Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance.
Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to mea...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Straczkowski, Marek [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2003 |
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| Anmerkung: |
© Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
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| Übergeordnetes Werk: |
Enthalten in: Cardiovascular diabetology - London : BioMed Central, 2002, 2(2003), 1 vom: 16. Mai |
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| Übergeordnetes Werk: |
volume:2 ; year:2003 ; number:1 ; day:16 ; month:05 |
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| DOI / URN: |
10.1186/1475-2840-2-5 |
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| Katalog-ID: |
SPR02853364X |
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| 520 | |a Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). | ||
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| 650 | 4 | |a obesity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a impaired glucose tolerance |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kowalska, Irina |4 aut | |
| 700 | 1 | |a Nikolajuk, Agnieszka |4 aut | |
| 700 | 1 | |a Dzienis-Straczkowska, Stella |4 aut | |
| 700 | 1 | |a Szelachowska, Malgorzata |4 aut | |
| 700 | 1 | |a Kinalska, Ida |4 aut | |
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10.1186/1475-2840-2-5 doi (DE-627)SPR02853364X (SPR)1475-2840-2-5-e DE-627 ger DE-627 rakwb eng Straczkowski, Marek verfasserin aut Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). interleukin 8 (dpeaa)DE-He213 obesity (dpeaa)DE-He213 impaired glucose tolerance (dpeaa)DE-He213 Kowalska, Irina aut Nikolajuk, Agnieszka aut Dzienis-Straczkowska, Stella aut Szelachowska, Malgorzata aut Kinalska, Ida aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 2(2003), 1 vom: 16. Mai (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:2 year:2003 number:1 day:16 month:05 https://dx.doi.org/10.1186/1475-2840-2-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2003 1 16 05 |
| spelling |
10.1186/1475-2840-2-5 doi (DE-627)SPR02853364X (SPR)1475-2840-2-5-e DE-627 ger DE-627 rakwb eng Straczkowski, Marek verfasserin aut Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). interleukin 8 (dpeaa)DE-He213 obesity (dpeaa)DE-He213 impaired glucose tolerance (dpeaa)DE-He213 Kowalska, Irina aut Nikolajuk, Agnieszka aut Dzienis-Straczkowska, Stella aut Szelachowska, Malgorzata aut Kinalska, Ida aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 2(2003), 1 vom: 16. Mai (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:2 year:2003 number:1 day:16 month:05 https://dx.doi.org/10.1186/1475-2840-2-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2003 1 16 05 |
| allfields_unstemmed |
10.1186/1475-2840-2-5 doi (DE-627)SPR02853364X (SPR)1475-2840-2-5-e DE-627 ger DE-627 rakwb eng Straczkowski, Marek verfasserin aut Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). interleukin 8 (dpeaa)DE-He213 obesity (dpeaa)DE-He213 impaired glucose tolerance (dpeaa)DE-He213 Kowalska, Irina aut Nikolajuk, Agnieszka aut Dzienis-Straczkowska, Stella aut Szelachowska, Malgorzata aut Kinalska, Ida aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 2(2003), 1 vom: 16. Mai (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:2 year:2003 number:1 day:16 month:05 https://dx.doi.org/10.1186/1475-2840-2-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2003 1 16 05 |
| allfieldsGer |
10.1186/1475-2840-2-5 doi (DE-627)SPR02853364X (SPR)1475-2840-2-5-e DE-627 ger DE-627 rakwb eng Straczkowski, Marek verfasserin aut Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). interleukin 8 (dpeaa)DE-He213 obesity (dpeaa)DE-He213 impaired glucose tolerance (dpeaa)DE-He213 Kowalska, Irina aut Nikolajuk, Agnieszka aut Dzienis-Straczkowska, Stella aut Szelachowska, Malgorzata aut Kinalska, Ida aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 2(2003), 1 vom: 16. Mai (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:2 year:2003 number:1 day:16 month:05 https://dx.doi.org/10.1186/1475-2840-2-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2003 1 16 05 |
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10.1186/1475-2840-2-5 doi (DE-627)SPR02853364X (SPR)1475-2840-2-5-e DE-627 ger DE-627 rakwb eng Straczkowski, Marek verfasserin aut Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). interleukin 8 (dpeaa)DE-He213 obesity (dpeaa)DE-He213 impaired glucose tolerance (dpeaa)DE-He213 Kowalska, Irina aut Nikolajuk, Agnieszka aut Dzienis-Straczkowska, Stella aut Szelachowska, Malgorzata aut Kinalska, Ida aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 2(2003), 1 vom: 16. Mai (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:2 year:2003 number:1 day:16 month:05 https://dx.doi.org/10.1186/1475-2840-2-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2003 1 16 05 |
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Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. |
| abstract |
Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| abstractGer |
Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| abstract_unstemmed |
Background Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). Methods A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/$ m^{2} $), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. Results The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-$ 8_{OGTT} $) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-$ 8_{OGTT} $ was positively related to postload glucose and negatively to insulin sensitivity. Conclusion Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). © Straczkowski et al; licensee BioMed Central Ltd. 2003. This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
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| title_short |
Plasma interleukin 8 concentrations in obese subjects with impaired glucose tolerance. |
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https://dx.doi.org/10.1186/1475-2840-2-5 |
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Kowalska, Irina Nikolajuk, Agnieszka Dzienis-Straczkowska, Stella Szelachowska, Malgorzata Kinalska, Ida |
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Kowalska, Irina Nikolajuk, Agnieszka Dzienis-Straczkowska, Stella Szelachowska, Malgorzata Kinalska, Ida |
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