Cancer immunotherapies targeting the PD-1 signaling pathway

Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successfu...
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Gespeichert in:

Autor*in:	Iwai, Yoshiko [verfasserIn] Hamanishi, Junzo Chamoto, Kenji Honjo, Tasuku

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	PD-1 PD-L1 Cancer immunotherapy Immune checkpoint

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: Journal of biomedical science - London : BioMed Central, 1994, 24(2017), 1 vom: 04. Apr.
Übergeordnetes Werk:	volume:24 ; year:2017 ; number:1 ; day:04 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s12929-017-0329-9

Katalog-ID:	SPR02849539X

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author_variant	y i yi j h jh k c kc t h th
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publishDate	2017
allfields	10.1186/s12929-017-0329-9 doi (DE-627)SPR02849539X (SPR)s12929-017-0329-9-e DE-627 ger DE-627 rakwb eng Iwai, Yoshiko verfasserin aut Cancer immunotherapies targeting the PD-1 signaling pathway 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. PD-1 (dpeaa)DE-He213 PD-L1 (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Immune checkpoint (dpeaa)DE-He213 Hamanishi, Junzo aut Chamoto, Kenji aut Honjo, Tasuku aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 24(2017), 1 vom: 04. Apr. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:24 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s12929-017-0329-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2017 1 04 04
spelling	10.1186/s12929-017-0329-9 doi (DE-627)SPR02849539X (SPR)s12929-017-0329-9-e DE-627 ger DE-627 rakwb eng Iwai, Yoshiko verfasserin aut Cancer immunotherapies targeting the PD-1 signaling pathway 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. PD-1 (dpeaa)DE-He213 PD-L1 (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Immune checkpoint (dpeaa)DE-He213 Hamanishi, Junzo aut Chamoto, Kenji aut Honjo, Tasuku aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 24(2017), 1 vom: 04. Apr. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:24 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s12929-017-0329-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2017 1 04 04
allfields_unstemmed	10.1186/s12929-017-0329-9 doi (DE-627)SPR02849539X (SPR)s12929-017-0329-9-e DE-627 ger DE-627 rakwb eng Iwai, Yoshiko verfasserin aut Cancer immunotherapies targeting the PD-1 signaling pathway 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. PD-1 (dpeaa)DE-He213 PD-L1 (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Immune checkpoint (dpeaa)DE-He213 Hamanishi, Junzo aut Chamoto, Kenji aut Honjo, Tasuku aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 24(2017), 1 vom: 04. Apr. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:24 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s12929-017-0329-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2017 1 04 04
allfieldsGer	10.1186/s12929-017-0329-9 doi (DE-627)SPR02849539X (SPR)s12929-017-0329-9-e DE-627 ger DE-627 rakwb eng Iwai, Yoshiko verfasserin aut Cancer immunotherapies targeting the PD-1 signaling pathway 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. PD-1 (dpeaa)DE-He213 PD-L1 (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Immune checkpoint (dpeaa)DE-He213 Hamanishi, Junzo aut Chamoto, Kenji aut Honjo, Tasuku aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 24(2017), 1 vom: 04. Apr. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:24 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s12929-017-0329-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2017 1 04 04
allfieldsSound	10.1186/s12929-017-0329-9 doi (DE-627)SPR02849539X (SPR)s12929-017-0329-9-e DE-627 ger DE-627 rakwb eng Iwai, Yoshiko verfasserin aut Cancer immunotherapies targeting the PD-1 signaling pathway 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. PD-1 (dpeaa)DE-He213 PD-L1 (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Immune checkpoint (dpeaa)DE-He213 Hamanishi, Junzo aut Chamoto, Kenji aut Honjo, Tasuku aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 24(2017), 1 vom: 04. Apr. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:24 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s12929-017-0329-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2017 1 04 04
language	English
source	Enthalten in Journal of biomedical science 24(2017), 1 vom: 04. Apr. volume:24 year:2017 number:1 day:04 month:04
sourceStr	Enthalten in Journal of biomedical science 24(2017), 1 vom: 04. Apr. volume:24 year:2017 number:1 day:04 month:04
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institution	findex.gbv.de
topic_facet	PD-1 PD-L1 Cancer immunotherapy Immune checkpoint
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container_title	Journal of biomedical science
authorswithroles_txt_mv	Iwai, Yoshiko @@aut@@ Hamanishi, Junzo @@aut@@ Chamoto, Kenji @@aut@@ Honjo, Tasuku @@aut@@
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spellingShingle	Iwai, Yoshiko misc PD-1 misc PD-L1 misc Cancer immunotherapy misc Immune checkpoint Cancer immunotherapies targeting the PD-1 signaling pathway
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topic_title	Cancer immunotherapies targeting the PD-1 signaling pathway PD-1 (dpeaa)DE-He213 PD-L1 (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Immune checkpoint (dpeaa)DE-He213
topic	misc PD-1 misc PD-L1 misc Cancer immunotherapy misc Immune checkpoint
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title	Cancer immunotherapies targeting the PD-1 signaling pathway
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title_sort	cancer immunotherapies targeting the pd-1 signaling pathway
title_auth	Cancer immunotherapies targeting the PD-1 signaling pathway
abstract	Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. © The Author(s). 2017
abstractGer	Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. © The Author(s). 2017
abstract_unstemmed	Abstract Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use. © The Author(s). 2017
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title_short	Cancer immunotherapies targeting the PD-1 signaling pathway
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