Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male...
Ausführliche Beschreibung
Autor*in: |
Kurosaka, Daitaro [verfasserIn] |
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E-Artikel |
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Englisch |
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2009 |
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Anmerkung: |
© Kurosaka et al; licensee BioMed Central Ltd. 2009 |
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Übergeordnetes Werk: |
Enthalten in: BMC musculoskeletal disorders - London : BioMed Central, 2000, 10(2009), 1 vom: 30. Apr. |
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Übergeordnetes Werk: |
volume:10 ; year:2009 ; number:1 ; day:30 ; month:04 |
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DOI / URN: |
10.1186/1471-2474-10-45 |
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Katalog-ID: |
SPR028010736 |
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520 | |a Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. | ||
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700 | 1 | |a Yamada, Akio |4 aut | |
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10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04 |
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10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04 |
allfields_unstemmed |
10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04 |
allfieldsGer |
10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04 |
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10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04 |
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elevation of bombina variegata peptide 8 in mice with collagen-induced arthritis |
title_auth |
Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis |
abstract |
Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. © Kurosaka et al; licensee BioMed Central Ltd. 2009 |
abstractGer |
Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. © Kurosaka et al; licensee BioMed Central Ltd. 2009 |
abstract_unstemmed |
Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. © Kurosaka et al; licensee BioMed Central Ltd. 2009 |
collection_details |
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container_issue |
1 |
title_short |
Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis |
url |
https://dx.doi.org/10.1186/1471-2474-10-45 |
remote_bool |
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author2 |
Noda, Kentaro Yoshida, Ken Furuya, Kazuhiro Ukichi, Taro Takahashi, Eigo Yanagimachi, Maimi Kingetsu, Isamu Saito, Saburo Yamada, Akio |
author2Str |
Noda, Kentaro Yoshida, Ken Furuya, Kazuhiro Ukichi, Taro Takahashi, Eigo Yanagimachi, Maimi Kingetsu, Isamu Saito, Saburo Yamada, Akio |
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doi_str |
10.1186/1471-2474-10-45 |
up_date |
2024-07-03T16:41:12.018Z |
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