Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective r...
Ausführliche Beschreibung
Autor*in: |
Weidner, Kathrin [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2018 |
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Übergeordnetes Werk: |
Enthalten in: Cardiovascular diabetology - London : BioMed Central, 2002, 17(2018), 1 vom: 10. Sept. |
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Übergeordnetes Werk: |
volume:17 ; year:2018 ; number:1 ; day:10 ; month:09 |
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DOI / URN: |
10.1186/s12933-018-0768-y |
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Katalog-ID: |
SPR028550609 |
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245 | 1 | 0 | |a Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
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520 | |a Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. | ||
650 | 4 | |a Ventricular tachyarrhythmias |7 (dpeaa)DE-He213 | |
650 | 4 | |a Diabetes |7 (dpeaa)DE-He213 | |
650 | 4 | |a Mortality |7 (dpeaa)DE-He213 | |
650 | 4 | |a Death |7 (dpeaa)DE-He213 | |
650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
650 | 4 | |a Sudden cardiac death |7 (dpeaa)DE-He213 | |
700 | 1 | |a Behnes, Michael |0 (orcid)0000-0001-5970-0093 |4 aut | |
700 | 1 | |a Schupp, Tobias |4 aut | |
700 | 1 | |a Rusnak, Jonas |4 aut | |
700 | 1 | |a Reiser, Linda |4 aut | |
700 | 1 | |a Bollow, Armin |4 aut | |
700 | 1 | |a Taton, Gabriel |4 aut | |
700 | 1 | |a Reichelt, Thomas |4 aut | |
700 | 1 | |a Ellguth, Dominik |4 aut | |
700 | 1 | |a Engelke, Niko |4 aut | |
700 | 1 | |a Hoppner, Jorge |4 aut | |
700 | 1 | |a El-Battrawy, Ibrahim |4 aut | |
700 | 1 | |a Mashayekhi, Kambis |4 aut | |
700 | 1 | |a Weiß, Christel |4 aut | |
700 | 1 | |a Borggrefe, Martin |4 aut | |
700 | 1 | |a Akin, Ibrahim |4 aut | |
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10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09 |
spelling |
10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09 |
allfields_unstemmed |
10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09 |
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10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09 |
allfieldsSound |
10.1186/s12933-018-0768-y doi (DE-627)SPR028550609 (SPR)s12933-018-0768-y-e DE-627 ger DE-627 rakwb eng Weidner, Kathrin verfasserin aut Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 Behnes, Michael (orcid)0000-0001-5970-0093 aut Schupp, Tobias aut Rusnak, Jonas aut Reiser, Linda aut Bollow, Armin aut Taton, Gabriel aut Reichelt, Thomas aut Ellguth, Dominik aut Engelke, Niko aut Hoppner, Jorge aut El-Battrawy, Ibrahim aut Mashayekhi, Kambis aut Weiß, Christel aut Borggrefe, Martin aut Akin, Ibrahim aut Enthalten in Cardiovascular diabetology London : BioMed Central, 2002 17(2018), 1 vom: 10. Sept. (DE-627)356593665 (DE-600)2093769-6 1475-2840 nnns volume:17 year:2018 number:1 day:10 month:09 https://dx.doi.org/10.1186/s12933-018-0768-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2018 1 10 09 |
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Enthalten in Cardiovascular diabetology 17(2018), 1 vom: 10. Sept. volume:17 year:2018 number:1 day:10 month:09 |
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Ventricular tachyarrhythmias Diabetes Mortality Death Prognosis Sudden cardiac death |
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Cardiovascular diabetology |
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Weidner, Kathrin @@aut@@ Behnes, Michael @@aut@@ Schupp, Tobias @@aut@@ Rusnak, Jonas @@aut@@ Reiser, Linda @@aut@@ Bollow, Armin @@aut@@ Taton, Gabriel @@aut@@ Reichelt, Thomas @@aut@@ Ellguth, Dominik @@aut@@ Engelke, Niko @@aut@@ Hoppner, Jorge @@aut@@ El-Battrawy, Ibrahim @@aut@@ Mashayekhi, Kambis @@aut@@ Weiß, Christel @@aut@@ Borggrefe, Martin @@aut@@ Akin, Ibrahim @@aut@@ |
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2018-09-10T00:00:00Z |
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Weidner, Kathrin |
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Weidner, Kathrin misc Ventricular tachyarrhythmias misc Diabetes misc Mortality misc Death misc Prognosis misc Sudden cardiac death Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
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Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias Ventricular tachyarrhythmias (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Death (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Sudden cardiac death (dpeaa)DE-He213 |
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Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
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Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
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Cardiovascular diabetology |
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Weidner, Kathrin Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Hoppner, Jorge El-Battrawy, Ibrahim Mashayekhi, Kambis Weiß, Christel Borggrefe, Martin Akin, Ibrahim |
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type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
title_auth |
Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
abstract |
Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. © The Author(s) 2018 |
abstractGer |
Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. © The Author(s) 2018 |
abstract_unstemmed |
Objectives The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years. Results In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias. Conclusion Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission. © The Author(s) 2018 |
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Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias |
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Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Bollow, Armin Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Hoppner, Jorge El-Battrawy, Ibrahim Mashayekhi, Kambis Weiß, Christel Borggrefe, Martin Akin, Ibrahim |
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score |
7.399047 |