Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias

Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective r...
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Autor*in:	Weidner, Kathrin [verfasserIn] Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Hoppner, Jorge El-Battrawy, Ibrahim Mashayekhi, Kambis Weiß, Christel Borggrefe, Martin Akin, Ibrahim

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Ventricular tachyarrhythmias Diabetes Mortality Death Prognosis Sudden cardiac death

Anmerkung:	© The Author(s) 2018

Übergeordnetes Werk:	Enthalten in: Cardiovascular diabetology - London : BioMed Central, 2002, 17(2018), 1 vom: 10. Sept.
Übergeordnetes Werk:	volume:17 ; year:2018 ; number:1 ; day:10 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12933-018-0768-y

Katalog-ID:	SPR028550609

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100	1		\|a Weidner, Kathrin \|e verfasserin \|4 aut
245	1	0	\|a Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
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520			\|a Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission.
650		4	\|a Ventricular tachyarrhythmias \|7 (dpeaa)DE-He213
650		4	\|a Diabetes \|7 (dpeaa)DE-He213
650		4	\|a Mortality \|7 (dpeaa)DE-He213
650		4	\|a Death \|7 (dpeaa)DE-He213
650		4	\|a Prognosis \|7 (dpeaa)DE-He213
650		4	\|a Sudden cardiac death \|7 (dpeaa)DE-He213
700	1		\|a Behnes, Michael \|0 (orcid)0000-0001-5970-0093 \|4 aut
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700	1		\|a Reichelt, Thomas \|4 aut
700	1		\|a Ellguth, Dominik \|4 aut
700	1		\|a Engelke, Niko \|4 aut
700	1		\|a Hoppner, Jorge \|4 aut
700	1		\|a El-Battrawy, Ibrahim \|4 aut
700	1		\|a Mashayekhi, Kambis \|4 aut
700	1		\|a Weiß, Christel \|4 aut
700	1		\|a Borggrefe, Martin \|4 aut
700	1		\|a Akin, Ibrahim \|4 aut
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allfields	10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09
spelling	10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09
allfields_unstemmed	10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09
allfieldsGer	10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09
allfieldsSound	10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09
language	English
source	Enthalten in Cardiovascular diabetology 17(2018), 1 vom: 10. Sept. volume:17 year:2018 number:1 day:10 month:09
sourceStr	Enthalten in Cardiovascular diabetology 17(2018), 1 vom: 10. Sept. volume:17 year:2018 number:1 day:10 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Ventricular tachyarrhythmias Diabetes Mortality Death Prognosis Sudden cardiac death
isfreeaccess_bool	true
container_title	Cardiovascular diabetology
authorswithroles_txt_mv	Weidner, Kathrin @@aut@@ Behnes, Michael @@aut@@ Schupp, Tobias @@aut@@ Rusnak, Jonas @@aut@@ Reiser, Linda @@aut@@ Bollow, Armin @@aut@@ Taton, Gabriel @@aut@@ Reichelt, Thomas @@aut@@ Ellguth, Dominik @@aut@@ Engelke, Niko @@aut@@ Hoppner, Jorge @@aut@@ El-Battrawy, Ibrahim @@aut@@ Mashayekhi, Kambis @@aut@@ Weiß, Christel @@aut@@ Borggrefe, Martin @@aut@@ Akin, Ibrahim @@aut@@
publishDateDaySort_date	2018-09-10T00:00:00Z
hierarchy_top_id	356593665
id	SPR028550609
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR028550609</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520012823.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12933-018-0768-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR028550609</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12933-018-0768-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Weidner, Kathrin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2018</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. 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author	Weidner, Kathrin
spellingShingle	Weidner, Kathrin misc Ventricular tachyarrhythmias misc Diabetes misc Mortality misc Death misc Prognosis misc Sudden cardiac death Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
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topic_title	Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213
topic	misc Ventricular tachyarrhythmias misc Diabetes misc Mortality misc Death misc Prognosis misc Sudden cardiac death
topic_unstemmed	misc Ventricular tachyarrhythmias misc Diabetes misc Mortality misc Death misc Prognosis misc Sudden cardiac death
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title	Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
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title_full	Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
author_sort	Weidner, Kathrin
journal	Cardiovascular diabetology
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author_browse	Weidner, Kathrin Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Hoppner, Jorge El-Battrawy, Ibrahim Mashayekhi, Kambis Weiß, Christel Borggrefe, Martin Akin, Ibrahim
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title_sort	type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
title_auth	Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
abstract	Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. © The Author(s) 2018
abstractGer	Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. © The Author(s) 2018
abstract_unstemmed	Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. © The Author(s) 2018
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title_short	Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
url	https://dx.doi.org/10.1186/s12933-018-0768-y
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author2	Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Hoppner, Jorge El-Battrawy, Ibrahim Mashayekhi, Kambis Weiß, Christel Borggrefe, Martin Akin, Ibrahim
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up_date	2024-07-03T20:10:19.758Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR028550609</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520012823.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12933-018-0768-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR028550609</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12933-018-0768-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Weidner, Kathrin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2018</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. 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Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias

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