Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study
Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe...
Ausführliche Beschreibung
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| Autor*in: |
Piza, Felipe Maia de Toledo [verfasserIn] Villarinho, Andrea Aparecida Rocco |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s). 2017 |
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| Übergeordnetes Werk: |
Enthalten in: BMC infectious diseases - London : BioMed Central, 2001, 17(2017), 1 vom: 19. Jan. |
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| Übergeordnetes Werk: |
volume:17 ; year:2017 ; number:1 ; day:19 ; month:01 |
| Links: |
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| DOI / URN: |
10.1186/s12879-017-2204-4 |
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SPR02808506X |
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| 100 | 1 | |a Piza, Felipe Maia de Toledo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study |
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| 520 | |a Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. | ||
| 650 | 4 | |a International Normalize Ratio |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Disseminate Intravascular Coagulation |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Corrêa, Thiago Domingos |4 aut | |
| 700 | 1 | |a Marra, Alexandre Rodrigues |4 aut | |
| 700 | 1 | |a Guerra, João Carlos Campos |4 aut | |
| 700 | 1 | |a Rodrigues, Roseny dos Reis |4 aut | |
| 700 | 1 | |a Villarinho, Andrea Aparecida Rocco |4 aut | |
| 700 | 1 | |a de Aranda, Valdir Fernandes |4 aut | |
| 700 | 1 | |a Shiramizo, Sandra Christina Pereira Lima |4 aut | |
| 700 | 1 | |a de Lima, Maria Roza de Jesus |4 aut | |
| 700 | 1 | |a Kallas, Esper Georges |4 aut | |
| 700 | 1 | |a Cavalcanti, Alexandre Biasi |4 aut | |
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10.1186/s12879-017-2204-4 doi (DE-627)SPR02808506X (SPR)s12879-017-2204-4-e DE-627 ger DE-627 rakwb eng Piza, Felipe Maia de Toledo verfasserin aut Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. International Normalize Ratio (dpeaa)DE-He213 Disseminate Intravascular Coagulation (dpeaa)DE-He213 Dengue Hemorrhagic Fever (dpeaa)DE-He213 Alpha Angle (dpeaa)DE-He213 Plasma Fibrinogen Level (dpeaa)DE-He213 Corrêa, Thiago Domingos aut Marra, Alexandre Rodrigues aut Guerra, João Carlos Campos aut Rodrigues, Roseny dos Reis aut Villarinho, Andrea Aparecida Rocco aut de Aranda, Valdir Fernandes aut Shiramizo, Sandra Christina Pereira Lima aut de Lima, Maria Roza de Jesus aut Kallas, Esper Georges aut Cavalcanti, Alexandre Biasi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 17(2017), 1 vom: 19. Jan. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:17 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s12879-017-2204-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 19 01 |
| spelling |
10.1186/s12879-017-2204-4 doi (DE-627)SPR02808506X (SPR)s12879-017-2204-4-e DE-627 ger DE-627 rakwb eng Piza, Felipe Maia de Toledo verfasserin aut Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. International Normalize Ratio (dpeaa)DE-He213 Disseminate Intravascular Coagulation (dpeaa)DE-He213 Dengue Hemorrhagic Fever (dpeaa)DE-He213 Alpha Angle (dpeaa)DE-He213 Plasma Fibrinogen Level (dpeaa)DE-He213 Corrêa, Thiago Domingos aut Marra, Alexandre Rodrigues aut Guerra, João Carlos Campos aut Rodrigues, Roseny dos Reis aut Villarinho, Andrea Aparecida Rocco aut de Aranda, Valdir Fernandes aut Shiramizo, Sandra Christina Pereira Lima aut de Lima, Maria Roza de Jesus aut Kallas, Esper Georges aut Cavalcanti, Alexandre Biasi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 17(2017), 1 vom: 19. Jan. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:17 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s12879-017-2204-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 19 01 |
| allfields_unstemmed |
10.1186/s12879-017-2204-4 doi (DE-627)SPR02808506X (SPR)s12879-017-2204-4-e DE-627 ger DE-627 rakwb eng Piza, Felipe Maia de Toledo verfasserin aut Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. International Normalize Ratio (dpeaa)DE-He213 Disseminate Intravascular Coagulation (dpeaa)DE-He213 Dengue Hemorrhagic Fever (dpeaa)DE-He213 Alpha Angle (dpeaa)DE-He213 Plasma Fibrinogen Level (dpeaa)DE-He213 Corrêa, Thiago Domingos aut Marra, Alexandre Rodrigues aut Guerra, João Carlos Campos aut Rodrigues, Roseny dos Reis aut Villarinho, Andrea Aparecida Rocco aut de Aranda, Valdir Fernandes aut Shiramizo, Sandra Christina Pereira Lima aut de Lima, Maria Roza de Jesus aut Kallas, Esper Georges aut Cavalcanti, Alexandre Biasi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 17(2017), 1 vom: 19. Jan. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:17 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s12879-017-2204-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 19 01 |
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10.1186/s12879-017-2204-4 doi (DE-627)SPR02808506X (SPR)s12879-017-2204-4-e DE-627 ger DE-627 rakwb eng Piza, Felipe Maia de Toledo verfasserin aut Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. International Normalize Ratio (dpeaa)DE-He213 Disseminate Intravascular Coagulation (dpeaa)DE-He213 Dengue Hemorrhagic Fever (dpeaa)DE-He213 Alpha Angle (dpeaa)DE-He213 Plasma Fibrinogen Level (dpeaa)DE-He213 Corrêa, Thiago Domingos aut Marra, Alexandre Rodrigues aut Guerra, João Carlos Campos aut Rodrigues, Roseny dos Reis aut Villarinho, Andrea Aparecida Rocco aut de Aranda, Valdir Fernandes aut Shiramizo, Sandra Christina Pereira Lima aut de Lima, Maria Roza de Jesus aut Kallas, Esper Georges aut Cavalcanti, Alexandre Biasi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 17(2017), 1 vom: 19. Jan. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:17 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s12879-017-2204-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 19 01 |
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10.1186/s12879-017-2204-4 doi (DE-627)SPR02808506X (SPR)s12879-017-2204-4-e DE-627 ger DE-627 rakwb eng Piza, Felipe Maia de Toledo verfasserin aut Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. International Normalize Ratio (dpeaa)DE-He213 Disseminate Intravascular Coagulation (dpeaa)DE-He213 Dengue Hemorrhagic Fever (dpeaa)DE-He213 Alpha Angle (dpeaa)DE-He213 Plasma Fibrinogen Level (dpeaa)DE-He213 Corrêa, Thiago Domingos aut Marra, Alexandre Rodrigues aut Guerra, João Carlos Campos aut Rodrigues, Roseny dos Reis aut Villarinho, Andrea Aparecida Rocco aut de Aranda, Valdir Fernandes aut Shiramizo, Sandra Christina Pereira Lima aut de Lima, Maria Roza de Jesus aut Kallas, Esper Georges aut Cavalcanti, Alexandre Biasi aut Enthalten in BMC infectious diseases London : BioMed Central, 2001 17(2017), 1 vom: 19. Jan. (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:17 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s12879-017-2204-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 19 01 |
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Piza, Felipe Maia de Toledo @@aut@@ Corrêa, Thiago Domingos @@aut@@ Marra, Alexandre Rodrigues @@aut@@ Guerra, João Carlos Campos @@aut@@ Rodrigues, Roseny dos Reis @@aut@@ Villarinho, Andrea Aparecida Rocco @@aut@@ de Aranda, Valdir Fernandes @@aut@@ Shiramizo, Sandra Christina Pereira Lima @@aut@@ de Lima, Maria Roza de Jesus @@aut@@ Kallas, Esper Georges @@aut@@ Cavalcanti, Alexandre Biasi @@aut@@ |
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So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. 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Piza, Felipe Maia de Toledo |
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Piza, Felipe Maia de Toledo misc International Normalize Ratio misc Disseminate Intravascular Coagulation misc Dengue Hemorrhagic Fever misc Alpha Angle misc Plasma Fibrinogen Level Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study |
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Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study International Normalize Ratio (dpeaa)DE-He213 Disseminate Intravascular Coagulation (dpeaa)DE-He213 Dengue Hemorrhagic Fever (dpeaa)DE-He213 Alpha Angle (dpeaa)DE-He213 Plasma Fibrinogen Level (dpeaa)DE-He213 |
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Piza, Felipe Maia de Toledo Corrêa, Thiago Domingos Marra, Alexandre Rodrigues Guerra, João Carlos Campos Rodrigues, Roseny dos Reis Villarinho, Andrea Aparecida Rocco de Aranda, Valdir Fernandes Shiramizo, Sandra Christina Pereira Lima de Lima, Maria Roza de Jesus Kallas, Esper Georges Cavalcanti, Alexandre Biasi |
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thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study |
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Thromboelastometry analysis of thrombocytopenic dengue patients: a cross-sectional study |
| abstract |
Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. © The Author(s). 2017 |
| abstractGer |
Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. © The Author(s). 2017 |
| abstract_unstemmed |
Background Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests. Methods This was a cross-sectional study conducted between April $ 6^{th} $ and May $ 5^{th} $ 2015 in São Paulo, Brazil during a dengue outbreak. Thromboelastometry (ROTEM®) and the conventional coagulation tests prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time (TT), platelet count and fibrinogen levels were performed in 53 patients with DVI and thrombocytopenia. Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. Clinical implications remain to be established. © The Author(s). 2017 |
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Results Despite a median interquartile range (IQR) platelet count of 77 (63–88) x $ 10^{9} $/L in DVI patients, conventional coagulation tests and plasma fibrinogen levels were within the normal range. Subjects demonstrated hypocoagulability in 71.7% (38/53) in INTEM and 54.7% (29/53) in EXTEM DVI patients. FIBTEM analyses detected only 5.7% (3/53) with hypocoagulability among this population. The median (IQR) clotting time (CT), clot formation time (CFT) and maximum clot firmness (MCF) on INTEM were, respectively, 177 (160–207) sec, 144 (108–178) sec and 48 (42–52) mm. On EXTEM, median (IQR) CT, CFT and MCF were, respectively, 69 (65–78) sec, 148 (126–198) sec and 49 (44–55) mm. Median (IQR) MCF on FIBTEM was 15 (13–18) mm. Conclusion Thromboelastometry impairment is highly prevalent in DVI patients with thrombocytopenia, particularly in INTEM and EXTEM analyses, while standard coagulation tests are normal in this setting. 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