Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)
Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to i...
Ausführliche Beschreibung
Autor*in: |
Picot, Valentina Sanchez [verfasserIn] |
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Englisch |
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2014 |
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© Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Übergeordnetes Werk: |
Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 14(2014), 1 vom: 10. Dez. |
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Übergeordnetes Werk: |
volume:14 ; year:2014 ; number:1 ; day:10 ; month:12 |
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DOI / URN: |
10.1186/s12879-014-0635-8 |
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SPR028061748 |
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520 | |a Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. | ||
650 | 4 | |a Pneumonia |7 (dpeaa)DE-He213 | |
650 | 4 | |a Children |7 (dpeaa)DE-He213 | |
650 | 4 | |a Case–control |7 (dpeaa)DE-He213 | |
650 | 4 | |a Etiology |7 (dpeaa)DE-He213 | |
650 | 4 | |a Developing and emerging countries |7 (dpeaa)DE-He213 | |
700 | 1 | |a Bénet, Thomas |4 aut | |
700 | 1 | |a Messaoudi, Melina |4 aut | |
700 | 1 | |a Telles, Jean-Noël |4 aut | |
700 | 1 | |a Chou, Monidarin |4 aut | |
700 | 1 | |a Eap, Tekchheng |4 aut | |
700 | 1 | |a Wang, Jianwei |4 aut | |
700 | 1 | |a Shen, Kunling |4 aut | |
700 | 1 | |a Pape, Jean-William |4 aut | |
700 | 1 | |a Rouzier, Vanessa |4 aut | |
700 | 1 | |a Awasthi, Shally |4 aut | |
700 | 1 | |a Pandey, Nitin |4 aut | |
700 | 1 | |a Bavdekar, Ashish |4 aut | |
700 | 1 | |a Sanghvi, Sonali |4 aut | |
700 | 1 | |a Robinson, Annick |4 aut | |
700 | 1 | |a Contamin, Bénédicte |4 aut | |
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700 | 1 | |a Sylla, Maryam |4 aut | |
700 | 1 | |a Diallo, Souleymane |4 aut | |
700 | 1 | |a Nymadawa, Pagbajabyn |4 aut | |
700 | 1 | |a Dash-Yandag, Budragchaagiin |4 aut | |
700 | 1 | |a Russomando, Graciela |4 aut | |
700 | 1 | |a Basualdo, Wilma |4 aut | |
700 | 1 | |a Siqueira, Marilda M |4 aut | |
700 | 1 | |a Barreto, Patricia |4 aut | |
700 | 1 | |a Komurian-Pradel, Florence |4 aut | |
700 | 1 | |a Vernet, Guy |4 aut | |
700 | 1 | |a Endtz, Hubert |4 aut | |
700 | 1 | |a Vanhems, Philippe |4 aut | |
700 | 1 | |a Paranhos-Baccalà, Gláucia |4 aut | |
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10.1186/s12879-014-0635-8 doi (DE-627)SPR028061748 (SPR)s12879-014-0635-8-e DE-627 ger DE-627 rakwb eng Picot, Valentina Sanchez verfasserin aut Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. Pneumonia (dpeaa)DE-He213 Children (dpeaa)DE-He213 Case–control (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 Developing and emerging countries (dpeaa)DE-He213 Bénet, Thomas aut Messaoudi, Melina aut Telles, Jean-Noël aut Chou, Monidarin aut Eap, Tekchheng aut Wang, Jianwei aut Shen, Kunling aut Pape, Jean-William aut Rouzier, Vanessa aut Awasthi, Shally aut Pandey, Nitin aut Bavdekar, Ashish aut Sanghvi, Sonali aut Robinson, Annick aut Contamin, Bénédicte aut Hoffmann, Jonathan aut Sylla, Maryam aut Diallo, Souleymane aut Nymadawa, Pagbajabyn aut Dash-Yandag, Budragchaagiin aut Russomando, Graciela aut Basualdo, Wilma aut Siqueira, Marilda M aut Barreto, Patricia aut Komurian-Pradel, Florence aut Vernet, Guy aut Endtz, Hubert aut Vanhems, Philippe aut Paranhos-Baccalà, Gláucia aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 14(2014), 1 vom: 10. Dez. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:14 year:2014 number:1 day:10 month:12 https://dx.doi.org/10.1186/s12879-014-0635-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 10 12 |
spelling |
10.1186/s12879-014-0635-8 doi (DE-627)SPR028061748 (SPR)s12879-014-0635-8-e DE-627 ger DE-627 rakwb eng Picot, Valentina Sanchez verfasserin aut Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. Pneumonia (dpeaa)DE-He213 Children (dpeaa)DE-He213 Case–control (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 Developing and emerging countries (dpeaa)DE-He213 Bénet, Thomas aut Messaoudi, Melina aut Telles, Jean-Noël aut Chou, Monidarin aut Eap, Tekchheng aut Wang, Jianwei aut Shen, Kunling aut Pape, Jean-William aut Rouzier, Vanessa aut Awasthi, Shally aut Pandey, Nitin aut Bavdekar, Ashish aut Sanghvi, Sonali aut Robinson, Annick aut Contamin, Bénédicte aut Hoffmann, Jonathan aut Sylla, Maryam aut Diallo, Souleymane aut Nymadawa, Pagbajabyn aut Dash-Yandag, Budragchaagiin aut Russomando, Graciela aut Basualdo, Wilma aut Siqueira, Marilda M aut Barreto, Patricia aut Komurian-Pradel, Florence aut Vernet, Guy aut Endtz, Hubert aut Vanhems, Philippe aut Paranhos-Baccalà, Gláucia aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 14(2014), 1 vom: 10. Dez. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:14 year:2014 number:1 day:10 month:12 https://dx.doi.org/10.1186/s12879-014-0635-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 10 12 |
allfields_unstemmed |
10.1186/s12879-014-0635-8 doi (DE-627)SPR028061748 (SPR)s12879-014-0635-8-e DE-627 ger DE-627 rakwb eng Picot, Valentina Sanchez verfasserin aut Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. Pneumonia (dpeaa)DE-He213 Children (dpeaa)DE-He213 Case–control (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 Developing and emerging countries (dpeaa)DE-He213 Bénet, Thomas aut Messaoudi, Melina aut Telles, Jean-Noël aut Chou, Monidarin aut Eap, Tekchheng aut Wang, Jianwei aut Shen, Kunling aut Pape, Jean-William aut Rouzier, Vanessa aut Awasthi, Shally aut Pandey, Nitin aut Bavdekar, Ashish aut Sanghvi, Sonali aut Robinson, Annick aut Contamin, Bénédicte aut Hoffmann, Jonathan aut Sylla, Maryam aut Diallo, Souleymane aut Nymadawa, Pagbajabyn aut Dash-Yandag, Budragchaagiin aut Russomando, Graciela aut Basualdo, Wilma aut Siqueira, Marilda M aut Barreto, Patricia aut Komurian-Pradel, Florence aut Vernet, Guy aut Endtz, Hubert aut Vanhems, Philippe aut Paranhos-Baccalà, Gláucia aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 14(2014), 1 vom: 10. Dez. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:14 year:2014 number:1 day:10 month:12 https://dx.doi.org/10.1186/s12879-014-0635-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 10 12 |
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10.1186/s12879-014-0635-8 doi (DE-627)SPR028061748 (SPR)s12879-014-0635-8-e DE-627 ger DE-627 rakwb eng Picot, Valentina Sanchez verfasserin aut Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. Pneumonia (dpeaa)DE-He213 Children (dpeaa)DE-He213 Case–control (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 Developing and emerging countries (dpeaa)DE-He213 Bénet, Thomas aut Messaoudi, Melina aut Telles, Jean-Noël aut Chou, Monidarin aut Eap, Tekchheng aut Wang, Jianwei aut Shen, Kunling aut Pape, Jean-William aut Rouzier, Vanessa aut Awasthi, Shally aut Pandey, Nitin aut Bavdekar, Ashish aut Sanghvi, Sonali aut Robinson, Annick aut Contamin, Bénédicte aut Hoffmann, Jonathan aut Sylla, Maryam aut Diallo, Souleymane aut Nymadawa, Pagbajabyn aut Dash-Yandag, Budragchaagiin aut Russomando, Graciela aut Basualdo, Wilma aut Siqueira, Marilda M aut Barreto, Patricia aut Komurian-Pradel, Florence aut Vernet, Guy aut Endtz, Hubert aut Vanhems, Philippe aut Paranhos-Baccalà, Gláucia aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 14(2014), 1 vom: 10. Dez. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:14 year:2014 number:1 day:10 month:12 https://dx.doi.org/10.1186/s12879-014-0635-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 10 12 |
allfieldsSound |
10.1186/s12879-014-0635-8 doi (DE-627)SPR028061748 (SPR)s12879-014-0635-8-e DE-627 ger DE-627 rakwb eng Picot, Valentina Sanchez verfasserin aut Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. Pneumonia (dpeaa)DE-He213 Children (dpeaa)DE-He213 Case–control (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 Developing and emerging countries (dpeaa)DE-He213 Bénet, Thomas aut Messaoudi, Melina aut Telles, Jean-Noël aut Chou, Monidarin aut Eap, Tekchheng aut Wang, Jianwei aut Shen, Kunling aut Pape, Jean-William aut Rouzier, Vanessa aut Awasthi, Shally aut Pandey, Nitin aut Bavdekar, Ashish aut Sanghvi, Sonali aut Robinson, Annick aut Contamin, Bénédicte aut Hoffmann, Jonathan aut Sylla, Maryam aut Diallo, Souleymane aut Nymadawa, Pagbajabyn aut Dash-Yandag, Budragchaagiin aut Russomando, Graciela aut Basualdo, Wilma aut Siqueira, Marilda M aut Barreto, Patricia aut Komurian-Pradel, Florence aut Vernet, Guy aut Endtz, Hubert aut Vanhems, Philippe aut Paranhos-Baccalà, Gláucia aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 14(2014), 1 vom: 10. Dez. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:14 year:2014 number:1 day:10 month:12 https://dx.doi.org/10.1186/s12879-014-0635-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2014 1 10 12 |
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Picot, Valentina Sanchez @@aut@@ Bénet, Thomas @@aut@@ Messaoudi, Melina @@aut@@ Telles, Jean-Noël @@aut@@ Chou, Monidarin @@aut@@ Eap, Tekchheng @@aut@@ Wang, Jianwei @@aut@@ Shen, Kunling @@aut@@ Pape, Jean-William @@aut@@ Rouzier, Vanessa @@aut@@ Awasthi, Shally @@aut@@ Pandey, Nitin @@aut@@ Bavdekar, Ashish @@aut@@ Sanghvi, Sonali @@aut@@ Robinson, Annick @@aut@@ Contamin, Bénédicte @@aut@@ Hoffmann, Jonathan @@aut@@ Sylla, Maryam @@aut@@ Diallo, Souleymane @@aut@@ Nymadawa, Pagbajabyn @@aut@@ Dash-Yandag, Budragchaagiin @@aut@@ Russomando, Graciela @@aut@@ Basualdo, Wilma @@aut@@ Siqueira, Marilda M @@aut@@ Barreto, Patricia @@aut@@ Komurian-Pradel, Florence @@aut@@ Vernet, Guy @@aut@@ Endtz, Hubert @@aut@@ Vanhems, Philippe @@aut@@ Paranhos-Baccalà, Gláucia @@aut@@ |
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Picot, Valentina Sanchez misc Pneumonia misc Children misc Case–control misc Etiology misc Developing and emerging countries Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) |
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Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) Pneumonia (dpeaa)DE-He213 Children (dpeaa)DE-He213 Case–control (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 Developing and emerging countries (dpeaa)DE-He213 |
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Picot, Valentina Sanchez Bénet, Thomas Messaoudi, Melina Telles, Jean-Noël Chou, Monidarin Eap, Tekchheng Wang, Jianwei Shen, Kunling Pape, Jean-William Rouzier, Vanessa Awasthi, Shally Pandey, Nitin Bavdekar, Ashish Sanghvi, Sonali Robinson, Annick Contamin, Bénédicte Hoffmann, Jonathan Sylla, Maryam Diallo, Souleymane Nymadawa, Pagbajabyn Dash-Yandag, Budragchaagiin Russomando, Graciela Basualdo, Wilma Siqueira, Marilda M Barreto, Patricia Komurian-Pradel, Florence Vernet, Guy Endtz, Hubert Vanhems, Philippe Paranhos-Baccalà, Gláucia |
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multicenter case–control study protocol of pneumonia etiology in children: global approach to biological research, infectious diseases and epidemics in low-income countries (gabriel network) |
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Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) |
abstract |
Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
abstractGer |
Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
abstract_unstemmed |
Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention. © Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network) |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR028061748</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519190837.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12879-014-0635-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR028061748</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12879-014-0635-8-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Picot, Valentina Sanchez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Picot et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. 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