Low responsiveness to thienopyridine in hemodialysis patients
Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Oshima, Shuichi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Anmerkung: |
© Japanese Association of Cardiovascular Intervention and Therapeutics 2009 |
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| Übergeordnetes Werk: |
Enthalten in: Cardiovascular intervention and therapeutics - Tokyo : Springer Japan, 2010, 25(2009), 1 vom: 01. Okt., Seite 18-23 |
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| Übergeordnetes Werk: |
volume:25 ; year:2009 ; number:1 ; day:01 ; month:10 ; pages:18-23 |
| Links: |
|---|
| DOI / URN: |
10.1007/s12928-009-0002-7 |
|---|
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SPR028479041 |
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| 520 | |a Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. | ||
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10.1007/s12928-009-0002-7 doi (DE-627)SPR028479041 (SPR)s12928-009-0002-7-e DE-627 ger DE-627 rakwb eng Oshima, Shuichi verfasserin aut Low responsiveness to thienopyridine in hemodialysis patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. Hemodialysis (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Thienopyridine low responsiveness (dpeaa)DE-He213 Noda, Katsuo aut Fukushima, Hironobu aut Nakamura, Shinichi aut Shono, Makoto aut Kugimiya, Fumihito aut Higa, Kenichiro aut Enthalten in Cardiovascular intervention and therapeutics Tokyo : Springer Japan, 2010 25(2009), 1 vom: 01. Okt., Seite 18-23 (DE-627)614093368 (DE-600)2526607-X 1868-4297 nnns volume:25 year:2009 number:1 day:01 month:10 pages:18-23 https://dx.doi.org/10.1007/s12928-009-0002-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2009 1 01 10 18-23 |
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10.1007/s12928-009-0002-7 doi (DE-627)SPR028479041 (SPR)s12928-009-0002-7-e DE-627 ger DE-627 rakwb eng Oshima, Shuichi verfasserin aut Low responsiveness to thienopyridine in hemodialysis patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. Hemodialysis (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Thienopyridine low responsiveness (dpeaa)DE-He213 Noda, Katsuo aut Fukushima, Hironobu aut Nakamura, Shinichi aut Shono, Makoto aut Kugimiya, Fumihito aut Higa, Kenichiro aut Enthalten in Cardiovascular intervention and therapeutics Tokyo : Springer Japan, 2010 25(2009), 1 vom: 01. Okt., Seite 18-23 (DE-627)614093368 (DE-600)2526607-X 1868-4297 nnns volume:25 year:2009 number:1 day:01 month:10 pages:18-23 https://dx.doi.org/10.1007/s12928-009-0002-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2009 1 01 10 18-23 |
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10.1007/s12928-009-0002-7 doi (DE-627)SPR028479041 (SPR)s12928-009-0002-7-e DE-627 ger DE-627 rakwb eng Oshima, Shuichi verfasserin aut Low responsiveness to thienopyridine in hemodialysis patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. Hemodialysis (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Thienopyridine low responsiveness (dpeaa)DE-He213 Noda, Katsuo aut Fukushima, Hironobu aut Nakamura, Shinichi aut Shono, Makoto aut Kugimiya, Fumihito aut Higa, Kenichiro aut Enthalten in Cardiovascular intervention and therapeutics Tokyo : Springer Japan, 2010 25(2009), 1 vom: 01. Okt., Seite 18-23 (DE-627)614093368 (DE-600)2526607-X 1868-4297 nnns volume:25 year:2009 number:1 day:01 month:10 pages:18-23 https://dx.doi.org/10.1007/s12928-009-0002-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2009 1 01 10 18-23 |
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10.1007/s12928-009-0002-7 doi (DE-627)SPR028479041 (SPR)s12928-009-0002-7-e DE-627 ger DE-627 rakwb eng Oshima, Shuichi verfasserin aut Low responsiveness to thienopyridine in hemodialysis patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. Hemodialysis (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Thienopyridine low responsiveness (dpeaa)DE-He213 Noda, Katsuo aut Fukushima, Hironobu aut Nakamura, Shinichi aut Shono, Makoto aut Kugimiya, Fumihito aut Higa, Kenichiro aut Enthalten in Cardiovascular intervention and therapeutics Tokyo : Springer Japan, 2010 25(2009), 1 vom: 01. Okt., Seite 18-23 (DE-627)614093368 (DE-600)2526607-X 1868-4297 nnns volume:25 year:2009 number:1 day:01 month:10 pages:18-23 https://dx.doi.org/10.1007/s12928-009-0002-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2009 1 01 10 18-23 |
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10.1007/s12928-009-0002-7 doi (DE-627)SPR028479041 (SPR)s12928-009-0002-7-e DE-627 ger DE-627 rakwb eng Oshima, Shuichi verfasserin aut Low responsiveness to thienopyridine in hemodialysis patients 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. Hemodialysis (dpeaa)DE-He213 Drug-eluting stent (dpeaa)DE-He213 Thienopyridine low responsiveness (dpeaa)DE-He213 Noda, Katsuo aut Fukushima, Hironobu aut Nakamura, Shinichi aut Shono, Makoto aut Kugimiya, Fumihito aut Higa, Kenichiro aut Enthalten in Cardiovascular intervention and therapeutics Tokyo : Springer Japan, 2010 25(2009), 1 vom: 01. Okt., Seite 18-23 (DE-627)614093368 (DE-600)2526607-X 1868-4297 nnns volume:25 year:2009 number:1 day:01 month:10 pages:18-23 https://dx.doi.org/10.1007/s12928-009-0002-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2009 1 01 10 18-23 |
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Low responsiveness to thienopyridine in hemodialysis patients |
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Low responsiveness to thienopyridine in hemodialysis patients |
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Oshima, Shuichi |
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Cardiovascular intervention and therapeutics |
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2009 |
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Oshima, Shuichi Noda, Katsuo Fukushima, Hironobu Nakamura, Shinichi Shono, Makoto Kugimiya, Fumihito Higa, Kenichiro |
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10.1007/s12928-009-0002-7 |
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low responsiveness to thienopyridine in hemodialysis patients |
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Low responsiveness to thienopyridine in hemodialysis patients |
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Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 |
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Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 |
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Abstract We sought to evaluate whether thienopyridine low responsiveness, a predictor of stent thrombosis, is found in hemodialysis patients. We measured platelet aggregation at the site of implantation of drug-eluting stents in 333 patients with angina pectoris undergoing dual anti-platelet therapy. Thirty-one patients were on hemodialysis (HD group), and 302 were not (N-HD group). We used a novel whole-blood aggregometer. The aggregometer used the screen filtration method, with adenosine diphosphate as an agonist. The concentration of agonist required to induce 50% of the maximum pressure rate was calculated and indicated as the platelet aggregatory threshold index (PATI). Low responsiveness for thienopyridine was defined if the PATI levels were <4 μmol/l. PATI levels (μmol/l) were significantly lower in the HD group than in the N-HD group (6.8 ± 4.8 vs. 9.1 ± 5.4, P = 0.023), and the rate of low responsiveness for thienopyridine was significantly higher in the HD group than in the N-HD group (45.7 vs. 26.8%, P = 0.019). Non-fatal myocardial infarction and stent thrombosis occurred in three of the HD group and in nine of the N-HD group (P = 0.122). Late stent thrombosis occurred at a significantly higher rate in the HD group than in the N-HD group (P = 0.002). The rate of target lesion revascularization was significantly higher in the HD group than in the N-HD group (38 vs. 11.8%, P = 0.0001). In conclusion, low responsiveness to thienopyridine, as an indicator of platelet reactivity, is found more frequently in hemodialysis patients. © Japanese Association of Cardiovascular Intervention and Therapeutics 2009 |
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Noda, Katsuo Fukushima, Hironobu Nakamura, Shinichi Shono, Makoto Kugimiya, Fumihito Higa, Kenichiro |
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