Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was...
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Autor*in:	Horner, Andreas [verfasserIn] Soriano, Joan B. Puhan, Milo A. Studnicka, Michael Kaiser, Bernhard Vanfleteren, Lowie E. G. W. Gnatiuc, Louisa Burney, Peter Miravitlles, Marc García-Rio, Francisco Ancochea, Julio Menezes, Ana M. Perez-Padilla, Rogelio Montes de Oca, Maria Torres-Duque, Carlos A. Caballero, Andres González-García, Mauricio Buist, Sonia Flamm, Maria Lamprecht, Bernd

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	COPD Geographical altitude Risk factors Underdiagnosis Epidemiology

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: Respiratory research - London : BioMed Central, 2001, 18(2017), 1 vom: 23. Aug.
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:1 ; day:23 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12931-017-0643-5

Katalog-ID:	SPR028523873

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100	1		\|a Horner, Andreas \|e verfasserin \|0 (orcid)0000-0001-7746-3335 \|4 aut
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520			\|a Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD.
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allfields	10.1186/s12931-017-0643-5 doi (DE-627)SPR028523873 (SPR)s12931-017-0643-5-e DE-627 ger DE-627 rakwb eng Horner, Andreas verfasserin (orcid)0000-0001-7746-3335 aut Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. COPD (dpeaa)DE-He213 Geographical altitude (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Underdiagnosis (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Soriano, Joan B. aut Puhan, Milo A. aut Studnicka, Michael aut Kaiser, Bernhard aut Vanfleteren, Lowie E. G. W. aut Gnatiuc, Louisa aut Burney, Peter aut Miravitlles, Marc aut García-Rio, Francisco aut Ancochea, Julio aut Menezes, Ana M. aut Perez-Padilla, Rogelio aut Montes de Oca, Maria aut Torres-Duque, Carlos A. aut Caballero, Andres aut González-García, Mauricio aut Buist, Sonia aut Flamm, Maria aut Lamprecht, Bernd aut Enthalten in Respiratory research London : BioMed Central, 2001 18(2017), 1 vom: 23. Aug. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:18 year:2017 number:1 day:23 month:08 https://dx.doi.org/10.1186/s12931-017-0643-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 23 08
spelling	10.1186/s12931-017-0643-5 doi (DE-627)SPR028523873 (SPR)s12931-017-0643-5-e DE-627 ger DE-627 rakwb eng Horner, Andreas verfasserin (orcid)0000-0001-7746-3335 aut Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. COPD (dpeaa)DE-He213 Geographical altitude (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Underdiagnosis (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Soriano, Joan B. aut Puhan, Milo A. aut Studnicka, Michael aut Kaiser, Bernhard aut Vanfleteren, Lowie E. G. W. aut Gnatiuc, Louisa aut Burney, Peter aut Miravitlles, Marc aut García-Rio, Francisco aut Ancochea, Julio aut Menezes, Ana M. aut Perez-Padilla, Rogelio aut Montes de Oca, Maria aut Torres-Duque, Carlos A. aut Caballero, Andres aut González-García, Mauricio aut Buist, Sonia aut Flamm, Maria aut Lamprecht, Bernd aut Enthalten in Respiratory research London : BioMed Central, 2001 18(2017), 1 vom: 23. Aug. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:18 year:2017 number:1 day:23 month:08 https://dx.doi.org/10.1186/s12931-017-0643-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 23 08
allfields_unstemmed	10.1186/s12931-017-0643-5 doi (DE-627)SPR028523873 (SPR)s12931-017-0643-5-e DE-627 ger DE-627 rakwb eng Horner, Andreas verfasserin (orcid)0000-0001-7746-3335 aut Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. COPD (dpeaa)DE-He213 Geographical altitude (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Underdiagnosis (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Soriano, Joan B. aut Puhan, Milo A. aut Studnicka, Michael aut Kaiser, Bernhard aut Vanfleteren, Lowie E. G. W. aut Gnatiuc, Louisa aut Burney, Peter aut Miravitlles, Marc aut García-Rio, Francisco aut Ancochea, Julio aut Menezes, Ana M. aut Perez-Padilla, Rogelio aut Montes de Oca, Maria aut Torres-Duque, Carlos A. aut Caballero, Andres aut González-García, Mauricio aut Buist, Sonia aut Flamm, Maria aut Lamprecht, Bernd aut Enthalten in Respiratory research London : BioMed Central, 2001 18(2017), 1 vom: 23. Aug. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:18 year:2017 number:1 day:23 month:08 https://dx.doi.org/10.1186/s12931-017-0643-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 23 08
allfieldsGer	10.1186/s12931-017-0643-5 doi (DE-627)SPR028523873 (SPR)s12931-017-0643-5-e DE-627 ger DE-627 rakwb eng Horner, Andreas verfasserin (orcid)0000-0001-7746-3335 aut Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. COPD (dpeaa)DE-He213 Geographical altitude (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Underdiagnosis (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Soriano, Joan B. aut Puhan, Milo A. aut Studnicka, Michael aut Kaiser, Bernhard aut Vanfleteren, Lowie E. G. W. aut Gnatiuc, Louisa aut Burney, Peter aut Miravitlles, Marc aut García-Rio, Francisco aut Ancochea, Julio aut Menezes, Ana M. aut Perez-Padilla, Rogelio aut Montes de Oca, Maria aut Torres-Duque, Carlos A. aut Caballero, Andres aut González-García, Mauricio aut Buist, Sonia aut Flamm, Maria aut Lamprecht, Bernd aut Enthalten in Respiratory research London : BioMed Central, 2001 18(2017), 1 vom: 23. Aug. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:18 year:2017 number:1 day:23 month:08 https://dx.doi.org/10.1186/s12931-017-0643-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 23 08
allfieldsSound	10.1186/s12931-017-0643-5 doi (DE-627)SPR028523873 (SPR)s12931-017-0643-5-e DE-627 ger DE-627 rakwb eng Horner, Andreas verfasserin (orcid)0000-0001-7746-3335 aut Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. COPD (dpeaa)DE-He213 Geographical altitude (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Underdiagnosis (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Soriano, Joan B. aut Puhan, Milo A. aut Studnicka, Michael aut Kaiser, Bernhard aut Vanfleteren, Lowie E. G. W. aut Gnatiuc, Louisa aut Burney, Peter aut Miravitlles, Marc aut García-Rio, Francisco aut Ancochea, Julio aut Menezes, Ana M. aut Perez-Padilla, Rogelio aut Montes de Oca, Maria aut Torres-Duque, Carlos A. aut Caballero, Andres aut González-García, Mauricio aut Buist, Sonia aut Flamm, Maria aut Lamprecht, Bernd aut Enthalten in Respiratory research London : BioMed Central, 2001 18(2017), 1 vom: 23. Aug. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:18 year:2017 number:1 day:23 month:08 https://dx.doi.org/10.1186/s12931-017-0643-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 23 08
language	English
source	Enthalten in Respiratory research 18(2017), 1 vom: 23. Aug. volume:18 year:2017 number:1 day:23 month:08
sourceStr	Enthalten in Respiratory research 18(2017), 1 vom: 23. Aug. volume:18 year:2017 number:1 day:23 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	COPD Geographical altitude Risk factors Underdiagnosis Epidemiology
isfreeaccess_bool	true
container_title	Respiratory research
authorswithroles_txt_mv	Horner, Andreas @@aut@@ Soriano, Joan B. @@aut@@ Puhan, Milo A. @@aut@@ Studnicka, Michael @@aut@@ Kaiser, Bernhard @@aut@@ Vanfleteren, Lowie E. G. W. @@aut@@ Gnatiuc, Louisa @@aut@@ Burney, Peter @@aut@@ Miravitlles, Marc @@aut@@ García-Rio, Francisco @@aut@@ Ancochea, Julio @@aut@@ Menezes, Ana M. @@aut@@ Perez-Padilla, Rogelio @@aut@@ Montes de Oca, Maria @@aut@@ Torres-Duque, Carlos A. @@aut@@ Caballero, Andres @@aut@@ González-García, Mauricio @@aut@@ Buist, Sonia @@aut@@ Flamm, Maria @@aut@@ Lamprecht, Bernd @@aut@@
publishDateDaySort_date	2017-08-23T00:00:00Z
hierarchy_top_id	326646485
id	SPR028523873
language_de	englisch
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We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. 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author	Horner, Andreas
spellingShingle	Horner, Andreas misc COPD misc Geographical altitude misc Risk factors misc Underdiagnosis misc Epidemiology Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study
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topic_title	Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study COPD (dpeaa)DE-He213 Geographical altitude (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Underdiagnosis (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213
topic	misc COPD misc Geographical altitude misc Risk factors misc Underdiagnosis misc Epidemiology
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title	Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study
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title_full	Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study
author_sort	Horner, Andreas
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author_browse	Horner, Andreas Soriano, Joan B. Puhan, Milo A. Studnicka, Michael Kaiser, Bernhard Vanfleteren, Lowie E. G. W. Gnatiuc, Louisa Burney, Peter Miravitlles, Marc García-Rio, Francisco Ancochea, Julio Menezes, Ana M. Perez-Padilla, Rogelio Montes de Oca, Maria Torres-Duque, Carlos A. Caballero, Andres González-García, Mauricio Buist, Sonia Flamm, Maria Lamprecht, Bernd
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title_sort	altitude and copd prevalence: analysis of the prepocol-platino-bold-epi-scan study
title_auth	Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study
abstract	Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. © The Author(s). 2017
abstractGer	Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. © The Author(s). 2017
abstract_unstemmed	Background COPD prevalence is highly variable and geographical altitude has been linked to it, yet with conflicting results. We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. However, high altitude itself was associated with an increased risk of undiagnosed COPD. © The Author(s). 2017
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title_short	Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study
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author2	Soriano, Joan B. Puhan, Milo A. Studnicka, Michael Kaiser, Bernhard Vanfleteren, Lowie E. G. W. Gnatiuc, Louisa Burney, Peter Miravitlles, Marc García-Rio, Francisco Ancochea, Julio Menezes, Ana M. Perez-Padilla, Rogelio Montes de Oca, Maria Torres-Duque, Carlos A. Caballero, Andres González-García, Mauricio Buist, Sonia Flamm, Maria Lamprecht, Bernd
author2Str	Soriano, Joan B. Puhan, Milo A. Studnicka, Michael Kaiser, Bernhard Vanfleteren, Lowie E. G. W. Gnatiuc, Louisa Burney, Peter Miravitlles, Marc García-Rio, Francisco Ancochea, Julio Menezes, Ana M. Perez-Padilla, Rogelio Montes de Oca, Maria Torres-Duque, Carlos A. Caballero, Andres González-García, Mauricio Buist, Sonia Flamm, Maria Lamprecht, Bernd
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We aimed to investigate this association, considering well known risk factors. Methods A pooled analysis of individual data from the PREPOCOL-PLATINO-BOLD-EPI-SCAN studies was used to disentangle the population effect of geographical altitude on COPD prevalence. Post-bronchodilator FEV1/FVC below the lower limit of normal defined airflow limitation consistent with COPD. High altitude was defined as >1500 m above sea level. Undiagnosed COPD was considered when participants had airflow limitation but did not report a prior diagnosis of COPD. Results Among 30,874 participants aged 56.1 ± 11.3 years from 44 sites worldwide, 55.8% were women, 49.6% never-smokers, and 12.9% (3978 subjects) were residing above 1500 m. COPD prevalence was significantly lower in participants living at high altitude with a prevalence of 8.5% compared to 9.9%, respectively (p < 0.005). However, known risk factors were significantly less frequent at high altitude. Hence, in the adjusted multivariate analysis, altitude itself had no significant influence on COPD prevalence. Living at high altitude, however, was associated with a significantly increased risk of undiagnosed COPD. Furthermore, subjects with airflow limitation living at high altitude reported significantly less respiratory symptoms compared to subjects residing at lower altitude. Conclusion Living at high altitude is not associated with a difference in COPD prevalence after accounting for individual risk factors. 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Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study

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