The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds

Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or...
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Autor*in:	Smith, Jacqueline [verfasserIn] Sadeyen, Jean-Remy Cavanagh, David Kaiser, Pete Burt, David W.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Chicken Infectious bronchitis virus Microarray Disease resistance Candidate gene

Anmerkung:	© Smith et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC veterinary research - London : BioMed Central, 2005, 11(2015), 1 vom: 09. Okt.
Übergeordnetes Werk:	volume:11 ; year:2015 ; number:1 ; day:09 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s12917-015-0575-6

Katalog-ID:	SPR028384121

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100	1		\|a Smith, Jacqueline \|e verfasserin \|4 aut
245	1	4	\|a The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
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520			\|a Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV.
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700	1		\|a Sadeyen, Jean-Remy \|4 aut
700	1		\|a Cavanagh, David \|4 aut
700	1		\|a Kaiser, Pete \|4 aut
700	1		\|a Burt, David W. \|4 aut
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912			\|a GBV_USEFLAG_A
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912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2011
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912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
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912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
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Indexfelder

author_variant	j s js j r s jrs d c dc p k pk d w b dw dwb
matchkey_str	article:17466148:2015----::herymueepneonetoociknwtifciubociivrsbis
hierarchy_sort_str	2015
publishDate	2015
allfields	10.1186/s12917-015-0575-6 doi (DE-627)SPR028384121 (SPR)s12917-015-0575-6-e DE-627 ger DE-627 rakwb eng Smith, Jacqueline verfasserin aut The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Smith et al. 2015 Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. Chicken (dpeaa)DE-He213 Infectious bronchitis virus (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Disease resistance (dpeaa)DE-He213 Candidate gene (dpeaa)DE-He213 Sadeyen, Jean-Remy aut Cavanagh, David aut Kaiser, Pete aut Burt, David W. aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 09. Okt. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:09 month:10 https://dx.doi.org/10.1186/s12917-015-0575-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 09 10
spelling	10.1186/s12917-015-0575-6 doi (DE-627)SPR028384121 (SPR)s12917-015-0575-6-e DE-627 ger DE-627 rakwb eng Smith, Jacqueline verfasserin aut The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Smith et al. 2015 Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. Chicken (dpeaa)DE-He213 Infectious bronchitis virus (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Disease resistance (dpeaa)DE-He213 Candidate gene (dpeaa)DE-He213 Sadeyen, Jean-Remy aut Cavanagh, David aut Kaiser, Pete aut Burt, David W. aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 09. Okt. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:09 month:10 https://dx.doi.org/10.1186/s12917-015-0575-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 09 10
allfields_unstemmed	10.1186/s12917-015-0575-6 doi (DE-627)SPR028384121 (SPR)s12917-015-0575-6-e DE-627 ger DE-627 rakwb eng Smith, Jacqueline verfasserin aut The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Smith et al. 2015 Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. Chicken (dpeaa)DE-He213 Infectious bronchitis virus (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Disease resistance (dpeaa)DE-He213 Candidate gene (dpeaa)DE-He213 Sadeyen, Jean-Remy aut Cavanagh, David aut Kaiser, Pete aut Burt, David W. aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 09. Okt. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:09 month:10 https://dx.doi.org/10.1186/s12917-015-0575-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 09 10
allfieldsGer	10.1186/s12917-015-0575-6 doi (DE-627)SPR028384121 (SPR)s12917-015-0575-6-e DE-627 ger DE-627 rakwb eng Smith, Jacqueline verfasserin aut The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Smith et al. 2015 Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. Chicken (dpeaa)DE-He213 Infectious bronchitis virus (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Disease resistance (dpeaa)DE-He213 Candidate gene (dpeaa)DE-He213 Sadeyen, Jean-Remy aut Cavanagh, David aut Kaiser, Pete aut Burt, David W. aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 09. Okt. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:09 month:10 https://dx.doi.org/10.1186/s12917-015-0575-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 09 10
allfieldsSound	10.1186/s12917-015-0575-6 doi (DE-627)SPR028384121 (SPR)s12917-015-0575-6-e DE-627 ger DE-627 rakwb eng Smith, Jacqueline verfasserin aut The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Smith et al. 2015 Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. Chicken (dpeaa)DE-He213 Infectious bronchitis virus (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Disease resistance (dpeaa)DE-He213 Candidate gene (dpeaa)DE-He213 Sadeyen, Jean-Remy aut Cavanagh, David aut Kaiser, Pete aut Burt, David W. aut Enthalten in BMC veterinary research London : BioMed Central, 2005 11(2015), 1 vom: 09. Okt. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:11 year:2015 number:1 day:09 month:10 https://dx.doi.org/10.1186/s12917-015-0575-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 09 10
language	English
source	Enthalten in BMC veterinary research 11(2015), 1 vom: 09. Okt. volume:11 year:2015 number:1 day:09 month:10
sourceStr	Enthalten in BMC veterinary research 11(2015), 1 vom: 09. Okt. volume:11 year:2015 number:1 day:09 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chicken Infectious bronchitis virus Microarray Disease resistance Candidate gene
isfreeaccess_bool	true
container_title	BMC veterinary research
authorswithroles_txt_mv	Smith, Jacqueline @@aut@@ Sadeyen, Jean-Remy @@aut@@ Cavanagh, David @@aut@@ Kaiser, Pete @@aut@@ Burt, David W. @@aut@@
publishDateDaySort_date	2015-10-09T00:00:00Z
hierarchy_top_id	489256538
id	SPR028384121
language_de	englisch
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author	Smith, Jacqueline
spellingShingle	Smith, Jacqueline misc Chicken misc Infectious bronchitis virus misc Microarray misc Disease resistance misc Candidate gene The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
authorStr	Smith, Jacqueline
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topic_title	The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds Chicken (dpeaa)DE-He213 Infectious bronchitis virus (dpeaa)DE-He213 Microarray (dpeaa)DE-He213 Disease resistance (dpeaa)DE-He213 Candidate gene (dpeaa)DE-He213
topic	misc Chicken misc Infectious bronchitis virus misc Microarray misc Disease resistance misc Candidate gene
topic_unstemmed	misc Chicken misc Infectious bronchitis virus misc Microarray misc Disease resistance misc Candidate gene
topic_browse	misc Chicken misc Infectious bronchitis virus misc Microarray misc Disease resistance misc Candidate gene
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title	The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
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title_full	The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
author_sort	Smith, Jacqueline
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author_browse	Smith, Jacqueline Sadeyen, Jean-Remy Cavanagh, David Kaiser, Pete Burt, David W.
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title_sort	early immune response to infection of chickens with infectious bronchitis virus (ibv) in susceptible and resistant birds
title_auth	The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
abstract	Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. © Smith et al. 2015
abstractGer	Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. © Smith et al. 2015
abstract_unstemmed	Background Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent bacterial infection) and lost egg production. The virus is difficult to control by vaccination, so new methods to curb the impact of the disease need to be sought. Here, we seek to identify genes conferring resistance to this coronavirus, which could help in selective breeding programs to rear chickens which do not succumb to the effects of this disease. Methods Whole genome gene expression microarrays were used to analyse the gene expression differences, which occur upon infection of birds with Infectious Bronchitis Virus (IBV). Tracheal tissue was examined from control and infected birds at 2, 3 and 4 days post-infection in birds known to be either susceptible or resistant to the virus. The host innate immune response was evaluated over these 3 days and differences between the susceptible and resistant lines examined. Results Genes and biological pathways involved in the early host response to IBV infection were determined andgene expression differences between susceptible and resistant birds were identified. Potential candidate genes for resistance to IBV are highlighted. Conclusions The early host response to IBV is analysed and potential candidate genes for disease resistance are identified. These putative resistance genes can be used as targets for future genetic and functional studies to prove a causative link with resistance to IBV. © Smith et al. 2015
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title_short	The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds
url	https://dx.doi.org/10.1186/s12917-015-0575-6
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author2	Sadeyen, Jean-Remy Cavanagh, David Kaiser, Pete Burt, David W.
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up_date	2024-07-03T19:08:49.471Z
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