Airway inflammation contributes to health status in COPD: a cross-sectional study

Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Snoeck-Stroband, Jiska B [verfasserIn] Postma, Dirkje S Lapperre, Thérèse S Gosman, Margot ME Thiadens, Henk A Kauffman, Henk F Sont, Jacob K Jansen, Désirée F Sterk, Peter J

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2006

Schlagwörter:	Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Airway Inflammation Tiotropium Airway Hyperresponsiveness

Anmerkung:	© Snoeck-Stroband et al. 2006

Übergeordnetes Werk:	Enthalten in: Respiratory research - London : BioMed Central, 2001, 7(2006), 1 vom: 30. Nov.
Übergeordnetes Werk:	volume:7 ; year:2006 ; number:1 ; day:30 ; month:11

Links:	Volltext

DOI / URN:	10.1186/1465-9921-7-140

Katalog-ID:	SPR028506472

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100	1		\|a Snoeck-Stroband, Jiska B \|e verfasserin \|4 aut
245	1	0	\|a Airway inflammation contributes to health status in COPD: a cross-sectional study
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520			\|a Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease.
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700	1		\|a Jansen, Désirée F \|4 aut
700	1		\|a Sterk, Peter J \|4 aut
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allfields	10.1186/1465-9921-7-140 doi (DE-627)SPR028506472 (SPR)1465-9921-7-140-e DE-627 ger DE-627 rakwb eng Snoeck-Stroband, Jiska B verfasserin aut Airway inflammation contributes to health status in COPD: a cross-sectional study 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Snoeck-Stroband et al. 2006 Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Airway Inflammation (dpeaa)DE-He213 Tiotropium (dpeaa)DE-He213 Airway Hyperresponsiveness (dpeaa)DE-He213 Postma, Dirkje S aut Lapperre, Thérèse S aut Gosman, Margot ME aut Thiadens, Henk A aut Kauffman, Henk F aut Sont, Jacob K aut Jansen, Désirée F aut Sterk, Peter J aut Enthalten in Respiratory research London : BioMed Central, 2001 7(2006), 1 vom: 30. Nov. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:7 year:2006 number:1 day:30 month:11 https://dx.doi.org/10.1186/1465-9921-7-140 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2006 1 30 11
spelling	10.1186/1465-9921-7-140 doi (DE-627)SPR028506472 (SPR)1465-9921-7-140-e DE-627 ger DE-627 rakwb eng Snoeck-Stroband, Jiska B verfasserin aut Airway inflammation contributes to health status in COPD: a cross-sectional study 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Snoeck-Stroband et al. 2006 Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Airway Inflammation (dpeaa)DE-He213 Tiotropium (dpeaa)DE-He213 Airway Hyperresponsiveness (dpeaa)DE-He213 Postma, Dirkje S aut Lapperre, Thérèse S aut Gosman, Margot ME aut Thiadens, Henk A aut Kauffman, Henk F aut Sont, Jacob K aut Jansen, Désirée F aut Sterk, Peter J aut Enthalten in Respiratory research London : BioMed Central, 2001 7(2006), 1 vom: 30. Nov. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:7 year:2006 number:1 day:30 month:11 https://dx.doi.org/10.1186/1465-9921-7-140 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2006 1 30 11
allfields_unstemmed	10.1186/1465-9921-7-140 doi (DE-627)SPR028506472 (SPR)1465-9921-7-140-e DE-627 ger DE-627 rakwb eng Snoeck-Stroband, Jiska B verfasserin aut Airway inflammation contributes to health status in COPD: a cross-sectional study 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Snoeck-Stroband et al. 2006 Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Airway Inflammation (dpeaa)DE-He213 Tiotropium (dpeaa)DE-He213 Airway Hyperresponsiveness (dpeaa)DE-He213 Postma, Dirkje S aut Lapperre, Thérèse S aut Gosman, Margot ME aut Thiadens, Henk A aut Kauffman, Henk F aut Sont, Jacob K aut Jansen, Désirée F aut Sterk, Peter J aut Enthalten in Respiratory research London : BioMed Central, 2001 7(2006), 1 vom: 30. Nov. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:7 year:2006 number:1 day:30 month:11 https://dx.doi.org/10.1186/1465-9921-7-140 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2006 1 30 11
allfieldsGer	10.1186/1465-9921-7-140 doi (DE-627)SPR028506472 (SPR)1465-9921-7-140-e DE-627 ger DE-627 rakwb eng Snoeck-Stroband, Jiska B verfasserin aut Airway inflammation contributes to health status in COPD: a cross-sectional study 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Snoeck-Stroband et al. 2006 Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Airway Inflammation (dpeaa)DE-He213 Tiotropium (dpeaa)DE-He213 Airway Hyperresponsiveness (dpeaa)DE-He213 Postma, Dirkje S aut Lapperre, Thérèse S aut Gosman, Margot ME aut Thiadens, Henk A aut Kauffman, Henk F aut Sont, Jacob K aut Jansen, Désirée F aut Sterk, Peter J aut Enthalten in Respiratory research London : BioMed Central, 2001 7(2006), 1 vom: 30. Nov. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:7 year:2006 number:1 day:30 month:11 https://dx.doi.org/10.1186/1465-9921-7-140 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2006 1 30 11
allfieldsSound	10.1186/1465-9921-7-140 doi (DE-627)SPR028506472 (SPR)1465-9921-7-140-e DE-627 ger DE-627 rakwb eng Snoeck-Stroband, Jiska B verfasserin aut Airway inflammation contributes to health status in COPD: a cross-sectional study 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Snoeck-Stroband et al. 2006 Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Airway Inflammation (dpeaa)DE-He213 Tiotropium (dpeaa)DE-He213 Airway Hyperresponsiveness (dpeaa)DE-He213 Postma, Dirkje S aut Lapperre, Thérèse S aut Gosman, Margot ME aut Thiadens, Henk A aut Kauffman, Henk F aut Sont, Jacob K aut Jansen, Désirée F aut Sterk, Peter J aut Enthalten in Respiratory research London : BioMed Central, 2001 7(2006), 1 vom: 30. Nov. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:7 year:2006 number:1 day:30 month:11 https://dx.doi.org/10.1186/1465-9921-7-140 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2006 1 30 11
language	English
source	Enthalten in Respiratory research 7(2006), 1 vom: 30. Nov. volume:7 year:2006 number:1 day:30 month:11
sourceStr	Enthalten in Respiratory research 7(2006), 1 vom: 30. Nov. volume:7 year:2006 number:1 day:30 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Airway Inflammation Tiotropium Airway Hyperresponsiveness
isfreeaccess_bool	true
container_title	Respiratory research
authorswithroles_txt_mv	Snoeck-Stroband, Jiska B @@aut@@ Postma, Dirkje S @@aut@@ Lapperre, Thérèse S @@aut@@ Gosman, Margot ME @@aut@@ Thiadens, Henk A @@aut@@ Kauffman, Henk F @@aut@@ Sont, Jacob K @@aut@@ Jansen, Désirée F @@aut@@ Sterk, Peter J @@aut@@
publishDateDaySort_date	2006-11-30T00:00:00Z
hierarchy_top_id	326646485
id	SPR028506472
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR028506472</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520013735.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2006 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1465-9921-7-140</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR028506472</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)1465-9921-7-140-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Snoeck-Stroband, Jiska B</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Airway inflammation contributes to health status in COPD: a cross-sectional study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2006</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Snoeck-Stroband et al. 2006</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. 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author	Snoeck-Stroband, Jiska B
spellingShingle	Snoeck-Stroband, Jiska B misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Airway Inflammation misc Tiotropium misc Airway Hyperresponsiveness Airway inflammation contributes to health status in COPD: a cross-sectional study
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topic_title	Airway inflammation contributes to health status in COPD: a cross-sectional study Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Chronic Obstructive Pulmonary Disease Patient (dpeaa)DE-He213 Airway Inflammation (dpeaa)DE-He213 Tiotropium (dpeaa)DE-He213 Airway Hyperresponsiveness (dpeaa)DE-He213
topic	misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Airway Inflammation misc Tiotropium misc Airway Hyperresponsiveness
topic_unstemmed	misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Airway Inflammation misc Tiotropium misc Airway Hyperresponsiveness
topic_browse	misc Chronic Obstructive Pulmonary Disease misc Chronic Obstructive Pulmonary Disease Patient misc Airway Inflammation misc Tiotropium misc Airway Hyperresponsiveness
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title	Airway inflammation contributes to health status in COPD: a cross-sectional study
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title_full	Airway inflammation contributes to health status in COPD: a cross-sectional study
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author_browse	Snoeck-Stroband, Jiska B Postma, Dirkje S Lapperre, Thérèse S Gosman, Margot ME Thiadens, Henk A Kauffman, Henk F Sont, Jacob K Jansen, Désirée F Sterk, Peter J
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author-letter	Snoeck-Stroband, Jiska B
doi_str_mv	10.1186/1465-9921-7-140
title_sort	airway inflammation contributes to health status in copd: a cross-sectional study
title_auth	Airway inflammation contributes to health status in COPD: a cross-sectional study
abstract	Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. © Snoeck-Stroband et al. 2006
abstractGer	Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. © Snoeck-Stroband et al. 2006
abstract_unstemmed	Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. This may provide a rationale for anti-inflammatory therapy in this disease. © Snoeck-Stroband et al. 2006
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title_short	Airway inflammation contributes to health status in COPD: a cross-sectional study
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR028506472</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520013735.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2006 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1465-9921-7-140</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR028506472</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)1465-9921-7-140-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Snoeck-Stroband, Jiska B</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Airway inflammation contributes to health status in COPD: a cross-sectional study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2006</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Snoeck-Stroband et al. 2006</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and airway inflammation, accompanied by decreased health status. It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD. Methods In 114 COPD patients (99 male, age: 62 ± 8 yr, 41 [31–55] pack-years, no inhaled or oral corticosteroids, postbronchodilator $ FEV_{1} $: 63 ± 9% pred, $ FEV_{1} $/IVC: 48 ± 9%) we obtained induced sputum and measured health status (St. George's respiratory questionnaire (SGRQ)), postbronchodilator $ FEV_{1} $, hyperinflation (RV/TLC), and airway hyperresponsiveness to methacholine ($ PC_{20} $). Sputum was induced by hypertonic saline and differential cell counts were obtained in 102 patients. Results Univariate analysis showed that SGRQ total and symptom score were positively associated with % sputum macrophages (r = 0.20, p = 0.05; and r = 0.20, p = 0.04, respectively). Multiple regression analysis confirmed these relationships, providing significant contributions of % sputum macrophages (B = 0.25, p = 0.021) and RV/TLC (B = 0.60, p = 0.002) to SGRQ total score. Furthermore, SGRQ symptom score was associated with % sputum macrophages (B = 0.30, p = 0.03) and RV/TLC (B = 0.48, p = 0.044), whilst SGRQ activity score was associated with % sputum macrophages (B = 0.46, p = 0.002), RV/TLC (B = 0.61, p = 0.015), and $ PC_{20} $ (B = -9.3, p = 0.024). Current smoking and $ FEV_{1} $ were not significantly associated with health status in the multiple regression analysis. Conclusion We conclude that worse health status in COPD patients is associated with higher inflammatory cell counts in induced sputum. Our findings suggest that airway inflammation and hyperinflation independently contribute to impaired health status in COPD. 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Airway inflammation contributes to health status in COPD: a cross-sectional study

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