Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis
Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jochems, Caroline [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Anmerkung: |
© Jochems et al; licensee BioMed Central Ltd. 2010 |
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| Übergeordnetes Werk: |
Enthalten in: BMC musculoskeletal disorders - London : BioMed Central, 2000, 11(2010), 1 vom: 16. Dez. |
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| Übergeordnetes Werk: |
volume:11 ; year:2010 ; number:1 ; day:16 ; month:12 |
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| DOI / URN: |
10.1186/1471-2474-11-284 |
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| Katalog-ID: |
SPR028012437 |
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| 520 | |a Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. | ||
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10.1186/1471-2474-11-284 doi (DE-627)SPR028012437 (SPR)1471-2474-11-284-e DE-627 ger DE-627 rakwb eng Jochems, Caroline verfasserin aut Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jochems et al; licensee BioMed Central Ltd. 2010 Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. Bone Mineral Density (dpeaa)DE-He213 Estradiol (dpeaa)DE-He213 Raloxifene (dpeaa)DE-He213 Selective Estrogen Receptor Modulator (dpeaa)DE-He213 Human Rheumatoid Arthritis (dpeaa)DE-He213 Islander, Ulrika aut Erlandsson, Malin aut Engdahl, Cecilia aut Lagerquist, Marie aut Gjertsson, Inger aut Ohlsson, Claes aut Holmdahl, Rikard aut Carlsten, Hans aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 11(2010), 1 vom: 16. Dez. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:11 year:2010 number:1 day:16 month:12 https://dx.doi.org/10.1186/1471-2474-11-284 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 16 12 |
| spelling |
10.1186/1471-2474-11-284 doi (DE-627)SPR028012437 (SPR)1471-2474-11-284-e DE-627 ger DE-627 rakwb eng Jochems, Caroline verfasserin aut Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jochems et al; licensee BioMed Central Ltd. 2010 Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. Bone Mineral Density (dpeaa)DE-He213 Estradiol (dpeaa)DE-He213 Raloxifene (dpeaa)DE-He213 Selective Estrogen Receptor Modulator (dpeaa)DE-He213 Human Rheumatoid Arthritis (dpeaa)DE-He213 Islander, Ulrika aut Erlandsson, Malin aut Engdahl, Cecilia aut Lagerquist, Marie aut Gjertsson, Inger aut Ohlsson, Claes aut Holmdahl, Rikard aut Carlsten, Hans aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 11(2010), 1 vom: 16. Dez. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:11 year:2010 number:1 day:16 month:12 https://dx.doi.org/10.1186/1471-2474-11-284 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 16 12 |
| allfields_unstemmed |
10.1186/1471-2474-11-284 doi (DE-627)SPR028012437 (SPR)1471-2474-11-284-e DE-627 ger DE-627 rakwb eng Jochems, Caroline verfasserin aut Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jochems et al; licensee BioMed Central Ltd. 2010 Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. Bone Mineral Density (dpeaa)DE-He213 Estradiol (dpeaa)DE-He213 Raloxifene (dpeaa)DE-He213 Selective Estrogen Receptor Modulator (dpeaa)DE-He213 Human Rheumatoid Arthritis (dpeaa)DE-He213 Islander, Ulrika aut Erlandsson, Malin aut Engdahl, Cecilia aut Lagerquist, Marie aut Gjertsson, Inger aut Ohlsson, Claes aut Holmdahl, Rikard aut Carlsten, Hans aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 11(2010), 1 vom: 16. Dez. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:11 year:2010 number:1 day:16 month:12 https://dx.doi.org/10.1186/1471-2474-11-284 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 16 12 |
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10.1186/1471-2474-11-284 doi (DE-627)SPR028012437 (SPR)1471-2474-11-284-e DE-627 ger DE-627 rakwb eng Jochems, Caroline verfasserin aut Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jochems et al; licensee BioMed Central Ltd. 2010 Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. Bone Mineral Density (dpeaa)DE-He213 Estradiol (dpeaa)DE-He213 Raloxifene (dpeaa)DE-He213 Selective Estrogen Receptor Modulator (dpeaa)DE-He213 Human Rheumatoid Arthritis (dpeaa)DE-He213 Islander, Ulrika aut Erlandsson, Malin aut Engdahl, Cecilia aut Lagerquist, Marie aut Gjertsson, Inger aut Ohlsson, Claes aut Holmdahl, Rikard aut Carlsten, Hans aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 11(2010), 1 vom: 16. Dez. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:11 year:2010 number:1 day:16 month:12 https://dx.doi.org/10.1186/1471-2474-11-284 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 16 12 |
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10.1186/1471-2474-11-284 doi (DE-627)SPR028012437 (SPR)1471-2474-11-284-e DE-627 ger DE-627 rakwb eng Jochems, Caroline verfasserin aut Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jochems et al; licensee BioMed Central Ltd. 2010 Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. Bone Mineral Density (dpeaa)DE-He213 Estradiol (dpeaa)DE-He213 Raloxifene (dpeaa)DE-He213 Selective Estrogen Receptor Modulator (dpeaa)DE-He213 Human Rheumatoid Arthritis (dpeaa)DE-He213 Islander, Ulrika aut Erlandsson, Malin aut Engdahl, Cecilia aut Lagerquist, Marie aut Gjertsson, Inger aut Ohlsson, Claes aut Holmdahl, Rikard aut Carlsten, Hans aut Enthalten in BMC musculoskeletal disorders London : BioMed Central, 2000 11(2010), 1 vom: 16. Dez. (DE-627)326643745 (DE-600)2041355-5 1471-2474 nnns volume:11 year:2010 number:1 day:16 month:12 https://dx.doi.org/10.1186/1471-2474-11-284 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2010 1 16 12 |
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Enthalten in BMC musculoskeletal disorders 11(2010), 1 vom: 16. Dez. volume:11 year:2010 number:1 day:16 month:12 |
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Bone Mineral Density Estradiol Raloxifene Selective Estrogen Receptor Modulator Human Rheumatoid Arthritis |
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Jochems, Caroline @@aut@@ Islander, Ulrika @@aut@@ Erlandsson, Malin @@aut@@ Engdahl, Cecilia @@aut@@ Lagerquist, Marie @@aut@@ Gjertsson, Inger @@aut@@ Ohlsson, Claes @@aut@@ Holmdahl, Rikard @@aut@@ Carlsten, Hans @@aut@@ |
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Jochems, Caroline misc Bone Mineral Density misc Estradiol misc Raloxifene misc Selective Estrogen Receptor Modulator misc Human Rheumatoid Arthritis Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis |
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Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis Bone Mineral Density (dpeaa)DE-He213 Estradiol (dpeaa)DE-He213 Raloxifene (dpeaa)DE-He213 Selective Estrogen Receptor Modulator (dpeaa)DE-He213 Human Rheumatoid Arthritis (dpeaa)DE-He213 |
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Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis |
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Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis |
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Jochems, Caroline Islander, Ulrika Erlandsson, Malin Engdahl, Cecilia Lagerquist, Marie Gjertsson, Inger Ohlsson, Claes Holmdahl, Rikard Carlsten, Hans |
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role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in b10.q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis |
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Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-$ ncf1^{*/*} $ mice with collagen-induced chronic arthritis |
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Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. © Jochems et al; licensee BioMed Central Ltd. 2010 |
| abstractGer |
Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. © Jochems et al; licensee BioMed Central Ltd. 2010 |
| abstract_unstemmed |
Background Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-$ ncf1^{*/*} $mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-$ ncf1^{*/*} $mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis. Methods Female B10.Q-$ ncf1^{*/*} $mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines. Results Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6. Conclusions This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA. © Jochems et al; licensee BioMed Central Ltd. 2010 |
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| score |
7.400221 |