Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era

Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yokoyama, Shintaro [verfasserIn] Mitsuoka, Masahiro Kinugasa, Tetsushi Hashiguchi, Toshihiro Matsumoto, Ryoichi Murakami, Daigo Nishi, Tatsuya Yoshiyama, Koichi Kashihara, Masaki Takamori, Shinzo Akagi, Yoshito

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Colorectal cancer Lung metastasectomy Prognostic factor Recurrence Survival

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC surgery - London : BioMed Central, 2001, 17(2017), 1 vom: 10. Mai
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:1 ; day:10 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12893-017-0252-8

Katalog-ID:	SPR028130251

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520			\|a Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease.
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allfields	10.1186/s12893-017-0252-8 doi (DE-627)SPR028130251 (SPR)s12893-017-0252-8-e DE-627 ger DE-627 rakwb eng Yokoyama, Shintaro verfasserin aut Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. Colorectal cancer (dpeaa)DE-He213 Lung metastasectomy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Mitsuoka, Masahiro aut Kinugasa, Tetsushi aut Hashiguchi, Toshihiro aut Matsumoto, Ryoichi aut Murakami, Daigo aut Nishi, Tatsuya aut Yoshiyama, Koichi aut Kashihara, Masaki aut Takamori, Shinzo aut Akagi, Yoshito aut Enthalten in BMC surgery London : BioMed Central, 2001 17(2017), 1 vom: 10. Mai (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:17 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s12893-017-0252-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 05
spelling	10.1186/s12893-017-0252-8 doi (DE-627)SPR028130251 (SPR)s12893-017-0252-8-e DE-627 ger DE-627 rakwb eng Yokoyama, Shintaro verfasserin aut Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. Colorectal cancer (dpeaa)DE-He213 Lung metastasectomy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Mitsuoka, Masahiro aut Kinugasa, Tetsushi aut Hashiguchi, Toshihiro aut Matsumoto, Ryoichi aut Murakami, Daigo aut Nishi, Tatsuya aut Yoshiyama, Koichi aut Kashihara, Masaki aut Takamori, Shinzo aut Akagi, Yoshito aut Enthalten in BMC surgery London : BioMed Central, 2001 17(2017), 1 vom: 10. Mai (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:17 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s12893-017-0252-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 05
allfields_unstemmed	10.1186/s12893-017-0252-8 doi (DE-627)SPR028130251 (SPR)s12893-017-0252-8-e DE-627 ger DE-627 rakwb eng Yokoyama, Shintaro verfasserin aut Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. Colorectal cancer (dpeaa)DE-He213 Lung metastasectomy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Mitsuoka, Masahiro aut Kinugasa, Tetsushi aut Hashiguchi, Toshihiro aut Matsumoto, Ryoichi aut Murakami, Daigo aut Nishi, Tatsuya aut Yoshiyama, Koichi aut Kashihara, Masaki aut Takamori, Shinzo aut Akagi, Yoshito aut Enthalten in BMC surgery London : BioMed Central, 2001 17(2017), 1 vom: 10. Mai (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:17 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s12893-017-0252-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 05
allfieldsGer	10.1186/s12893-017-0252-8 doi (DE-627)SPR028130251 (SPR)s12893-017-0252-8-e DE-627 ger DE-627 rakwb eng Yokoyama, Shintaro verfasserin aut Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. Colorectal cancer (dpeaa)DE-He213 Lung metastasectomy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Mitsuoka, Masahiro aut Kinugasa, Tetsushi aut Hashiguchi, Toshihiro aut Matsumoto, Ryoichi aut Murakami, Daigo aut Nishi, Tatsuya aut Yoshiyama, Koichi aut Kashihara, Masaki aut Takamori, Shinzo aut Akagi, Yoshito aut Enthalten in BMC surgery London : BioMed Central, 2001 17(2017), 1 vom: 10. Mai (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:17 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s12893-017-0252-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 05
allfieldsSound	10.1186/s12893-017-0252-8 doi (DE-627)SPR028130251 (SPR)s12893-017-0252-8-e DE-627 ger DE-627 rakwb eng Yokoyama, Shintaro verfasserin aut Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. Colorectal cancer (dpeaa)DE-He213 Lung metastasectomy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Mitsuoka, Masahiro aut Kinugasa, Tetsushi aut Hashiguchi, Toshihiro aut Matsumoto, Ryoichi aut Murakami, Daigo aut Nishi, Tatsuya aut Yoshiyama, Koichi aut Kashihara, Masaki aut Takamori, Shinzo aut Akagi, Yoshito aut Enthalten in BMC surgery London : BioMed Central, 2001 17(2017), 1 vom: 10. Mai (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:17 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s12893-017-0252-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 05
language	English
source	Enthalten in BMC surgery 17(2017), 1 vom: 10. Mai volume:17 year:2017 number:1 day:10 month:05
sourceStr	Enthalten in BMC surgery 17(2017), 1 vom: 10. Mai volume:17 year:2017 number:1 day:10 month:05
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authorswithroles_txt_mv	Yokoyama, Shintaro @@aut@@ Mitsuoka, Masahiro @@aut@@ Kinugasa, Tetsushi @@aut@@ Hashiguchi, Toshihiro @@aut@@ Matsumoto, Ryoichi @@aut@@ Murakami, Daigo @@aut@@ Nishi, Tatsuya @@aut@@ Yoshiyama, Koichi @@aut@@ Kashihara, Masaki @@aut@@ Takamori, Shinzo @@aut@@ Akagi, Yoshito @@aut@@
publishDateDaySort_date	2017-05-10T00:00:00Z
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author	Yokoyama, Shintaro
spellingShingle	Yokoyama, Shintaro misc Colorectal cancer misc Lung metastasectomy misc Prognostic factor misc Recurrence misc Survival Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era
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topic_title	Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era Colorectal cancer (dpeaa)DE-He213 Lung metastasectomy (dpeaa)DE-He213 Prognostic factor (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Survival (dpeaa)DE-He213
topic	misc Colorectal cancer misc Lung metastasectomy misc Prognostic factor misc Recurrence misc Survival
topic_unstemmed	misc Colorectal cancer misc Lung metastasectomy misc Prognostic factor misc Recurrence misc Survival
topic_browse	misc Colorectal cancer misc Lung metastasectomy misc Prognostic factor misc Recurrence misc Survival
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title	Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era
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title_full	Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era
author_sort	Yokoyama, Shintaro
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author_browse	Yokoyama, Shintaro Mitsuoka, Masahiro Kinugasa, Tetsushi Hashiguchi, Toshihiro Matsumoto, Ryoichi Murakami, Daigo Nishi, Tatsuya Yoshiyama, Koichi Kashihara, Masaki Takamori, Shinzo Akagi, Yoshito
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author-letter	Yokoyama, Shintaro
doi_str_mv	10.1186/s12893-017-0252-8
title_sort	survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era
title_auth	Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era
abstract	Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. © The Author(s). 2017
abstractGer	Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. © The Author(s). 2017
abstract_unstemmed	Background A clear survival benefit has been reported for lung metastasectomy for colorectal cancer, and several clinicopathological prognostic factors have been proposed in the past. However, clinical advances, such as chemotherapy and radiographic imaging, should have improved patient outcome and may have altered prognosticators. This study aimed to assess patient survival and determine prognostic factors for survival and recurrence in patients who underwent initial lung metastasectomy for colorectal cancer in the modern clinical era. Methods Clinicopathological data and outcomes of 59 patients who underwent curative initial lung metastasectomy for colorectal cancer from 2004 to 2012 at a single institution in Japan were retrospectively investigated. Survival was estimated using the Kaplan - Meier method, and Cox proportional hazards regression models were used to estimate the prognostic impacts of each variable in univariate and multivariate analysis. Results The 5-years overall and disease-free survival rates were 54.3 and 40.6%, respectively. A disease-free interval < 24 months after colorectal cancer resection (P = 0.004) and a serum carcinoembryonic antigen ≥ 5.0 ng/mL before initial lung metastasectomy (P = 0.015) were independent predictors for poor overall survival. Moreover, the disease-free interval after colorectal cancer resection < 24 months (P = 0.010) and a colorectal cancer with N2 stage disease (P = 0.018) were independently associated with poor disease-free survival. On the other hand, the number of lung metastasis was not identified as a poor prognostic factor for both overall and disease-free survival. Conclusions Our findings demonstrated similar or slightly better overall survival, and substantially favorable disease-free survival as compared with past reports. Poor prognostic factors for overall survival appeared not to differ from those of past studies, although this modern series did not determine the number of lung metastasis as a poor prognostic factor, which should be investigated in future studies. Moreover, initial lung metastasectomy is not expected to be a curable treatment for patients with both a short disease-free survival after colorectal cancer resection and colorectal cancers with N2 stage disease. © The Author(s). 2017
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title_short	Survival after initial lung metastasectomy for metastatic colorectal cancer in the modern chemotherapeutic era
url	https://dx.doi.org/10.1186/s12893-017-0252-8
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author2	Mitsuoka, Masahiro Kinugasa, Tetsushi Hashiguchi, Toshihiro Matsumoto, Ryoichi Murakami, Daigo Nishi, Tatsuya Yoshiyama, Koichi Kashihara, Masaki Takamori, Shinzo Akagi, Yoshito
author2Str	Mitsuoka, Masahiro Kinugasa, Tetsushi Hashiguchi, Toshihiro Matsumoto, Ryoichi Murakami, Daigo Nishi, Tatsuya Yoshiyama, Koichi Kashihara, Masaki Takamori, Shinzo Akagi, Yoshito
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