Hematological and histopathological effects of swainsonine in mouse

Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine....
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Autor*in:	Wu, Chenchen [verfasserIn] Liu, Xiaoxue Ma, Feng Zhao, Baoyu

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Swainsonine Locoweed Hemosiderin deposits Mouse

Anmerkung:	© Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: BMC veterinary research - London : BioMed Central, 2005, 11(2015), 1 vom: 03. Feb.
Übergeordnetes Werk:	volume:11 ; year:2015 ; number:1 ; day:03 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12917-015-0336-6

Katalog-ID:	SPR028381475

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520			\|a Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present.
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Indexfelder

author_variant	c w cw x l xl f m fm b z bz
matchkey_str	article:17466148:2015----::eaooiaaditptooiaefcsfw
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publishDate	2015
allfields	10.1186/s12917-015-0336-6 doi (DE-627)SPR028381475 (SPR)s12917-015-0336-6-e DE-627 ger DE-627 rakwb eng Wu, Chenchen verfasserin aut Hematological and histopathological effects of swainsonine in mouse 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. Swainsonine (dpeaa)DE-He213 Locoweed (dpeaa)DE-He213 Hemosiderin deposits (dpeaa)DE-He213 Mouse (dpeaa)DE-He213 Liu, Xiaoxue aut Ma, Feng aut Zhao, Baoyu aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 03. Feb. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:03 month:02 https://dx.doi.org/10.1186/s12917-015-0336-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 03 02
spelling	10.1186/s12917-015-0336-6 doi (DE-627)SPR028381475 (SPR)s12917-015-0336-6-e DE-627 ger DE-627 rakwb eng Wu, Chenchen verfasserin aut Hematological and histopathological effects of swainsonine in mouse 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. Swainsonine (dpeaa)DE-He213 Locoweed (dpeaa)DE-He213 Hemosiderin deposits (dpeaa)DE-He213 Mouse (dpeaa)DE-He213 Liu, Xiaoxue aut Ma, Feng aut Zhao, Baoyu aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 03. Feb. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:03 month:02 https://dx.doi.org/10.1186/s12917-015-0336-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 03 02
allfields_unstemmed	10.1186/s12917-015-0336-6 doi (DE-627)SPR028381475 (SPR)s12917-015-0336-6-e DE-627 ger DE-627 rakwb eng Wu, Chenchen verfasserin aut Hematological and histopathological effects of swainsonine in mouse 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. Swainsonine (dpeaa)DE-He213 Locoweed (dpeaa)DE-He213 Hemosiderin deposits (dpeaa)DE-He213 Mouse (dpeaa)DE-He213 Liu, Xiaoxue aut Ma, Feng aut Zhao, Baoyu aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 03. Feb. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:03 month:02 https://dx.doi.org/10.1186/s12917-015-0336-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 03 02
allfieldsGer	10.1186/s12917-015-0336-6 doi (DE-627)SPR028381475 (SPR)s12917-015-0336-6-e DE-627 ger DE-627 rakwb eng Wu, Chenchen verfasserin aut Hematological and histopathological effects of swainsonine in mouse 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. Swainsonine (dpeaa)DE-He213 Locoweed (dpeaa)DE-He213 Hemosiderin deposits (dpeaa)DE-He213 Mouse (dpeaa)DE-He213 Liu, Xiaoxue aut Ma, Feng aut Zhao, Baoyu aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 03. Feb. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:03 month:02 https://dx.doi.org/10.1186/s12917-015-0336-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 03 02
allfieldsSound	10.1186/s12917-015-0336-6 doi (DE-627)SPR028381475 (SPR)s12917-015-0336-6-e DE-627 ger DE-627 rakwb eng Wu, Chenchen verfasserin aut Hematological and histopathological effects of swainsonine in mouse 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. Swainsonine (dpeaa)DE-He213 Locoweed (dpeaa)DE-He213 Hemosiderin deposits (dpeaa)DE-He213 Mouse (dpeaa)DE-He213 Liu, Xiaoxue aut Ma, Feng aut Zhao, Baoyu aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 03. Feb. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:03 month:02 https://dx.doi.org/10.1186/s12917-015-0336-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 03 02
language	English
source	Enthalten in BMC veterinary research 11(2015), 1 vom: 03. Feb. volume:11 year:2015 number:1 day:03 month:02
sourceStr	Enthalten in BMC veterinary research 11(2015), 1 vom: 03. Feb. volume:11 year:2015 number:1 day:03 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Swainsonine Locoweed Hemosiderin deposits Mouse
isfreeaccess_bool	true
container_title	BMC veterinary research
authorswithroles_txt_mv	Wu, Chenchen @@aut@@ Liu, Xiaoxue @@aut@@ Ma, Feng @@aut@@ Zhao, Baoyu @@aut@@
publishDateDaySort_date	2015-02-03T00:00:00Z
hierarchy_top_id	489256538
id	SPR028381475
language_de	englisch
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. 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author	Wu, Chenchen
spellingShingle	Wu, Chenchen misc Swainsonine misc Locoweed misc Hemosiderin deposits misc Mouse Hematological and histopathological effects of swainsonine in mouse
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topic_title	Hematological and histopathological effects of swainsonine in mouse Swainsonine (dpeaa)DE-He213 Locoweed (dpeaa)DE-He213 Hemosiderin deposits (dpeaa)DE-He213 Mouse (dpeaa)DE-He213
topic	misc Swainsonine misc Locoweed misc Hemosiderin deposits misc Mouse
topic_unstemmed	misc Swainsonine misc Locoweed misc Hemosiderin deposits misc Mouse
topic_browse	misc Swainsonine misc Locoweed misc Hemosiderin deposits misc Mouse
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title	Hematological and histopathological effects of swainsonine in mouse
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title_full	Hematological and histopathological effects of swainsonine in mouse
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author_browse	Wu, Chenchen Liu, Xiaoxue Ma, Feng Zhao, Baoyu
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doi_str_mv	10.1186/s12917-015-0336-6
title_sort	hematological and histopathological effects of swainsonine in mouse
title_auth	Hematological and histopathological effects of swainsonine in mouse
abstract	Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Livestock that consume locoweed exhibit multiple neurological symptoms, including dispirited behavior, staggered gait, trembling, ataxia, impaired reproductive function and cellular vacuolar degeneration of multiple tissues due to toxicity from plant-derived alkaloids such as swainsonine. Results Swainsonine was administered to $ F_{0} $ and $ F_{1} $ mice by intraperitoneal injection before, during and after pregnancy at the following doses: 0.525 mg/kg BW(I), 0.2625 mg/kg BW(II), 0.175 mg/kg BW(III) and 0 mg/kg BW(IV). Hemosiderin deposits were observed the lamina propria of endometrium in uterus and the red pulp of spleen. Ovary corpus lutea counts in $ F_{0} $ mice were higher in swainsonine-treated mice compared to control mice. Indirect bilirubin content and reticulocyte numbers were increased in swainsonine-treated $ F_{0} $ and $ F_{1} $ generation mice compared to control group (P < 0.05). Lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase content in $ F_{0} $-I and $ F_{0} $-II mice were significantly increased compared with $ F_{0} $-IV group mice (P < 0.05). Red blood cells, hemoglobin and mean corpuscular hemoglobin levels were significantly decreased in $ F_{0} $ and $ F_{1} $ mice compared with the control group (P < 0.05). Conclusions Swainsonine exerts effects on estrus period and reproductive ability, and offspring of dams dosed with swainsonine were affected in-utero or from nursing. Damage to liver, uterus and spleen, as well as hematological changes, are observable before neurological symptoms present. © Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Hematological and histopathological effects of swainsonine in mouse
url	https://dx.doi.org/10.1186/s12917-015-0336-6
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Hematological and histopathological effects of swainsonine in mouse

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