Novel molecular imaging platform for monitoring oncological kinases

Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion'...
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Autor*in:	Nyati, Shyam [verfasserIn] Ross, Brian D Rehemtulla, Alnawaz Bhojani, Mahaveer S

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Molecular Imaging Firefly Luciferase Complementation Assay Gaussia Luciferase Bioluminescence Activity

Anmerkung:	© Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Cancer cell international - London : BioMed Central, 2001, 10(2010), 1 vom: 08. Juli
Übergeordnetes Werk:	volume:10 ; year:2010 ; number:1 ; day:08 ; month:07

Links:	Volltext

DOI / URN:	10.1186/1475-2867-10-23

Katalog-ID:	SPR028580877

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allfields	10.1186/1475-2867-10-23 doi (DE-627)SPR028580877 (SPR)1475-2867-10-23-e DE-627 ger DE-627 rakwb eng Nyati, Shyam verfasserin aut Novel molecular imaging platform for monitoring oncological kinases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. Molecular Imaging (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Complementation Assay (dpeaa)DE-He213 Gaussia Luciferase (dpeaa)DE-He213 Bioluminescence Activity (dpeaa)DE-He213 Ross, Brian D aut Rehemtulla, Alnawaz aut Bhojani, Mahaveer S aut Enthalten in Cancer cell international London : BioMed Central, 2001 10(2010), 1 vom: 08. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:10 year:2010 number:1 day:08 month:07 https://dx.doi.org/10.1186/1475-2867-10-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 08 07
spelling	10.1186/1475-2867-10-23 doi (DE-627)SPR028580877 (SPR)1475-2867-10-23-e DE-627 ger DE-627 rakwb eng Nyati, Shyam verfasserin aut Novel molecular imaging platform for monitoring oncological kinases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. Molecular Imaging (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Complementation Assay (dpeaa)DE-He213 Gaussia Luciferase (dpeaa)DE-He213 Bioluminescence Activity (dpeaa)DE-He213 Ross, Brian D aut Rehemtulla, Alnawaz aut Bhojani, Mahaveer S aut Enthalten in Cancer cell international London : BioMed Central, 2001 10(2010), 1 vom: 08. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:10 year:2010 number:1 day:08 month:07 https://dx.doi.org/10.1186/1475-2867-10-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 08 07
allfields_unstemmed	10.1186/1475-2867-10-23 doi (DE-627)SPR028580877 (SPR)1475-2867-10-23-e DE-627 ger DE-627 rakwb eng Nyati, Shyam verfasserin aut Novel molecular imaging platform for monitoring oncological kinases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. Molecular Imaging (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Complementation Assay (dpeaa)DE-He213 Gaussia Luciferase (dpeaa)DE-He213 Bioluminescence Activity (dpeaa)DE-He213 Ross, Brian D aut Rehemtulla, Alnawaz aut Bhojani, Mahaveer S aut Enthalten in Cancer cell international London : BioMed Central, 2001 10(2010), 1 vom: 08. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:10 year:2010 number:1 day:08 month:07 https://dx.doi.org/10.1186/1475-2867-10-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 08 07
allfieldsGer	10.1186/1475-2867-10-23 doi (DE-627)SPR028580877 (SPR)1475-2867-10-23-e DE-627 ger DE-627 rakwb eng Nyati, Shyam verfasserin aut Novel molecular imaging platform for monitoring oncological kinases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. Molecular Imaging (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Complementation Assay (dpeaa)DE-He213 Gaussia Luciferase (dpeaa)DE-He213 Bioluminescence Activity (dpeaa)DE-He213 Ross, Brian D aut Rehemtulla, Alnawaz aut Bhojani, Mahaveer S aut Enthalten in Cancer cell international London : BioMed Central, 2001 10(2010), 1 vom: 08. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:10 year:2010 number:1 day:08 month:07 https://dx.doi.org/10.1186/1475-2867-10-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 08 07
allfieldsSound	10.1186/1475-2867-10-23 doi (DE-627)SPR028580877 (SPR)1475-2867-10-23-e DE-627 ger DE-627 rakwb eng Nyati, Shyam verfasserin aut Novel molecular imaging platform for monitoring oncological kinases 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. Molecular Imaging (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Complementation Assay (dpeaa)DE-He213 Gaussia Luciferase (dpeaa)DE-He213 Bioluminescence Activity (dpeaa)DE-He213 Ross, Brian D aut Rehemtulla, Alnawaz aut Bhojani, Mahaveer S aut Enthalten in Cancer cell international London : BioMed Central, 2001 10(2010), 1 vom: 08. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:10 year:2010 number:1 day:08 month:07 https://dx.doi.org/10.1186/1475-2867-10-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1 08 07
language	English
source	Enthalten in Cancer cell international 10(2010), 1 vom: 08. Juli volume:10 year:2010 number:1 day:08 month:07
sourceStr	Enthalten in Cancer cell international 10(2010), 1 vom: 08. Juli volume:10 year:2010 number:1 day:08 month:07
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topic_facet	Molecular Imaging Firefly Luciferase Complementation Assay Gaussia Luciferase Bioluminescence Activity
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container_title	Cancer cell international
authorswithroles_txt_mv	Nyati, Shyam @@aut@@ Ross, Brian D @@aut@@ Rehemtulla, Alnawaz @@aut@@ Bhojani, Mahaveer S @@aut@@
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author	Nyati, Shyam
spellingShingle	Nyati, Shyam misc Molecular Imaging misc Firefly Luciferase misc Complementation Assay misc Gaussia Luciferase misc Bioluminescence Activity Novel molecular imaging platform for monitoring oncological kinases
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topic_title	Novel molecular imaging platform for monitoring oncological kinases Molecular Imaging (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Complementation Assay (dpeaa)DE-He213 Gaussia Luciferase (dpeaa)DE-He213 Bioluminescence Activity (dpeaa)DE-He213
topic	misc Molecular Imaging misc Firefly Luciferase misc Complementation Assay misc Gaussia Luciferase misc Bioluminescence Activity
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title	Novel molecular imaging platform for monitoring oncological kinases
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title_sort	novel molecular imaging platform for monitoring oncological kinases
title_auth	Novel molecular imaging platform for monitoring oncological kinases
abstract	Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysregulated kinases and associated changes in signaling cascade received the lion's share of scientific attention and have been under extensive investigations with goal of targeting them for anti-cancer therapy. Discovery of new drugs is immensely facilitated by molecular imaging technology which enables non-invasive, real time, dynamic imaging and quantification of kinase activity. Here, we review recent development of novel kinase reporters based on conformation dependent complementation of firefly luciferase to monitor kinase activity. Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions. © Nyati et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Novel molecular imaging platform for monitoring oncological kinases
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Novel molecular imaging platform for monitoring oncological kinases

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