Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population
Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kainu, Annette [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Anmerkung: |
© Kainu et al. 2009 |
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| Übergeordnetes Werk: |
Enthalten in: Respiratory research - London : BioMed Central, 2001, 10(2009), 1 vom: 28. Juli |
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| Übergeordnetes Werk: |
volume:10 ; year:2009 ; number:1 ; day:28 ; month:07 |
| Links: |
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| DOI / URN: |
10.1186/1465-9921-10-71 |
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| Katalog-ID: |
SPR028509293 |
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| 100 | 1 | |a Kainu, Annette |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population |
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| 520 | |a Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. | ||
| 650 | 4 | |a Chronic Obstructive Pulmonary Disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Forced Vital Capacity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Airflow Limitation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Concurrent Change |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Bronchodilation Response |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lindqvist, Ari |4 aut | |
| 700 | 1 | |a Sarna, Seppo |4 aut | |
| 700 | 1 | |a Lundbäck, Bo |4 aut | |
| 700 | 1 | |a Sovijärvi, Anssi |4 aut | |
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| 773 | 1 | 8 | |g volume:10 |g year:2009 |g number:1 |g day:28 |g month:07 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/1465-9921-10-71 |z kostenfrei |3 Volltext |
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10.1186/1465-9921-10-71 doi (DE-627)SPR028509293 (SPR)1465-9921-10-71-e DE-627 ger DE-627 rakwb eng Kainu, Annette verfasserin aut Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kainu et al. 2009 Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Forced Vital Capacity (dpeaa)DE-He213 Airflow Limitation (dpeaa)DE-He213 Concurrent Change (dpeaa)DE-He213 Bronchodilation Response (dpeaa)DE-He213 Lindqvist, Ari aut Sarna, Seppo aut Lundbäck, Bo aut Sovijärvi, Anssi aut Enthalten in Respiratory research London : BioMed Central, 2001 10(2009), 1 vom: 28. Juli (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:10 year:2009 number:1 day:28 month:07 https://dx.doi.org/10.1186/1465-9921-10-71 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 28 07 |
| spelling |
10.1186/1465-9921-10-71 doi (DE-627)SPR028509293 (SPR)1465-9921-10-71-e DE-627 ger DE-627 rakwb eng Kainu, Annette verfasserin aut Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kainu et al. 2009 Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Forced Vital Capacity (dpeaa)DE-He213 Airflow Limitation (dpeaa)DE-He213 Concurrent Change (dpeaa)DE-He213 Bronchodilation Response (dpeaa)DE-He213 Lindqvist, Ari aut Sarna, Seppo aut Lundbäck, Bo aut Sovijärvi, Anssi aut Enthalten in Respiratory research London : BioMed Central, 2001 10(2009), 1 vom: 28. Juli (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:10 year:2009 number:1 day:28 month:07 https://dx.doi.org/10.1186/1465-9921-10-71 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 28 07 |
| allfields_unstemmed |
10.1186/1465-9921-10-71 doi (DE-627)SPR028509293 (SPR)1465-9921-10-71-e DE-627 ger DE-627 rakwb eng Kainu, Annette verfasserin aut Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kainu et al. 2009 Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Forced Vital Capacity (dpeaa)DE-He213 Airflow Limitation (dpeaa)DE-He213 Concurrent Change (dpeaa)DE-He213 Bronchodilation Response (dpeaa)DE-He213 Lindqvist, Ari aut Sarna, Seppo aut Lundbäck, Bo aut Sovijärvi, Anssi aut Enthalten in Respiratory research London : BioMed Central, 2001 10(2009), 1 vom: 28. Juli (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:10 year:2009 number:1 day:28 month:07 https://dx.doi.org/10.1186/1465-9921-10-71 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 28 07 |
| allfieldsGer |
10.1186/1465-9921-10-71 doi (DE-627)SPR028509293 (SPR)1465-9921-10-71-e DE-627 ger DE-627 rakwb eng Kainu, Annette verfasserin aut Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kainu et al. 2009 Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Forced Vital Capacity (dpeaa)DE-He213 Airflow Limitation (dpeaa)DE-He213 Concurrent Change (dpeaa)DE-He213 Bronchodilation Response (dpeaa)DE-He213 Lindqvist, Ari aut Sarna, Seppo aut Lundbäck, Bo aut Sovijärvi, Anssi aut Enthalten in Respiratory research London : BioMed Central, 2001 10(2009), 1 vom: 28. Juli (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:10 year:2009 number:1 day:28 month:07 https://dx.doi.org/10.1186/1465-9921-10-71 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 28 07 |
| allfieldsSound |
10.1186/1465-9921-10-71 doi (DE-627)SPR028509293 (SPR)1465-9921-10-71-e DE-627 ger DE-627 rakwb eng Kainu, Annette verfasserin aut Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kainu et al. 2009 Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Forced Vital Capacity (dpeaa)DE-He213 Airflow Limitation (dpeaa)DE-He213 Concurrent Change (dpeaa)DE-He213 Bronchodilation Response (dpeaa)DE-He213 Lindqvist, Ari aut Sarna, Seppo aut Lundbäck, Bo aut Sovijärvi, Anssi aut Enthalten in Respiratory research London : BioMed Central, 2001 10(2009), 1 vom: 28. Juli (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:10 year:2009 number:1 day:28 month:07 https://dx.doi.org/10.1186/1465-9921-10-71 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1 28 07 |
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Enthalten in Respiratory research 10(2009), 1 vom: 28. Juli volume:10 year:2009 number:1 day:28 month:07 |
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Chronic Obstructive Pulmonary Disease Forced Vital Capacity Airflow Limitation Concurrent Change Bronchodilation Response |
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Kainu, Annette @@aut@@ Lindqvist, Ari @@aut@@ Sarna, Seppo @@aut@@ Lundbäck, Bo @@aut@@ Sovijärvi, Anssi @@aut@@ |
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Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. 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Kainu, Annette |
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Kainu, Annette misc Chronic Obstructive Pulmonary Disease misc Forced Vital Capacity misc Airflow Limitation misc Concurrent Change misc Bronchodilation Response Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population |
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Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population Chronic Obstructive Pulmonary Disease (dpeaa)DE-He213 Forced Vital Capacity (dpeaa)DE-He213 Airflow Limitation (dpeaa)DE-He213 Concurrent Change (dpeaa)DE-He213 Bronchodilation Response (dpeaa)DE-He213 |
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Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population |
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Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population |
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Kainu, Annette |
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Kainu, Annette Lindqvist, Ari Sarna, Seppo Lundbäck, Bo Sovijärvi, Anssi |
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Kainu, Annette |
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10.1186/1465-9921-10-71 |
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responses of $ fev_{6} $, fvc, and fet to inhaled bronchodilator in the adult general population |
| title_auth |
Responses of $ FEV_{6} $, FVC, and FET to inhaled bronchodilator in the adult general population |
| abstract |
Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. © Kainu et al. 2009 |
| abstractGer |
Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. © Kainu et al. 2009 |
| abstract_unstemmed |
Background The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds ($ FEV_{6} $), and FET in the bronchodilation test among patients with obstructive airways disease or in the general population. The aim of this study was to assess the changes in $ FEV_{6} $, FVC, and FET, and their relationships in a standardized bronchodilation test in the general population. Methods We studied bronchodilation response in a general adult population sample of 628 individuals (260 men, 368 women) with flow-volume spirometry. The largest FVC, the corresponding FET and the largest $ FEV_{6} $ both at the baseline and after 0.4 mg of inhaled salbutamol were selected for analysis. Results After administration of salbutamol $ FEV_{6} $ decreased on average -13.4 (95% CI -22.3 to -4.5) ml or -0.2% (-0.4% to 0.0%) from the baseline. The $ 95^{th} $ percentile of change in $ FEV_{6} $ was 169.1 ml and 5.0%. FVC decreased on average -42.8 (-52.4 to -33.3) ml or -1.0% (-1.2% to -0.7%). Concurrently FET changed on average -0.2 (-0.4 to 0.0) seconds or 0.4% (-1.4% to 2.3%). There were four subjects with an increase of FVC over 12% and only one of these was associated with prolonged FET after salbutamol. Changes in $ FEV_{6} $ and FVC were more frequently positive in subjects with reduced $ FEV_{1} $/FVC in baseline spirometry. Conclusion In general adult population, both $ FEV_{6} $ and FVC tended to decrease, but FET remained almost unchanged, in the bronchodilation test. However, those subjects with signs of airflow limitation at the baseline showed frequently some increase of $ FEV_{6} $ and FVC in the bronchodilation test without change in FET. We suggest that $ FEV_{6} $ could be used in assessment of bronchodilation response in lieu of FVC removing the need for regulation of FET during bronchodilation testing. © Kainu et al. 2009 |
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7.40018 |