE-He213 Single Photon Emission Compute Tomography Study (dpeaa)DE-He213 Hamilton Depression Rate Scale Score (dpeaa)DE-He213 Joensuu, Mikko aut Saarinen, Pirjo Irmeli aut Mussalo, Hanna aut Ahola, Pasi aut Vanninen, Ritva aut Kuikka, Jyrki aut Tiihonen, Jari aut Lehtonen, Johannes aut Enthalten in BMC psychiatry London : BioMed Central, 2001 4(2004), 1 vom: 13. Sept. (DE-627)331018799 (DE-600)2050438-X 1471-244X nnns volume:4 year:2004 number:1 day:13 month:09 https://dx.doi.org/10.1186/1471-244X-4-27 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 13 09
allfields_unstemmed	10.1186/1471-244X-4-27 doi (DE-627)SPR027777871 (SPR)1471-244X-4-27-e DE-627 ger DE-627 rakwb eng Tolmunen, Tommi verfasserin aut Elevated midbrain serotonin transporter availability in mixed mania: a case report 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. Single Photon Emission Compute Tomography (dpeaa)DE-He213 Single Photon Emission Compute Tomography Imaging (dpeaa)DE-He213 Hamilton Depression Rate Scale (dpeaa)DE-He213 Single Photon Emission Compute Tomography Study (dpeaa)DE-He213 Hamilton Depression Rate Scale Score (dpeaa)DE-He213 Joensuu, Mikko aut Saarinen, Pirjo Irmeli aut Mussalo, Hanna aut Ahola, Pasi aut Vanninen, Ritva aut Kuikka, Jyrki aut Tiihonen, Jari aut Lehtonen, Johannes aut Enthalten in BMC psychiatry London : BioMed Central, 2001 4(2004), 1 vom: 13. Sept. (DE-627)331018799 (DE-600)2050438-X 1471-244X nnns volume:4 year:2004 number:1 day:13 month:09 https://dx.doi.org/10.1186/1471-244X-4-27 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 13 09
allfieldsGer	10.1186/1471-244X-4-27 doi (DE-627)SPR027777871 (SPR)1471-244X-4-27-e DE-627 ger DE-627 rakwb eng Tolmunen, Tommi verfasserin aut Elevated midbrain serotonin transporter availability in mixed mania: a case report 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. Single Photon Emission Compute Tomography (dpeaa)DE-He213 Single Photon Emission Compute Tomography Imaging (dpeaa)DE-He213 Hamilton Depression Rate Scale (dpeaa)DE-He213 Single Photon Emission Compute Tomography Study (dpeaa)DE-He213 Hamilton Depression Rate Scale Score (dpeaa)DE-He213 Joensuu, Mikko aut Saarinen, Pirjo Irmeli aut Mussalo, Hanna aut Ahola, Pasi aut Vanninen, Ritva aut Kuikka, Jyrki aut Tiihonen, Jari aut Lehtonen, Johannes aut Enthalten in BMC psychiatry London : BioMed Central, 2001 4(2004), 1 vom: 13. Sept. (DE-627)331018799 (DE-600)2050438-X 1471-244X nnns volume:4 year:2004 number:1 day:13 month:09 https://dx.doi.org/10.1186/1471-244X-4-27 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 13 09
allfieldsSound	10.1186/1471-244X-4-27 doi (DE-627)SPR027777871 (SPR)1471-244X-4-27-e DE-627 ger DE-627 rakwb eng Tolmunen, Tommi verfasserin aut Elevated midbrain serotonin transporter availability in mixed mania: a case report 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. Single Photon Emission Compute Tomography (dpeaa)DE-He213 Single Photon Emission Compute Tomography Imaging (dpeaa)DE-He213 Hamilton Depression Rate Scale (dpeaa)DE-He213 Single Photon Emission Compute Tomography Study (dpeaa)DE-He213 Hamilton Depression Rate Scale Score (dpeaa)DE-He213 Joensuu, Mikko aut Saarinen, Pirjo Irmeli aut Mussalo, Hanna aut Ahola, Pasi aut Vanninen, Ritva aut Kuikka, Jyrki aut Tiihonen, Jari aut Lehtonen, Johannes aut Enthalten in BMC psychiatry London : BioMed Central, 2001 4(2004), 1 vom: 13. Sept. (DE-627)331018799 (DE-600)2050438-X 1471-244X nnns volume:4 year:2004 number:1 day:13 month:09 https://dx.doi.org/10.1186/1471-244X-4-27 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2004 1 13 09
language	English
source	Enthalten in BMC psychiatry 4(2004), 1 vom: 13. Sept. volume:4 year:2004 number:1 day:13 month:09
sourceStr	Enthalten in BMC psychiatry 4(2004), 1 vom: 13. Sept. volume:4 year:2004 number:1 day:13 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Single Photon Emission Compute Tomography Single Photon Emission Compute Tomography Imaging Hamilton Depression Rate Scale Single Photon Emission Compute Tomography Study Hamilton Depression Rate Scale Score
isfreeaccess_bool	false
container_title	BMC psychiatry
authorswithroles_txt_mv	Tolmunen, Tommi @@aut@@ Joensuu, Mikko @@aut@@ Saarinen, Pirjo Irmeli @@aut@@ Mussalo, Hanna @@aut@@ Ahola, Pasi @@aut@@ Vanninen, Ritva @@aut@@ Kuikka, Jyrki @@aut@@ Tiihonen, Jari @@aut@@ Lehtonen, Johannes @@aut@@
publishDateDaySort_date	2004-09-13T00:00:00Z
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author	Tolmunen, Tommi
spellingShingle	Tolmunen, Tommi misc Single Photon Emission Compute Tomography misc Single Photon Emission Compute Tomography Imaging misc Hamilton Depression Rate Scale misc Single Photon Emission Compute Tomography Study misc Hamilton Depression Rate Scale Score Elevated midbrain serotonin transporter availability in mixed mania: a case report
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topic_title	Elevated midbrain serotonin transporter availability in mixed mania: a case report Single Photon Emission Compute Tomography (dpeaa)DE-He213 Single Photon Emission Compute Tomography Imaging (dpeaa)DE-He213 Hamilton Depression Rate Scale (dpeaa)DE-He213 Single Photon Emission Compute Tomography Study (dpeaa)DE-He213 Hamilton Depression Rate Scale Score (dpeaa)DE-He213
topic	misc Single Photon Emission Compute Tomography misc Single Photon Emission Compute Tomography Imaging misc Hamilton Depression Rate Scale misc Single Photon Emission Compute Tomography Study misc Hamilton Depression Rate Scale Score
topic_unstemmed	misc Single Photon Emission Compute Tomography misc Single Photon Emission Compute Tomography Imaging misc Hamilton Depression Rate Scale misc Single Photon Emission Compute Tomography Study misc Hamilton Depression Rate Scale Score
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title	Elevated midbrain serotonin transporter availability in mixed mania: a case report
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title_full	Elevated midbrain serotonin transporter availability in mixed mania: a case report
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author_browse	Tolmunen, Tommi Joensuu, Mikko Saarinen, Pirjo Irmeli Mussalo, Hanna Ahola, Pasi Vanninen, Ritva Kuikka, Jyrki Tiihonen, Jari Lehtonen, Johannes
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doi_str_mv	10.1186/1471-244X-4-27
title_sort	elevated midbrain serotonin transporter availability in mixed mania: a case report
title_auth	Elevated midbrain serotonin transporter availability in mixed mania: a case report
abstract	Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Results obtained from brain imaging studies indicate that serotonin transporter (SERT) and dopamine transporter (DAT) densities are altered in major depression. However, no such studies have been published on current mania or hypomania. Case presentation In this single photon emission computed tomography (SPECT) study with [123I]nor-β-CIT we present a case with simultaneous symptoms of major depression and hypomania. She had an elevated serotonin transporter availability (SERT) in the midbrain and elevated dopamine transporter availability (DAT) in the striatum, which normalised in a one-year follow-up period during which she received eight months of psychodynamic psychotherapy. Conclusions To our knowledge, this is the first report on SERT and DAT associated with mania. In our case the availability of both SERT in the midbrain and DAT in the striatum were elevated at baseline and declined during psychotherapy, while the SERT and DAT of the depressed controls increased during psychotherapy. Symptoms of hypomania in the case were alleviated during psychotherapy. Clinical recovery was also reflected in the Hamilton Depression Rating Scale (HDRS) scores. © Tolmunen et al; licensee BioMed Central Ltd. 2004. This article is published under license to BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Elevated midbrain serotonin transporter availability in mixed mania: a case report
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author2	Joensuu, Mikko Saarinen, Pirjo Irmeli Mussalo, Hanna Ahola, Pasi Vanninen, Ritva Kuikka, Jyrki Tiihonen, Jari Lehtonen, Johannes
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