Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There...
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Autor*in:	Palócz, Orsolya [verfasserIn] Gál, János Clayton, Paul Dinya, Zoltán Somogyi, Zoltán Juhász, Csaba Csikó, György

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Pasteurella multocida β-glucan Rabbit

Anmerkung:	© Palócz et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: BMC veterinary research - London : BioMed Central, 2005, 10(2014), 1 vom: 25. Nov.
Übergeordnetes Werk:	volume:10 ; year:2014 ; number:1 ; day:25 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12917-014-0276-6

Katalog-ID:	SPR028379101

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520			\|a Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis.
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allfields	10.1186/s12917-014-0276-6 doi (DE-627)SPR028379101 (SPR)s12917-014-0276-6-e DE-627 ger DE-627 rakwb eng Palócz, Orsolya verfasserin aut Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Palócz et al.; licensee BioMed Central Ltd. 2014 Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Pasteurella multocida (dpeaa)DE-He213 β-glucan (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 Gál, János aut Clayton, Paul aut Dinya, Zoltán aut Somogyi, Zoltán aut Juhász, Csaba aut Csikó, György aut Enthalten in BMC veterinary research London : BioMed Central, 2005 10(2014), 1 vom: 25. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:10 year:2014 number:1 day:25 month:11 https://dx.doi.org/10.1186/s12917-014-0276-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 1 25 11
spelling	10.1186/s12917-014-0276-6 doi (DE-627)SPR028379101 (SPR)s12917-014-0276-6-e DE-627 ger DE-627 rakwb eng Palócz, Orsolya verfasserin aut Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Palócz et al.; licensee BioMed Central Ltd. 2014 Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Pasteurella multocida (dpeaa)DE-He213 β-glucan (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 Gál, János aut Clayton, Paul aut Dinya, Zoltán aut Somogyi, Zoltán aut Juhász, Csaba aut Csikó, György aut Enthalten in BMC veterinary research London : BioMed Central, 2005 10(2014), 1 vom: 25. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:10 year:2014 number:1 day:25 month:11 https://dx.doi.org/10.1186/s12917-014-0276-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 1 25 11
allfields_unstemmed	10.1186/s12917-014-0276-6 doi (DE-627)SPR028379101 (SPR)s12917-014-0276-6-e DE-627 ger DE-627 rakwb eng Palócz, Orsolya verfasserin aut Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Palócz et al.; licensee BioMed Central Ltd. 2014 Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Pasteurella multocida (dpeaa)DE-He213 β-glucan (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 Gál, János aut Clayton, Paul aut Dinya, Zoltán aut Somogyi, Zoltán aut Juhász, Csaba aut Csikó, György aut Enthalten in BMC veterinary research London : BioMed Central, 2005 10(2014), 1 vom: 25. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:10 year:2014 number:1 day:25 month:11 https://dx.doi.org/10.1186/s12917-014-0276-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 1 25 11
allfieldsGer	10.1186/s12917-014-0276-6 doi (DE-627)SPR028379101 (SPR)s12917-014-0276-6-e DE-627 ger DE-627 rakwb eng Palócz, Orsolya verfasserin aut Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Palócz et al.; licensee BioMed Central Ltd. 2014 Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Pasteurella multocida (dpeaa)DE-He213 β-glucan (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 Gál, János aut Clayton, Paul aut Dinya, Zoltán aut Somogyi, Zoltán aut Juhász, Csaba aut Csikó, György aut Enthalten in BMC veterinary research London : BioMed Central, 2005 10(2014), 1 vom: 25. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:10 year:2014 number:1 day:25 month:11 https://dx.doi.org/10.1186/s12917-014-0276-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 1 25 11
allfieldsSound	10.1186/s12917-014-0276-6 doi (DE-627)SPR028379101 (SPR)s12917-014-0276-6-e DE-627 ger DE-627 rakwb eng Palócz, Orsolya verfasserin aut Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Palócz et al.; licensee BioMed Central Ltd. 2014 Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. Pasteurella multocida (dpeaa)DE-He213 β-glucan (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213 Gál, János aut Clayton, Paul aut Dinya, Zoltán aut Somogyi, Zoltán aut Juhász, Csaba aut Csikó, György aut Enthalten in BMC veterinary research London : BioMed Central, 2005 10(2014), 1 vom: 25. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:10 year:2014 number:1 day:25 month:11 https://dx.doi.org/10.1186/s12917-014-0276-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2014 1 25 11
language	English
source	Enthalten in BMC veterinary research 10(2014), 1 vom: 25. Nov. volume:10 year:2014 number:1 day:25 month:11
sourceStr	Enthalten in BMC veterinary research 10(2014), 1 vom: 25. Nov. volume:10 year:2014 number:1 day:25 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pasteurella multocida β-glucan Rabbit
isfreeaccess_bool	true
container_title	BMC veterinary research
authorswithroles_txt_mv	Palócz, Orsolya @@aut@@ Gál, János @@aut@@ Clayton, Paul @@aut@@ Dinya, Zoltán @@aut@@ Somogyi, Zoltán @@aut@@ Juhász, Csaba @@aut@@ Csikó, György @@aut@@
publishDateDaySort_date	2014-11-25T00:00:00Z
hierarchy_top_id	489256538
id	SPR028379101
language_de	englisch
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They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. 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author	Palócz, Orsolya
spellingShingle	Palócz, Orsolya misc Pasteurella multocida misc β-glucan misc Rabbit Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
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topic_title	Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits Pasteurella multocida (dpeaa)DE-He213 β-glucan (dpeaa)DE-He213 Rabbit (dpeaa)DE-He213
topic	misc Pasteurella multocida misc β-glucan misc Rabbit
topic_unstemmed	misc Pasteurella multocida misc β-glucan misc Rabbit
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title	Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
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title_full	Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
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author_browse	Palócz, Orsolya Gál, János Clayton, Paul Dinya, Zoltán Somogyi, Zoltán Juhász, Csaba Csikó, György
container_volume	10
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author-letter	Palócz, Orsolya
doi_str_mv	10.1186/s12917-014-0276-6
title_sort	alternative treatment of serious and mild pasteurella multocida infection in new zealand white rabbits
title_auth	Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
abstract	Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. © Palócz et al.; licensee BioMed Central Ltd. 2014
abstractGer	Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. © Palócz et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Background Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species. Results Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics. Conclusions In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis. © Palócz et al.; licensee BioMed Central Ltd. 2014
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title_short	Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
url	https://dx.doi.org/10.1186/s12917-014-0276-6
remote_bool	true
author2	Gál, János Clayton, Paul Dinya, Zoltán Somogyi, Zoltán Juhász, Csaba Csikó, György
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up_date	2024-07-03T19:06:46.111Z
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Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

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