Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients

Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of conf...
Ausführliche Beschreibung

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Autor*in:	Drummond, Marta [verfasserIn] Winck, João C Guimarães, João T Santos, Ana C Almeida, João Marques, José A

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Obstructive Sleep Apnoea Intermittent Hypoxia Respiratory Disturbance Index Obstructive Sleep Apnoea Patient Obstructive Sleep Apnoea Severity

Anmerkung:	© Drummond et al; licensee BioMed Central Ltd. 2008

Übergeordnetes Werk:	Enthalten in: BMC pulmonary medicine - London : BioMed Central, 2001, 8(2008), 1 vom: 01. Okt.
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1 ; day:01 ; month:10

Links:	Volltext

DOI / URN:	10.1186/1471-2466-8-21

Katalog-ID:	SPR027985539

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520			\|a Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels.
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700	1		\|a Marques, José A \|4 aut
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allfields	10.1186/1471-2466-8-21 doi (DE-627)SPR027985539 (SPR)1471-2466-8-21-e DE-627 ger DE-627 rakwb eng Drummond, Marta verfasserin aut Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Drummond et al; licensee BioMed Central Ltd. 2008 Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. Obstructive Sleep Apnoea (dpeaa)DE-He213 Intermittent Hypoxia (dpeaa)DE-He213 Respiratory Disturbance Index (dpeaa)DE-He213 Obstructive Sleep Apnoea Patient (dpeaa)DE-He213 Obstructive Sleep Apnoea Severity (dpeaa)DE-He213 Winck, João C aut Guimarães, João T aut Santos, Ana C aut Almeida, João aut Marques, José A aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 8(2008), 1 vom: 01. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:8 year:2008 number:1 day:01 month:10 https://dx.doi.org/10.1186/1471-2466-8-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 01 10
spelling	10.1186/1471-2466-8-21 doi (DE-627)SPR027985539 (SPR)1471-2466-8-21-e DE-627 ger DE-627 rakwb eng Drummond, Marta verfasserin aut Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Drummond et al; licensee BioMed Central Ltd. 2008 Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. Obstructive Sleep Apnoea (dpeaa)DE-He213 Intermittent Hypoxia (dpeaa)DE-He213 Respiratory Disturbance Index (dpeaa)DE-He213 Obstructive Sleep Apnoea Patient (dpeaa)DE-He213 Obstructive Sleep Apnoea Severity (dpeaa)DE-He213 Winck, João C aut Guimarães, João T aut Santos, Ana C aut Almeida, João aut Marques, José A aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 8(2008), 1 vom: 01. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:8 year:2008 number:1 day:01 month:10 https://dx.doi.org/10.1186/1471-2466-8-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 01 10
allfields_unstemmed	10.1186/1471-2466-8-21 doi (DE-627)SPR027985539 (SPR)1471-2466-8-21-e DE-627 ger DE-627 rakwb eng Drummond, Marta verfasserin aut Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Drummond et al; licensee BioMed Central Ltd. 2008 Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. Obstructive Sleep Apnoea (dpeaa)DE-He213 Intermittent Hypoxia (dpeaa)DE-He213 Respiratory Disturbance Index (dpeaa)DE-He213 Obstructive Sleep Apnoea Patient (dpeaa)DE-He213 Obstructive Sleep Apnoea Severity (dpeaa)DE-He213 Winck, João C aut Guimarães, João T aut Santos, Ana C aut Almeida, João aut Marques, José A aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 8(2008), 1 vom: 01. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:8 year:2008 number:1 day:01 month:10 https://dx.doi.org/10.1186/1471-2466-8-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 01 10
allfieldsGer	10.1186/1471-2466-8-21 doi (DE-627)SPR027985539 (SPR)1471-2466-8-21-e DE-627 ger DE-627 rakwb eng Drummond, Marta verfasserin aut Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Drummond et al; licensee BioMed Central Ltd. 2008 Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. Obstructive Sleep Apnoea (dpeaa)DE-He213 Intermittent Hypoxia (dpeaa)DE-He213 Respiratory Disturbance Index (dpeaa)DE-He213 Obstructive Sleep Apnoea Patient (dpeaa)DE-He213 Obstructive Sleep Apnoea Severity (dpeaa)DE-He213 Winck, João C aut Guimarães, João T aut Santos, Ana C aut Almeida, João aut Marques, José A aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 8(2008), 1 vom: 01. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:8 year:2008 number:1 day:01 month:10 https://dx.doi.org/10.1186/1471-2466-8-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 01 10
allfieldsSound	10.1186/1471-2466-8-21 doi (DE-627)SPR027985539 (SPR)1471-2466-8-21-e DE-627 ger DE-627 rakwb eng Drummond, Marta verfasserin aut Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Drummond et al; licensee BioMed Central Ltd. 2008 Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. Obstructive Sleep Apnoea (dpeaa)DE-He213 Intermittent Hypoxia (dpeaa)DE-He213 Respiratory Disturbance Index (dpeaa)DE-He213 Obstructive Sleep Apnoea Patient (dpeaa)DE-He213 Obstructive Sleep Apnoea Severity (dpeaa)DE-He213 Winck, João C aut Guimarães, João T aut Santos, Ana C aut Almeida, João aut Marques, José A aut Enthalten in BMC pulmonary medicine London : BioMed Central, 2001 8(2008), 1 vom: 01. Okt. (DE-627)335489125 (DE-600)2059871-3 1471-2466 nnns volume:8 year:2008 number:1 day:01 month:10 https://dx.doi.org/10.1186/1471-2466-8-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1 01 10
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source	Enthalten in BMC pulmonary medicine 8(2008), 1 vom: 01. Okt. volume:8 year:2008 number:1 day:01 month:10
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topic_facet	Obstructive Sleep Apnoea Intermittent Hypoxia Respiratory Disturbance Index Obstructive Sleep Apnoea Patient Obstructive Sleep Apnoea Severity
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authorswithroles_txt_mv	Drummond, Marta @@aut@@ Winck, João C @@aut@@ Guimarães, João T @@aut@@ Santos, Ana C @@aut@@ Almeida, João @@aut@@ Marques, José A @@aut@@
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author	Drummond, Marta
spellingShingle	Drummond, Marta misc Obstructive Sleep Apnoea misc Intermittent Hypoxia misc Respiratory Disturbance Index misc Obstructive Sleep Apnoea Patient misc Obstructive Sleep Apnoea Severity Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients
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topic_title	Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients Obstructive Sleep Apnoea (dpeaa)DE-He213 Intermittent Hypoxia (dpeaa)DE-He213 Respiratory Disturbance Index (dpeaa)DE-He213 Obstructive Sleep Apnoea Patient (dpeaa)DE-He213 Obstructive Sleep Apnoea Severity (dpeaa)DE-He213
topic	misc Obstructive Sleep Apnoea misc Intermittent Hypoxia misc Respiratory Disturbance Index misc Obstructive Sleep Apnoea Patient misc Obstructive Sleep Apnoea Severity
topic_unstemmed	misc Obstructive Sleep Apnoea misc Intermittent Hypoxia misc Respiratory Disturbance Index misc Obstructive Sleep Apnoea Patient misc Obstructive Sleep Apnoea Severity
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title	Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients
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title_full	Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients
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author_browse	Drummond, Marta Winck, João C Guimarães, João T Santos, Ana C Almeida, João Marques, José A
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title_sort	autoadjusting-cpap effect on serum leptin concentrations in obstructive sleep apnoea patients
title_auth	Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients
abstract	Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. © Drummond et al; licensee BioMed Central Ltd. 2008
abstractGer	Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. © Drummond et al; licensee BioMed Central Ltd. 2008
abstract_unstemmed	Background Leptin is an hormone that regulates body weight. Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. Treatment with Autoadjusting-CPAP has a small effect on leptin levels. © Drummond et al; licensee BioMed Central Ltd. 2008
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title_short	Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients
url	https://dx.doi.org/10.1186/1471-2466-8-21
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author2	Winck, João C Guimarães, João T Santos, Ana C Almeida, João Marques, José A
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up_date	2024-07-03T16:31:16.672Z
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Studies have shown increasing leptin concentrations according to body mass index (BMI) and intermittent hypoxia. Our aim is to evaluate the basal leptin levels in OSA patients and its possible relation to OSA severity, independently of confounders and investigate the Autoadjusting-CPAP effect on leptin values. Methods In ninety eight male patients with moderate to severe OSA leptin serum levels were evaluated before therapy, 9 days and 6 months after therapy. Results In this group mean age was 55.3 years, mean BMI was 33.2 Kg/m2 and mean Apnoea- Hypopnea Index (AHI) was 51.7/h. Mean basal serum leptin value was 12.1 ug/L. Univariate analysis showed a significant correlation between serum leptin values and BMI (R = 0.68; p < 0.001), waist-hip ratio (R = 0.283; p = 0.004) and AHI (R = 0.198; p = 0.048); in stepwise multiple regression analysis only BMI (p < 0.001) was a predictor of serum leptin values. One week after therapy, mean leptin serum level decreased to 11.0 ug/L and 6 months after it was 11.4 ug/L. (p = 0.56 and p = 0.387, respectively) Conclusion Baseline leptin serum levels positively correlate with BMI, fat distributioand OSA severity. BMI is the only predictor of basal leptin levels. 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Autoadjusting-CPAP effect on serum Leptin concentrations in Obstructive Sleep Apnoea patients

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