Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol

Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bachmann, Lucas M [verfasserIn] Bischof, Dominique B Bischofberger, Stephan A Bonani, Marco G Osann, Franziska M Steurer, Johann

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2002

Schlagwörter:	False Positive Rate Acute Appendicitis Pretest Probability Diagnostic Odds Ratio Summary Receiver Operating Characteristic

Anmerkung:	© Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Übergeordnetes Werk:	Enthalten in: BMC surgery - London : BioMed Central, 2001, 2(2002), 1 vom: 10. Apr.
Übergeordnetes Werk:	volume:2 ; year:2002 ; number:1 ; day:10 ; month:04

Links:	Volltext

DOI / URN:	10.1186/1471-2482-2-2

Katalog-ID:	SPR028479459

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520			\|a Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research.
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allfields	10.1186/1471-2482-2-2 doi (DE-627)SPR028479459 (SPR)1471-2482-2-2-e DE-627 ger DE-627 rakwb eng Bachmann, Lucas M verfasserin aut Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. False Positive Rate (dpeaa)DE-He213 Acute Appendicitis (dpeaa)DE-He213 Pretest Probability (dpeaa)DE-He213 Diagnostic Odds Ratio (dpeaa)DE-He213 Summary Receiver Operating Characteristic (dpeaa)DE-He213 Bischof, Dominique B aut Bischofberger, Stephan A aut Bonani, Marco G aut Osann, Franziska M aut Steurer, Johann aut Enthalten in BMC surgery London : BioMed Central, 2001 2(2002), 1 vom: 10. Apr. (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:2 year:2002 number:1 day:10 month:04 https://dx.doi.org/10.1186/1471-2482-2-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2002 1 10 04
spelling	10.1186/1471-2482-2-2 doi (DE-627)SPR028479459 (SPR)1471-2482-2-2-e DE-627 ger DE-627 rakwb eng Bachmann, Lucas M verfasserin aut Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. False Positive Rate (dpeaa)DE-He213 Acute Appendicitis (dpeaa)DE-He213 Pretest Probability (dpeaa)DE-He213 Diagnostic Odds Ratio (dpeaa)DE-He213 Summary Receiver Operating Characteristic (dpeaa)DE-He213 Bischof, Dominique B aut Bischofberger, Stephan A aut Bonani, Marco G aut Osann, Franziska M aut Steurer, Johann aut Enthalten in BMC surgery London : BioMed Central, 2001 2(2002), 1 vom: 10. Apr. (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:2 year:2002 number:1 day:10 month:04 https://dx.doi.org/10.1186/1471-2482-2-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2002 1 10 04
allfields_unstemmed	10.1186/1471-2482-2-2 doi (DE-627)SPR028479459 (SPR)1471-2482-2-2-e DE-627 ger DE-627 rakwb eng Bachmann, Lucas M verfasserin aut Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. False Positive Rate (dpeaa)DE-He213 Acute Appendicitis (dpeaa)DE-He213 Pretest Probability (dpeaa)DE-He213 Diagnostic Odds Ratio (dpeaa)DE-He213 Summary Receiver Operating Characteristic (dpeaa)DE-He213 Bischof, Dominique B aut Bischofberger, Stephan A aut Bonani, Marco G aut Osann, Franziska M aut Steurer, Johann aut Enthalten in BMC surgery London : BioMed Central, 2001 2(2002), 1 vom: 10. Apr. (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:2 year:2002 number:1 day:10 month:04 https://dx.doi.org/10.1186/1471-2482-2-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2002 1 10 04
allfieldsGer	10.1186/1471-2482-2-2 doi (DE-627)SPR028479459 (SPR)1471-2482-2-2-e DE-627 ger DE-627 rakwb eng Bachmann, Lucas M verfasserin aut Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. False Positive Rate (dpeaa)DE-He213 Acute Appendicitis (dpeaa)DE-He213 Pretest Probability (dpeaa)DE-He213 Diagnostic Odds Ratio (dpeaa)DE-He213 Summary Receiver Operating Characteristic (dpeaa)DE-He213 Bischof, Dominique B aut Bischofberger, Stephan A aut Bonani, Marco G aut Osann, Franziska M aut Steurer, Johann aut Enthalten in BMC surgery London : BioMed Central, 2001 2(2002), 1 vom: 10. Apr. (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:2 year:2002 number:1 day:10 month:04 https://dx.doi.org/10.1186/1471-2482-2-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2002 1 10 04
allfieldsSound	10.1186/1471-2482-2-2 doi (DE-627)SPR028479459 (SPR)1471-2482-2-2-e DE-627 ger DE-627 rakwb eng Bachmann, Lucas M verfasserin aut Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol 2002 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. False Positive Rate (dpeaa)DE-He213 Acute Appendicitis (dpeaa)DE-He213 Pretest Probability (dpeaa)DE-He213 Diagnostic Odds Ratio (dpeaa)DE-He213 Summary Receiver Operating Characteristic (dpeaa)DE-He213 Bischof, Dominique B aut Bischofberger, Stephan A aut Bonani, Marco G aut Osann, Franziska M aut Steurer, Johann aut Enthalten in BMC surgery London : BioMed Central, 2001 2(2002), 1 vom: 10. Apr. (DE-627)331018837 (DE-600)2050442-1 1471-2482 nnns volume:2 year:2002 number:1 day:10 month:04 https://dx.doi.org/10.1186/1471-2482-2-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2002 1 10 04
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author	Bachmann, Lucas M
spellingShingle	Bachmann, Lucas M misc False Positive Rate misc Acute Appendicitis misc Pretest Probability misc Diagnostic Odds Ratio misc Summary Receiver Operating Characteristic Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol
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topic_title	Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol False Positive Rate (dpeaa)DE-He213 Acute Appendicitis (dpeaa)DE-He213 Pretest Probability (dpeaa)DE-He213 Diagnostic Odds Ratio (dpeaa)DE-He213 Summary Receiver Operating Characteristic (dpeaa)DE-He213
topic	misc False Positive Rate misc Acute Appendicitis misc Pretest Probability misc Diagnostic Odds Ratio misc Summary Receiver Operating Characteristic
topic_unstemmed	misc False Positive Rate misc Acute Appendicitis misc Pretest Probability misc Diagnostic Odds Ratio misc Summary Receiver Operating Characteristic
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title	Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol
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title_sort	systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol
title_auth	Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol
abstract	Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
abstractGer	Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
abstract_unstemmed	Background Suspected acute appendicitis is the most frequent cause for emergency operations in visceral surgery worldwide. In approximately twenty percent of all cases however, the diagnosis is incorrect and patients undergo surgery without having acute appendicitis. Operations of bland appendices put patients at risk and entail a serious waste of resources. Several highly accurate tests have been introduced to diagnose acute appendicitis. The false positive rate however, has not changed over the last twenty years. Given the variation that exists in both practice and research, the uncertainty regarding the quality of the underlying evidence, there is a clear need for comprehensive, systematic and quantitative overviews of the diagnostic value of the various tests purported to be predictive of acute appendicitis. Methods Literature will be identified searching general bibliographic databases (MEDLINE and EMBASE), specialist computer databases (DARE, Cochrane Database of Systematic Reviews, conference proceedings, MEDION, SCISEARCH, BIOSIS) without language restrictions. We will contact experts and the manufacturers of tests. Hand-searching will complete our searches. Identified articles will be selected according to populations, tests, outcomes and study design. Papers meeting the selection criteria will be appraised to rate their methodological quality. Analysis will include exploration of heterogeneity in results. We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. Discussion These reviews should lead to formulation of recommendations for current practice and future research. © Bachmann et al; licensee BioMed Central Ltd. 2002. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
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title_short	Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol
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We will conduct meta-analyses to generate summary estimates of test accuracy measures and summary ROC curves where appropriate. If meta-analysis is considered to be inappropriate, we will describe the identified evidence in the context of appraised quality. 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Systematic quantitative overviews of the literature to determine the value of diagnostic tests for predicting acute appendicitis: study protocol

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