Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011

Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a me...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ward, Keith J [verfasserIn] Nemeth, Margaret A Brownie, Cavell Hong, Bonnie Herman, Rod A Oberdoerfer, Regina

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Linear Mixed Model Equivalence Test European Food Safety Authority Commercial Variety Equivalence Limit

Anmerkung:	© Ward et al; licensee BioMed Central Ltd. 2012

Übergeordnetes Werk:	Enthalten in: BMC biotechnology - London : BioMed Central, 2001, 12(2012), 1 vom: 25. Apr.
Übergeordnetes Werk:	volume:12 ; year:2012 ; number:1 ; day:25 ; month:04

Links:	Volltext

DOI / URN:	10.1186/1472-6750-12-13

Katalog-ID:	SPR028401492

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allfields	10.1186/1472-6750-12-13 doi (DE-627)SPR028401492 (SPR)1472-6750-12-13-e DE-627 ger DE-627 rakwb eng Ward, Keith J verfasserin aut Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ward et al; licensee BioMed Central Ltd. 2012 Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. Linear Mixed Model (dpeaa)DE-He213 Equivalence Test (dpeaa)DE-He213 European Food Safety Authority (dpeaa)DE-He213 Commercial Variety (dpeaa)DE-He213 Equivalence Limit (dpeaa)DE-He213 Nemeth, Margaret A aut Brownie, Cavell aut Hong, Bonnie aut Herman, Rod A aut Oberdoerfer, Regina aut Enthalten in BMC biotechnology London : BioMed Central, 2001 12(2012), 1 vom: 25. Apr. (DE-627)332164837 (DE-600)2052746-9 1472-6750 nnns volume:12 year:2012 number:1 day:25 month:04 https://dx.doi.org/10.1186/1472-6750-12-13 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 25 04
spelling	10.1186/1472-6750-12-13 doi (DE-627)SPR028401492 (SPR)1472-6750-12-13-e DE-627 ger DE-627 rakwb eng Ward, Keith J verfasserin aut Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ward et al; licensee BioMed Central Ltd. 2012 Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. Linear Mixed Model (dpeaa)DE-He213 Equivalence Test (dpeaa)DE-He213 European Food Safety Authority (dpeaa)DE-He213 Commercial Variety (dpeaa)DE-He213 Equivalence Limit (dpeaa)DE-He213 Nemeth, Margaret A aut Brownie, Cavell aut Hong, Bonnie aut Herman, Rod A aut Oberdoerfer, Regina aut Enthalten in BMC biotechnology London : BioMed Central, 2001 12(2012), 1 vom: 25. Apr. (DE-627)332164837 (DE-600)2052746-9 1472-6750 nnns volume:12 year:2012 number:1 day:25 month:04 https://dx.doi.org/10.1186/1472-6750-12-13 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 25 04
allfields_unstemmed	10.1186/1472-6750-12-13 doi (DE-627)SPR028401492 (SPR)1472-6750-12-13-e DE-627 ger DE-627 rakwb eng Ward, Keith J verfasserin aut Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ward et al; licensee BioMed Central Ltd. 2012 Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. Linear Mixed Model (dpeaa)DE-He213 Equivalence Test (dpeaa)DE-He213 European Food Safety Authority (dpeaa)DE-He213 Commercial Variety (dpeaa)DE-He213 Equivalence Limit (dpeaa)DE-He213 Nemeth, Margaret A aut Brownie, Cavell aut Hong, Bonnie aut Herman, Rod A aut Oberdoerfer, Regina aut Enthalten in BMC biotechnology London : BioMed Central, 2001 12(2012), 1 vom: 25. Apr. (DE-627)332164837 (DE-600)2052746-9 1472-6750 nnns volume:12 year:2012 number:1 day:25 month:04 https://dx.doi.org/10.1186/1472-6750-12-13 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 25 04
allfieldsGer	10.1186/1472-6750-12-13 doi (DE-627)SPR028401492 (SPR)1472-6750-12-13-e DE-627 ger DE-627 rakwb eng Ward, Keith J verfasserin aut Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ward et al; licensee BioMed Central Ltd. 2012 Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. Linear Mixed Model (dpeaa)DE-He213 Equivalence Test (dpeaa)DE-He213 European Food Safety Authority (dpeaa)DE-He213 Commercial Variety (dpeaa)DE-He213 Equivalence Limit (dpeaa)DE-He213 Nemeth, Margaret A aut Brownie, Cavell aut Hong, Bonnie aut Herman, Rod A aut Oberdoerfer, Regina aut Enthalten in BMC biotechnology London : BioMed Central, 2001 12(2012), 1 vom: 25. Apr. (DE-627)332164837 (DE-600)2052746-9 1472-6750 nnns volume:12 year:2012 number:1 day:25 month:04 https://dx.doi.org/10.1186/1472-6750-12-13 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 25 04
allfieldsSound	10.1186/1472-6750-12-13 doi (DE-627)SPR028401492 (SPR)1472-6750-12-13-e DE-627 ger DE-627 rakwb eng Ward, Keith J verfasserin aut Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ward et al; licensee BioMed Central Ltd. 2012 Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. Linear Mixed Model (dpeaa)DE-He213 Equivalence Test (dpeaa)DE-He213 European Food Safety Authority (dpeaa)DE-He213 Commercial Variety (dpeaa)DE-He213 Equivalence Limit (dpeaa)DE-He213 Nemeth, Margaret A aut Brownie, Cavell aut Hong, Bonnie aut Herman, Rod A aut Oberdoerfer, Regina aut Enthalten in BMC biotechnology London : BioMed Central, 2001 12(2012), 1 vom: 25. Apr. (DE-627)332164837 (DE-600)2052746-9 1472-6750 nnns volume:12 year:2012 number:1 day:25 month:04 https://dx.doi.org/10.1186/1472-6750-12-13 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2012 1 25 04
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source	Enthalten in BMC biotechnology 12(2012), 1 vom: 25. Apr. volume:12 year:2012 number:1 day:25 month:04
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author	Ward, Keith J
spellingShingle	Ward, Keith J misc Linear Mixed Model misc Equivalence Test misc European Food Safety Authority misc Commercial Variety misc Equivalence Limit Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011
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title	Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011
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title_full	Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011
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title_sort	comments on the paper "a statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der voet et al. 2011
title_auth	Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011
abstract	Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. © Ward et al; licensee BioMed Central Ltd. 2012
abstractGer	Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. © Ward et al; licensee BioMed Central Ltd. 2012
abstract_unstemmed	Abstract van der Voet et al. (2011) describe statistical methodology that the European Food Safety Authority expects an applicant to adopt when making a GM crop regulatory submission. Key to their proposed methodology is the inclusion of reference varieties in the experimental design to provide a measure of natural variation amongst commercially grown crops. While taking proper account of natural variation amongst commercial varieties in the safety assessment of GM plants makes good sense, the methodology described by the authors is shown here to be fundamentally flawed and consequently cannot be considered fit for purpose in its current form. © Ward et al; licensee BioMed Central Ltd. 2012
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title_short	Comments on the paper "A statistical assessment of differences and equivalences between genetically modified and reference plant varieties" by van der Voet et al. 2011
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