Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve

Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Engelen, Carolin [verfasserIn] Moritz, Andreas Barthel, Franziska Bauer, Natali

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Feline Hypercoagulable TEG Velocity curve

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: BMC veterinary research - London : BioMed Central, 2005, 13(2017), 1 vom: 29. Nov.
Übergeordnetes Werk:	volume:13 ; year:2017 ; number:1 ; day:29 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12917-017-1278-y

Katalog-ID:	SPR028391721

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100	1		\|a Engelen, Carolin \|e verfasserin \|0 (orcid)0000-0002-5172-8291 \|4 aut
245	1	0	\|a Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
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520			\|a Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory.
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700	1		\|a Bauer, Natali \|4 aut
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matchkey_str	article:17466148:2017----::rlmnrrfrnenevladhipcoctaetrgtmfrhoblsorpynasn
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allfields	10.1186/s12917-017-1278-y doi (DE-627)SPR028391721 (SPR)s12917-017-1278-y-e DE-627 ger DE-627 rakwb eng Engelen, Carolin verfasserin (orcid)0000-0002-5172-8291 aut Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. Feline (dpeaa)DE-He213 Hypercoagulable (dpeaa)DE-He213 TEG (dpeaa)DE-He213 Velocity curve (dpeaa)DE-He213 Moritz, Andreas aut Barthel, Franziska aut Bauer, Natali aut Enthalten in BMC veterinary research London : BioMed Central, 2005 13(2017), 1 vom: 29. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:13 year:2017 number:1 day:29 month:11 https://dx.doi.org/10.1186/s12917-017-1278-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 29 11
spelling	10.1186/s12917-017-1278-y doi (DE-627)SPR028391721 (SPR)s12917-017-1278-y-e DE-627 ger DE-627 rakwb eng Engelen, Carolin verfasserin (orcid)0000-0002-5172-8291 aut Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. Feline (dpeaa)DE-He213 Hypercoagulable (dpeaa)DE-He213 TEG (dpeaa)DE-He213 Velocity curve (dpeaa)DE-He213 Moritz, Andreas aut Barthel, Franziska aut Bauer, Natali aut Enthalten in BMC veterinary research London : BioMed Central, 2005 13(2017), 1 vom: 29. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:13 year:2017 number:1 day:29 month:11 https://dx.doi.org/10.1186/s12917-017-1278-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 29 11
allfields_unstemmed	10.1186/s12917-017-1278-y doi (DE-627)SPR028391721 (SPR)s12917-017-1278-y-e DE-627 ger DE-627 rakwb eng Engelen, Carolin verfasserin (orcid)0000-0002-5172-8291 aut Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. Feline (dpeaa)DE-He213 Hypercoagulable (dpeaa)DE-He213 TEG (dpeaa)DE-He213 Velocity curve (dpeaa)DE-He213 Moritz, Andreas aut Barthel, Franziska aut Bauer, Natali aut Enthalten in BMC veterinary research London : BioMed Central, 2005 13(2017), 1 vom: 29. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:13 year:2017 number:1 day:29 month:11 https://dx.doi.org/10.1186/s12917-017-1278-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 29 11
allfieldsGer	10.1186/s12917-017-1278-y doi (DE-627)SPR028391721 (SPR)s12917-017-1278-y-e DE-627 ger DE-627 rakwb eng Engelen, Carolin verfasserin (orcid)0000-0002-5172-8291 aut Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. Feline (dpeaa)DE-He213 Hypercoagulable (dpeaa)DE-He213 TEG (dpeaa)DE-He213 Velocity curve (dpeaa)DE-He213 Moritz, Andreas aut Barthel, Franziska aut Bauer, Natali aut Enthalten in BMC veterinary research London : BioMed Central, 2005 13(2017), 1 vom: 29. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:13 year:2017 number:1 day:29 month:11 https://dx.doi.org/10.1186/s12917-017-1278-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 29 11
allfieldsSound	10.1186/s12917-017-1278-y doi (DE-627)SPR028391721 (SPR)s12917-017-1278-y-e DE-627 ger DE-627 rakwb eng Engelen, Carolin verfasserin (orcid)0000-0002-5172-8291 aut Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. Feline (dpeaa)DE-He213 Hypercoagulable (dpeaa)DE-He213 TEG (dpeaa)DE-He213 Velocity curve (dpeaa)DE-He213 Moritz, Andreas aut Barthel, Franziska aut Bauer, Natali aut Enthalten in BMC veterinary research London : BioMed Central, 2005 13(2017), 1 vom: 29. Nov. (DE-627)489256538 (DE-600)2191675-5 1746-6148 nnns volume:13 year:2017 number:1 day:29 month:11 https://dx.doi.org/10.1186/s12917-017-1278-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 29 11
language	English
source	Enthalten in BMC veterinary research 13(2017), 1 vom: 29. Nov. volume:13 year:2017 number:1 day:29 month:11
sourceStr	Enthalten in BMC veterinary research 13(2017), 1 vom: 29. Nov. volume:13 year:2017 number:1 day:29 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Feline Hypercoagulable TEG Velocity curve
isfreeaccess_bool	true
container_title	BMC veterinary research
authorswithroles_txt_mv	Engelen, Carolin @@aut@@ Moritz, Andreas @@aut@@ Barthel, Franziska @@aut@@ Bauer, Natali @@aut@@
publishDateDaySort_date	2017-11-29T00:00:00Z
hierarchy_top_id	489256538
id	SPR028391721
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR028391721</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519184805.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2017 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12917-017-1278-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR028391721</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12917-017-1278-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Engelen, Carolin</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-5172-8291</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s). 2017</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. 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author	Engelen, Carolin
spellingShingle	Engelen, Carolin misc Feline misc Hypercoagulable misc TEG misc Velocity curve Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
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topic_title	Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve Feline (dpeaa)DE-He213 Hypercoagulable (dpeaa)DE-He213 TEG (dpeaa)DE-He213 Velocity curve (dpeaa)DE-He213
topic	misc Feline misc Hypercoagulable misc TEG misc Velocity curve
topic_unstemmed	misc Feline misc Hypercoagulable misc TEG misc Velocity curve
topic_browse	misc Feline misc Hypercoagulable misc TEG misc Velocity curve
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
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title_full	Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
author_sort	Engelen, Carolin
journal	BMC veterinary research
journalStr	BMC veterinary research
lang_code	eng
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author_browse	Engelen, Carolin Moritz, Andreas Barthel, Franziska Bauer, Natali
container_volume	13
format_se	Elektronische Aufsätze
author-letter	Engelen, Carolin
doi_str_mv	10.1186/s12917-017-1278-y
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normlink_prefix_str_mv	(orcid)0000-0002-5172-8291
title_sort	preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
title_auth	Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
abstract	Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. © The Author(s). 2017
abstractGer	Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. © The Author(s). 2017
abstract_unstemmed	Background Thrombelastography is a useful tool in assessment of hemostasis. Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. Because of the impact of citrate storage time on thrombelastography, reference intervals have to be established using a specific and constant storage time in each laboratory. © The Author(s). 2017
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title_short	Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve
url	https://dx.doi.org/10.1186/s12917-017-1278-y
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author2	Moritz, Andreas Barthel, Franziska Bauer, Natali
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Beside the traditional variables, the velocity curve and the variable delta have lately earned attention. The velocity curve provides knowledge about the speed of clot formation including information about thrombin generation. Delta, which only reflects enzymatic coagulation, allows the determination of the origin of hypercoagulability when compared to clot rigidity, a variable that reflects both platelet and enzymatic activity. The aim was to establish preliminary reference intervals for feline thrombelastography including the velocity curve variables and delta obtained after 60 min of storage including the assessment of coefficients of variation. Furthermore, the effect of citrate storage time (30 versus 60 min) on feline thrombelastography will be determined. Results Prolonged storage times significantly reduced reaction (R) (P = 0.019) and clotting (K) (P = 0.008) times, split point (SP) (P = 0.019) and time to maximum rate of thrombus generation (TMRTG) (P = 0.023) values whereas maximum rate of thrombus generation (MRTG) significantly increased (P = 0.040). Preliminary reference intervals: R (min): 2.7–18.1; K (min): 0.8–3.9; alpha (°): 27.6–75.2; maximum amplitude (mm): 18.5–62.5; clot rigidity (dyn/$ cm^{2} $): 1.2–8.2; coagulation index: −4.6 – 2.6; SP (min): 2.4–15.4; delta (min): 0.3–3.1; thrombus generation (mm/min): 255.3–751.2; MRTG (mm/min): 4.0–19.3; TMRTG (min): 3.5–22.0; maximum rate of lysis (mm/min): 0.0–4.7 and time to maximum rate of lysis (min): 0.4–55.8. Conclusion Storage for 60 versus 30 min induces hypercoagulable tracings including the velocity curve, some of which variables (MRTG, TMRTG) might function as sensitive markers for changes in the coagulation activity. 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Preliminary reference intervals and the impact of citrate storage time for thrombelastography in cats including delta and the velocity curve

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