Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel str...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Miki, Takayuki [verfasserIn] Itoh, Takahito Sunaga, Daisuke Miura, Tetsuji

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Diabetes mellitus Infarct size Preconditioning Postconditioning

Anmerkung:	© Miki et al.; licensee BioMed Central Ltd. 2012

Übergeordnetes Werk:	Enthalten in: Cardiovascular diabetology - London : BioMed Central, 2002, 11(2012), 1 vom: 13. Juni
Übergeordnetes Werk:	volume:11 ; year:2012 ; number:1 ; day:13 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1475-2840-11-67

Katalog-ID:	SPR028539028

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allfields	10.1186/1475-2840-11-67 doi (DE-627)SPR028539028 (SPR)1475-2840-11-67-e DE-627 ger DE-627 rakwb eng Miki, Takayuki verfasserin aut Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Miki et al.; licensee BioMed Central Ltd. 2012 Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. Diabetes mellitus (dpeaa)DE-He213 Infarct size (dpeaa)DE-He213 Preconditioning (dpeaa)DE-He213 Postconditioning (dpeaa)DE-He213 Itoh, Takahito aut Sunaga, Daisuke aut Miura, Tetsuji aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 11(2012), 1 vom: 13. Juni (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:11 year:2012 number:1 day:13 month:06 https://dx.doi.org/10.1186/1475-2840-11-67 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1 13 06
spelling	10.1186/1475-2840-11-67 doi (DE-627)SPR028539028 (SPR)1475-2840-11-67-e DE-627 ger DE-627 rakwb eng Miki, Takayuki verfasserin aut Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Miki et al.; licensee BioMed Central Ltd. 2012 Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. Diabetes mellitus (dpeaa)DE-He213 Infarct size (dpeaa)DE-He213 Preconditioning (dpeaa)DE-He213 Postconditioning (dpeaa)DE-He213 Itoh, Takahito aut Sunaga, Daisuke aut Miura, Tetsuji aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 11(2012), 1 vom: 13. Juni (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:11 year:2012 number:1 day:13 month:06 https://dx.doi.org/10.1186/1475-2840-11-67 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1 13 06
allfields_unstemmed	10.1186/1475-2840-11-67 doi (DE-627)SPR028539028 (SPR)1475-2840-11-67-e DE-627 ger DE-627 rakwb eng Miki, Takayuki verfasserin aut Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Miki et al.; licensee BioMed Central Ltd. 2012 Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. Diabetes mellitus (dpeaa)DE-He213 Infarct size (dpeaa)DE-He213 Preconditioning (dpeaa)DE-He213 Postconditioning (dpeaa)DE-He213 Itoh, Takahito aut Sunaga, Daisuke aut Miura, Tetsuji aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 11(2012), 1 vom: 13. Juni (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:11 year:2012 number:1 day:13 month:06 https://dx.doi.org/10.1186/1475-2840-11-67 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1 13 06
allfieldsGer	10.1186/1475-2840-11-67 doi (DE-627)SPR028539028 (SPR)1475-2840-11-67-e DE-627 ger DE-627 rakwb eng Miki, Takayuki verfasserin aut Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Miki et al.; licensee BioMed Central Ltd. 2012 Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. Diabetes mellitus (dpeaa)DE-He213 Infarct size (dpeaa)DE-He213 Preconditioning (dpeaa)DE-He213 Postconditioning (dpeaa)DE-He213 Itoh, Takahito aut Sunaga, Daisuke aut Miura, Tetsuji aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 11(2012), 1 vom: 13. Juni (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:11 year:2012 number:1 day:13 month:06 https://dx.doi.org/10.1186/1475-2840-11-67 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1 13 06
allfieldsSound	10.1186/1475-2840-11-67 doi (DE-627)SPR028539028 (SPR)1475-2840-11-67-e DE-627 ger DE-627 rakwb eng Miki, Takayuki verfasserin aut Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Miki et al.; licensee BioMed Central Ltd. 2012 Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. Diabetes mellitus (dpeaa)DE-He213 Infarct size (dpeaa)DE-He213 Preconditioning (dpeaa)DE-He213 Postconditioning (dpeaa)DE-He213 Itoh, Takahito aut Sunaga, Daisuke aut Miura, Tetsuji aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 11(2012), 1 vom: 13. Juni (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:11 year:2012 number:1 day:13 month:06 https://dx.doi.org/10.1186/1475-2840-11-67 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2012 1 13 06
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sourceStr	Enthalten in Cardiovascular diabetology 11(2012), 1 vom: 13. Juni volume:11 year:2012 number:1 day:13 month:06
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topic_facet	Diabetes mellitus Infarct size Preconditioning Postconditioning
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authorswithroles_txt_mv	Miki, Takayuki @@aut@@ Itoh, Takahito @@aut@@ Sunaga, Daisuke @@aut@@ Miura, Tetsuji @@aut@@
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topic_title	Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning Diabetes mellitus (dpeaa)DE-He213 Infarct size (dpeaa)DE-He213 Preconditioning (dpeaa)DE-He213 Postconditioning (dpeaa)DE-He213
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title	Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
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title_full	Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
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author_browse	Miki, Takayuki Itoh, Takahito Sunaga, Daisuke Miura, Tetsuji
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title_sort	effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
title_auth	Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
abstract	Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. © Miki et al.; licensee BioMed Central Ltd. 2012
abstractGer	Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. © Miki et al.; licensee BioMed Central Ltd. 2012
abstract_unstemmed	Abstract In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts. © Miki et al.; licensee BioMed Central Ltd. 2012
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title_short	Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
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Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

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