Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis

Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male...
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Autor*in:	Kurosaka, Daitaro [verfasserIn] Noda, Kentaro Yoshida, Ken Furuya, Kazuhiro Ukichi, Taro Takahashi, Eigo Yanagimachi, Maimi Kingetsu, Isamu Saito, Saburo Yamada, Akio

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Ankle Joint Arthritic Joint Arthritis Score Nichirei Bioscience VEGF mRNA Expression

Anmerkung:	© Kurosaka et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: BMC musculoskeletal disorders - London : BioMed Central, 2000, 10(2009), 1 vom: 30. Apr.
Übergeordnetes Werk:	volume:10 ; year:2009 ; number:1 ; day:30 ; month:04

Links:	Volltext

DOI / URN:	10.1186/1471-2474-10-45

Katalog-ID:	SPR028010736

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245	1	0	\|a Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
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520			\|a Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis.
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author_variant	d k dk k n kn k y ky k f kf t u tu e t et m y my i k ik s s ss a y ay
matchkey_str	article:14712474:2009----::lvtoobmiaaigtppieimcwtcla
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publishDate	2009
allfields	10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04
spelling	10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04
allfields_unstemmed	10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04
allfieldsGer	10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04
allfieldsSound	10.1186/1471-2474-10-45 doi (DE-627)SPR028010736 (SPR)1471-2474-10-45-e DE-627 ger DE-627 rakwb eng Kurosaka, Daitaro verfasserin aut Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kurosaka et al; licensee BioMed Central Ltd. 2009 Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213 Noda, Kentaro aut Yoshida, Ken aut Furuya, Kazuhiro aut Ukichi, Taro aut Takahashi, Eigo aut Yanagimachi, Maimi aut Kingetsu, Isamu aut Saito, Saburo aut Yamada, Akio aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 10(2009), 1 vom: 30. Apr. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:10 year:2009 number:1 day:30 month:04 https://dx.doi.org/10.1186/1471-2474-10-45 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 30 04
language	English
source	Enthalten in BMC musculoskeletal disorders 10(2009), 1 vom: 30. Apr. volume:10 year:2009 number:1 day:30 month:04
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author	Kurosaka, Daitaro
spellingShingle	Kurosaka, Daitaro misc Ankle Joint misc Arthritic Joint misc Arthritis Score misc Nichirei Bioscience misc VEGF mRNA Expression Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
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topic_title	Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis Ankle Joint (dpeaa)DE-He213 Arthritic Joint (dpeaa)DE-He213 Arthritis Score (dpeaa)DE-He213 Nichirei Bioscience (dpeaa)DE-He213 VEGF mRNA Expression (dpeaa)DE-He213
topic	misc Ankle Joint misc Arthritic Joint misc Arthritis Score misc Nichirei Bioscience misc VEGF mRNA Expression
topic_unstemmed	misc Ankle Joint misc Arthritic Joint misc Arthritis Score misc Nichirei Bioscience misc VEGF mRNA Expression
topic_browse	misc Ankle Joint misc Arthritic Joint misc Arthritis Score misc Nichirei Bioscience misc VEGF mRNA Expression
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title	Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
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title_full	Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
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author_browse	Kurosaka, Daitaro Noda, Kentaro Yoshida, Ken Furuya, Kazuhiro Ukichi, Taro Takahashi, Eigo Yanagimachi, Maimi Kingetsu, Isamu Saito, Saburo Yamada, Akio
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title_sort	elevation of bombina variegata peptide 8 in mice with collagen-induced arthritis
title_auth	Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
abstract	Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. © Kurosaka et al; licensee BioMed Central Ltd. 2009
abstractGer	Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. © Kurosaka et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background Bombina variegate peptide 8 (Bv8) is a small protein secreted by frog skin. Recently it has been shown to contribute to tumor angiogenesis in mouse model. The purpose of this study was to investigate Bv8 in mice with type II collagen-induced arthritis (CIA). Methods We induced CIA in male DBA/1J mice. The severity of arthritis was evaluated based on an arthritis score. RNA was extracted from the joint, and examined for Bv8 mRNA expression by RT-PCR and real-time RT-PCR. Synovial tissue and bone marrow were immunohistochemically examined using anti-Bv8 antibody. Results The level of Bv8 mRNA expression in the joint was below the detection limit in the control group, but was elevated in the CIA group, and was correlated with the arthritis score. In addition, an increase in Bv8-positive cells was observed in the synovium and bone marrow in the CIA group. Conclusion Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. © Kurosaka et al; licensee BioMed Central Ltd. 2009
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container_issue	1
title_short	Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis
url	https://dx.doi.org/10.1186/1471-2474-10-45
remote_bool	true
author2	Noda, Kentaro Yoshida, Ken Furuya, Kazuhiro Ukichi, Taro Takahashi, Eigo Yanagimachi, Maimi Kingetsu, Isamu Saito, Saburo Yamada, Akio
author2Str	Noda, Kentaro Yoshida, Ken Furuya, Kazuhiro Ukichi, Taro Takahashi, Eigo Yanagimachi, Maimi Kingetsu, Isamu Saito, Saburo Yamada, Akio
ppnlink	326643745
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doi_str	10.1186/1471-2474-10-45
up_date	2024-07-03T16:41:12.018Z
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Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis

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