The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments

Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the...
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Autor*in:	Li, Min [verfasserIn] Xu, Xue Yang, Xinyu Kwong, Joey S. W. Shang, Hongcai

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	NC Cardioprotective effects Antiarrhythmic effects Animal experiments Cell experiments

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC complementary and alternative medicine - London : BioMed Central, 2001, 17(2017), 1 vom: 10. Aug.
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:1 ; day:10 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12906-017-1910-1

Katalog-ID:	SPR028145887

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520			\|a Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies.
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allfields	10.1186/s12906-017-1910-1 doi (DE-627)SPR028145887 (SPR)s12906-017-1910-1-e DE-627 ger DE-627 rakwb eng Li, Min verfasserin aut The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. NC (dpeaa)DE-He213 Cardioprotective effects (dpeaa)DE-He213 Antiarrhythmic effects (dpeaa)DE-He213 Animal experiments (dpeaa)DE-He213 Cell experiments (dpeaa)DE-He213 Xu, Xue aut Yang, Xinyu aut Kwong, Joey S. W. aut Shang, Hongcai aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 17(2017), 1 vom: 10. Aug. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:17 year:2017 number:1 day:10 month:08 https://dx.doi.org/10.1186/s12906-017-1910-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 08
spelling	10.1186/s12906-017-1910-1 doi (DE-627)SPR028145887 (SPR)s12906-017-1910-1-e DE-627 ger DE-627 rakwb eng Li, Min verfasserin aut The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. NC (dpeaa)DE-He213 Cardioprotective effects (dpeaa)DE-He213 Antiarrhythmic effects (dpeaa)DE-He213 Animal experiments (dpeaa)DE-He213 Cell experiments (dpeaa)DE-He213 Xu, Xue aut Yang, Xinyu aut Kwong, Joey S. W. aut Shang, Hongcai aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 17(2017), 1 vom: 10. Aug. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:17 year:2017 number:1 day:10 month:08 https://dx.doi.org/10.1186/s12906-017-1910-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 08
allfields_unstemmed	10.1186/s12906-017-1910-1 doi (DE-627)SPR028145887 (SPR)s12906-017-1910-1-e DE-627 ger DE-627 rakwb eng Li, Min verfasserin aut The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. NC (dpeaa)DE-He213 Cardioprotective effects (dpeaa)DE-He213 Antiarrhythmic effects (dpeaa)DE-He213 Animal experiments (dpeaa)DE-He213 Cell experiments (dpeaa)DE-He213 Xu, Xue aut Yang, Xinyu aut Kwong, Joey S. W. aut Shang, Hongcai aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 17(2017), 1 vom: 10. Aug. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:17 year:2017 number:1 day:10 month:08 https://dx.doi.org/10.1186/s12906-017-1910-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 08
allfieldsGer	10.1186/s12906-017-1910-1 doi (DE-627)SPR028145887 (SPR)s12906-017-1910-1-e DE-627 ger DE-627 rakwb eng Li, Min verfasserin aut The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. NC (dpeaa)DE-He213 Cardioprotective effects (dpeaa)DE-He213 Antiarrhythmic effects (dpeaa)DE-He213 Animal experiments (dpeaa)DE-He213 Cell experiments (dpeaa)DE-He213 Xu, Xue aut Yang, Xinyu aut Kwong, Joey S. W. aut Shang, Hongcai aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 17(2017), 1 vom: 10. Aug. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:17 year:2017 number:1 day:10 month:08 https://dx.doi.org/10.1186/s12906-017-1910-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 08
allfieldsSound	10.1186/s12906-017-1910-1 doi (DE-627)SPR028145887 (SPR)s12906-017-1910-1-e DE-627 ger DE-627 rakwb eng Li, Min verfasserin aut The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. NC (dpeaa)DE-He213 Cardioprotective effects (dpeaa)DE-He213 Antiarrhythmic effects (dpeaa)DE-He213 Animal experiments (dpeaa)DE-He213 Cell experiments (dpeaa)DE-He213 Xu, Xue aut Yang, Xinyu aut Kwong, Joey S. W. aut Shang, Hongcai aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 17(2017), 1 vom: 10. Aug. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:17 year:2017 number:1 day:10 month:08 https://dx.doi.org/10.1186/s12906-017-1910-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2017 1 10 08
language	English
source	Enthalten in BMC complementary and alternative medicine 17(2017), 1 vom: 10. Aug. volume:17 year:2017 number:1 day:10 month:08
sourceStr	Enthalten in BMC complementary and alternative medicine 17(2017), 1 vom: 10. Aug. volume:17 year:2017 number:1 day:10 month:08
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institution	findex.gbv.de
topic_facet	NC Cardioprotective effects Antiarrhythmic effects Animal experiments Cell experiments
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container_title	BMC complementary and alternative medicine
authorswithroles_txt_mv	Li, Min @@aut@@ Xu, Xue @@aut@@ Yang, Xinyu @@aut@@ Kwong, Joey S. W. @@aut@@ Shang, Hongcai @@aut@@
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An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). 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author	Li, Min
spellingShingle	Li, Min misc NC misc Cardioprotective effects misc Antiarrhythmic effects misc Animal experiments misc Cell experiments The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
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topic_title	The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments NC (dpeaa)DE-He213 Cardioprotective effects (dpeaa)DE-He213 Antiarrhythmic effects (dpeaa)DE-He213 Animal experiments (dpeaa)DE-He213 Cell experiments (dpeaa)DE-He213
topic	misc NC misc Cardioprotective effects misc Antiarrhythmic effects misc Animal experiments misc Cell experiments
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title	The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
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title_full	The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
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journal	BMC complementary and alternative medicine
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author_browse	Li, Min Xu, Xue Yang, Xinyu Kwong, Joey S. W. Shang, Hongcai
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author-letter	Li, Min
doi_str_mv	10.1186/s12906-017-1910-1
title_sort	cardioprotective and antiarrhythmic effects of nardostachys chinensis in animal and cell experiments
title_auth	The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
abstract	Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. © The Author(s). 2017
abstractGer	Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. © The Author(s). 2017
abstract_unstemmed	Background Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). Conclusion The above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies. © The Author(s). 2017
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
url	https://dx.doi.org/10.1186/s12906-017-1910-1
remote_bool	true
author2	Xu, Xue Yang, Xinyu Kwong, Joey S. W. Shang, Hongcai
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up_date	2024-07-03T17:34:58.778Z
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An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments. Methods To review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction. Results A total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels ($ I_{k} $, $ I_{k1} $, $ I_{Na} $, $ I_{Ca-L} $, $ I_{to} $). 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The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments

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